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Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass

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Chinese Medical Journal 2005年第15期118卷 1235-1244页

作者： Volodymyr Dvornyk LIU Peng-yuan LONG Ji-rong ZHANG Yuan-yuan lei shu-feng Robert R Recker DENG Hong-wen Laboratory of Molecular and Statistical Genetics College of Life Sciences Hunan Normal University Changsha 410081 China Osteoporosis Research Center and Department of Biomedical Sciences Creighton University Medical centre Omaha NE 68131 USA

Background Ethnicity is shown to be one of important factors affacting bone mineral density （BMD）. The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods The studied restriction fragment length polymorphisms were BsaH Ⅰ of the calcium-sensing receptor gene, Sac Ⅰ of the α2HS-glycoprotein （AHSG） gene, Pvu Ⅱ and Xba Ⅰ of the oestrogen receptor α gene, Apa Ⅰ of the vitamin D receptor （VDR） gene and BstB Ⅰ of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results Two polymorphisms, AHSG-Sac Ⅰ and VDR-Apa Ⅰ , showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.

关键词： bone mineral density genotype ethnicity association osteoporosis

ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior

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Chinese Medical Journal 2012年第6期125卷 1127-1134页

作者： CHEN Xiang-ding XIONG Dong-hai YANG Tie-lin PEI Yu-fang GUO Yan-fang LI Jian YANG Fang PAN feng TAN Li-jun YAN Han LIU Xiao-gang lei shu-feng LI Xi NING Ling-ling ZHU Xue-zhen Shawn Levy Henry R. Kranzler Lindsay A. Farrer Joel Gelernter Robert R. Recker DENG Hong-wen Laboratory of Molecular and Statistical Genetics Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College of Life Sciences Hunan Institute of Biology Hunan Normal University Changsha Hunan 410081 China Departments of Orthopedic Surgery and Basic Medical Sciences University of Missouri-Kansas City Kansas City MO 64108 USA Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics School of Life Science and Technology Xi＇an Jiaotong University Xi＇an Shannxi 710049 China Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN 37232 USA University of Connecticut Health Center Farmington CT 06030 USA Boston University School of Medicine Boston MA 02118 USA Department of Psychiatry Yale University School of Medicine West Haven CT 06516 USA Osteoporosis research Center Creighton University Omaha NE 68131 USA Systematic Biomedicine Research Center University of Shanghai for Science and Technology Shanghai 200093 China

Background Alcohol dependence （AD） is a complex disorder characterized by impaired control over drinking. It is determined by both genetic and environmental factors. The recent approach of genome-wide association study （GWAS） is a powerful tool for identifying complex disease-associated susceptibility alleles, however, a few GWASs have been conducted for AD, and their results are largely inconsistent. The present study aimed to screen the loci associated with alcohol-related phenotypes using GWAS technology. Methods A genome-wide association study with the behavior of regular alcohol drinking and alcohol consumption was performed to identify susceptibility genes associated with AD, using the Affymetrix 500K SNP array in an initial sample consisting of 904 unrelated Caucasian subjects. Then, the initial results in GWAS were replicated in three independent samples： 1972 Caucasians in 593 nuclear families, 761 unrelated Caucasian subjects, and 2955 unrelated Chinese Hans. Results Several genes were associated with the alcohol-related phenotypes at the genome-wide significance level, with the ankyrin repeat domain 7 gene （ANKRDT） showing the strongest statistical evidence for regular alcohol drinking and suggestive statistical evidence for alcohol consumption. In addition, certain haplotypes within the ANKRD7 and cytokine-likel （CYTL 1） genes were significantly associated with regular drinking behavior, such as one ANKRD7 block composed of the SNPs rs6466686-rs4295599-rs12531066 （P = 6.51×10^-8）. The association of alcohol consumption was successfully replicated with rs4295599 in ANKRD7 gene in independent Caucasian nuclear families and independent unrelated Chinese Hans, and with rs16836497 in CYTL1 gene in independent unrelated Caucasians. Meta-analyses based on both the GWAS and replication samples further supported the observed significant associations between the ANKRDTor CYTL1 gene and alcohol consumption. Conclusion The evidence suggests that ANKRD7 and CYTL 1 ge

关键词： alcohol dependence ANKRD7 CYTL1 genome-wide association study

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信号弹高度测试技术

光电技术应用 2011年第3期26卷 74-77页

作者：张磊磊雷树峰冯巧玲王高中北大学仪器科学与动态测试教育部重点实验室山西太原030051 山西北方晋东化工有限公司山西阳泉045000

信号弹的发射高度是信号弹的重要技术参数。为了测试信号弹发射高度,通过建立数学模型,提出采用单个面阵CMOS相机对信号弹高度进行测试的技术。通过前期相机工作视场角标定,对CMOS相机采集的视频图像采用MATLAB进行处理,实现对信号弹发... 详细信息

信号弹的发射高度是信号弹的重要技术参数。为了测试信号弹发射高度,通过建立数学模型,提出采用单个面阵CMOS相机对信号弹高度进行测试的技术。通过前期相机工作视场角标定,对CMOS相机采集的视频图像采用MATLAB进行处理,实现对信号弹发射高度的实时测试。同时分析了误差来源,估算了系统误差精度。最终测得某信号弹的发射高度在159.348～167.567m之间。结果表明,该测试系统具有成本低、操作简单、布站方便、测量精度高、自动化程度高、不受测量场地的限制、排除了人工读取误差等优点。

关键词：高度测试面阵CMOS 信号弹图像处理

SPE-GC-MSSIM测定水节霉发生地河水中半挥发性有机物

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环境科学研究 2014年第6期27卷 670-675页

作者：雷书凤王海燕苑泉周岳溪王业耀赵华杨耀军中国环境科学研究院环境基准与风险评估国家重点实验室水污染控制技术研究中心北京100012 中国环境监测总站北京100012

为测定水节霉发生地河水中ρ（SVOCs）（SVOCs为半挥发性有机物）,比较了LLE（液液萃取）和SPE（固相萃取）前处理法提取加标空白水样中ρ（SVOCs）的GC-MS/SIM测定结果,确定并采用重现性好的SPE-GC-MS/SIM法测定了水节霉发生地河水中... 详细信息

为测定水节霉发生地河水中ρ（SVOCs）（SVOCs为半挥发性有机物）,比较了LLE（液液萃取）和SPE（固相萃取）前处理法提取加标空白水样中ρ（SVOCs）的GC-MS/SIM测定结果,确定并采用重现性好的SPE-GC-MS/SIM法测定了水节霉发生地河水中的ρ（SVOCs）.结果表明,LLE和SPE法对SVOCs的加标回收率分别为41.8%-121.5%和31.5%-124.4%,相对标准偏差分别为6.0%-18.0%和0.9%-14.5%,二者回收率相差不大,但SPE法的相对标准偏差小于LLE法,SPE法重现性较好,因此采用SPE-GC-MS/SIM法测定2011年2月水节霉发生地河水中的ρ（SVOCs）,共检出29种SVOCs,其中ρ（邻苯二甲酸二乙酯）、ρ（∑PAHs）、ρ（硝基苯）、ρ（1,2-二氯苯）和ρ（1,4-二氯苯）分别为1 020.59、532.14、43.39、38.52和19.57 ng/L,均未超出GB5749—2006《生活饮用水卫生标准》相关限值,表明水节霉发生地未发生SVOCs污染.

关键词：固相萃取(SPE) 液液萃取(LLE) 气质联用色谱(GC-MS) 水节霉发生地半挥发性有机物(SVOCs)

微生物相关基因富集分析法鉴定风湿病相关肠道微生物群

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中华疾病控制杂志 2021年第8期25卷 874-878,986页

作者：何培王曼利曹蓉蓉董晨悦邓飞艳雷署丰苏州大学医学部公共卫生学院遗传流行病与基因组学中心苏州215123 九江市第一人民医院肾内科九江332000

目的鉴定与类风湿关节炎(rheumatoid arthritis,RA)、系统性红斑狼疮(systemic lupus erythematosus,SLE)和强直性脊柱炎(ankylosing spondylitis,AS)相关的肠道微生物群。方法利用已发表的全基因组关联研究(genome-wide association study,GWAS)和肠道微生物群GWAS的总结数据,运用肠道微生物群相关基因富集分析(gene set enrichment analysis,GSEA)方法检测肠道微生物群和风湿病之间的关联。结果通过鉴定发现多个肠道微生物群均与三种风湿病相关(均有P<0.05)。其中,瘤胃球菌属(Ruminococcaceae_UCG-009)与RA、SLE和AS均相关(均有P<0.05);Intestinibacter属和发酵性厌氧梭菌潜在新物种(Candidatus_Soleaferrea)则与RA和SLE相关(均有P<0.05)。结论部分肠道微生物群可能通过其代谢物的作用成为新的风湿病调节因子,这为揭示肠道微生物群在风湿病中的作用提供了新的线索。

关键词：风湿病肠道微生物全基因组关联研究肠道微生物群相关基因富集分析

绝经前的健康女性中瘦体重、体脂含量和骨密度的关系

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湖南师范大学自然科学学报 2007年第1期30卷 107-109页

作者：李远能陈湘定雷署丰邓红文湖南师范大学生命科学学院教育部蛋白质化学和发育生物学重点实验室和分子与统计遗传学研究室中国长沙410081

从长沙地区的汉族人群中征集了878名年龄在20～45岁绝经前的健康女性样本，采用Hologic QDR4500W双能量X射线骨密度仪（DXA）来测量腰椎（L1.4）、髋部和全身其他部位的骨密度、瘦体重、体脂含量．应用SAS软件进行瘦体重和体脂含量与骨... 详细信息

从长沙地区的汉族人群中征集了878名年龄在20～45岁绝经前的健康女性样本，采用Hologic QDR4500W双能量X射线骨密度仪（DXA）来测量腰椎（L1.4）、髋部和全身其他部位的骨密度、瘦体重、体脂含量．应用SAS软件进行瘦体重和体脂含量与骨密度的Pearson相关分析和多元回归分析．发现瘦体重和体脂含量都与骨密度正相关，而且瘦体重对骨密度变异的贡献是8．0％～11．4％，体脂含量对骨密度变异的贡献是0．2％～2．5％．表明在绝经前的健康女性中，瘦体重是比体脂含量更加重要的决定骨密度变异的因素。

关键词：骨质疏松症骨密度体脂含量瘦体重

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基于共振瑞利散射法的人血清蛋白浓度的研究

光散射学报 2012年第4期24卷 392-396页

作者：薛忠晋冯巧玲王高雷树峰高曰云周汉昌中北大学仪器科学与动态测试教育部重点实验室电子测试技术国家重点实验室太原030051 中北大学信息与通信工程学院太原030051 山西北方晋东化工有限公司计量与检测中心阳泉045000

文章针对人标准血清总蛋白浓度的定量测定,建立了以四羧基金属酞菁锌为光谱探针检测蛋白质的共振光散射的新方法。该方法的实质是将人标准血清总蛋白和酞菁锌溶液混合,当光源照射到样品池中的混合液时,将激发出强烈的共振瑞利散射荧光信... 详细信息

文章针对人标准血清总蛋白浓度的定量测定,建立了以四羧基金属酞菁锌为光谱探针检测蛋白质的共振光散射的新方法。该方法的实质是将人标准血清总蛋白和酞菁锌溶液混合,当光源照射到样品池中的混合液时,将激发出强烈的共振瑞利散射荧光信号,根据信号强度的强弱,计算血清蛋白浓度的大小。自行设计的测试装置采用了薄壁试管的样品皿,减小了激光光波穿过溶液时的光程,可得到更强的探测信号。测试结果表明:根据数字示波器显示的探测器信号,可得出电压的峰峰值,体现了荧光的大小,从而可以进一步计算出血清蛋白的浓度。

关键词：共振瑞利散射人标准血清蛋白浓度电压四羧基酞菁锌

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高发期海浪河流域水节霉生长变化及影响因素

环境科学研究 2011年第8期24卷 835-841页

作者：张召跃王海燕朱灵峰张乐雷书凤周岳溪王业耀中国环境科学研究院水污染控制技术研究中心北京100012 华北水利水电学院环境与市政工程学院河南郑州450011 中国环境监测总站北京100012

海浪河流域2006年2月曾发生水节霉污染事件,目前每年的水节霉高发期(1—2月)在海浪河流域河夹村大坝河段仍有少量水节霉滋生.为了防止水节霉再次大规模爆发,通过显微镜观察及现场水质监测方法,研究了高发期海浪河流域水节霉生长变化及... 详细信息

海浪河流域2006年2月曾发生水节霉污染事件,目前每年的水节霉高发期(1—2月)在海浪河流域河夹村大坝河段仍有少量水节霉滋生.为了防止水节霉再次大规模爆发,通过显微镜观察及现场水质监测方法,研究了高发期海浪河流域水节霉生长变化及其影响因素.结果表明,具有明显"缩缢"态的水节霉开始出现于1月下旬,约9 d后开始在微生物共生体中占优势,再经过21 d后(即2月底)由优势转为不占优势;"缩缢"态水节霉出现时间段为1月26日—2月24日,约1个月左右,是水节霉污染防治重点时段.1—2月河夹村大坝水节霉出现与溶解氧,pH和一定浓度的碳及氮有机物等因素相关,上述因素共同作用导致水节霉滋生.

关键词：海浪河水节霉生长变化影响因素

Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-feng Fu Li-Fen Yang lei Tian Song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report