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Electrocardiographic changes during induced therapeutic hypothermia in comatose survivors after cardiac arrest

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World Journal of Cardiology 2015年第7期7卷 423-430页

作者： Pablo Salinas Esteban Lopez-de-Sa laura Pena-Conde Ana Viana-Tejedor Juan Ramon Rey-Blas Eduardo Armada Jose Luis Lopez-Sendon Instituto Cardiovascular Hospital Clínico San Carlos Acute Cardiac Care Unit Division of CardiologyHospital Universitario La Paz

AIM: To assess the safety of therapeutic hypothermia(TH) concerning arrhythmias we analyzed serial electrocardiograms(ECG) during ***: All patients recovered from a cardiac arrest with Glasgow < 9 at admission were treated with induced mild TH to 32-34℃. TH was obtained with cool fluid infusion or a specific intravascular device. Twelvelead ECG before,during,and after TH,as well as ECG telemetry data was recorded in all patients. From a total of 54 patients admitted with cardiac arrest during the study period,47 patients had the 3 ECG and telemetry data available. ECG analysis was blinded and performed with manual caliper by two independent cardiologists from blinded copies of original ECG,recorded at 25 mm/s and 10 mm/m V. Coronary care unit staff analyzed ECG telemetry for rhythm disturbances. Variables measured in ECG were rhythm,RR,PR,QT and corrected QT(QTc by Bazett formula,measured in lead v2) intervals,QRS duration,presence of Osborn's J wave and U wave,as well as ST segment displacement and T wave amplitude in leads Ⅱ,v2 and ***: Heart rate went down an average of 19 bpm during hypothermia and increased again 16 bpm with rewarming(P < 0.0005,both). There was a nonsignificant prolongation of the PR interval during TH and a significant decrease with rewarming(P = 0.041). QRS duration significantly prolonged(P = 0.041) with TH and shortened back(P < 0.005) with rewarming. QTc interval presented a mean prolongation of 58 ms(P < 0.005) during TH and a significant shortening with rewarming of 22.2 ms(P = 0.017). Osborn or J wave was found in 21.3% of the patients. New arrhythmias occurred in 38.3% of the patients. Most frequent arrhythmia was non-sustained ventricular tachycardia(19.1%),followed by severe bradycardia or paced rhythm(10.6%),accelerated nodal rhythm(8.5%) and atrial fibrillation(6.4%). No life threatening arrhythmias(sustained ventricular tachycardia,polymorphic ventricular tachycardia or ventricular fibrillation) occurred during TH.

关键词： Cardiac arrest Therapeutic hypothermia Post-cardiac arrest síndrome Cardiac arrythmias QT interval

Post-Occupancy Evaluation (POE) Using Space Syntax: A Case Study of Urban Parks in the South of Brazil

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Journal of Civil Engineering and Architecture 2020年第11期14卷 609-616页

作者： Alcindo Neckel Laércio Stolfo Maculan Anaise Breda Daniela Maroni Edilaine Cristina Becker Isabelle Risson laura Pasa Cambrussi Michele Bianchini Julian Grub Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb—UNISINOS) São Leopoldo/RS93022-750Brazil

This study is based on strategies for reading and representing the environment,associated with the theory of social logic of space(space syntax).The general objective of this study is to understand and compare the use of space syntax in relation to connectivity,integration and choice of axial routes of the urban parks of Porto Alegre,in the state of Rio Grande do Sul,south of *** method applied was the capture of georeferenced images for data analysis by using the Theory of Space Syntax(TSE).Thus,three variables were considered for interpretation:choice,connectivity and integration,and they were correlated to statistical data on urban *** results demonstrated the possibility of obtaining significant improvements in the studied urban parks due to the need to create guidelines related to connection and integration that directly impact users'choice strategies when they move around the city.

关键词： Walkability choice connectivity integration urban parks space syntax

血管外科手术病人中的血小板基因多态性和心脏风险评估

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国外医学（麻醉学与复苏分册） 2005年第1期26卷 58-61页

作者： Nauder Faraday Elizabeth A.martinez Robert B.Scharpf laura Kasch-Semenza Todd Dorman Peter J.Pronovost Bruce Perler Gary Gerstenblith Paul F.Bray Lee A.Fleisher 李敬远(译) 曾因明(审) Department of Anesthesiology and Critical Care Medicine and Department of Surgery(Vascular) Johns Hopkins School of MedicineBaltimoreMaryland Department of Biostatistics Johns Hopkins Bloomberg School of PublicHealthBaltimoreMaryland Genetics Core Lab Methods Development Department of GeneticsJohns Hopkins School of MedicineBaltimoreMaryland Department of Surgery(Vascular) Johns Hopkins School of MedicineBaltimoreMaryland Department of Medicine(Cardiology) Johns Hopkins School of MedicineBaltimoreMaryland Department of Medicine(Hematology) Baylor College of MedicineHoustonTexas 美国哈佛大学麻省总医院中国医科大学第一临床学院麻醉科徐州医学院江苏省麻醉学重点实验室

背景:目前围术期心脏风险评估工具是沿用外科手术影响因素对病人进行分级.血小板糖蛋白Ⅲa(GPⅢa)及GPIbα和非外科手术情况下的心肌缺血相关,但他们与围术期心肌缺血的关系并不清楚.作者提出假说血小板基因型和临床因素结合起来可成为... 详细信息

背景:目前围术期心脏风险评估工具是沿用外科手术影响因素对病人进行分级.血小板糖蛋白Ⅲa(GPⅢa)及GPIbα和非外科手术情况下的心肌缺血相关,但他们与围术期心肌缺血的关系并不清楚.作者提出假说血小板基因型和临床因素结合起来可成为围术期心肌缺血的预测指标。

关键词：血管外科手术血小板基因多态性心脏疾病围术期心肌缺血

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艺术中的医学,艺术如何救死扶伤

艺术与设计 2020年第3期9卷 192-195页

作者：乔治·博尔丁劳拉·波罗·迪安布罗西邵池(译) 无不详《艺术中的医学》

3月11日,世界卫生组织(WHO)终于宣布,目前状况可以定性为"全球大流行(pandemic)"。这是世卫组织此前一直极力避免使用的说法。疫情,在改变人们现实生活轨迹的同时,也在放大人们特殊时期的精神图谱。在疫情推进的全程中,艺术与设计的创... 详细信息

3月11日,世界卫生组织(WHO)终于宣布,目前状况可以定性为"全球大流行(pandemic)"。这是世卫组织此前一直极力避免使用的说法。疫情,在改变人们现实生活轨迹的同时,也在放大人们特殊时期的精神图谱。在疫情推进的全程中,艺术与设计的创作从来就没有消失过。在当前情况下,作为一名创意杂志的编辑,脑海中一直萦绕的问题就是艺术、设计与文明和人文关怀如何体现在救死扶伤之中。在寻找的过程中,《艺术中的医学》这本书又重新回到我们的视野。

关键词：世卫组织艺术与设计生活轨迹救死扶伤人文关怀医学疫情

Intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Pseudopemphigoid as caused by topical drugs and pemphigus disease

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World Journal of Ophthalmology 2015年第1期5卷 1-15页

作者： laura C Huang James R Wong Javier Alonso-Llamazares Carlos H Nousari Victor L Perez Guillermo Amescua Carol L Karp Anat Galor Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFL 33136United States Department of Dermatology and Cutaneous Surgery Miami Veterans Administration Medical CenterMiamiFL 33136United States Institute for Immunofluorescence Pompano BeachFL 33069United States Ameripath/Quest South Florida Pompano BeachFL 33069United States Department of Dermatology and Cutaneous Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Department of Ophthalmology Miami Veterans Administration Medical CenterMiamiFL 33136United States

Pseudopemphigoid can cause a chronic cicatricial conjunctivitis that is clinically identical to the manifestations seen in mucous membrane pemphigoid, a disorder with a common clinical phenotype and multiple autoimmune links. For the purpose of this review, we will describe pseudopemphigoid as caused by topical drugs, the most common etiology with ocular manifestations, and as caused by the pemphigus disease, a more rare etiology. Specifically, we will discuss the ophthalmological features of drug-induced cicatricial conjunctivitis, pemphigus vulgaris, and paraneoplastic pemphigus. Other etiologies of pseudopemphigoid exist that will not be described in this review including autoimmune or inflammatory conditions such as lichen planus, sarcoidosis, granulomatosis with polyangiitis(Wegener's granulomatosis), erythema multiforme(minor, major, and Stevens-Johnson syndrome), bullous pemphigoid, skin-dominated linear IgA bullous dermatosis, and skin-dominated epidermolysis bullosa acquisita. Prompt diagnosis of the underlying etiology in pseudopemphigoid is paramount to the patient's outcome as certain diseases are associated with a more severe clinical course, increased ocular involvement, and differential response to treatment. A completehistory and ocular examination may find early cicatricial changes in the conjunctiva that are important to note and evaluate to avoid progression to more severe disease manifestations. When such cicatricial changes are noted, proper diagnostic techniques are needed to help elucidate a diagnosis. Lastly, collaboration between ophthalmologists and subspecialists such as dermatologists, pathologists, immunologists, and others involved in the care of the patient is needed to ensure optimal management of disease.

关键词： Pseudopemphigoid Mucous membrane pemphigoid Cicatricial conjunctivitis Pemphigus vulgaris Paraneoplastic pemphigus Drug-induced conjunctival cicatrization

ERCP in acute pancreatitis:What takes place in routine clinical practice?

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World Journal of Gastrointestinal Endoscopy 2010年第9期2卷 308-313页

作者： Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo Department of Surgical and Gastroenterological Sciences University of Verona Department of Digestive Diseases and Internal Medicine S.Orsola-Malpighi Hospital Department of Internal Medicine Department of Surgery Humanitas Hospital Department of Emergency Surgery Fondazione IRCCS MaggioreMangiagalli and Regina Elena Hospital Digestive Endoscopy Unit "Agostino Gemelli" University HospitalCatholic University of Rome Rome 00100 Italy Department of Surgery University Vita e Salute

AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the ***:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of *** main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) *** success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic ***:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy.

关键词： Acute pancreatitis Epidemiology,Endoscopic retrograde cholangiopancreatography Data collection

淡水豚类mtDNA 16S rRNA基因的系统发生

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南京师大学报（自然科学版） 2000年第3期23卷 74-78页

作者：刘珊杨光周开亚 Ricardo Bastida laura Rivero 南京师范大学生命科学学院遗传资源研究所南京210097 Departamento de Ciencias Marinas Casillade Correo43 7600 MardelPlataArgentina Departamento de Ciencias Marinas Casillade Correo43 7600Mardel PlataArgentina

mt DNA 16 S r RNA基因序列分析支持将现生淡水豚 4个属归入不同的科 ,即白暨豚科(L ipotiidae)、恒河豚科 (Platanistidae)、亚河豚科 (Iniidae)和弗西豚科 (Pontoporidae) .基于邻接法的系统发生分析显示淡水豚类由白暨豚 +恒河豚和... 详细信息

mt DNA 16 S r RNA基因序列分析支持将现生淡水豚 4个属归入不同的科 ,即白暨豚科(L ipotiidae)、恒河豚科 (Platanistidae)、亚河豚科 (Iniidae)和弗西豚科 (Pontoporidae) .基于邻接法的系统发生分析显示淡水豚类由白暨豚 +恒河豚和弗西豚 +亚河豚两个单系组成 ,但两个单系之间并无姊妹关系 .淡水豚类是并系的 .16 S r RNA基因的系统发生树与 mt DNA细胞色素 b基因和12 S r RNA基因的系统发生树并不完全一致 .这种差异一方面可能反映了不同的基因树间的差异 ,但也可能与本文分析的 16 S r RNA基因片段中变异位点数和简约信息位点数较少有关 .因此 ,有必要增加序列长度来进一步验证 .

关键词：淡水豚类 16SrRNA基因系统发生 mtDNA 分类

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凸多面体,代数几何学和组合学

数学译林 2020年第4期39卷 307-316页

作者： laura Escobar Kiumars Kaveh 赵振江(译) 燕敦验(校) St.Louis华盛顿大学匹兹堡大学不详

在最近的几十年,凸几何学方法被证明在代数几何学中是非常有用的,尤其是在理解代数簇的离散不变量上.研究代数簇的一个方法是把组合对象的一个对应的族赋予簇的一个族,这些对象编码了簇的几何信息.由此引出的这些组合对象经常是凸多面体... 详细信息

在最近的几十年,凸几何学方法被证明在代数几何学中是非常有用的,尤其是在理解代数簇的离散不变量上.研究代数簇的一个方法是把组合对象的一个对应的族赋予簇的一个族,这些对象编码了簇的几何信息.由此引出的这些组合对象经常是凸多面体,而凸几何学一直是这一策略的根本工具.

关键词：凸多面体组合学代数簇几何信息几何学方法