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Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： Lan Yang lai-yu Kwok Zhihong Sun Heping Zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

Volume-complementary bipolar layered oxide enables stable symmetric sodium-ion batteries

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Nano Research 2024年第5期17卷 4125-4133页

作者： Bo Peng Feng Wang Nazir Ahmad lai yu Shenghua Chen Genqiang Zhang School of Materials Science and Engineering Key Laboratory of Efficient Conversion and Solid-state Storage of Hydrogen and Electricity of Anhui ProvinceAnhui University of TechnologyMa’anshan 243002China Hefei National Research Center for Physical Sciences at the Microscale Chinese Academy of Sciences(CAS)Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

The commercialization of sodium-ion batteries is based on developing low-cost,highly stable,and safe cathode and anode ***,the promising hard carbon anode and layered oxide cathode suffer from low sodium-embedded potential near 0.1 V and severe phase transitions,which cause safe problem and short lifespan,***,we design a low-strain bipolar P2-Na_(0.7)Ni_(0.25)Fe_(0.2)Ti_(0.55)O_(2) to solve the mentioned obstacles,whereas(Ni,Fe)and Ti provide charge compensation when it is used as cathode and anode,*** is revealed that the bipolar layered oxide undergoes solid-solution reaction when used as cathode or anode,and exhibits volume-complementary feature in a sodium-ion full-cell,as identified by in-situ X-ray ***,the safe symmetric sodium-ion full-cell exhibits excellent cyclic stability with 91.7%capacity retention after 200 *** work will provide a new horizon for designing safe and stable sodium-ion batteries.

关键词： sodium-ion batteries bipolar layered oxides solid-solution reaction volume complementation symmetric battery

Rotating Massive Strangeon Stars and X-Ray Plateau of Short GRBs

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Research in Astronomy and Astrophysics 2024年第3期24卷 47-57页

作者： Xi-Yan Yang Xiao-yu lai Wei-Wei Tan Ren-Xin Xu School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China Research Center for Astronomy Hubei University of EducationWuhan 4300205China Key Laboratory of Quark and Lepton Physics Central China Normal UniversityMinistry of EducationWuhan 430079China School of Physics Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Strangeon stars,which are proposed to describe the nature of pulsar-like compact stars,have passed various observational *** maximum mass of a non-rotating strangeon star could be high,which implies that the remnants of binary strangeon star mergers could even be long-lived massive strangeon *** study rigidly rotating strangeon stars in the slowly rotating approximation,using the Lennard-Jones model for the equation of *** can significantly increase the maximum mass of strangeon stars with unchanged baryon numbers,enlarging the mass-range of long-lived strangeon *** spin-down after merger,the decrease of radius of the remnant will lead to the release of gravitational *** into account the efficiency of converting the gravitational energy luminosity to the observed X-ray luminosity,we find that the gravitational energy could provide an alternative energy source for the plateau emission of X-ray *** fitting results of X-ray plateau emission of some short gamma-ray bursts suggest that the magnetic dipole field strength of the remnants can be much smaller than that of expected when the plateau emission is powered only by spin-down luminosity of magnetars.

关键词： dense matter-(stars) pulsars general-(stars) gamma-ray burst general

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： Jian-yu Liu Yao-Yao Jiang Peng-Jie Li Bo Yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-yu lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota

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Food Science and Human Wellness 2024年第5期13卷 2690-2702页

作者： Qing Liu Teng Ma Cuijiao Feng Yalin Li Hao Jin Xuan Shi lai-yu Kwok Yan Shi Tingtao Chen Heping Zhang Affiliated Stomatological Hospital of Nanchang University Nanchang 330000China Department of Endodontics Affiliated Stomatological Hospital of Nanchang UniversityThe Key Laboratory of Oral Biomedicine of Jiangxi ProvinceJiangxi Province Clinical Research Center for Oral DiseasesNanchang 330000China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010000China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010000China Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010000China National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchang 330000China

Conventional filling therapy fails to fundamentally reduce oral cariogenic ***,oral microbiota follow-up intervention after filling would be necessary for improving dental caries *** recruited 9 caries-free individuals,and 89 dental caries subjects(5 dropouts).Eighty-nine patients were randomized into three groups:caries(n=8;no treatment),control(n=40;filling),and postbiotics(n=41;filling and 14-day Probio-Eco®intervention).Salivary samples were collected at 0 day(after filling)and 14 *** results showed that the diversity of dental caries oral microbiota was significantly increased compared with healthy subjects,and filling could restore a healthier oral microbiota partially and *** intervention keeps a low ***-occurrence network analysis showed that a more stable oral microbiota structure after postbiotics *** and functional annotation of the microbiota revealed that postbiotics co-treatment significantly:increased the relative abundance of Pseudomonas and ***,decreased the relative abundance of Prevotella shahii,and enriched the energy metabolism-related ***-predicted phenotypes inferred to an oral microbiota with decreased potential pathogenic bacteria and increased oxidative stress-tolerant bacteria after postbiotics ***,it suggested that postbiotics co-treatment could be a promising strategy that restores the oral microecological balance for dental caries.

关键词： Postbiotics Oral microbiota Salivary microbiota Dental caries Pacific Biosciences(PacBio)single molecule real-time(SMRT)sequencing Dental filling

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Predicting Lactobacillus delbrueckii subsp. bulgaricusStreptococcus thermophilus interactions based on a highly accurate semi-supervised learning method

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Science China Life Sciences 2024年

作者： Shujuan Yang Mei Bai Weichi Liu Weicheng Li Zhi Zhong lai-yu Kwok Gaifang Dong Zhihong Sun Key Laboratory of Dairy Biotechnology and Engineering Ministry of Education Inner Mongolia Agricultural University Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural Affairs Inner Mongolia Agricultural University Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural University Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products Ministry of Education Inner Mongolia Agricultural University College of Computer and Information Engineering Inner Mongolia Agricultural University Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application of Agriculture and Animal Husbandry

Lactobacillus delbrueckii subsp. bulgaricus(L. bulgaricus) and Streptococcus thermophilus(S. thermophilus) are commonly used starters in milk fermentation. Fermentation experiments revealed that L. bulgaricus-S. thermophilus interactions(LbSt I) substantially impact dairy product quality and production. Traditional biological humidity experiments are time-consuming and labor-intensive in screening interaction combinations, an artificial intelligence-based method for screening interactive starter combinations is necessary. However,in the current research on artificial intelligence based interaction prediction in the field of bioinformatics, most successful models adopt supervised learning methods, and there is a lack of research on interaction prediction with only a small number of labeled ***, this study aimed to develop a semi-supervised learning framework for predicting LbSt I using genomic data from 362 isolates(181per species). The framework consisted of a two-part model: a co-clustering prediction model(based on the Kyoto Encyclopedia of Genes and Genomes(KEGG) dataset) and a Laplacian regularized least squares prediction model(based on K-mer analysis and gene composition of all isolates datasets). To enhance accuracy, we integrated the separate outcomes produced by each component of the two-part model to generate the ultimate LbSt I prediction results, which were verified through milk fermentation experiments. Validation through milk fermentation experiments confirmed a high precision rate of 85%(17/20; validated with 20 randomly selected combinations of expected interacting isolates). Our data suggest that the biosynthetic pathways of cysteine, riboflavin, teichoic acid, and exopolysaccharides, as well as the ATP-binding cassette transport systems, contribute to the mutualistic relationship between these starter bacteria during milk fermentation. However, this finding requires further experimental verification. The presented model and data are valua

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晚明文人旅游的心性执念及文化建构

深圳大学学报（人文社会科学版） 2024年第2期41卷 25-35页

作者：赖玉芹中南民族大学民族学与社会学学院湖北武汉430074

在晚明兴起的旅游热潮中,晚明文人尤为活跃,引领着旅游风尚。他们或为追求舒适和娱乐而游,或为摆脱社会竞争中的身份焦虑、为塑造自身文化品位、区隔大众而游。更重要的是,晚明特殊的社会境况及阳明心学的影响使文人们对旅游产生一种心... 详细信息

在晚明兴起的旅游热潮中,晚明文人尤为活跃,引领着旅游风尚。他们或为追求舒适和娱乐而游,或为摆脱社会竞争中的身份焦虑、为塑造自身文化品位、区隔大众而游。更重要的是,晚明特殊的社会境况及阳明心学的影响使文人们对旅游产生一种心性执念。在自我意识的觉醒后,面对山水的强烈吸引,他们投身其中,以游为“乐业”。在旅游的过程中,他们将其他文化爱好融于其中,形成本阶层独特的文化品位和生活方式;旅游不只是一般的消遣和娱乐,而是具有需认真对待、倾心投入的文化旨趣。他们以游为志,实现价值追求;游必有作,藉创作完成文化使命;寻求“游趣”,体现本阶层文雅和新异特色。他们不避艰险,勇于探索,率性而游,注重生命体验,堪称“性灵游”。作为具有高度文化艺术修养的群体,晚明文人融文化于旅游,对旅游进行了重要文化建构:赋诗作画、纪游品评,为山水打上文化印记,建构出富有晚明时代气息的文化山水;考察历史,鉴别古迹;保护文物,恢复遗存;制造新游具,开辟游赏新方式;对旅游传统进行思考和传承,不断丰富旅游的人文内涵。晚明文人在“性灵游”中所做的文化建构,在中国旅游史上写下了浓墨重彩的一笔。

关键词：晚明文人旅游心性执念文化建构阳明心学

基于CiteSpace的医学免疫学实验教学研究现状、热点及发展趋势的可视化分析

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中国免疫学杂志 2024年第6期40卷 1271-1275,1282页

作者：张会择赖宇成都中医药大学基础医学院成都611137

医学免疫学是连接基础医学和临床医学的重要桥梁课程,也是医学生基础医学理论学习中的重点和难点。医学免疫学实验可将基础知识进行系统串联,并融入学生实际操作、主动观察和积极思考的过程中,有助于学生系统地理解和掌握免疫学基本概... 详细信息

医学免疫学是连接基础医学和临床医学的重要桥梁课程,也是医学生基础医学理论学习中的重点和难点。医学免疫学实验可将基础知识进行系统串联,并融入学生实际操作、主动观察和积极思考的过程中,有助于学生系统地理解和掌握免疫学基本概念和原理。医学免疫学实验教学研究现状、热点及发展趋势已成为教师们关注的重点话题。本文通过运用CiteSpace软件对2010至2021年间中国知网收录的医学免疫学实验教学研究文献的发文量、作者合作网络、关键词共现网络、关键词聚类图谱、关键词时间线图谱以及关键词突现图谱6个方面进行可视化分析。结果显示,该领域近10年发文量较为平稳;已初步形成内部合作关系紧密的代表性研究团队;关键词共现图谱中具有较高中介中心性的关键词包括实验教学、免疫学、教学改革、实验课及医学生。同时,该领域研究内容已较为成熟,涵盖医学免疫学实验教学改革的整体研究,具体包括教学方法的实践探究、教学实践中特定学生及教师群体的研究3个方面。值得注意的是,“以学生为中心”的教育理念在实验教学方法的改革创新研究中得到各类医学高校专业教师的重视,注重培养学生科研思维、创新精神、自主学习能力以及综合素质的教学模式正日趋成型。本研究将有助于广大教师把握该领域的现状、热点及发展趋势,为提升课堂教学质量与开展后续教学改革提供理论支持和参考。

关键词：医学免疫学实验教学 CiteSpace 知识图谱分析

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基于边界特征融合和前景引导的伪装目标检测

电子学报 2024年第7期52卷 2279-2290页

作者：刘文犀张家榜李悦洲赖宇牛玉贞福州大学计算机与大数据学院福建福州350108

伪装目标检测旨在检测隐藏在复杂环境中的高度隐蔽物体,在医学、农业等多个领域有重要应用价值.现有方法结合边界先验过分强调边界区域,对伪装目标内部信息的表征不足,导致模型对伪装目标的内部区域检测不准确.同时,已有方法缺乏对伪装... 详细信息

伪装目标检测旨在检测隐藏在复杂环境中的高度隐蔽物体,在医学、农业等多个领域有重要应用价值.现有方法结合边界先验过分强调边界区域,对伪装目标内部信息的表征不足,导致模型对伪装目标的内部区域检测不准确.同时,已有方法缺乏对伪装目标前景特征的有效挖掘,使背景区域被误检为伪装目标.为解决上述问题,本文提出一种基于边界特征融合和前景引导的伪装目标检测方法,该方法由特征提取、边界特征融合、主干特征增强和预测等若干个阶段构成.在边界特征融合阶段,首先,通过边界特征提取模块获得边界特征并预测边界掩码;然后,边界特征融合模块将边界特征和边界掩码与最低层次的主干特征有效融合;同时,加强伪装目标边界位置及内部区域特征.此外,设计前景引导模块,利用预测的伪装目标掩码增强主干特征,即将前一层特征预测的伪装目标掩码作为当前层特征的前景注意力,并对特征执行空间交互,提升网络对空间关系的识别能力,使网络关注精细而完整的伪装目标区域.本文在4个广泛使用的基准数据集上的实验结果表明,提出的方法优于对比的19个主流方法,对伪装目标检测任务具有更强鲁棒性和泛化能力.

关键词：伪装目标检测边界先验前景引导边界特征边界掩码空间交互

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