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正压流体中具有β效应与地形效应的强迫Rossby孤立波

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物理学报 2010年第7期59卷 4756-4760页

作者：宋健赖俊峰内蒙古工业大学理学院数学系呼和浩特010051

正压流体中,从有外源的准地转位涡方程出发采用摄动方法和时空伸长变换推导了具有β效应、地形效应和外源的强迫Rossby孤立波方程,得到孤立Rossby波振幅的演变满足带有地形与外源强迫的非齐次Boussinesq方程的结论.通过分析孤立Rossby... 详细信息

正压流体中,从有外源的准地转位涡方程出发采用摄动方法和时空伸长变换推导了具有β效应、地形效应和外源的强迫Rossby孤立波方程,得到孤立Rossby波振幅的演变满足带有地形与外源强迫的非齐次Boussinesq方程的结论.通过分析孤立Rossby波振幅的演变,指出β效应、地形效应以及外源都是诱导Rossby孤立波产生的重要因素,说明在地形强迫效应和非线性作用相平衡的假定下,Rossby孤立波振幅的演变满足非齐次Boussinesq方程,给出在切变基本气流下地形和正压流体中Rossby波的相互作用.

关键词：非齐次Boussinesq方程 β效应地形外源

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基于禁忌搜索的组播路由算法(英文)

大连理工大学学报 2010年第5期50卷 801-805页

作者：黄林赖俊峰侯剑杜学武大连理工大学数学科学学院辽宁大连116024 中国计量学院数学系浙江杭州310018 内蒙古工业大学理学院内蒙古呼和浩特010021

实时多媒体网络中,带延迟与延迟抖动约束的斯坦利树问题是一个研究热点.这种带约束的斯坦利树被证明是NP-完全问题.提出了一种基于禁忌搜索的带延迟与延迟抖动约束最小代价组播路由算法.实验结果表明,该算法对于实际网络是有效的.这种... 详细信息

实时多媒体网络中,带延迟与延迟抖动约束的斯坦利树问题是一个研究热点.这种带约束的斯坦利树被证明是NP-完全问题.提出了一种基于禁忌搜索的带延迟与延迟抖动约束最小代价组播路由算法.实验结果表明,该算法对于实际网络是有效的.这种方法使得IP组播把数据同时发送到组成员时有效地利用了网络资源.

关键词：组播禁忌搜索延迟约束延迟抖动约束

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开绕组感应电机无权重系数预测转矩控制策略

电力电子技术 2021年第7期55卷 84-87页

作者：向婉芹赖俊峰重庆电力高等专科学校电力工程学院重庆400053 重庆大学自动化学院重庆400044

为了提高开绕组感应电机(OEWIM)驱动系统的控制性能,设计了一种新颖的无权重系数预测转矩控制(PTC)策略。传统模型预测方案采用单一成本函数实现转矩控制、定子磁链控制和开关频率限制控制等多个控制目标,故存在权重系数整定繁琐且复杂... 详细信息

为了提高开绕组感应电机(OEWIM)驱动系统的控制性能,设计了一种新颖的无权重系数预测转矩控制(PTC)策略。传统模型预测方案采用单一成本函数实现转矩控制、定子磁链控制和开关频率限制控制等多个控制目标,故存在权重系数整定繁琐且复杂的问题。而新方案将转矩和定子磁链控制目标糅合,并结合有限预测电压矢量的简单排序分析代替了单一成本函数,实现了无权重系数的PTC,可以规避与权重系数设置相关的所有问题。利用双逆变器驱动OEWIM实验平台开展了实验测试,实验结果验证了新PTC方案的控制性能。

关键词：开绕组感应电机预测转矩控制无权重系数

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang jun Zhan Yiyuan Xue feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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一般抽样设计下方差的随机组估计

内蒙古农业大学学报（自然科学版） 2012年第2期33卷 226-229页

作者：赖俊峰闫在在王鑫内蒙古工业大学理学院呼和浩特010051 内蒙古财经学院网络中心呼和浩特010070

随机化调查技术现在已有很多的方法,本文用一般化调查技术,结合方差估计的随机组方法,讨论了任意抽样设计p(s)(s为样本)下估计量的期望和方差的估计,并且求出了相应的置信区间。

关键词：随机组方差估计抽样设计

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao feng lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

基于随机缺失和非随机缺失下的高斯混合聚类插补方法

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数学的实践与认识 2024年第11期54卷 195-209页

作者：张诗博赖俊峰张改梅席梦瑶内蒙古工业大学理学院内蒙古呼和浩特010051 呼和浩特市第一医院内蒙古呼和浩特010030

数据缺失在不同缺失机制下存在不同的解决方案.将优化完整策略与高斯混合聚类结合,提出了一种高斯混合聚类插补方法处理数据缺失问题,并严格推导了该方法的数学过程,相比于传统的优化完整策略,该方法能够避免因初始缺失值的不同导致出... 详细信息

数据缺失在不同缺失机制下存在不同的解决方案.将优化完整策略与高斯混合聚类结合,提出了一种高斯混合聚类插补方法处理数据缺失问题,并严格推导了该方法的数学过程,相比于传统的优化完整策略,该方法能够避免因初始缺失值的不同导致出现的数据偏差.相比于传统的机器学习方法,该方法不仅充分利用了样本的观测信息,并且考虑了随机缺失和非随机缺失两种缺失机制.通过数值模拟,首先验证高斯混合聚类插补法具有收敛性,其次对比随机森林模型,结果表明所提出的新方法优于已有的随机森林插补方法.最后,将新方法应用于鸢尾花数据集中实验结果进一步表明新方法较随机森林方法更为稳健.

关键词：缺失数据随机缺失机制高斯混合聚类插补

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han jun Xiao Jian-feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway