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Effect of WeiJia on carbon tetrachloride induced chronic liver injury

World Journal of Gastroenterology 2006年第12期12卷 1912-1917页

作者： Pik-Yuen Cheung QiZhang Gan-Rong Bai Chi-Chun Fong lin Shi Yue-Feng Shi Meng-SuYang DepartmentofBiology Ya-Ou Zhang Marie Chia-Mi lin Bernard Chan jay Chun Hsiang-Fu Kung Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee AvenuKowloonHong Kong SARChina life Science Division Tsinghua University Graduate School at ShenzhenTsinghua CampusUniversity TownShenzhenChina Institute of Molecular Biology The University of Hong KongPokfulamHong KongSARChina life Tec Enterprise limited CentralHong KongSARChina The Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongShatinN.T.Hong Kong SARChina

AIM： To study the effect of WeiJia on chronic liver injury using carbon tetrachloride （CCh） induced liver injury animal model. METHODS： Wistar rats weighing 180-220g were randomly divided into three groups： normal control group （Group A）, CCh induced liver injury control group （Group B） and CCI4 induction with WeiJia treatment group （Group C）. Each group consisted of 14 rats. liver damage and fibrosis was induced by subcutaneous injection with 40% CCh in olive oil at 3 ml/kg body weight twice a week for eight weeks for Groups B and C rats whereas olive oil was used for Group A rats. Starting from the third week, Group C rats also received daily intraperitoneal injection of *** at a dose of 1.25 μg/kg body weight. Animals were sacrificed at the fifth week （4 male, 3 female）, and eighth week （4 male, 3 female） respectively. Degree of fibrosis were measured and serological markers for liver fibrosis and function including hyaluronic acid （HA）, type Ⅳ collagen （CIV）, γ-glutamyl transferase （γ-GT）, alanine aminotransferase （AlT） and aspartate aminotransferase （AST） were determined. Alpha smooth muscle actin （α-SMA） and proliferating cell nuclear antigen （PCNA） immunohistochemistry were also performed. RESUlTS： CCl4 induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV,AlT, AST and γ-GT levels after eight weeks of treatment for Group C rats were 58±22 μg/l （P〈0.01）, 57±21 μg/l （P〈0.01）, 47±10 U/l （P〈0.01）, 139±13 U/l （P〈0.05） and 52±21 U/l （P〉0.05） respectively, similar to normal control group （Group A）, but significantly different from CCh induced liver injury control group （Group B）. An increase in PCNA and decrease in α-SMA expression level was also obs

关键词： WeiJia Carbon tetrachloride liver fibrosis

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A review of potential conservation and fisheries benefits of breaching four dams in the lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert l.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael J.Parsley Edward Bowles Robert M.Hughes jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific lamprey,and(10)Snake River Basin Pacific lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

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心肌缺血再灌注后蛋白质的硝基化及缺血预处理的影响

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生物物理学报 2009年第S1期25卷 396-397页

作者：刘斌 Arun K.Tewari liwen Zhang Kari B.Green-Church jay l.Zweier Yeong-Renn Chen Guanglong He 汕头大学医学院心血管研究中心 Center for Biomedical EPR Spectroscopy and Imaging Davis Heart and Lung Research Instituteand Division of Cardiovascular MedicineDepartment of Internal MedicineCollege of Medicinethe Ohio State UniversityColumbusOH43210USA Campus Chemical Instrument Center/Mass Spectrometry and Proteomics Facility the Ohio State UniversityColumbusOH43210USA

心肌缺血后再灌注时会爆发式地产生大量的一氧化氮(NO)和超氧阴离子自由基(O2?-),二者可以极快的速度反应生成过氧亚硝基阴离子(ONOO-)。

关键词：缺血再灌注活性氧/活性氮蛋白质硝基化缺血预处理

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Scoring Cercospora leaf Spot on Sugar Beet:Comparison of UGV and UAV Phenotyping Systems

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Plant Phenomics 2020年第1期2卷 225-242页

作者： S.jay A.Comar R.Benicio J.Beauvois D.Dutartre G.Daubige W.li J.labrosse S.Thomas N.Henry M.Weiss F.Baret INRAE UMR 114 EMMAHUMT CAPTEF-84914 AvignonFrance HIPHEN SAS 84000 AvignonFrance ARVAlIS-Institut du végétal 84000 AvignonFrance Florimond Desprez 59242 Capelle-en-PévèleFrance

Selection of sugar beet(Beta vulgaris l.)cultivars that are resistant to Cercospora leaf Spot(ClS)disease is critical to increase *** selection requires an automatic,fast,and objective method to assess ClS severity on thousands of cultivars in the *** this purpose,we compare the use of submillimeter scale RGB imagery acquired from an Unmanned Ground Vehicle(UGV)under active illumination and centimeter scale multispectral imagery acquired from an Unmanned Aerial Vehicle(UAV)under passive *** variables are extracted from the images(spot density and spot size for UGV,green fraction for UGV and UAV)and related to visual scores assessed by an *** show that spot density and green fraction are critical variables to assess low and high ClS severities,respectively,which emphasizes the importance of having submillimeter images to early detect ClS in field *** sensitivity to ClS can then be accurately retrieved based on time integrals of UGV-and UAV-derived *** UGV shows the best estimation performance,UAV can show accurate estimates of cultivar sensitivity if the data are properly *** and limitations of UGV,UAV,and visual scoring methods are finally discussed in the perspective of high-throughput phenotyping.

关键词： illumination millimeter critical

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Synergistic effect of Mucuna pruriens and Withania somnifera in a paraquat induced Parkinsonian mouse model

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Advances in Bioscience and Biotechnology 2013年第11期4卷 1-9页

作者： jay Prakash Satyndra Kumar Yadav Shikha Chouhan Satya Prakash Surya Pratap Singh 1Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India Biomedical Technology and Cell Therapy Research laboratory Department of Biomedical Engineering Faculty of Medicine McGill University Montreal Canada Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the development of rigidity, resting tremors and postural instability. Recently, the focus of PD’s treatment has shifted towards herbal medicines. Mucuna pruriens (Mp) and Withania somnifera (Ws) are traditional herbal medicines known to have neuro-protective effects due to the l-DOPA present in Mp seed powder and withanoloides present in Ws root extract. Here, the synergistic effect of Mp and Ws in Parkinsonian mice induced by chronic exposure to paraquat was evaluated. Co-treatment with Mp and Ws for 9 weeks, significantly decreased the elevated nitrite levels and lipid peroxidation found in Parkinsonian mice. In behavioural tests, Mp and Ws treated mice showed a significant decrease in the time taken to cross a narrow beam, an increase in the time of stay on drum in rotarod test and an improvement in the hanging time. Furthermore, it was found that the use of Mp and Ws considerably improved the tyrosine hydroxylase expression in the substantianigra region of the brain. The results suggest that Mp and Ws may provide a platform for future drug discoveries and novel treatment strategies for PD.

关键词： Withinia somnifera Mucuna pruriens Oxidative Stress Tyrosine Hydroxylase Parkinson’s Disease Substantia nigra Motor Dysfunctions

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没职业也挣钱 90年代版

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丛书名：成功者实用技巧译丛

1996年

作者：（美）杰伊·莱文森jay conrad levinson 姜永鹏译

本书介绍了许多不需要很高学历或很大投资就能挣钱的点子。

ISBN: (数字)7501129835

ISBN: (纸本)7501129835

本书介绍了许多不需要很高学历或很大投资就能挣钱的点子。

关键词：商业经营学科基本知识私人投资

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第59届金球奖

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电影评介 2002年第3期 50-51页

作者：阿jay

l历年每届金球奖的颁奖结果都会成为当年奥斯卡奖项的一个重要指标,因此金球奖甚至成为奥斯卡的前奏,许多在金球奖上获奖的电影人似乎都看到奥斯卡小金人向自己挥手。但是,今年第59届金球奖显然把大家期望中明朗的奥斯卡争夺局势弄... 详细信息

l历年每届金球奖的颁奖结果都会成为当年奥斯卡奖项的一个重要指标,因此金球奖甚至成为奥斯卡的前奏,许多在金球奖上获奖的电影人似乎都看到奥斯卡小金人向自己挥手。但是,今年第59届金球奖显然把大家期望中明朗的奥斯卡争夺局势弄得更加扑朔迷离,获奖影片、影人喜悦兴奋的同时,也有一批同样优秀的影片、影人被忽略。这样的情况与往年只有一。

关键词：奥斯卡喜剧片拉塞尔女主角好莱坞女配角男配角美国电影学会影片男主角

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Continuous Bioethanol Production Using Saccharomyces cerevisiae Cells Immobilized In Nata De Coco （Biocellulose）

Continuous Bioethanol Production Using Saccharomyces cerevis...

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2012 2nd International Conference on Environment and Industrial Innovation（ICEII 2012）

作者： Charlimagne M.Montealegre Emerson R.Dionisio lawrence V.Sumera jay R T.Adolacion Rizalinda l.De leon Biochemical Engineering laboratory Department of Chemical Engineering College of EngineeringUniversity of the Philipines Diliman Quezon City 1101 Philippines

The performance of Nata de coco （NDC） and Calcium alginate （CA） as an immobilization medium for Saccharomyces cerevisiae cells are compared in terms of production rate and conversion. S. cerevisiae cells are immobilized in NDC and CA beads using a cell suspension with an average approximate live cell density of 232.1288 ± 1.5387 cells/ml. The biocatalysts NDC and CA are charged into horizontal fermentation reactors. A centrifugal pump and manifold is used to control the flow rate to a desired flow rate of 9 ml/hr. Samples are collected every 12 hours and tested for ethanol by gas chromatography and glucose concentration by colorimetry. The average steady state effluent ethanol concentration, productivity and conversion in NDC are 5.093 % by volume, 52.329 ml/hr and 0.7779, respectively. One-way ANOVA showed that the immobilization medium has a significant effect on the parameters under consideration. T-test is further performed between NDC and CA biocatalysts which showed that effluent ethanol concentration, productivity and conversion of NDC and CA are statistically equal. The study showed that the NDC biocatalyst performs equally well in the conditions optimized for CA biocatalyst. The structural strength and cost effectiveness of Nata de Coco makes it a very promising immobilization medium for continuous bioethanol production.

关键词： Immobilization Biocellulose Calcium Alginate Continuous Fermentation Horizontal Reactor Baker’s Yeast

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伦敦商学院和南加州大学马歇尔商学院面向股东还是面向利益相关者?

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董事会 2008年第6期 98-99页

作者： jay A. Conger Edward E. lawler III Davi l. Finegold

面向股东还是面向利益相关者？在日本的董事会会议上，不管是股东还是高管人员都被潜在地施加了压力，以便于他们关注利益相关人的利益而不是股东利益。当然，现在他们改革的压力也很大：而在美国的董事会会议上，20年的治理改革以及坚... 详细信息

面向股东还是面向利益相关者？在日本的董事会会议上，不管是股东还是高管人员都被潜在地施加了压力，以便于他们关注利益相关人的利益而不是股东利益。当然，现在他们改革的压力也很大：而在美国的董事会会议上，20年的治理改革以及坚定的树立了“股东价值最大化”的概念，这就增强了董事会相对于管理层的独立性，并更加密切的适合董事会和公司业主的利益。

关键词：伦敦商学院南加州大学马歇尔利益相关者股东价值最大化股东利益利益相关人董事会

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Prediction of transitional lumbosacral anatomy on magnetic resonance imaging of the lumbar spine

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World Journal of Radiology 2012年第3期4卷 97-101页

作者： Majid Chalian Theodoros Soldatos John A Carrino Alan J Belzberg jay Khanna Avneesh Chhabra Russell H.Morgan Department of Radiology and Radiological Science The Johns Hopkins Hospital Department of Neurosurgery The Johns Hopkins Hospital Department of Orthopaedic Surgery The Johns Hopkins Hospital

AIM: To evaluate two simple angle measurements for predicting lumbosacral transitional vertebra (lSTV) in magnetic resonance imaging (MRI) studies of the spine. METHODS: The lumbar spine MRI studies of 50 subjects with lSTV and 50 subjects with normal lumbosacral anatomy were retrospectively evaluated. In each study, the mid-sagittal T2-weighted image was used to measure the angle formed by a line parallel to the superior surface of the sacrum and a line perpendicular to the axis of the scan table (A-angle), as well as the angle formed by a line parallel to the superior endplate of the l3 vertebra and a line parallel to the superior surface of the sacrum (B-angle). RESUlTS: The total study population consisted of 100 subjects (46 males, 54 females, 51 ± 16 years old). There were no differences in age and sex between the two groups. Both A-angle and B-angle were significantly increased in subjects with lSTV compared to controls (P l cut-off values of A-angle and B-angle for the prediction of lSTV were 39.8° (sensitivity = 80%, specificity = 80%, accuracy = 83%; 95% confidence interval = 74%-89%, P = 0.0001) and 35.9° (sensitivity = 80%, specificity = 54%, accuracy = 69%; 95% confidence interval = 59%-78%, P = 0.0005), respectively. CONClUSION: On sagittal MR images of the lumbar spine, an increased A-angle and/or B-angle should alert the radiologist to the presence of lSTV.

关键词： lumbosacral transitional vertebra Magnetic resonance imaging lumbar spine Angle Prediction

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