检索结果-南通市图书馆

Photonics Research 2020年第12期8卷 1888-1894页

作者： WEI LUO YING XUE JIE HUANG LIYING LIN BEI SHI KEI MAY lau Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Semiconductor lasers directly grown on silicon offer great potential as critical components in high-volume,lowcost integrated silicon photonics *** InAs/InP quantum dash(QDash)lasers on native InP substrate emitting at 1.5μm(C-band)have demonstrated notable performance,the growth of InAs/InP QDash lasers on silicon remains undeveloped because of the 8%lattice mismatch between InP and *** we report advances of growth techniques leading to the first C-band room-temperature continuous-wave electrically pumped QDash lasers on CMOS standard(001)silicon substrates by metalorganic chemical vapor deposition.A correlation between various material characterizations and device performance is analyzed for different QDash laser structures grown on planar nominal(001)*** the optimized QDash growth and improved fabrication process,the lowest threshold current density of 1.5 ka∕cm^(2) was determined on an 8μm×1.5 mmdevice on planar silicon with a single facet output power exceeding 14 *** device results illustrate the good material quality of the QDash lasers grown on silicon,suggesting potential applications for other active components of photonic integrated circuits,such as semiconductor optical amplifiers,modulators,and photodetectors.

关键词： pumped quantum wave

A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Yin lau Lee kai-Fai Lee Stephen Cho Wing Sze Wei Qiao Kelvin Wai-Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

2008欧洲卒中组织缺血性卒中及短暂性脑缺血发作治疗指南——一级预防部分

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国卒中杂志 2008年第12期3卷 925-930页

作者：邹昕颖高山黄家星首都医科大学附属北京天坛医院神经内科北京市100050 中国医学科学院中国协和医科大学北京协和医院神经内科香港中文大学威尔斯亲王医院内科与治疗学系

本文是欧洲卒中促进组织(European Stroke Initiative,EUSI)对卒中治疗指南的更新,指南包括缺血性卒中以及短暂性脑缺血发作(transient ischaemic attack,TIA),目前认为后者是独立事件。如果针对上述两者的建议不同,需明确列出,否则将... 详细信息

本文是欧洲卒中促进组织(European Stroke Initiative,EUSI)对卒中治疗指南的更新,指南包括缺血性卒中以及短暂性脑缺血发作(transient ischaemic attack,TIA),目前认为后者是独立事件。如果针对上述两者的建议不同,需明确列出,否则将同时适用于两者。根据欧洲神经病学会联盟(European Federation of Neurological Societies,EFNS)制定的标准规定指南建议的分类及水平如下(表1,2)。

关键词：卒中,缺血性脑缺血发作,短暂性指南欧洲

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

Tp receptor activation impairs endothelial nitric oxide-dependent vasorelaxation to isoprenaline:role of rho kinase in endothelium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tp receptor activation impairs endothelial nitric oxide-depe...

Avian influenza virus directly infects human natural killer cells and inhibits cell activity

浙江省生理科学会2008年学术年会

作者： Fung Ping Leung Chi Wai lau Department of Physiology Chinese University of Hong KongChina

Activation of TP receptors causes potent vasoconstriction,which contributes to increased vascular tone and blood *** present study was designed to examine the hypothesis that stimulation of TP receptor impairs endothe... 详细信息

关键词： Endothelium Isoprenaline Nitric oxide TP receptor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Virologica Sinica 2017年第2期32卷 122-129页

作者： Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung lau Wenwei Tu Department of Paediatrics The University of Hong Kong - Shenzhen Hospital Shenzhen 518000 China Department of Paediatrics & Adolescent Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Department of Microbiology The University of Hong Kong Hong Kong SAR China Shenzhen Engineering Laboratory of PID Diagnosis & Therapy Technology Shenzhen 518000 China

Natural killer （NK） cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza HIN1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza, and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.

关键词： natural killer (NK) cell avian influenza virus (AIV) immunoevasion directioninfection inhibition cytotoxicity

医学专科学院的培训功能对医学界和公众的影响

在线全文

学校读者我要写书评

暂无评论

中国毕业后医学教育 2017年第1期1卷 66-70页

作者：刘泽星李国栋香港医学专科学院

香港医学专科学院(医专)负责监察及评核香港的医学专科训练,并颁授院士资格,同时也负责提供继续医学教育。本研究引用医专作为例子,介绍医专的成立过程、所担当的独特法定角色、培训功能、院士资格在本地和海外的认可性、使命和工作,从... 详细信息

香港医学专科学院(医专)负责监察及评核香港的医学专科训练,并颁授院士资格,同时也负责提供继续医学教育。本研究引用医专作为例子,介绍医专的成立过程、所担当的独特法定角色、培训功能、院士资格在本地和海外的认可性、使命和工作,从而阐述医学专科学院对于培训和维持医师执业水平的重要性,以及通过专科培训改善当地医疗服务的质量,为公众带来裨益。中国正推进专科培训方面的发展,已经正式启动住院医师培训及为落实《关于开展专科医师规范化培训制度试点的指导意见》开始着手工作。制定全面培训系统,落实严格制度才能有效加强和保证医师队伍的素质,提升医疗服务的水平。医专作为中国的一个重要范例,首先,香港特别行政区为中国的一部分,有着共同的文化;其次,医专及分科学院具备规范化培训的相关经验,而且与国外著名学院关系密切,培训水平与国际标准接轨。因此,如果内地落实设立跟医专的架构和功能相似的培训机构,对推动专科医师培训的工作有非常大的帮助。本研究所论述的要点能为相关部门和机构在制定专科培训制度和实践提供具体参考。

关键词：毕业后医学教育继续医学教育医学专科评核学院

无症状大脑中动脉狭窄患者脑白质改变进展的危险因素

在线全文

学校读者我要写书评

暂无评论

中国神经精神疾病杂志 2010年第7期36卷 389-392页

作者：范玉华孙健莫仲棠黄家星曾进胜中山大学附属第一医院神经科ICU 广州510080 中山大学肿瘤防治中心华南肿瘤学重点实验室香港中文大学内科及药物治疗学系

目的对一项随机研究进行分析,探讨无症状大脑中动脉狭窄患者脑白质改变(white matter changes,WMC)发生和进展的危险因素。方法对无中风症状,但存在动脉硬化危险因素的患者进行磁共振检查,入选大脑中动脉(middle cerebral artery,MCA)... 详细信息

目的对一项随机研究进行分析,探讨无症状大脑中动脉狭窄患者脑白质改变(white matter changes,WMC)发生和进展的危险因素。方法对无中风症状,但存在动脉硬化危险因素的患者进行磁共振检查,入选大脑中动脉(middle cerebral artery,MCA)狭窄的患者。记录临床特点和基础血生化指标,随访2年,随访结束时再次行磁共振检查。WMC采用定量分析,体积增加超过所有患者WMC体积增加的平均值被定义为有进展。Logistic回归分析确定WMC发生和进展的独立危险因素。结果 220例无症状MCA狭窄者患中,69例存在WMC,Logistic回归分析显示年龄(OR=1.096,P<0.001)和高血压(OR=2.370,P=0.024)是WMC发生的独立危险因素。在进入研究时,69例的WMC平均体积为4.23cm3,经过两年时间增加至5.49cm3,有6例未能完成随访。随访结束时发现63例中24例(38.1%)WMC有进展。Logistic回归分析发现仅有基础WMC体积是预测WMC进展的独立危险因素(OR=1.329,P=0.003)。结论年龄和高血压是WMC发生的独立预测因素,而对于WMC的进展则是基础WMC体积更有预测意义,也就是说发现时WMC越严重,进展的机会越多,尽早发现WMC可能对于预防进展更有意义。

关键词：脑白质改变磁共振进展

The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2015年第1期4卷 371-381页

作者： Juan Yang Mark Jit kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.lau Joseph T.Wu Hong-jie Yu Key Laboratory of Surveillance and Early-warning on Infectious Disease Division of Infectious DiseaseChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206China Modelling and Economics Unit of Public Health in England LondonUK Department of Infectious Disease Epidemiology London School of Hygiene and Tropical MedicineLondonUK WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong Kong2/F North WingPatrick Manson Building7 Sassoon RoadPok Fu LamHong Kong Special Administrative RegionChina

Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy ***:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal *** participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in ***-reported costs from the survey were validated by a review of hospital accounts for a small sample of the ***:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying *** average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),*** medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,*** influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 ***$146;inpatients:US$1,800 ***$1,189).In the baseline ana

关键词： Influenza Cost analysis China