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The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan Hailin Tang lewei zhu Yutian Zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

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Effect of radical scavenger on electrical tree in cross-linked polyethylene with large harmonic superimposed DC voltage

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High Voltage 2023年第4期8卷 739-748页

作者： lewei zhu Zhonglei Li Kai Hou Maritime College Tianjin Key Laboratory for Control Theory and Applications in Complicated Industry SystemsTianjin University of TechnologyTianjinChina Key Laboratory of Smart Grid of Ministry of Education School of Electrical and Information EngineeringTianjin UniversityTianjinChina

In this study,three kinds of radical scavenger Chimassorb 944,Tinuvin 622,and Tinuvin 770 are used to suppress the growth of electrical trees in cross-linked polyethylene(XLPE)with transient superimposed voltage under the temperature *** tree morphology,tree length,accumulated damage,and time to breakdown are used to investigate the effect of radical scavenger on the electrical treeing *** is found that under the temperature gradient caused by the temperature rise on the high voltage side,only Tinuvin 622 can always suppress the electrical tree as the temperature gradient *** the temperature gradient caused by the temperature rise on the ground side,the three radical scavengers can all suppress the electrical *** breakdown of electrical tree exhibits the strong DC polarity ***,energy levels of these three radical scavengers are calculated through quantum chemistry,and the results indicate that radical scavengers have greater electron affinity,smaller ionisation energy,and smaller energy gap than *** to the surface potential decay test results at 60℃,it is found that all three radical scavengers can introduce deep *** different performances of radical scavengers under different temperature gradients and voltages are determined by the trap distribution characteristics,the molecular structure and chemical reaction of the additives *** is concluded that Tinuvin 622 has potential for use in high voltage direct current XLPE cable application.

关键词： radical electrical harmonic

Impact Increment Based Hybrid Reliability Assessment Method for Transmission Systems

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 317-328页

作者： Yunkai Lei Yeguang Sun Kai Hou Pei Zhang lewei zhu Xiaoxi Yang Xiaonan Liu State Grid Sichuan Economic Research Institute Chengdu610000 China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China State Grid Customer Service Center Tianjin 300072China School of Electrical and Automation Engineering East China Jiaotong UnviersityNanchang 330052China Maritime College Tianjin University of TechnologyTianjin 300384China College of Economics and Management Southwest Petroleum UniversityChengdu 610000China State Grid Tianjin Electric Power Research Institute Tianjin 300072China

This paper proposes an impact-increment-based hybrid(IIHybrid)reliability assessment approach for power transmission *** proposed approach integrates the advantages of the impact-increment-based state enumeration method(IISE)and impact-increment-based Monte Carlo simulation(IIMC)to improve computational efficiency and *** IISE can efficiently assess the impacts of low-order *** accuracy is,however,sacrificed as highorder contingencies are usually *** IIMC is more suitable for large-scale contingency spaces compared with IISE,although the calculation process is *** this paper,the proposed IIHybrid takes advantage of its strengths while avoiding its *** IISE and the IIMC are applied to lower and higher contingency spaces *** high-order contingencies elimination technique proposed in our previous studies is still applicable to the *** addition,efficiency can be controlled by modifying the preset parameters to adapt to various *** studies are performed on the IEEE 118-bus test system and PEGASE *** results show that the proposed approach is more efficient and practicable than traditional methods.

关键词： Hybrid method impact-increment reliability assessment transmission system

Effect of High Fiber Diet Combined with Rope Skipping on Gut Microbiota and Cognitive Function in Undergraduates: a 12-week Randomized Control Trial

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Effect of High Fiber Diet Combined with Rope Skipping on Gut...

支管轴压下高强钢圆管X形节点的承载力计算公式

中国营养学会第十五届全国营养科学大会

作者： lewei zhu Miao Wu Yanna zhu School of Public Health Sun Yat-sen University

Previous studies have suggested that high fiber diet and aerobic exercise may effectively improve cognitive function by altering the gut microbiota of the host. However, evidence for the effects of combined high fiber diet and aerobic exercise interventions on cognitive function in humans remains unclear. The benefits of high fiber diet and aerobic exercise on human gut microbiota as well as the relationship between gut microbiota and cognitive function is still uncertain. This study was designed to investigate the effect of high fiber diet, rope skipping, and high fiber diet combined rope skipping on the gut microbiota and cognitive function in undergraduates. Methods In this 12-week parallel-design randomized control trial performed between September 2020 and December 2020 in Sun Yat-sen University, Guangzhou, China, 128 undergraduates who met the inclusion and exclusion criteria(no mental disease, no major changes occurred recently, no vital organ serious disease or movement disorders, no food taboos or food allergies, haven t taken drugs that affect cognition, willing to cooperate and voluntarily sign informed consent) were recruited and randomly assigned into one of the 4 groups: high-fiber diet(HF) group, ropeskipping(RS) group, high-fiber diet with rope-skipping(HF-RS) group and control group(n=32, respectively). The HF group was asked to consume at least 20 grams dietary fiber per day from diverse recommended food rich in dietary fiber including whole grains, fruits, and vegetables. The RS group was asked to jump rope 2000 a time, three times a week under the guidance of the professional sports teacher. The HF-RS group combined the interventions of the HF group and the RS group. The control group kept their own diet and exercise habits without guidance. All the participants were followed up regularly and recorded their diet or/and exercise situation. The measure of cognitive function focuses on the individual s self-evaluation of memory and executive functio

关键词： students high fiber diet exercise cognitive function memory gut microbiota

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同济大学学报（自然科学版） 2024年第1期52卷 49-58,85页

作者：宁鹏童乐为朱小利同济大学土木工程防灾国家重点实验室上海200092 上海中侨职业技术大学建筑工程学院上海201514

研究了支管受压的Q460、Q690、Q960高强钢圆管X形节点的静力性能。采用经试验数据验证的有限元模型进行节点有限元参数分析,研究高强钢牌号、支管与主管外径之比(β)、主管外径与其管壁厚度之比(2γ)、主管轴向应力比(n)对节点性能的影... 详细信息

研究了支管受压的Q460、Q690、Q960高强钢圆管X形节点的静力性能。采用经试验数据验证的有限元模型进行节点有限元参数分析,研究高强钢牌号、支管与主管外径之比(β)、主管外径与其管壁厚度之比(2γ)、主管轴向应力比(n)对节点性能的影响;与有限元参数分析和文献中试验结果对比,评价我国钢结构设计标准计算公式的适用性。结果表明,节点发生主管塑性破坏,节点承载力多由主管局部变形限值(3%主管外径)确定;多数情况下钢结构设计标准计算公式高估了高强钢圆管X形节点的承载力;主管受到压力或较大拉力时均会降低节点承载力。最后,针对不同钢材牌号的圆管X形节点给出了建议的2γ范围。基于主管塑性破坏,提出了考虑高强钢屈服强度、主管拉压效应的圆管X形节点承载力计算公式。

关键词：高强钢系列圆管X形节点有限元分析主管拉压效应承载力

含高比例可再生能源的电力系统运行可靠性解析评估方法综述

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高电压技术 2023年第7期49卷 2697-2710页

作者：侯恺刘泽宇贾宏杰穆云飞朱乐为曲嘉伟天津大学智能电网教育部重点实验室天津300072 天津理工大学海运学院天津300384

随着“双碳”目标的推进,高比例可再生能源广泛接入,电力系统呈现出不确定性因素多、源荷变化快、多重随机性强等特点,给电网的安全稳定运行带来了新的挑战。解析法是最常用的运行可靠性评估方法之一,具有数学模型清晰、计算效率稳定、... 详细信息

随着“双碳”目标的推进,高比例可再生能源广泛接入,电力系统呈现出不确定性因素多、源荷变化快、多重随机性强等特点,给电网的安全稳定运行带来了新的挑战。解析法是最常用的运行可靠性评估方法之一,具有数学模型清晰、计算效率稳定、枚举状态关系明确等优势,有助于保障电力能源的安全可靠供应。从电力系统运行可靠性的概念和评估流程出发,归纳亟待解决的问题。在此基础上,从可靠性评估效率提升、考虑极端灾害的不确定性建模和序贯解析评估3个方面归纳了现有研究成果及其存在的不足。最后,展望了含高比例可再生能源的电力系统运行可靠性解析评估方法的未来研究方向。

关键词：高比例可再生能源新型电力系统运行可靠性评估解析法模型驱动数据驱动

Digitally Controlled Boost PFC Converters Operating with Large Scale Load Fluctuations

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Transactions of Tianjin University 2014年第4期20卷 292-298页

作者：刘艳丽王清龙王宇翠张烨朱乐为 School of Electrical Engineering and Automation Tianjin University

When boost power factor correction(PFC) circuit works with large scale load fluctuations, it is easy to cause a higher total harmonic distortion and a lower power factor because of traditional controllers and inductor current mode. To solve this problem, this paper proposes a PFC control system, which can operate with load fluctuations up to 1 000 W by using duty cycle feed-forward control theory to achieve smooth switching mode. The duty cycles in the next period of the control system are pre-estimated in the current cycle, which enhances the speeds of AD samplers and switching frequency, and reduces the cost and volume of the equipment to some extent. Introductions of system decoupling and feed-forward of input-voltage greatly improve the system performance. Both theoretical simulation and experimental results prove the advantage of the proposed scheme.

关键词： PFC 升压式负载数字控制转换器功率因数校正控制系统电路工作原理

基于有限差分扩展卡尔曼滤波的锂离子电池SOC估计

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电工技术学报 2014年第1期29卷 221-228页

作者：刘艳莉戴胜程泽朱乐为天津大学电气与自动化工程学院天津300072

锂离子电池荷电状态的快速准确估计是电池管理系统的关键技术。针对锂离子电池这一动态非线性系统,以二阶RC等效电路模型为基础,采用递推最小二乘法估算模型参数,运用有限差分扩展卡尔曼滤波算法对电池荷电状态进行估算。仿真结果表明,... 详细信息

锂离子电池荷电状态的快速准确估计是电池管理系统的关键技术。针对锂离子电池这一动态非线性系统,以二阶RC等效电路模型为基础,采用递推最小二乘法估算模型参数,运用有限差分扩展卡尔曼滤波算法对电池荷电状态进行估算。仿真结果表明,该模型能较好地体现电池的动态特性,有限差分扩展卡尔曼滤波算法在估算过程中能保持很好的精度,并可以有效地减小由模型误差引入的荷电状态估计误差。

关键词：锂离子电池荷电状态参数辨识有限差分扩展卡尔曼滤波

一流专业建设背景下船舶电气实验教学改革探索

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天津航海 2023年第3期 56-58页

作者：朱乐为李雷斌魏鹏韩廷选天津理工大学海运学院天津300384

在建设国家一流本科专业的过程中,需要强化学生实验创新能力,提高实验教学质量和实践育人水平。文章通过对船舶电气实验进行改革探索,利用微视频、模拟器、VR仿真技术和DMSCTS学习软件等创新教学方式与技术,实现课前预习、课中思考、课... 详细信息

在建设国家一流本科专业的过程中,需要强化学生实验创新能力,提高实验教学质量和实践育人水平。文章通过对船舶电气实验进行改革探索,利用微视频、模拟器、VR仿真技术和DMSCTS学习软件等创新教学方式与技术,实现课前预习、课中思考、课后总结三个过程,打造更加专题化和开放式的航海类实验教学资源,促进航海类教育专业发展,进一步提高学生实践能力,激发学生创新思维。

关键词：船舶电气实验改革微视频