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高频振荡通气联合容量保证通气在超早产儿呼吸窘迫综合征的应用价值

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中国全科医学 2024年第13期27卷 1616-1622页

作者：娄五斌李芳张卫星沈洁河南省新乡市中心医院(新乡医学院第四临床学院)新生儿重症监护病房 453000 河南省新乡市中心医院(新乡医学院第四临床学院)小儿康复科 453000

背景超早产儿早期低碳酸血症与脑室内出血(IVh)和支气管肺发育不良(BPD)有关。国外研究结果显示高频振荡通气联合容量保证通气(hFOV+VG)可以减少早产儿的低碳酸血症,但胎龄0.05)。结论与SIMV通气相比,hFOV+VG通气应用于胎龄<28周的超早... 详细信息

背景超早产儿早期低碳酸血症与脑室内出血(IVh)和支气管肺发育不良(BPD)有关。国外研究结果显示高频振荡通气联合容量保证通气(hFOV+VG)可以减少早产儿的低碳酸血症,但胎龄hFOV+VG的研究甚少。目的探讨hFOV+VG治疗超早产儿呼吸窘迫综合征的临床疗效。方法选择2020年3月—2023年3月新乡市中心医院(新乡医学院第四临床学院)NICU收治的胎龄hFOV+VG组和同步间歇指令通气(SIMV)组。试验开始后48 h检查动脉血气分析,观察2组的有创通气时间、总呼吸支持时间、病死率以及低碳酸血症、脑室周围白质软化(PVl)、早产儿视网膜病变(ROP)、晚发型败血症(lOS)、气胸、呼吸机相关性肺炎(VAP)、BPD、新生儿坏死性小肠结肠炎(NEC)及3~4级脑室周围-脑室内出血(IVh)发生率。结果hFOV+VG组有创通气时间、总呼吸支持时间较SIMV组短,低碳酸血症、PVl的发生率均低于SIMV组(PlOS、气胸、VAP、BPD、NEC及3~4级IVh发生率比较,差异均无统计学意义(P>0.05)。结论与SIMV通气相比,hFOV+VG通气应用于胎龄<28周的超早产儿RDS临床效果更好,且不增加不良反应。

关键词：呼吸窘迫综合征超早产儿高频振荡通气容量保证随机对照试验

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Impacts of major volcanic eruptions over the past two millennia on both global and Chinese climates:A review

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Science China Earth Sciences 2024年第1期67卷 61-78页

作者： Weiyi SUN Deliang ChEN Guonian lÜ liang NING Chaochao GAO Renhe ZhANG Bin WANG Jian lIU Key laboratory for Virtual Geographic Environment Ministry of EducationState Key Laboratory Cultivation Base of Geographical Environment Evolution of Jiangsu ProvinceJiangsu Center for Collaborative Innovation in Geographical Information Resource Development and ApplicationSchool of Geography ScienceNanjing Normal UniversityNanjing 210023China Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden College of Environmental and Resource Science Zhejiang UniversityHangzhou 310058China Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200437China Department of Atmospheric Sciences and Atmosphere-Ocean Research Center University of Hawaii at ManoaHonoluluHI 96825USA Jiangsu Provincial Key laboratory for Numerical Simulation of large Scale Complex Systems School of Mathematical ScienceNanjing Normal UniversityNanjing 210023China Open Studio for the Simulation of Ocean-Climate-Isotope Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Major volcanic eruptions(MVEs)have attracted increasing attention from the scientific *** studies have explored the climatic impact of MVEs over the past two ***,proxy-based reconstructions and climate model simulations indicate divergent responses of global and China’s regional climates to ***,we used multiple data from observations,reconstructions,simulations,and assimilations to summarize the historical facts of MVEs,the characteristics and mechanisms of their climatic impact,and directions for future *** reviewed volcanic datasets and determined intensive MVE periods;these periods corresponded to the years 530–700,1200‒1460,and 1600‒1840 *** tropical MVEs,a substantial cooling effect is observed throughout the globe and China on the interannual-interdecadal time scales but an inconsistent cooling magnitude is detected between reconstructions and *** the first summer after tropical MVEs,a decrease in global and monsoonal precipitation is *** reconstructions and simulations,an increased precipitation is seen for the Yangtze River Basin,while large uncertainties in precipitation changes are present for other regions of *** drought can be induced by frequent eruptions and volcanism superimposed on low solar irradiation and internal *** affect climate directly through the radiative effect and indirectly by modulating internal variability,such as the El Niño‒Southern Oscillation(ENSO)and Atlantic Multidecadal Oscillation(AMO).however,changes in the phase,amplitude,and periodicity of ENSO and AMO after MVEs and the associated mechanisms remain controversial,which could account for model-reconstruction ***,other internal variability,uncertainties in reconstruction methods and aerosol‒climate models,and climate background may also induce model-reconstruction *** gaps and directions for future research are also discussed.

关键词： Major volcanic eruption Climate variability Mechanism Past two millennia Internal variability

Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen h.Y.Chen M.l.Chen S.J.Chen S.l.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui h.l.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong l.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Y.Y.Duan Z.h.Duan P.Egorov Y.h.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli l.Fava F.Feldbauer G.Felici C.Q.Feng J.h.Feng Y.T.Feng M.Fritsch C.D.Fu J.l.Fu Y.W.Fu h.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia l.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen l.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.l.Guan A.Q.Guo l.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.l.han T.T.han F.hanisch X.Q.hao F.A.harris K.K.he K.l.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou Z.l.hou B.Y.hu h.M.hu J.F.hu S.l.hu T.hu Y.hu G.S.huang K.X.huang l.Q.huang X.T.huang Y.P.huang T.hussain F.hölzken N.hüsken N.in der Wiesche J.Jackson S.Janchiv J.h.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.l.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.l.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.lane P.larin l.lavezzi T.T.lei Z.h.lei M.lellmann T.lenz C.li C.li C.h.li Cheng li D.M.li F.li G.li h.B.li h.J.li h.N.li hui li J.R.li J.S.li Ke li l.J.li l.K.li lei li M.h.li P.R.li Q.M.li Q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.h.li X.l.li X.Z.li Xi Institute of high Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process hadronic events BESⅢdetector

Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and human Wellness 2024年第3期13卷 1608-1616页

作者： hyo-Geun lee h.h.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.liyanage Kyung-Mo Song Yun-Sang Choi Seung-hong lee You-Jin Jeon Min-Cheol Kang Department of Marine life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-l1 cells and high-fat diet(hFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-l1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an hFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

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白石水库总氮污染负荷分布组成特征分析

黑龙江水利科技 2024年第2期52卷 49-52页

作者：娄利华辽宁省朝阳水文局辽宁朝阳122000

文章结合白石水库2011—2020年各形态氮及总氮浓度监测数据,研究分析了入库支流总氮输出浓度特征、水库总氮的变化趋势及其主要来源,结合实际情况提出水源区总氮防控对策。结果表明:近10a白石水库总氮浓度稍有增加,总体处于0.5~1.0mg/l... 详细信息

文章结合白石水库2011—2020年各形态氮及总氮浓度监测数据,研究分析了入库支流总氮输出浓度特征、水库总氮的变化趋势及其主要来源,结合实际情况提出水源区总氮防控对策。结果表明:近10a白石水库总氮浓度稍有增加,总体处于0.5~1.0mg/l之间;大凌河、牤牛河和凉水河等入库河流总氮浓度略高,其中面源对总氮贡献率约60%,硝态氮为总氮主要成分。

关键词：总氮浓度污染负荷组成特征防治对策白石水库

Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： lhAASO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen h.X.Chen liang Chen lin Chen long Chen M.J.Chen M.l.Chen Q.h.Chen S.Chen S.h.Chen S.Z.Chen T.l.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.W.Cui X.h.Cui Y.D.Cui B.Z.Dai h.l.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.h.Fan Y.Z.Fan J.Fang J.h.Fang K.Fang C.F.Feng h.Feng l.Feng S.h.Feng X.T.Feng Y.Feng Y.l.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge l.S.Geng G.Giacinti G.h.Gong Q.B.Gou M.h.Gu F.l.Guo X.l.Guo Y.Q.Guo Y.Y.Guo Y.A.han M.hasan h.h.he h.N.he J.Y.he Y.he Y.K.hor B.W.hou C.hou X.hou h.B.hu Q.hu S.C.hu D.h.huang T.Q.huang W.J.huang X.T.huang X.Y.huang Y.huang X.l.Ji h.Y.Jia K.Jia K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.li C.M.li Cheng li Cong li D.li F.li h.B.li h.C.li Jian li Jie li K.li S.D.li W.l.li W.l.li X.R.li Xin li Y.Z.li Zhe li Zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu D.B.liu h.liu h.D.liu J.liu J.l.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu Q.luo Y.luo h.K.lv B.Q.Ma l.l.Ma X.h.Ma J.R.Mao Z.Min W.Mitthumsiri h.J.Mu Y.C.Nan A.Neronov l.J.Ou P.Pattarakijwanich Z.Y.Pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz l.Shao O.Shchegolev X.D.Sheng F.W.Shu h.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata P.h.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang h.G.Wang h.h.Wang J.C.Wang Kai Wang Kai Wang l.P.Wang l.Y.Wang P.h.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.h.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu h.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.l.Xin Y.Xing D.R.Xiong Z.Xiong D.l.Xu R.F.Xu R.X.Xu W.l.Xu l.Xue D.h.Yan J.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang l.l.Yang M.J.Yang R.Z.Yang W.X.Yang Y.h.Yao Z.G.Yao l.Q.Yin N.Yin X.h.You Z.Y.You Y.h.Yu Q.Yuan h.Yue h.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang h.Zhang 不详 Key laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key laboratory of Particle Detection and Electronics China Key laboratory of Dark Matter and Space Astronomy&Key laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the large high Altitude Air Shower Observatory(lhAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** lhAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-lAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UhE c-ray Cosmic rays SNR W51C Star clusters

老年下肢骨折手术采取不同麻醉方式对患者术后认知功能的影响

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中华灾害救援医学 2024年第8期11卷 906-908页

作者：娄保锋任晶潍坊市第二人民医院麻醉科山东潍坊261042 潍坊市第二人民医院呼吸二部山东潍坊261042

目的比较老年下肢骨折手术患者采取全身麻醉和硬膜外麻醉后,对患者术后认知功能及手术相关指标的影响。方法收集2022年4月至2024年4月于潍坊市第二人民医院接受下肢骨折手术的100例老年患者,根据麻醉方式的不同分为硬膜外麻醉组和全身... 详细信息

目的比较老年下肢骨折手术患者采取全身麻醉和硬膜外麻醉后,对患者术后认知功能及手术相关指标的影响。方法收集2022年4月至2024年4月于潍坊市第二人民医院接受下肢骨折手术的100例老年患者,根据麻醉方式的不同分为硬膜外麻醉组和全身麻醉组,每组各50例。比较两组患者手术相关指标、认知功能、术后并发症。结果硬膜外麻醉组患者手术时间长于全身麻醉组(Ph、12h、24h硬膜外麻醉组患者简易精神状态检查量表(Mini Mental Status Examination,MMSE)评分显著高于全身麻醉组患者(P<0.05)。硬膜外麻醉组患者术后并发症总发生率为8.00%,显著低于全身麻醉组的24.00%,差异有统计学意义(P<0.05)。结论对于下肢骨折手术的老年患者,采取硬膜外的麻醉方式不仅镇痛效果良好,而且对认知功能影响小,有利于术后恢复。

关键词：麻醉麻醉,硬膜外老年人医院,骨科

封闭负压引流联合自体微粒皮移植治疗慢性难愈性创面的效果观察

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中国基层医药 2024年第3期31卷 437-440页

作者：楼丽霞邢晓威戴振华金华市第五医院普外科金华321000

目的探讨封闭负压引流(VSD)联合自体微粒皮移植治疗慢性难愈性创面的临床效果。方法采用前瞻性研究,连续性纳入2020年1月至2022年12月金华市第五医院普外科诊断的慢性难愈性创面患者共90例,采用随机数字表法分为对照组和观察组各45例。... 详细信息

目的探讨封闭负压引流(VSD)联合自体微粒皮移植治疗慢性难愈性创面的临床效果。方法采用前瞻性研究,连续性纳入2020年1月至2022年12月金华市第五医院普外科诊断的慢性难愈性创面患者共90例,采用随机数字表法分为对照组和观察组各45例。对照组采用VSD联合常规植皮术,观察组采用VSD联合自体微粒皮移植。比较两组VSD后7 d肉芽成熟率、移植成活率、术后14 d创面愈合率和完全愈合时间、总住院时间和并发症发生率、术后6个月温哥华瘢痕评估量表评价瘢痕程度、术后3 d和7 d疼痛视觉模拟量表(VAS)评分以及血清细胞因子[包括超敏C反应蛋白(hs-CRP)、白细胞介素6(Il-6)、肿瘤坏死因子α(TNF-α)、表皮生长因子(EGF)和碱性成纤维细胞生长因子(bFGF)]水平。结果两组患者均顺利完成手术和临床随访,两组基线资料(包括性别、年龄、创面面积和分布、疾病类型)差异均无统计学意义(均P>0.05)。观察组VSD后7 d肉芽成熟率88.89%(40/45)、术后14 d创面愈合率84.44%(38/45),均高于对照组的71.11%(32/45)和64.44%(29/45)(χ^(2)=4.44、4.73,均Phs-CRP、Il-6和TNF-α分别为(5.51±0.67)mg/l、(7.69±0.84)mg/l、(3.44±0.45)mg/l,均低于对照组的(3.54±0.33)mg/l、(3.97±0.56)mg/l、(1.68±0.20)mg/l;观察组EGF和bFGF分别为(15.64±4.53)mg/l、(30.26±6.92)mg/l,均高于对照组的(31.25±7.82)mg/l、(45.67±9.84)mg/l(t=17.42、24.72、23.98、11.59、8.59,均P<0.001)。观察组总并发症发生率为6.67%(3/45),低于对照组的22.22%(10/45)(χ^(2)=4.41,P<0.05)。结论VSD联合自体微粒皮移植治疗慢性难愈性创面有较好的安全性和临床疗效,能够显著提高创面愈合质量,降低供区创面的瘢痕风险,与多种细胞因子的改善有关。

关键词：引流术负压伤口疗法皮肤移植手术后并发症瘢痕疼痛炎症表皮生长因子

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卡培他滨致中毒性白质脑病的临床特点与分析

中国医院药学杂志 2024年第16期44卷 1920-1925页

作者：黄静龚筱弦楼国东宁波大学附属第一医院药学部浙江宁波315010 浙江大学医学院附属邵逸夫医院神经内科浙江杭州310016 浙江大学医学院附属邵逸夫医院药学部浙江杭州310016

目的:分析卡培他滨导致的中毒性白质脑病的临床特点。方法:通过检索PubMed、Embase、维普、中国知网、万方数据库,以及浙江大学医学院附属邵逸夫医院病例,共收集了卡培他滨导致的中毒性白质脑病个案报道34例进行病例分析。结果:34例病例... 详细信息

目的:分析卡培他滨导致的中毒性白质脑病的临床特点。方法:通过检索PubMed、Embase、维普、中国知网、万方数据库,以及浙江大学医学院附属邵逸夫医院病例,共收集了卡培他滨导致的中毒性白质脑病个案报道34例进行病例分析。结果:34例病例中,女性26例(76.47%),男性8例(23.53%),中位年龄52.5(34,82)岁。临床症状表现多样,主要有言语障碍(64.71%)、共济失调(17.65%)、意识障碍(17.65%)、癫痫发作(14.71%)等。87.10%的患者临床症状发生在第一次接受卡培他滨化疗期间,64.52%发生在7 d内。头颅核磁共振(magnetic resonance imaging,MRI)影像涉及脑白质异常信号,弥散加权成像、T2加权成像、液体衰减反转恢复序列的高信号和/或弥散受限,26例(76.47%)涉及胼胝体的异常,其余受累的区域包括半卵圆中心、深部白质、大脑半球皮质下白质、脑干、丘脑、放射冠、皮质脊髓束、小脑中脚、基底节、脑室周围区域等。采用的治疗手段主要是停药,临床症状中位转归时间为3 d(10 h, 20 d),32例(94.12%)病例在停药以及对应治疗6个月内影像学都出现明显好转或完全正常。结论:卡培他滨可致中毒性白质脑病发生,早期识别和及时停用卡培他滨可获得较好的临床预后。

关键词：卡培他滨白质脑病胼胝体细胞毒性水肿可逆性后部白质脑病综合征神经毒性