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Multifunctional Polymer-Protein Conjugates Generated by Multicomponent Reactions

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Chinese Journal of Chemistry 2021年第8期39卷 2287-2295页

作者： Tengfei Mao Chongyu Zhu lei tao State Key Laboratory of NBC Protection for Civilian Beijing 102205China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Department of Materials Science Fudan UniversityShanghai 200433China

Recently,multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions(MCRs).In this mini-review,current progress in the generation of multifuncti onal polymers with protei n-reactive groups via MCRs is *** mult functional polymers react with model therapeutic proteins,forming multifunctional polymer-protein conjugates,which are prototypes of sophisticated theranostic agents and antibacterial vaccine *** comparison with the traditional multi-step synthesis,the preparation of multifunctional polymers for protein conjugation through MCRs is straightforward and *** to these properties,MCRs have the potential to become a new general strategy to achieve polymer-protein conjugates for biological and medical applications.

关键词： Protein modifications Conjugation Poly(ethylene glycol)(PEG) Multicomponent reactions Polymers

Power-law statistics of synchronous transition in inhibitory neuronal networks

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Chinese Physics B 2022年第8期31卷 310-316页

作者： lei tao Sheng-Jun Wang School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China

We investigate the relationship between the synchronous transition and the power law behavior in spiking networks which are composed of inhibitory neurons and balanced by dc current. In the region of the synchronous transition, the avalanche size and duration distribution obey a power law distribution. We demonstrate the robustness of the power law for event sizes at different parameters and multiple time scales. Importantly, the exponent of the event size and duration distribution can satisfy the critical scaling relation. By changing the network structure parameters in the parameter region of transition, quasicriticality is observed, that is, critical exponents depart away from the criticality while still hold approximately to a dynamical scaling relation. The results suggest that power law statistics can emerge in networks composed of inhibitory neurons when the networks are balanced by external driving signal.

关键词： power-law inhibitory synchronization neuronal networks

State of art on energy management strategy for hybrid-powered unmanned aerial vehicle

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Chinese Journal of Aeronautics 2019年第6期32卷 1488-1503页

作者： tao lei Zhou YANG Zicun LIN Xiaobin ZHANG School of Automation Northwestern Polytechnic UniversityXi’an 710129China Key Laboratory of Aircraft Electric Propulsion Technology Ministry of Industry and Information Technology of ChinaXi’an 710129China

New energy sources such as solar energy and hydrogen energy have been applied to the Unmanned Aerial Vehicle(UAV), which could be formed as the hybrid power sources due to the requirement of miniaturization, lightweight, and environmental protection issue for UAV. Hybrid electrical propulsion technology has been used in UAV and it further enforces this trend for the evolution to the Hybrid-Powered System(HPS). In order to realize long endurance flight mission and improve the energy efficiency of UAV, many researching works are focused on the Energy Management Strategy(EMS) of the HPS with digital simulation, ground demonstration platforms and a few flight tests for the UAV in recent years. energy management strategy, in which off-line or on-line control algorithms acted as the core part, could optimize dynamic electrical power distribution further and directly affect the efficiency and fuel economy of hybrid-powered system *** order to give the guideline for this emerging technology for UAV, this paper presents a review of the topic highlighting energy optimal management strategies of UAV. The characteristics of typical new energy sources applied in UAV are summarized firstly, and then the classification and analysis of the architecture for hybrid power systems in UAV are presented. In the context of new energy sources and configuration of energy system, a comprehensive comparison and analysis for the state of art of EMS are presented, and the various levels of complexity and accuracy of EMS are considered in terms of real time, computational burden and optimization performance based on the optimal control and operational modes of UAV. Finally, the tendency and challenges of energy management strategy applied to the UAV have been forecasted.

关键词： Energy management strategy(EMS) Hybrid power system(HPS) New energy sources Optimization algorithms UAV

Dual-modal Physiological Feature Fusion-based Sleep Recognition Using CFS and RF Algorithm

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International Journal of Automation and computing 2019年第3期16卷 286-296页

作者： Bing-tao Zhang Xiao-Peng Wang Yu Shen tao lei School of Electronic and Information Engineering Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Opto-technology and Intelligent Conrtol Ministry of Education Lanzhou Jiaotong UniverstiyLanzhou 730070China School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China College of Electronical and Information Engineering Shaanxi University of Science and TechnologyXi'an 710021China

Research has demonstrated a significant overlap between sleep issues and other medical *** this paper,we consider mild difficulty in falling asleep(MDFA).Recognition of MDFA has the potential to assist in the provision of appropriate treatment plans for both sleep issues and related medical *** issue in the diagnosis of MDFA lies in *** address this issue,a decision support tool based on dual-modal physiological feature fusion which is able to automatically identify MDFA is proposed in this *** attention is given to the problem of how to extract candidate features and fuse dual-modal *** the identification of the optimal feature set,this study considers the correlations between each feature and class and evaluates correlations between the inter-modality ***,the recognition accuracy was measured using 10-fold cross *** experimental results for our method demonstrate improved *** highest recognition rate of MDFA using the optimal feature set can reach 96.22%.Based on the results of current study,the authors will,in projected future research,develop a real-time MDFA recognition system.

关键词： Feature fusion mild difficulty in falling asleep(MDFA) decision support tool sleep issues optimal feature set

One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

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Chemical Research in Chinese Universities 2013年第4期29卷 710-713页

作者： JIN Li-li lei Yun-tao College of Sciences China Pharmaceutical University Nanjing 210009 P. R. China

An effcient synthetic protocol for the β-amino carbonyl compounds was developed via one-pot three- component Mannich reaction of aromatic aldehydes, aromatic amines and cyclohexanone catalyzed by 2-hydroxylpy- ridine under mild reaction conditions, β-Amino carbonyl compounds were obtained in moderate to good yields and rea- sonable diastereoselectivities. The effects of different solvents, catalyst amounts and the scope of different substrates on the Mannich reactions were investigated. The plausible reaction mechanism was also discussed.

关键词： 2-Hydroxylpyridine Catalyze Mannich reaction fl-Amino carbonyl compound

Experimental research on aero-propulsion coupling characteristics of a distributed electric propulsion aircraft

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Chinese Journal of Aeronautics 2023年第2期36卷 201-212页

作者： Xingyu ZHANG Wei ZHANG Weilin LI Xiaobin ZHANG tao lei School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Key Laboratory of Aircraft Electric Propulsion Technology Ministry of Industry and Information TechnologyXi'an 710072China School of Automation Northwestern Polytechnical UniversityXi'an 710072China

Distributed Electric Propulsion(DEP)aircraft use multiple electric motors to drive the propulsors,which gives potential benefits to aerodynamic-propulsion *** investigate and quantify the aerodynamic-propulsion interaction effect of the wing section,we built a DEP demonstrator with 24"high-lift"Electric Ducted Fans(EDFs)distributed along the wing’s trailing *** paper explores and compares the aero-propulsion coupling characteristics under various upstream speed,throttle,and EDF mounting surface deflection angles using a series of wind tunnel *** compare various lift-augmentation power conditions to the clean configuration without propulsion unit under the experiment condition of 15-25 m/s freestream flow and angles of attack from-4°to 16°.The comparison of computational results to the experimental results verifies the effectiveness of the computational fluid dynamic analysis method and the modeling method for the DEP *** results show that the EDFs can produce significant lift increment and drag reduction simultaneously,which is accordant with the potential benefit of Boundary Layer Ingestion(BLI)at low airspeed.

关键词： Aero-propulsion coupling Boundary layer ingestion Distributed electric propulsion Short Take-Off and Landing(STOL) Wind-tunnel experiment

Solving DCLAP-MSN based on hybrid genetic algorithm

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Journal of Systems Engineering and Electronics 2010年第5期21卷 806-811页

作者： Hongtao lei Bo Guo tao Zhang College of Information Systems and Management National University of Defense Technology Changsha 410073 E R. China

The dynamic capacitated location allocation problem in the military supportive network（DCLAP-MSN） is a representative of combinative optimization problems,and its optimization process is *** this reason,a dynamic capacitated location allocation model is provided ***,a hybrid heuristic algorithm which combines genetic algorithm,repair algorithm of solutions and greedy search,is proposed as the solving *** optimization performance is improved by effectively integrating the repair algorithm of solutions and greedy search with genetic *** experiment results indicate that the proposed algorithm is a feasible and effective method for the problem.

关键词： dynamic location allocation military supportive network genetic algorithm repair algorithm greedy search.

Fabrication and sustained release properties of porous hollow silica nanoparticles

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Science China Chemistry 2010年第3期53卷 555-560页

作者： Xu, Hong tao Wang, Xin Shou tao, lei Ming Wu, Si Xin Key Laboratory for Special Functional Materials of Ministry of Education Henan University Kaifeng 475004 China

MCM-41-type mesoporous silica nanospheres(MSN) have been prepared using n-cetyltrimethylammonium bromide(CTAB) as a soft *** pseudo-moire' rotational pattern inside the MSN results in many interior *** mesoporous silica(HMS) spheres were synthesized by solvent extraction of the template from *** morphology and structure of MSN and HMS were studied by TEM,XRD and nitrogen sorption techniques.A model drug,bromocresol green dye,was packed inside different regions of HMS through impregnation at different pressures and temperatures,and the drug release performance of the resulting materials was *** results showed that vacuum evaporation of solvents may enhance the controlled release properties.

关键词： pseudo-moire’ rotational pattern hollow silica release

Pre-scan based fast handoff scheme for enterprise IEEE 802.11 networks

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The Journal of China Universities of Posts and Telecommunications 2016年第6期23卷 60-67页

作者： Zhang Biao Wen Xiangming Lu Zhaoming lei tao Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and Telecommunications

In IEEE 802.11 networks, many access points（APs） are required to cover a large area due to the limited coverage range of APs, and frequent handoffs may occur while a station（STA） is moving in an area covered by several APs. However, traditional handoff mechanisms employed at STAs introduce a few hundred milliseconds delay, which is far longer than what can be tolerated by some multimedia streams such as voice over Internet protocol（Vo IP）, it is a challenging issue for supporting seamless handoff service in IEEE 802.11 networks. In this paper, we propose a pre-scan based fast handoff scheme within an IEEE 802.11 enterprise wireless local area network（EWLAN） environment. The proposed scheme can help STA obtain the best alternative AP in advance after the pre-scan process, and when the handoff is actually triggered, STA can perform the authentication and reassociation process toward the alternative AP directly. Furthermore, we adopt Kalman filter to minimize the fluctuation of received signal strength（RSS）, thus reducing the unnecessary pre-scan process and handoffs. We performed simulations to evaluate performance, and the simulation results show that the proposed scheme can effectively reduce the handoff delay.

关键词： fast handoff IEEE 802.11 networks handoff delay enterprise WLAN