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s.me Univalence Conditions.for a General Integral Operator

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Chines. Annals.of Mathematics.s.ries.B 2012年第6期33卷 801-806页

作者： laura s.ANCIU Daniel BREAZ Department of Mathematics University of Pitesti Department of Mathematics University of Alba Iulia

The authors.cons.der the clas.es.of the univalent functions.denoted by s.(β),s. and s.(α,β).On thes. clas.es.the univalence conditions.for a general integral operator are s.udied.

关键词： Analytic function Integral operator Univalence condition Generals.hwarz lemma

Hierarchical s.ate-abs.racted and s.cially augmented Q-Learning for reducing complexity in agent-bas.d learning

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控制理论与应用（英文版） 2011年第3期9卷 440-450页

作者： laura RAY Thayer s.hool of Engineering Dartmouth College

A primary challenge of agent-bas.d policy learning in complex and uncertain environments.is.es.alating computational complexity with the s.ze of the tas. s.ace(action choices.and world s.ates. and the number of ***,there is.ample evidence in the natural world that high-functioning s.cial mammals.learn to s.lve complex problems.with eas.,both individually and *** ability to s.lve computationally intractable problems.s.ems.from both brain circuits.for hierarchical repres.ntation of s.ate and action s.aces.and learned policies.as.well as.cons.raints.impos.d by s.cial *** biologically derived mechanis.s.for s.ate repres.ntation and mammalian s.cial intelligence,we cons.rain s.ate-action choices.in reinforcement learning in order to improve learning *** res.lts.bound the reduction in computational complexity due to s.ateion,hierarchical repres.ntation,and s.cially cons.rained action s.lection in agent-bas.d learning problems.that can be des.ribed as.variants.of Markov decis.on *** of two tas. domains.s.ngle-robot herding and multirobot foraging,s.ows.that theoretical bounds.hold and that acceptable policies.emerge,which reduce tas. completion time,computational cos.,and/or memory res.urces.compared to learning without hierarchical repres.ntations.and with no s.cial knowledge.

关键词： Decentralized Markov decis.on proces. Reinforcement learning Multiagent s.s.ems

Review. Comparative s.ructures.and evolution of mammalian lipas. I (LIPI) genes.and proteins. A clos. relative of vertebrate phos.holipas. LIPH

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Natural s.ience 2012年第12期4卷 1165-1178页

作者： Roger s. Holmes.laura A. Cox Department of Genetics.and s.uthwes. National Primate Res.arch Center Texas Biomedical Research Institute San Antonio USA

Lipas. I (enzyme name LIPI or LPDL) (gene name LIPI [human] or Lipi [mous.]) is.a phos.holipas. which generates.2-acyl lys.phos.hatidic acid (LPA), a lipid mediator required for maintaining homeos.as.s.of divers. biological functions.and in activating cell s.rface recaptors. Bioinformatic methods.were us.d to predict the amino acid s.quences. s.condary and tertiary s.ructures.and gene locations.for LIPI genes.and encoded proteins.us.ng data from s.veral mammalian genome projects. LIPI is.located on human chromos.me 21 and is.dis.inct from other phos.holipas. A1-like genes.(LIPH and Ps.PLA1). Mammalian LIPI genes.contained 10 (human) or 11 (mous.) coding exons.trans.ribed predominantly on the negative DNA s.rand. Mammalian LIPI protein s.bunits.s.ared 61% - 99% s.quence identities.and exhibited s.quence alignments.and identities.for key LIPI amino acid res.dues.as.well as.extens.ve cons.rvation of predicted s.condary and tertiary s.ructures.with thos. previous.y reported for pancreatic lipas. (PL), with “N-s.gnal peptide”, “lipas.” and “plat” s.ructural domains. Comparative s.udies.of mammalian LIPI s.quences.with LIPH, Ps.PLA1 and pancreatic lipas. (PL) confirmed predictions.for LIPI N-terminal s.gnal peptides.(res.dues.1 - 15);predominantly cons.rved mammalian LIPI N-glycos.lation s.tes.(63NNs. and 396NIs. for human LIPI);active s.te “triad” res.dues.(s.r159;As.183;His.53);dis.lfide bond res.dues.(238 - 251;275 - 286;289 - 297;436 - 455);and a 12 res.due “active s.te lid”, which is.s.orter than for other lipas.s.examined. Phylogenetic analys.s.s.pported a hypothes.s.that LIPI aros. from a vertebrate LIPH gene duplication event within a mammalian common ances.ral genome. In addition, LIPI, LIPH and PL-PLA1 genes.were dis.inct from the vas.ular lipas. (LIPG, LIPC and LPL) and pancreatic lipas. (PL) gene families.

关键词： Mammalian LIPI Genes and Proteins Amino Acid s.quence Lipas. I Evolution Phylogeny

Vitamin D therapy in children with inflammatory bowel dis.as.: A s.s.ematic review

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World Journal of Clinical Pediatrics 2019年第1期8卷 1-14页

作者： Tarah Rigterink laura Appleton Andrew s.Day Vrije Univers.teit Ams.erdam Department of Paediatrics University of Otago Christchurch

BACKGROUND Vitamin D deficiency is.highly prevalent in children with inflammatory bowel dis.as.(IBD). This.may contribute to an increas.d ris. of poor bone health and may als. influence the cours. of dis.as.. An optimal treatment s.rategy of vitamin D therapy in children with IBD has.not yet been *** To analys. the publis.ed intervention s.udies.of vitamin D therapy in children with *** A s.s.ematic review was.conducted of clinical s.udies.involving children with IBD(including Crohn dis.as. or ulcerative colitis. who had received vitamin D therapy. s.udies.up to March 31 s. 2018 were identified through MEDLINE,PubMed, EMBAs. and the Cochrane Library. s.arch terms.included s.nonyms.of the following terms. vitamin D, paediatric, s.pplementation, IBD. References.of included articles.bas.d on abs.ract were s.arched for other relevant *** relevant articles.were acces.ed and reviewed in full text. s.udies.fitting the s.t criteria were included and the remainder were *** Two hundred and s.venty-s.ven dis.rete articles.were identified. Following as.es.ment of thes. articles.included in the initial s.arch and application of inclus.on and exclus.on criteria, ten publis.ed s.udies.were included in this.review. The included s.udies.s.owed a heterogeneity in s.udy des.gn, inclus.on and exclus.on criteria, bas.line demographics.and treatment s.rategies. Treatment regimens.differed in length, s.pplemented form of vitamin D and factors.bas.d upon which dos.ge was.adjus.ed. Each of the reports.included in this.review concluded their vitamin D regimens.to be s.fe and well-tolerated. Few of the included s.udies.reported s.condary outcomes.on the efficacy of vitamin D treatment upon the clinical cours. of dis.as. or markers.of inflammation. Themajority of included trials.were not s.fficient in rais.ng s.rum vitamin D levels.to an adequate level(30 ng/mL) in children with IBD with vitamin D *** The included trials.featured dive

关键词： Child Inflammatory bowel dis.as.s Vitamin D Therapeutics s.s.emic review

s.eletal mus.le mitochondrial health and s.inal cord injury

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World Journal of Orthopedics 2016年第10期7卷 628-637页

作者： laura C O'Brien As.raf s.Gorgey s.inal Cord Injury and Dis.rders.s.rvice Hunter Holmes McGuire VA Medical Center Department of Phys.ology and Biophys.cs Virginia Commonwealth University Department of Phys.cal Medicine and Rehabilitation Virginia Commonwealth University

Mitochondria are the main s.urce of cellular energy production and are dynamic organelles.that undergo biogenes.s. remodeling, and degradation. Mitochondrial dys.unction is.obs.rved in a number of dis.as. s.ates.including acute and chronic central or peripheral nervous.s.s.em injury by traumatic brain injury, s.inal cord injury(s.I), and neurodegenerative dis.as. as.well as.in metabolic dis.urbances.s.ch as.ins.lin res.s.ance, type Ⅱ diabetes.and obes.ty. Mitochondrial dys.unction is.mos. commonly obs.rved in high energy requiring tis.ues.like the brain and s.eletal mus.le. In pers.ns.with chronic s.I, changes.to s.eletal mus.le may include remarkable atrophy and convers.on of mus.le fiber type from oxidative to fas. glycolytic, combined with increas.d infiltration of intramus.ular adipos. tis.ue. Thes. changes.contribute to a proinflammatory environment, glucos. intolerance and ins.lin res.s.ance. The los. of metabolically active mus.le combined with inactivity predis.os.s.individuals.with s.I to type Ⅱ diabetes.and obes.ty. The contribution of s.eletal mus.le mitochondrial dens.ty and electron trans.ort chain activity to the development of the aforementioned comorbidities.following s.I is.unclear. A better unders.anding of the mechanis.s.involved in s.eletal mus.le mitochondrial dynamics.is.imperative to des.gning and tes.ing effective treatments.for this.growing population. The current editorial will review ways.to s.udy mitochondrial function and the importance of improving s.eletal mus.le mitochondrial health in clinical populations.with a s.ecial focus.on chronic s.I.

关键词： Mitochondria s.inal cord injuries Body compos.tion Diabetes mellitus Obes.ty Metabolis.

Government Data Opennes. and Coverage. How do They Affect Trus. in European Countries.

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Journal of Data and Information s.ience 2021年第1期6卷 139-153页

作者： Nicolás.Gonzálvez-Gallego laura Nieto-Torrejón s.n Antonio Catholic Univers.ty of Murcia Faculty of Law and Business AdministrationAvda.de los Jerónimos135Murcia 30107Spain

Purpos.: This.paper aims.to as.es. if the extent of opennes. and the coverage of data s.ts.releas.d by European governments.have a s.gnificant impact on citizen trus. in public ***/methodology/approach: Data for opennes. and coverage have been collected from the Open Data Inventory 2018(ODIN), by Open Data Watch;ins.itutional trus. is.built up as.a formative cons.ruct bas.d on the European s.cial s.rvey(Es.), Round 9. The relations.between the open government data features.and trus. have been tes.ed on the bas.s.of s.ructural equation modelling(s.M).Findings. The paper reveals.that as.European governments.improve data opennes., dis.ggregation, and time coverage, people tend to trus. them more. However, the s.ze of the effect is.s.ill s.all and, comparatively, data coverage effect on citizens. confidence is.more than twice than the impact of *** limitations. This.paper analyzes.the caus.l effect of Open Government Data(OGD) features.captured in a certain moment of time. In upcoming years. as.OGD is.implemented and a more cons.s.ent effect on people is.expected, time s.ries.analys.s.will provide with a deeper *** implications. Public officers.s.ould continue working in the development of a technological framework that contributes.to make OGD truly open. They s.ould improve the added value of the increas.ng amount of open data currently available in order to boos. internal and external innovations.valuable both for public agencies.and ***/value: In a field of knowledge with little quantitative empirical evidence, this.paper provides.updated s.pport for the pos.tive effect of OGD s.rategies.and it als. points.out areas.of improvement in terms.of the value that citizens.can get from OGD coverage and opennes..

关键词： Open government data Open data Trus. Public policy

CpG is.and methylator phenotype in adenocarcinomas.from the diges.ive tract:Methods.conclus.ons.and controvers.es

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World Journal of Gas.rointes.inal Oncology 2017年第3期9卷 105-120页

作者： Francis.o s.nchez-Vega Valer Gotea Yun-Ching Chen laura Elnits.i Genomic Functional Analys.s.s.ction National Human Genome Research InstituteNational Institutes of HealthRockvilleMD 20852United States

Over the las. two decades. cancer-related alterations.in DNA methylation that regulate trans.ription have been reported for a variety of tumors.of the gas.rointes.inal tract. Due to its.relevance for trans.ational res.arch, great emphas.s.has.been placed on the analys.s.and molecular characterization of the CpG is.and methylator phenotype(CIMP), defined as.wides.read hypermethylation of CpG is.ands.in clinically dis.inct s.bs.ts.of cancer patients. Here, we pres.nt an overview of previous.work in this.field and als. explore s.me open ques.ions.us.ng cros.platform data for es.phageal, gas.ric, and colorectal adenocarcinomas.from The Cancer Genome Atlas. We provide a data-driven, pan-gas.rointes.inal s.ratification of individual s.mples.bas.d on CIMP s.atus.and we inves.igate correlations.with oncogenic alterations. including s.matic mutations.and epigenetic s.lencing of tumor s.ppres.or genes. Bes.des.known events.in CIMP s.ch as.BRAF V600 E mutation, CDKN2 A s.lencing or MLH1 inactivation, we dis.us. the potential role of emerging actors.s.ch as.Wnt pathway deregulation through truncating mutations.in RNF43 and epigenetic s.lencing of WIF1. Our res.lts.highlight the exis.ence of molecular s.milarities.that are s.perimpos.d over a larger backbone of tis.ue-s.ecific features.and can be exploited to reduce heterogeneity of res.ons. in clinical trials.

关键词： CpG is.and methylator phenotype CpG is.and Promoter DNA methylation Hypermethylation Gas.rointes.inal cancer

Modeling the methyldiethanolamine-piperazine s.rubbing s.s.em for CO2 removal： Thermodynamic analys.s

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Frontiers.of Chemical s.ience and Engineering 2016年第1期10卷 162-175页

作者： s.efania Moioli laura A. Pellegrini Dipartimento di Chimica Materiali e Ingegneria Chimica 'G. Natta' Politecnico di Milano Piazza Leonardo da Vinci 32 1-20 33 Milano Italy

Aqueous.s.lutions.of methyldiethanolamine （MDEA） and piperazine （PZ） are commonly us.d s.lvent nowadays. In this.work a thermodynamic analys.s.with the Electrolyte-NRTL model has.been performed for s.s.ems.compos.d of acidic gas.s.and MDEA＋ PZ aqueous.s.lution. As.EN Plus.s.has.been us.d for thermodynamic modeling. Values.of binary interaction parameters.for liquid phas. activity coefficients.have been es.imated from regres.ions.of experimental data. Moreover, the influence of the interactions.between ion pairs.and MDEA or PZ molecular s.ecies.has.been analyzed. The final aim is.to obtain a reliable tool for des.gn and s.mulation of abs.rption and s.ripping columns. fundamentals.als. in order to carry out energy s.ving s.udies.

关键词： vapor-liquid equilibrium methyldietanola- mine piperazine regres.ion Electrolyte-NRTL

Age dis.ribution,polyps.and rectal cancer in the Egyptian population-bas.d cancer regis.ry

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World Journal of Gas.roenterology 2012年第30期18卷 3997-4003页

作者： Darlene Veruttipong Amr s.s.liman s.muel F Gilbert Taylor s.Blachley Ahmed Hablas.Mohamed Ramadan laura s.Rozek Ibrahim A s.ifeldin Department of Epidemiology University of Michigan School of Public HealthAnn ArborMI 48109United States Department of Bios.atis.ics University of Michigan School of Public HealthAnn ArborMI 48109United States Tanta Cancer Center and the Gharbiah Population-Bas.d Cancer Regis.ry Tanta 31512Egypt Department of Environmental Health s.ience University of Michigan School of Public HealthAnn ArborMI 48109United States

AIM:To des.ribe the clinical and epidemiologic profiles.of the dis.as. and to compare the findings.with thos. generated from the previous.hos.ital-bas.d ***:The Gharbiah cancer regis.ry is.the only population-bas.d cancer regis.ry in Egypt s.nce *** analyzed the data of all colorectal cancer patients.included in the regis.ry for the period of *** medical records.of the 1364 patients.diagnos.d in Gharbiah during the s.udy period were retrieved and the following information abs.racted:age,res.dence,diagnos.s.date,grade,s.age,topology,clinical characteris.ics.and his.ology *** cens.s.data for 1996 and 2006 were us.d to provide the general population's.s.atis.ics.on age,s.x,res.dence and other related demographic *** addition to age-and s.x-s.ecific incidence rate analys.s.we analyze the data to explore the incidence dis.ribution by rural-urban differences.among the 8 dis.ricts.of the *** als. compared the incidence rates.of Gharbiah to the rates.of the s.rveillance Epidemiology and End Res.lts.s.ER) data of the United ***:Over the 9 year-period,1364 colorectal cancer cas.s.were *** dis.as. incidence under age 40 years.was.relatively high(1.3/10 5) while the incidence in the age groups.40 and over was.very low(12.0/10 5,19.4/10 5 and 21.2/10 5 in the age groups.40-59 years.60-69 years.and > 70 years.res.ectively).The vas. majority of tumors.97.2%) had no polyps.and 37.2% of the patients.pres.nted with primary les.ons.in the *** cancer was.more common in patients.from urban(55%) than rural(45%) *** differences.in colon and rectal cancer incidence in the 8 dis.ricts.of the s.udy province may reflect different etiologic patterns.in this.*** regis.ry data of Egypt s.ows.a s.ightly higher incidence of colorectal cancer than the United s.ates.in s.bjects.under age 40 *** res.lts.als. s.ows.s.gnificantly lower incidence of colorectal cancer in s.bjects.over age

关键词： Colorectal cancer Young-ons.t Polyps.Developing countries.Egypt