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circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM_(2.5)

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Journal of Environmental Sciences 2024年第3期137卷 527-539页

作者： Qingping Liu Yaling Zhang Bin Han Mengruo Wang Huaifang Hu Jie Ning Wentao Hu Meiyu Chen Yaxian Pang Yuanyuan Chen lei bao Yujie Niu Rong Zhang Department of Toxicology Hebei Medical UniversityShijiazhuang 050017China State Key Laboratory of Environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Occupational Health and Environmental Health Hebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Environment and Human Health Hebei Medical UniversityShijiazhuang 050017China

As an environmental pollutant,ambient fine particulate matter (PM_(2.5)) was linked to cardiovascular diseases.The molecular mechanisms underlying PM_(2.5)-induced extrapulmonary disease has not been elucidated clearly.In this study the ambient PM_(2.5)exposure mice model we established was to explore adverse effects of vessel and potential mechanisms.Long-term PM_(2.5)exposure caused reduced lung function and vascular stiffness in mice.And chronic PM_(2.5)induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2B cells.After PM_(2.5)treatment,the circRNAs and mRNAs levels of exosomes released by BEAS-2B cells were detected by competing endogenous RNA (ceRNA) array,which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed m RNAs (DE-mRNAs).By bioinformatics analysis on host genes of DE-circRNAs,vascular diseases and some pathways related to vascular diseases including focal adhesion,tight junction and adherens junction were enriched.Then,ceRNA network was constructed,and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis,which indicated that hsa_circ_0012627,hsa_circ_0053261and hsa_circ_0052810 were related to vascular endothelial dysfunction.Furthermore,it was verified experimentally that Exo^(PM2.5)could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in vitro.In present study,we investigated in-depth knowledge into the molecule events related to PM_(2.5) toxicity and pathogenesis of vascular diseases.

关键词： Fine particulate matter Vascular stiffness Exosome ceRNA microarray Endothelial dysfunction

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Pyrylium salts acting as both energy transfer and electron transfer photocatalysts for E → Z isomerization of activated alkenes and cyclization of cinnamic or biaryl carboxylic acids

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Organic Chemistry Frontiers 2022年第4期9卷 973-978页

作者： lei bao Jin-Tang Cheng Zhi-Xiang Wang Xiang-Yu Chen School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

2,4,6-Triarylpyrylium salts are stable,readily available and cheap.However,only their electron transfer oxi-dation ability has been explored.We herein report that they could perform both energy transfer and elec-tron transfer activation modes for the photocascade E→Z isomerization/cyclizations,E→Z isomerization of activated alkenes and oxidative cyclizations.

关键词： cyclization salts transfer

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Engineered T cells and their therapeutic applications in autoimmune diseases

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Zoological Research 2022年第2期43卷 150-165页

作者： lei bao Xiao-Chen Bo Huai-Wen Cao Chen Qian Zeng Wang Bin Li Department of Immunology and Microbiology Shanghai Institute of ImmunologyShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200025China

Chimeric antigen receptor T cells(CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases.Furthermore, regulatory T cells(Treg), a subset of CD4 T cells exhibiting immunosuppressive functions,have attracted increasing attention regarding CARTreg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.

关键词： Chimeric antigen receptor T cells Cell immunotherapy Autoimmune diseases

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结合自适应步长策略和数据增强机制提升对抗攻击迁移性

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电子学报 2024年第1期52卷 157-169页

作者：鲍蕾陶蔚陶卿中国人民解放军陆军炮兵防空兵学院信息工程系安徽合肥230031 中国人民解放军军事科学院北京100091

深度神经网络具有脆弱性,容易被精心设计的对抗样本攻击.梯度攻击方法在白盒模型上攻击成功率较高,但在黑盒模型上的迁移性较弱.基于Heavy-ball型动量和Nesterov型动量的梯度攻击方法由于在更新方向上考虑了历史梯度信息,提升了对抗样... 详细信息

深度神经网络具有脆弱性,容易被精心设计的对抗样本攻击.梯度攻击方法在白盒模型上攻击成功率较高,但在黑盒模型上的迁移性较弱.基于Heavy-ball型动量和Nesterov型动量的梯度攻击方法由于在更新方向上考虑了历史梯度信息,提升了对抗样本的迁移性.为了进一步使用历史梯度信息,本文针对收敛性更好的Nesterov型动量方法,使用自适应步长策略代替目前广泛使用的固定步长,提出了一种方向和步长均使用历史梯度信息的迭代快速梯度方法(Nesterov and Adaptive-learning-rate based Iterative Fast Gradient Method,NAI-FGM).此外,本文还提出了一种线性变换不变性(Linear-transformation Invariant Method,LIM)的数据增强方法 .实验结果证实了NAI-FGM攻击方法和LIM数据增强策略相对于同类型方法均具有更高的黑盒攻击成功率.组合NAI-FGM方法和LIM策略生成对抗样本,在常规训练模型上的平均黑盒攻击成功率达到87.8%,在对抗训练模型上的平均黑盒攻击成功率达到57.5%,在防御模型上的平均黑盒攻击成功率达到67.2%,均超过现有最高水平.

关键词：对抗样本迁移性 Nesterov型动量自适应步长线性变换不变性

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Phase I trial of human umbilical cord-derived mesenchymal stem cells for treatment of severe bronchopulmonary dysplasia

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Genes & Diseases 2023年第2期10卷 521-530页

作者： Yunqiu Xia Tingyuan Lang Yuqin Niu Xian Wu Ou Zhou Jihong Dai lei bao Ke Yang Lin Zou Zhou Fu Gang Geng Department of Dermatology Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gynecologic Oncology School of MedicineChongqing University Cancer HospitalChongqing UniversityChongqing 400030China The First Affiliated Hospital School of MedicineShihezi UniversityShiheziXinjiang 832008China Department of Respiratory Medicine West China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Respiratory Medicine Children's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Neonatology Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Engineering Technology Research Center of Stem Cell Therapy Children's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Clinical Molecular Medicine Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Severe bronchopulmonary dysplasia(BPD)is a chronic lung disorder that primarily affects premature babies with extremely low birth weight and involves in multiple organ system;no effective pharmacotherapy for this disease exists,and mortality remains high.Based on the evidence from previous preclinical studies and phase I clinical trials,this study aims to test the safety of intravenous application of a single dose of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)in patients with severe BPD.The Mesenchymal Stem cells for Bronchopulmonary Dysplasia Treatment(MSBDT)trial is a single center,open-label,dose-escalation phase I clinical trial.Severe BPD patients were enrolled in Children Hospital of Chongqing Medical University,Chongqing,China.The first six patients were treated with low-dose hUC-MSCs(1×10^(6) cells/kg)and the next seven patients were treated with high-dose hUC-MSCs(5×10^(6) cells/kg).This study is registered with ClinicalTrials.gov,number NCT03558334.No prespecified infusion-associated adverse events,immediate complication,respiratory or cardiovascular compromise were observed during infusion and 24 h after infusion.No significant changes in safety laboratory values were observed.One death event occurred in the low-dose group on study day 10,and one death event occurred in the high-dose group on study day 24,while,after review in detail,the two cases are not believed to be infusion-associated events.In conclusion,intravenous application of a single dose of hUC-MSCs was tolerated in thirteen patients with severe BPD.

关键词： Bronchopulmonary dysplasia Dose escalation Human umbilical cord-derived mesenchymal stem cells Intravenous treatment Phase I trial

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一种基于稀疏优化和Nesterov动量策略的模型剪枝算法

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数据采集与处理 2024年第3期39卷 659-667页

作者：周强陈军鲍蕾陶卿陆军炮兵防空兵学院信息工程系合肥230031

随着深度学习快速发展,模型的参数量和计算复杂度爆炸式增长,在移动终端上部署面临挑战,模型剪枝成为深度学习模型落地应用的关键。目前,基于正则化的剪枝方法通常采用L2正则化并结合基于数量级的重要性标准,是一种经验性的方法,缺乏理... 详细信息

随着深度学习快速发展,模型的参数量和计算复杂度爆炸式增长,在移动终端上部署面临挑战,模型剪枝成为深度学习模型落地应用的关键。目前,基于正则化的剪枝方法通常采用L2正则化并结合基于数量级的重要性标准,是一种经验性的方法,缺乏理论依据,精度难以保证。受Proximal梯度方法求解稀疏优化问题的启发,本文提出一种能够在深度神经网络上直接产生稀疏解的Prox⁃NAG优化方法,并设计了与之配套的迭代剪枝算法。该方法基于L1正则化,利用Nesterov动量求解优化问题,克服了原有正则化剪枝方法对L2正则化和数量级标准的依赖,是稀疏优化从传统机器学习向深度学习的自然推广。在CIFAR10数据集上对ResNet系列模型进行剪枝实验,实验结果证明Prox⁃NAG剪枝算法较原有剪枝算法性能有所提升。

关键词：稀疏优化剪枝算法 Proximal梯度方法 Nesterov加速梯度(Nesterov accelerated gradient,NAG)

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生态环境损害赔偿金纳入政府非税收入的正当性

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中南民族大学学报（人文社会科学版） 2024年第3期44卷 113-121,186页

作者：熊伟曹保磊武汉大学法学院湖北武汉430072

生态环境损害赔偿金纳入政府非税收入,不应局限于解决生态环境损害赔偿金的预算列支问题,还应考虑生态环境损害救济规则的变动,以避免法秩序内部的矛盾。《生态环境损害赔偿制度改革方案》中政府主导的生态环境损害替代修复机制不同于... 详细信息

生态环境损害赔偿金纳入政府非税收入,不应局限于解决生态环境损害赔偿金的预算列支问题,还应考虑生态环境损害救济规则的变动,以避免法秩序内部的矛盾。《生态环境损害赔偿制度改革方案》中政府主导的生态环境损害替代修复机制不同于《民法典》确立的生态环境损害私法救济规则。在公共财产权体系下,建立政府与生态环境损害致害者之间的报偿关系,可以弥补生态环境损害赔偿金纳入政府非税收入正当性之不足。生态环境损害赔偿金作为受损生态环境损害的修复资金,应当作为政府非税收入中的“社会公共财产收入”,列入我国公共财产权体系,参照政府性基金预算进行支出管理。

关键词：生态环境损害赔偿金政府非税收入公共财产权

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杨慎对王维诗歌的选录与评析--以《升庵诗话》《丹铅总录》等为中心

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西部学刊 2024年第10期 162-166,172页

作者：鲍蕾四川省社会科学院文学研究所成都610065

作为明代中期的著名诗词评点家,杨慎对王维的研究可谓用功颇深。《绝句衍义》等唐绝系列选本所承载的选诗、序文等内容凸显出杨慎的独特的诗学观念,即重视绝句的音乐属性和体制要求,追求风雅格调,而这种观念与杨慎对王维绝句高手地位的... 详细信息

作为明代中期的著名诗词评点家,杨慎对王维的研究可谓用功颇深。《绝句衍义》等唐绝系列选本所承载的选诗、序文等内容凸显出杨慎的独特的诗学观念,即重视绝句的音乐属性和体制要求,追求风雅格调,而这种观念与杨慎对王维绝句高手地位的话语建构实相呼应。《升庵诗话》《丹铅总录》两部著作共同呈现了作者对王维诗歌的多角度观照:在诗歌风格论中,重视王维浑融含蓄的审美倾向;在艺术手法论中,推崇王维精妙的字法与句法;在诗歌流变论中,辨析王诗的渊源与影响,还由此引发对宋诗价值的重新审察。通过“以经史考据之法治诗”,杨慎力图在重视原典、文字校勘、词句笺释三个层面把握王维等人的诗歌本貌。

关键词：杨慎王维选录评析《升庵诗话》

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应用细胞块技术筛查非人乳头状瘤病毒依赖型宫颈原位腺癌1例

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中华病理学杂志 2024年第1期53卷 98-100页

作者：戈文舜耿文沈寅包磊李美平绍兴市妇幼保健院病理科绍兴312000

非典型小叶状宫颈腺体增生作为非人乳头状瘤病毒(HPV)依赖型宫颈原位腺癌的一种组织类型,可能源于小叶状宫颈腺体增生和简单型胃型腺体化生。本文报道1例非HPV依赖型宫颈原位腺癌(非典型小叶状宫颈腺体增生),临床表现为长期阴道排液,HP... 详细信息

非典型小叶状宫颈腺体增生作为非人乳头状瘤病毒(HPV)依赖型宫颈原位腺癌的一种组织类型,可能源于小叶状宫颈腺体增生和简单型胃型腺体化生。本文报道1例非HPV依赖型宫颈原位腺癌(非典型小叶状宫颈腺体增生),临床表现为长期阴道排液,HPV阴性。宫颈脱落细胞学检查镜下见富腺细胞,排列拥挤、重叠,胞质丰富透亮、部分稠厚、个别略呈淡黄色,核略大、可见嗜酸性小核仁,判读为非典型腺细胞,无具体指定,其细胞块及宫颈管搔刮中黏液腺体胞质同步呈现免疫组织化学MUC6弥漫强阳性并特殊染色阿辛蓝-过碘酸雪夫(AB-PAS)染色玫红显色模式,提示存在胃型分化腺体。全子宫标本中宫颈管近内口距表层4.5 mm间质见非典型小叶状宫颈腺体增生。免疫表型:Ki-67阳性指数约5%,DPC4弥漫强阳性,p53野生型模式,PAX2小叶状腺体阳性、非典型腺体弱阳性,p16阴性;MUC6、AB-PAS与细胞块表达模式一致。回顾其诊疗经过并复习相关文献,有助于宫颈胃型腺癌及癌前病变的筛查与诊断。

关键词：宫颈原位腺癌宫颈腺体细胞块特殊染色胃型宫颈管阳性指数人乳头状瘤病毒

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Effects of Nd/Gd value on the microstructures and mechanical properties of Mg-Gd-Y-Nd-Zr alloys

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Journal of Magnesium and Alloys 2016年第3期4卷 214-219页

作者： Xuan Liu Zhiqiang Zhang Qichi Le lei bao Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern University314MailboxShenyang 1100819China

Four Mg–Gd–Y–Nd–Zr alloys were prepared by mold casting to investigate the effects of Nd/Gd ratios on microstructures and mechanical properties.The as-cast alloys mainly consist ofα-Mg andβ-Mg5(GdYNd).Volume fractions of the second phase increase and grains were slightly refined with the rising Nd/Gd ratio,when the alloying addition is equal.Meanwhile,fibers of second phase also increase in the extruded alloys when the Nd/Gd value increases.However,the Nd/Gd ratio could hardly influence the mechanical properties of the extruded alloys.The aging hardening response of the extruded alloy differs due to different Nd/Gd ratios.The potential mechanisms have also been discussed in detail.

关键词： Mg-Gd-Y-Nd-Zr alloy Microstructure Inverted extrusion Heat treatment Mechanical properties

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