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Identification of new skin whitening ingredient: Hei Lao Hu extract reduces melanin synthesis

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Identification of new skin whitening ingredient: Hei Lao Hu ...

丹参提取物对皮肤表皮分化和水合促进作用的研究

第九届中国化妆品学术研讨会

作者： GOH myeong jin NA yong joo TAI mei ling JUNG hae jin YEON jae ho HA jeong cheol HE quan quan CHENG liang KONG de yun lee hae kwang CHO jun cheol Amore-Pacific Corporation R&D Center

We isolated various extracts from Hei Lao Hu, a well known traditional Chinese medicine, and found inhibitory effect on melanogenesis. Among them, an extract dose-dependently inhibited melanin synthesis in melan-a, mouse melanocytes. The extract showed more effectiveness than arbutin;melanin synthesis inhibitory activity treated with 2ppm of the extract was better than that with 50 ppm of arbutin. Using further high performance liquid chromatography(HPLC) analysis, we identified a novel compound, kadsuralignan F with strong melanin synthesis inhibition in melan-a cells(IC50=2.7ppm). Western blot analysis demonstrated that kadsuralignan F significantly reduced melanogenic proteins including tyrosinase, tyrosinase related protein(TRP)-1, and TRP-2. These results suggested Hei Lao Hu has potential as an effective skin whitening agent.

关键词： Hei Lao Hu melanin Skin whitening

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丹参提取物对皮肤表皮分化和水合促进作用的研究

Electron beam deposition and characterization of thin film Ti-Ni for shape memory applications

第九届中国化妆品学术研讨会

作者： lee Jin Young KIM Han Byul lee Sung Hoon lee Ok Chan BAE Ji Hyun lee hae kwang Amorepacific Corporation R&D Center

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得... 详细信息

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得到评估。在本研究中,我们发现丹参提取物(ESM)可以刺激正常人角质细胞和Amo Re Skin(本实验室建立的重建人类皮肤模型)中丝聚蛋白的表达。实时定量PCR试验证实了这一结论,丹参提取物(ESM)干预能够上调角质细胞中丝聚蛋白m RNA的表达。免疫染色试验证实丹参提取物(ESM)干预后Amo Re Skin中丝聚蛋白的表达增加。此外,实时定量PCR试验也证实角质细胞中表皮分化的标志物角蛋白1 m RNA的量增多。这些结果表明,丹参提取物(ESM)可以增强表皮分化和水合的活性,可能会增强表皮对抗皮肤老化的功能。

关键词：丹参丝聚合蛋白表皮分化

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Rare Metals 2006年第Z2期25卷 237-242页

作者： NOH hae-Yong JEE kwang-Koo lee Kyu-Hwan lee Young-Kook Department of Metallurgical System Yonsei University Seoul 120-749 KoreaAdvanced Materials Research Center Division of Materials Korea Institute of Science and Technology Cheongryang Seoul 130-650 Korea Advanced Materials Research Center Division of Materials Korea Institute of Science and Technology Cheongryang Seoul 130-650 Korea Department of Metallurgical System Yonsei University Seoul 120-749 Korea

Thin film of Ti-Ni alloy has a potential to perform the microactuation functions required in the microelectromechanical system (MEMS). It is essential, however, to have good uniformity in both chemical composition and thickness to realize its full potential as an active component of MEMS devices. Electron beam evaporation technique was employed in this study to fabricate the thin films of Ti-Ni alloy on different substrates. The targets used for the evaporation were first prepared by electron beam melting. The uniformity of composition and microstructure of the thin films were characterized by electron probe microanalysis (EPMA), Auger electron spectroscopy (AES), X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM). The mechanical property of the thin films was evaluated by the nano-indentation test. The martensitic transformation temperature was measured by differential scanning calorimetry (DSC). It is confirmed that the chemical composition of deposited thin films is identical to that of the target materials. Furthermore, results from depth profiling of the chemical composition variation reveal that the electron beam evaporation process yields better compositional homogeneity than other conventional methods such as sputtering and thermal evaporation. Microstructural observation by TEM shows that nanometer size precipitates are preferentially distributed along the grain boundaries of a few micron size grains. The hardness and elastic modulus of thin films decreases with an increase in Ti contents.

关键词： electron beam evaporation TiNi SMA thin film martensitic transformation reverse martensitic transformation

Changes of the intestinal endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma (3LL): An immunohistochemical quantitative study

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World Journal of Gastroenterology 2005年第35期11卷 5460-5467页

作者： Sae-kwang Ku Seung-Kyoo Seong Dae-Young Kim Hyeung-Sik lee Jong-Dae Kim hae-Yun Choi Bu-Il Seo Jae-Hyun lee Pharmacology and Toxicology Laboratory Central Research Laboratories Dong-Wha Pharmaceutical Industrial Co Ltd Anyang 430-017 Republic of Korea Developmental Biology/Embryology Division of Biological Science Gachon Medical School Kanghwha 417-840 Republic of Korea Department of Herbal Biotechnology Daegu Haany University Gyeongsan 712-715 Republic of Korea College of Oriental Medicine Daegu Haany University Gyeongsan 712-715 Republic of Korea Laboratory of Histology College of Veterinary Medicine Kyungpook National University Taegu 702-701 Republic of Korea

AIM: To study the distributions and frequencies of intestinal endocrine cells in the C57BL/6 mouse with immunohistochemical method using seven types of specific antisera against chromogranin A (CGA), serotonin,somatostatin, glucagons, gastrin, cholecystokinin (CCK)-8 and human pancreatic polypeptide (hPP) after abdominal subcutaneous implantation of murine lung carcinoma (3LL).METHODS: The experimental animals were divided into two groups, one is non-implanted Sham and the other is 3LL-implanted group. Samples were collected from six regions of intestinal tract at 28th d after implantation of 3LL cells (1×105 cell/mouse).RESULTS: In this study, five types of immunoreactive (IR) cells were identified except for gastrin and hPP. The regional distributions of the intestinal endocrine cells in the 3LL-implanted group were similar to those of the non-implanted Sham. However, significant decreases of IR cells were detected in 3LL-implanted group compared to those of non-implanted Sham. CGA- and serotonin-IR cells significantly decreased in 3LL-implanted groups compared to that of non-implanted Sham. Somatostatin-IR cells in the jejunum and ileum and CCK-8-IR cells in the jejunum of 3LL-implanted groups significantly decreased compared to that of non-implanted Sham. In addition,glucagon-IR cells were restricted to the ileum and colon of non-implanted ***: Implantation of tumor cell mass (3LL)induced severe quantifiable changes of intestinal endocrine cell density and the abnormality in density of intestinal endocrine cells may contribute to the development of gastrointestinal symptoms such as anorexia and indigestion, frequently encountered in patients with cancer.

关键词： Intestinal endocrine cell Immunohistochemistry C57BL/6 mouse 3LL Tumor

Implementation of spatial touch system using time-of-flight camera

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重庆邮电大学学报（自然科学版） 2009年第2期21卷 222-227页

作者： AHN Yang-Keun PARK Young-Choong CHOI kwang-Soon PARK Woo-Chool SEO hae-Moon JUNG kwang-Mo Intelligent Home Platform Research Center Korea Electronics Technology Institute Seoul Korea

Recently developed time-of-flight principle based depth-sensing video camera technologies provide precise per-pixel range data in addition to color video. Such cameras will find application in robotics and vision-based human computer interaction scenarios such as games and gesture input systems. Time-of-flight principle range cameras are becoming more and more available. They promise to make the 3D reconstruction of scenes easier, avoiding the practical issues resulting from 3D imaging techniques based on triangulation or disparity estimation. A spatial touch system was presented which uses a depth-sensing camera to touch spatial objects and details on its implementation, and how this technology will enable new spatial interactions was speculated.

关键词：飞行时间输入系统空间对象照相机三维成像技术空间相互作用彩色图像人机交互

Thick free-standing electrode based on carbon-carbon nitride microspheres with large mesopores for high-energy-density lithium-sulfur batteries

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Carbon Energy 2021年第3期3卷 410-423页

作者： Hui-Ju Kang Tae-Gyu lee Heejin Kim Jae-Woo Park Hyun Jin Hwang Hyeonseok Hwang kwang-Suk Jang hae Jin Kim Yun Suk Huh Won Bin Im Young-Si Jun Department of Advanced Chemicals&Engineering Chonnam National UniversityBuk-guGwangjuRepublic of Korea Division of Analytical Science Korea Basic Science Institute(KBSI)Yuseong-guDaejeonRepublic of Korea School of Chemical Engineering Chonnam National UniversityBuk-guGwangjuRepublic of Korea Department of Applied Chemistry Hanyang UniversityAnsanGyeonggi-doRepublic of Korea Department of Biological Engineering Inha UniversityNam-guIncheonRepublic of Korea Division of Materials Science and Engineering Hanyang UniversitySeongdong-guSeoulRepublic of Korea

The development of sulfur cathodes with high areal capacity and high energy density is crucial for the practical application of lithium-sulfur batteries(LSBs).LSBs can be built by employing(ultra)high-loading sulfur cathodes,which have rarely been realized due to massive passivation and ***,microspheres of a carbon-carbon nitride composite(C@CN)with large mesopores are fabricated via molecular cooperative *** the C@CN-based electrodes,the effects of the large mesopores and N-functional groups on the electrochemical behavior of sulfur in LSB cells are thoroughly investigated under ultrahigh sulfur-loading conditions(>15 mgS cm^(-2)).Furthermore,for high-energy-density LSBs,the C@CN powders are pelletized into a thick free-standing electrode(thickness:500^m;diameter:11 mm)via a simple briquette process;here,the total amount of energy stored by the LSB cells is 39 mWh,corresponding to a volumetric energy density of 440 Wh L-1 with an areal capacity of 24.9 and 17.5 mAh cm^(-2) at 0.47 and 4.7 mA cm^(-2),respectively(at 24mgS cm^(-2)).These results have significantly surpassed most recent records due to the synergy among the large mesopores,(poly)sulfide-philic surfaces,and thick *** developed strategy with its potential for scale-up successfully fills the gap between laboratory-scale cells and practical cells without sacrificing the high areal capacity and high energy density,providing a solid foundation for the development of practical LSBs.

关键词： briquette process carbon nitride free-standing electrode high energy density lithium-sulfur batteries mesopores

The Effects of Sleep Deprivation on the Biophysical Properties of Facial Skin

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 34-47页

作者： Min Ah Kim Eun Joo Kim Byung Young Kang hae kwang lee Skincare Research Institute AMOREPACIFIC R & D Center Yongin Korea

Lack of sleep is a problem in today’s society, and many people are concerned about changes in their outward appearance due to lack of sleep. People generally come up with some noticeable skin attributes as symptoms of sleep deficiency including rough, dull, and dry skin as well as droopy eyelids and dark eye circles. Several previous reports also suggested that poor sleep could affect the skin condition. The purpose of this study was to evaluate the effect of one night of sleep deprivation on various skin biophysical properties. Twenty four healthy females participated in a study of one night of sleep deprivation. Subjects were kept awake for one night in a laboratory with controlled temperature and relative humidity. The skin condition of each subject was evaluated after normal sleep pattern and after one night of sleep deprivation. The measured skin biophysical parameters included transepidermal water loss, facial pore size, and skin tone, hydration, elasticity, desquamation, translucency, and blood flow. The cheek, eye, and lip areas were evaluated. After one night of sleep deprivation, multiple skin biophysical parameters showed changes when compared to the baseline measurements. A significant decrease in skin hydration and impaired barrier function were observed (p leep deficiency actually showed remarkable differences after a period of sleep deprivation, and some of these features were confirmed in the eye, lip, as well as the cheek areas. This study revealed a significant association between sleep deprivation and skin biophysical properties by scientific measuring.

关键词： Sleep Deprivation Skin Biophysical Property Hydration Skin Barrier

Differences between Cheeks and Dorsal Hands Skin Properties during Skiing in a Cold and Windy Environment

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 27-33页

作者： Sue Im Jang Jiyei Choi Jiyeon Han Eun Joo Kim hae kwang lee AMORE PACIFIC Corporation/R & D CENTER Yongin Korea

Background/Purpose: The skin protects against external factors and this skin function can be affected by environmental conditions, including low temperature, low humidity, and high altitude. Therefore, it is important to study the relationship between the environment and the skin. The purpose of this study is to determine how the skin barrier functions change at low temperatures. Methods: This study was performed at a Korean ski resort on January 2015 and evaluated 10 subjects skin condition during skiing. Skin properties were examined at 2 sites (cheeks and dorsal hands) and four time points (indoor;baseline, outdoor;after first skiing and after second skiing, indoor;after taking a shower). Results: The skin hydration on the cheek decreased after the second skiing session and the erythema decreased only after the first skiing while this value on dorsal hand was not changed by skiing. The brightness and yellowness of cheek skin increased and redness decreased therefore, skin color became pale during skiing. The extensibility of cheeks and dorsal hands decreased after skiing. We found positive correlation between skin temperature and redness (r2 = 0.707, p Conclusions: Low temperatures can affect human skin color so that the skin color becomes pale because capillary blood vessels shrink when skin is exposed to cold environment. The cheek skin tends to change easily than dorsal hand during ambient temperature change.

关键词： Low Temperature Environment Skiing Hydration Skin Color Elasticity Skin Temperature Skin Redness

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung haesong lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee kwang-Hyeon Liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin