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Bidirectional rotating direct-current triboelectric nanogenerator with self-adaptive mechanical switching for harvesting reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan lee Joonmin Chae Sumin Cho Jong Woo Kim Awais Ahmad Mohammad Rezaul Karim Moonwoo La Sung Jea Park Dongwhi Choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,owing to the working mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,we propose a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of swinging doors and waves were demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

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Autonomous self-healing 3D micro-suction adhesives for multi-layered amphibious soft skin electronics

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InfoMat 2024年第10期6卷 65-79页

作者： Dohyun Lim Min Woo Jeong Hyeongho Min Yeon Soo lee Gui Won Hwang Seung Hwan Jeon Kyu Ho Jung Ngoc Thanh Phuong Vo Min-Seok Kim Da Wan Kim Jin Young Oh Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonGyeonggi-doRepublic of Korea Department of Chemical Engineering(Integrated Engineering Program) Kyung Hee UniversityYonginGyeonggiRepublic of Korea Convergence Research Group for Meta-Touch Korea Research Institute of Standards and ScienceDaejeonRepublic of Korea Department of Electronic Engineering Korea National University of TransportationChungju-siChungbukRepublic of Korea Samsung Advanced Institute for Health Sciences and Technology(SAIHST) Sungkyunkwan UniversitySuwonGyunggi-doRepublic of Korea

Autonomously self-healing, reversible, and soft adhesive microarchitecturesand structured electric elements could be important features in stable and versatilebioelectronic devices adhere to complex surfaces of the human body(rough, dry, wet, and vulnerable). In this study, we propose an autonomousself-healing multi-layered adhesive patch inspired by the octopus, which possessself-healing and robust adhesion properties in dry/underwater *** implement autonomously self-healing octopus-inspired architectures, adynamic polymer reflow model based on structural and material design suggestscriteria for three-dimensional patterning self-healing elastomers. In addition,self-healing multi-layered microstructures with different moduli endowsefficient self-healing ability, human-friendly reversible bio-adhesion, and stablemechanical deformability. Through programmed molecular behavior ofmicrolevel hybrid multiscale architectures, the bioinspired adhesive patchexhibited robust adhesion against rough skin surface under both dry andunderwater conditions while enabling autonomous adhesion restoring performanceafter damaged (over 95% healing efficiency under both conditions for24 h at 30℃). Finally, we developed a self-healing skin-mountable adhesiveelectronics with repeated attachment and minimal skin irritation by laminatingthin gold electrodes on octopus-like structures. Based on the robust adhesionand intimate contact with skin, we successfully obtained reliable measurements during dynamic motion under dry, wet, and damagedconditions.

关键词： biomimetics dry adhesive self-healing polymer stretchable electronics

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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 02447Republic of Korea BioNanocomposite Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea College of Korean Medicine Kyung Hee UniversitySeoul 02447Republic of Korea Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju 52828Republic of Korea Department of Anatomy&Information Sciences College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea

Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut *** has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely *** purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut *** AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11)***-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and *** microbiota was profiled using 16S rRNA gene sequencing from fecal *** Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of *** beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated ***,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the *** attenuated these abnormalities,which was gut *** Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for

关键词： Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function

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Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi

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Chinese Journal of Natural Medicines 2014年第2期12卷 121-125页

作者： KIM Jong-Hwan LIU Xiang-Qian DAI Ling YOOK Chang-Soo lee Kyung-Tae Herbal Medicine Research Division Korea Food & Drug Administration Hunan Key Laboratory of Traditional Chinese Medicine modernization School of Pharmacy Hunan University of Chinese Medicine College of Pharmacy Kyung-Hee University

AIM: To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. METHOD: The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide(LPS)-induced nitric oxide, prostaglandin E2, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages. RESULTS: The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase(iNOS) at the protein levels in a concentration-dependent manner. CONCLUSION: The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.

关键词： Acanthopanax henryi(Oliv.) Harms Root bark extract Cytotoxic activity Anti-inflammatory activity

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Inhibitory activity of Cinnamomum Cassia extract on hypersensitivity in mice

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中国药理学与毒理学杂志 2015年第S1期29卷 67-67页

作者： Seunggyeong lee Jungbin SONG Donghun lee Young Sik KIM HyunSoo KIM Hailing GUO Juyeon PARK Hocheol KIM Department of Herbal Pharmacology College of Korean Medicine Kyung hee University Seoul Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Republic of Korea

OBJECTIVE Cinnamomum cassia has been used in traditional medicine in East Asian countries to treatallergic *** studies have demonstrated that *** the development of mite antigen-induced skin lesions in NC/Nga mice by suppressing the Thelper 2cell *** objective of this study is to investigate whether *** has an efficient inhibition on systemic anaphylaxis and contact hypersensitivity in *** To induce systemic anaphylaxis,mice were injected intraperitoneally with compound 48/*** was monitored for 1h after the *** hypersensitivity reaction was induced by topical application of 2,4-dinitrofluorobenzene(DNFB)to the ears of *** DNFBchallenge,ear thickness was measured 0,24 and *** We discovered that *** significantly inhibited compound 48/80-induced anaphylaxis and DNFB-induced ear *** 48/80-induced anaphylaxiswas completely inhibited at the dose of 60mg·kg-1 body *** swelling at 24 h after DNFB-challenge was significantly less than that in the control group(0.16±0.03 vs.0.32±0.03 mm,P<0.01),while *** was administered at the dose of 200mg·*** These findings indicate that *** allergic reactions,thus has potential value for mitigation of atopic dermatitis.

关键词： Cinnamomum Cassia hypersensitivity,contact hyperse

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Acupuncture for Treating Attention Deficit Hyperactivity Disorder:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2011年第4期17卷 257-260页

作者： Myeong Soo lee Tae-Young Choi Jong-In Kim Lakhyung Kim Edzard Ernst Brain Disease Research Centre Korea Institute of Oriental MedicineDaejeon(305-811)South Korea Complementary Medicine Peninsula College of Medicine and DentistryUniversity of ExeterExeter(EX2 4NT)UK College of Oriental Medicine Kyung Hee University Medical CenterSeoul(130-702)South Korea College of Oriental Medicine Woosuk UniversityWanju(565-701)South Korea

Objective：To assess the effectiveness of acupuncture as a treatment option for attention deficit hyperactivity disorder（ADHD）.Methods：The literatures were searched using 15 databases,including MEDLINE, AMED,CINAHL,EMBASE,Psyclnfo,the Cochrane Central Register of Controlled Trials,the Cochrane Database of Systematic Reviews,six Korean medical databases and two Chinese databases without language *** controlled clinical studies of any type of acupuncture therapy for ADHD autistic patients were *** in which acupuncture was part of a complex intervention were also *** articles were read by two independent reviewers,who extracted data from the articles according to predefined criteria. Risk of bias was assessed using the Cochrane risk of bias ***：Of 114 articles,only three randomized clinical trials（RCTs） met our inclusion *** RCT found that electroacupuncture（EA） plus behavioural treatment was superior to sham EA plus behavioural *** RCTs reported a significant benefit of acupuncture or auricular acupuncture over conventional drug ***：Limited evidence exists for the effectiveness of acupuncture as a symptomatic treatment of *** that the risk of bias of the included studies was high,firm conclusions cannot be drawn.

关键词： acupuncture attention deficit hyperactivity disorder systematic review

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阳极氧化及模拟体液沉积后的铌金属表面特性研究

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中华口腔医学研究杂志（电子版） 2010年第5期4卷 33-36页

作者：金光春朴炯镐李世钟元大喜李敏镐滨州医学院口腔医学研究所烟台264003 韩国全北大学齿科大学韩国蔚山大学韩国顺天大学

目的评价纯铌(Nb)金属在DL-α磷酸甘油与醋酸钙阳极氧化处理后的表面特性。方法所有Nb试件在模拟体液(SBF)沉浸30d。用扫描电镜观察膜层的表面形态,用X射线光电子能谱(XPS)分析膜层的电子结合能元素分布。结果 Nb试件电镜观察结果,阳极... 详细信息

目的评价纯铌(Nb)金属在DL-α磷酸甘油与醋酸钙阳极氧化处理后的表面特性。方法所有Nb试件在模拟体液(SBF)沉浸30d。用扫描电镜观察膜层的表面形态,用X射线光电子能谱(XPS)分析膜层的电子结合能元素分布。结果 Nb试件电镜观察结果,阳极氧化处理的表面呈现多孔重叠的微孔,阳极氧化及300℃高温蒸汽压下2h热处理,SBF沉积后的表面呈现微细的结晶,其微孔逐渐减少。XPS分析所有Nb试样上观察Nb、Ca、C、O谱及微量的P谱。结论阳极氧化及热处理可诱导Nb金属表面形成氧化膜层,提高其生物活性。

关键词：水热处理铌模拟体液阳极氧化 X射线光电子能谱

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Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung CHAE,Kyung-mi PARK,Geun-youn lee,Gi-seup JEONG,Hyung-rae PARK,Hyung-min KIM,Soo-wan CHAE,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

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Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

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^18F-FDG PET/CT显像能否鉴别诊断特发性肺纤维化患者的孤立性肺结节?

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中华核医学与分子影像杂志 2018年第12期38卷 840-840页

作者：唐军(译) Suk Hyun lee Changhwan Sung Hyo Sang lee hee-young Yoon Soo-Jong Kim Jungsu S.Oh Jin Woo Song Mi Young Kim Jin-Sook Ryu 上海交通大学医学院附属苏州九龙医院核医学科 215021 Department of Nuclear Medicine Asan Medical Center University of Ulsan College of MedicineSeoul South Korea

目的特发性肺纤维化(IPF)患者的肺癌发生率高,患者肺功能差,易发生气胸,因此对CT发现的孤立性肺结节(SPN)不宜采用侵入性诊断方法,否则可能导致严重的不良后果。^18F-脱氧葡萄糖(FDG)PET/CT可用于非IPF患者SPN的良恶性鉴别,但在IPF患者... 详细信息

目的特发性肺纤维化(IPF)患者的肺癌发生率高,患者肺功能差,易发生气胸,因此对CT发现的孤立性肺结节(SPN)不宜采用侵入性诊断方法,否则可能导致严重的不良后果。^18F-脱氧葡萄糖(FDG)PET/CT可用于非IPF患者SPN的良恶性鉴别,但在IPF患者中的诊断准确性尚无研究。因此该研究拟调查^18F-FDGPET/CT是否能鉴别诊断IPF患者的SPN。方法回顾性分析来自该院的55例IPF患者[男54例、女1例,年龄(67.8±7.6)岁],患者SPN大小为8~30(18.5±5.7)mm,所有患者在2004年4月至2016年3月间行胸部CT和^18F-FDGPET/CT显像。对SPN的^18F-FDG摄取行视觉分析和半定量分析,图像结果与最终病理诊断(n=52)或影像学随访(n=3)结果进行比较。结果最终诊断结果表明,41个(75%)SPNs为恶性(21个鳞状细胞癌、9个腺癌、5个小细胞癌、4个混合类型癌、1个大细胞神经内分泌癌和1个肉瘤样癌),14个(25%)为良性。视觉分析PET/CT图像诊断SPN为恶性病变的灵敏度、特异性、阳性预测值(PPV)和阴性预测值(NPV)分别为98%、86%、95%和92%。使用最大标准摄取值(SUVmax)为2.0行半定量分析诊断的灵敏度、特异性、PPV和NPV分别为95%、93%、98%和87%。结论^18F-FDGPET/CT可用于IPF患者SPN的良恶性鉴别,如其用于非IPF患者一样。

关键词： ^18F-FDG 正电子发射断层显像术肺癌孤立性肺结节特发性肺纤维化

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