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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan Fen Neoh Tiek ying lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

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Antimicrobial resistance, genotypic characterization and pulsed-field gel electrophoresis typing of extended spectrum β-lactamases-producing clinical Escherichia coli strains in Macao, China

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Chinese Medical Journal 2011年第17期124卷 2701-2707页

作者： YE Qian-hong lau ying LIANG Bin TIAN Su-fei School of Health Sciences Macao Polytechnic Institute Macao Special Administrative Region (SAR) China School of Health Sciences China Medical University Shenyang Liaoning 110001 China Department of Laboratory Medicine First Affiliated Hospital China Medical University Shenyang Liaoning 110001 China

Background The rise of the production of CTX-M class extended spectrum β-lactamases （ESBLs） has been well documented in traveling countries but no data are found for Macao, an international travel city. The objectives of this study were to identify the antimicrobial resistance pattern, and determine the prevalence, genotype and clonal relationship of ESBLs in 209 clinical Escherichia coli strains from Macao, China. Methods Antimicrobial susceptibility test was performed to determine the resistance patterns of the isolates using the disk diffusion method with 17 antimicrobial agents. Phenotypic detection was screened and confirmed according to the Clinical and Laboratory Standards Institute. Genotypic characterization was detected by isoelectric focusing analysis, polymerase chain reaction and sequencing. The clonal relationship between the different ESBL isolates was studied by pulsed-field gel electrophoresis （PFGE）. Results Imipenem and meropenem exhibited 100% susceptible among 209 strains. Overall, 82.3%, 67.3%, 52.9%, 51.2% and 51.0% of the isolates displayed resistance to ampicillin, tetracylcline, ciprofloxacin, sulfamethoxazole trimethoprin and gentamycin. The prevalence rate of ESBLs was 30.1%. Antibiotic resistances were found to be significantly higher among the ESBL producing group compared to non-ESBL producing group. We detected CTX-M-14 to be the major genotypic characterization of ESBLs （76.2%）. Two strains showed indistinguishable patterns by PFGE. Conclusions The prevalence of antimicrobial resistance is alarming high in Macao. Antimicrobial resistance is significantly higher among the ESBL producing group. This study documented CTX-M-14 as the predominant ESBL type. Although indistinguishable pattern was found between two strains, it was too small to decide whether any of the investigated strains was epidemic. Our findings may be also pertinent for other geographic areas undergoing similar travel characteristics to understand the corresponding eff

关键词： antimicrobial resistance Escherichia coli pulsed-field gel electrophoresis extended spectrum β-lactamases Macao

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Is it safe to perform operation for colorectal malignancy in Chinese patients without DVT prophylaxis？ An 8-year experience from a regional hospital in Hong Kong

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Chinese Medical Journal 2010年第15期123卷 1973-1975页

作者： Day Weida lau ying Yu Patrick Yip Wai Chun Andrew Department of Surgery Kwong Wah Hospital Hong Kong China

Background Colorectal surgery was regarded as one of the high risk surgery for post-operative deep vein thrombosis （DVT） and pulmonary embolism. This study aimed at investigating the incidence of venous thromboembolism （VTE） after colorectal surgery for *** Data were collected from the prospective database of colorectal malignancy from 2000 to 2008. A total of 1421 colorectal （open and laparoscopic） operations were performed for the colorectal malignancy without DVT *** Only seven patients （0.5%） developed symptomatic DVT and one of them had complication of pulmonary embolism without mortality. Open operation for colorectal malignancy was identified as possible risk factor of DVT,however, risk factors like operative time, low anterior resection, sex, age etc. were not *** Risk of venous thromboembolism after colorectal operation is low in Chinese of our locality and it might be safe to perform colorectal operation for malignancy without DVT prophylaxis.

关键词： colorectal carcinoma deep vein thrombosis

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Effectiveness of digital psychotherapeutic intervention among perinatal women:A systematic review and meta-analysis of randomized controlled trials

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World Journal of Psychiatry 2021年第4期11卷 133-152页

作者： ying lau Jing-ying Cheng Sai-Ho Wong Kai-Yoong Yen Ling-Jie Cheng Alice Lee Centre for Nursing Studies Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Nursing Research Unit Department of NursingKhoo Teck Puat HospitalYishun Health CampusNational Healthcare GroupSingapore 768828Singapore

BACKGROUND The perinatal period is a challenging time of substantial emotional,physiological,social,and relational ***,anxiety,and stress symptoms are common,and co-exist in the perinatal *** technology continues to grow at an unprecedented pace with wide application,including psychotherapeutic intervention.A growing number of meta-analyses supported the application of digital psychotherapeutic intervention across different populations,but relatively few meta-and meta-regression analyses have concentrated on perinatal *** To evaluate the effectiveness of digital psychotherapeutic intervention on improving psychological outcomes among perinatal women and identify its essential *** Randomized controlled trials(RCTs)were obtained from eight databases,including Cumulative Index to Nursing and Allied Health Literature,Cochrane Library,Embase,Scopus,PsycINFO,PubMed,Web of Science,and ProQuest Dissertation and Theses from inception up until November 24,*** Meta-analysis 3.0 software was used to conduct meta-and metaregression *** Cochrane risk-of-bias tool and the Grading of the Recommendation,Assessment,Development,and Evaluation system were adopted to assess the individual and overall qualities of the evidence,*** A total of 25 RCTs that included 3239 women were ***-analyses revealed that intervention significantly improved depression(Hedges’s g=0.49),anxiety(g=0.25),and stress(g=0.47)symptoms compared to the *** analyses demonstrated that a website platform with≥eight therapistguided sessions using the theoretical principle of cognitive behavioral therapy was more effective than other treatments in improving depression symptoms in postnatal ***-regression analyses observed that the age of perinatal women and the type of psychotherapy also had statistically significant effects on depression ***’s regression asymmetry tests suggested that no pub

关键词： Digital psychotherapeutic intervention Perinatal women Meta-analysis Meta-regression

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Single incision laparoscopic right hemicolectomy： different approaches

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Chinese Medical Journal 2013年第2期126卷 238-241页

作者： WONG Tak-man DAY Weida KWOK Shu-yan lau ying-yu Patrick YIP Wai-chun Andrew Department of Surgery Kwong Wah Hospital Hong Kong China

Background Single incision laparoscopic colectomy has been performed in recent years, and has been shown to be feasible and safe. This study was to assess the feasibility of single incision laparoscopic right hemicolectomy and to compare the differences in different approaches. Methods This retrospective study included eighteen patients with carcinoma of caecum and ascending colon, undergoing single incision laparoscopic right hemicolectomy. This study also compared single incision laparoscopic right hemicolectomy using different approaches：（1） single incision multiport, （2） single access port and （3） glove port. Results There was no statistical difference in surgical outcomes. Concerning the surgeon＇s satisfaction toward three methods, overcrowding and durability were similar but the single incision multiport was associated with the highest gas-leak and the ＂glove＂ port was associated with poor durability. However, the method of single incision multiport has the lowest average cost of the special trocar or port in each operation. The operative time and blood loss of the operations in this study were comparable to previous publications. Conclusion There was no significant difference between different approaches of single incision laparoscopic right hemicolectomy for colonic cancer in right side colon.

关键词： colonic neoplasms, colectomy instrumentation, laparoscopy methods equipment design

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Potential Antiviral Target for SARS-CoV-2:A Key Early Responsive Kinase during Viral Entry

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CCS Chemistry 2022年第1期4卷 112-121页

作者： Siwen Liu Lin Zhu Guangshan Xie Bobo Wing-Yee Mok Zhu Yang Shaofeng Deng Siu-ying lau Pin Chen Pui Wang Honglin Chen Zongwei Cai State Key Laboratory for Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongPok Fu LamHong Kong SAR 999077 State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityKowloonHong Kong SAR 999077 HKBU Shenzhen Institute of Research and Continuing Education Shenzhen 518000 Beijing Normal University-Hong Kong Baptist University United International College Zhuhai 519087

Currently,there is no effective antiviral medication for coronavirus disease 2019(COVID-19)and the knowledge on the potential therapeutic target is in great *** by a time-course transmission electron microscope(TEM)imaging,we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral *** on alterations in the phosphorylation events,we found that kinase activities such as protein kinase C(PKC),interleukin-1 receptor-associated kinase 4(IRAK4),MAP/microtubule affinity-regulating kinase 3(MARK3),and TANK-binding kinase 1(TBK1)were affected within 15 min of *** of the corresponding kinase inhibitors of PKC,IRAK4,and p38 showed significant inhibition of SARS-CoV-2 ***,proinflammatory cytokine production was reduced by applying PKC and p38 *** an acquisition of a combined image data using positiveand negative-sense RNA probes,as well as pseudovirus entry assay,we demonstrated that PKC contributed to viral entry into the host cell,and therefore,could be a potential COVID-19 therapeutic target.

关键词： SARS-CoV-2 viral entry phosphoproteomics early responsive kinase antiviral target PKC

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粤英记者会同传的翻译倾向

粤英记者会同传的翻译倾向

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作者：刘晓盈（lau Hiu ying）北京外国语大学

学位级别：硕士

莫娜·贝克提出翻译中会出现一些倾向。然而,这种说法是基于以欧洲语言的语言对和可比性低的数据。语料库中的数据常因长度、体裁、时期、正式或非正式和其他因变量而异。因此,本研究旨在以最有限的变量研究正式场合中粤语口译英语的倾... 详细信息

莫娜·贝克提出翻译中会出现一些倾向。然而,这种说法是基于以欧洲语言的语言对和可比性低的数据。语料库中的数据常因长度、体裁、时期、正式或非正式和其他因变量而异。因此,本研究旨在以最有限的变量研究正式场合中粤语口译英语的倾向。为了验证粤语到英语的口译有同样的口译倾向,这个研究比较了粤语的演讲(源语演讲)、香港的英语口译(目标语口译)和香港的英语演讲(目标语演讲)。这些数据摘自中/英政治口译语料库。总体而言,结果表明粤语-英语同声传译中的香港口译英语和自然生产的香港英语很相似,但口译英语仍存在显化倾向。

关键词：翻译普遍性显化粤英同传语料库口译研究

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近红外光的可视化及其应用

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液晶与显示 2021年第1期36卷 78-104页

作者：刘映雪朱福荣香港浸会大学物理系有机电子科学卓越研究中心先进材料研究所中国香港999077

开发高性能的近红外可视化器件在生物成像、食物检测、健康监测和环境分析等领域有着重要意义。近红外可视化器件由光探测单元和发光单元组成,可将人眼不可视的近红外光转换为可见光。其工作机制是,光探测单元作为发光单元的载流子注入... 详细信息

开发高性能的近红外可视化器件在生物成像、食物检测、健康监测和环境分析等领域有着重要意义。近红外可视化器件由光探测单元和发光单元组成,可将人眼不可视的近红外光转换为可见光。其工作机制是,光探测单元作为发光单元的载流子注入层,在近红外光下产生光电流,因而被近红外光照射的区域会产生电荷注入,在发光单元的对应区域复合发光,发射可见光。没有近红外光照射时,光探测单元中不产生光电流,将抑制发光单元中的电荷注入,因而不发光。因此,近红外可视化器件可用于对辐射、反射或吸收近红外光的物质成像。本综述介绍了近红外可视化器件的工作原理和最新进展,包括基于无机、有机半导体等不同材料的近红外可视化器件。研究发现,近红外可视化器件的光子转换效率由近红外光探测单元和发光单元的光电转换效率决定。本文归纳了提高近红外可视化器件的光子-光子转换效率的方法和相关工作,探讨和展望了近红外光的可视化技术在三维图像分析、近红外检测卡、生物成像、健康和环境监测与检测的应用前景。

关键词：近红外可视化器件近红外光电探测器近红外光电探测晶体管发光二极管光子上转换效率光亮度开关比

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基础医学多元化教学:降低“考试领导学习”的初探

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中国循证医学杂志 2006年第9期6卷 659-661页

作者：蔡青枝楼迎统长庚大学医学院生理暨药理学科台湾桃园33302

目的尝试在生理学教学方面推动考试外的其它学习项目,而非仅以研读共笔及考古题的方式评估学生成绩来评估学生的学习成效。方法我们将生理学学习成绩分为两部分,传统考试占学期成绩70％,“非考试”之评估占30％,我们将此30％成绩分别以... 详细信息

目的尝试在生理学教学方面推动考试外的其它学习项目,而非仅以研读共笔及考古题的方式评估学生成绩来评估学生的学习成效。方法我们将生理学学习成绩分为两部分,传统考试占学期成绩70％,“非考试”之评估占30％,我们将此30％成绩分别以生理学相关论文研读及口头报告、问题导向学习(PBL)及平时成绩之方式计分。采用学生意见问卷调查,统计学生投入多少时间用于准备考试、口头报告及PBL。结果学生在“非考试”项目中表现很高的学习意愿,且与准备考试相比学习成效并无差异。结论本研究的结果显示,医学生实行生理学多元化教学方式不会负面影响其学习成效。

关键词：多元化教学考试口头报告问题导向学习

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超越论的自我论之批判与意识的非自我论理解——年青萨特的贡献

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同济大学学报（社会科学版） 2005年第5期16卷 13-21页

作者：刘国英香港中文大学哲学系

本文以萨特的早期文献为依据,探讨了萨特思想得以形成的基础和过程。年青萨特通过研读胡塞尔的现象学,澄清了胡塞尔现象学与康德哲学在主体课题上的重要分野;进而又通过对胡塞尔的超越论的自我思想的批判,推进了早期胡塞尔的非观念论现... 详细信息

本文以萨特的早期文献为依据,探讨了萨特思想得以形成的基础和过程。年青萨特通过研读胡塞尔的现象学,澄清了胡塞尔现象学与康德哲学在主体课题上的重要分野;进而又通过对胡塞尔的超越论的自我思想的批判,推进了早期胡塞尔的非观念论现象学的进路;并在此基础上,提出了他的非自我论的意识概念,从而为他后来的存在主义思想奠定了基础。

关键词：年青萨特超越论的自我非自我论的意识

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