检索结果-南通市图书馆

ePOXYDON─lIKe ANTIBIOTICS

在线全文

学校读者我要写书评

暂无评论

中国抗生素杂志 1986年第6期11卷 474-484页

作者： G.P.Orezzi,e.Arlandini,M.Ballabio,G.Cassinelli,e.DiMatteo,M.l.Garofano,A.Inventi-Solari,e.Arcamone Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs Farmitalia Carlo erba SpA Research labs 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy 20146 Milan Via dei Gracchi 35 Italy

SUMMARY A treptomyces species,designed No.2061 FCe,was found to produce twoantibacterial antibiotics belonging to the epoxidon group, Structural studiesdemonstrated the identity of the less polar active constituent 2061-A(Ⅰ)with an-tibiotic G-7063-2 and the novelty of the most polar one 2061-B(Ⅱ),whosestructure correspondes to that of 5-dihydroderivative of Ⅰ.2061-A and 2061-Bdisplay respectively a moderate and weak activity against gram-positive and gramnegative bacteria“in vitro”.Chemical,physico-chemical and some biological proper-ties of compounds belonging to the epoxidon group are also reviewed.

关键词： Figure lIKe ANTIBIOTICS ePOXYDON

Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 514-522页

作者： Wang-Xia Wang Paresh Prajapati Hemendra J.Vekaria Malinda Spry Amber l.Cloud Patrick G.Sullivan Joe e.Springer Sanders Brown Center on Aging University of KentuckyLexingtonKYUSA Spinal Cord and Brain Injury Research Center University of KentuckyLexingtonKYUSA Department of Pathology&laboratory Medicine University of KentuckyLexingtonKYUSA Department of Neuroscience University of KentuckyLexingtonKYUSA

MicroRNAs(miRNAs)are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular *** previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation(i.e.,miR-142-3p,miR-142-5p,and miR-146a)are altered in the hippocampus at 3–12 hours following a severe traumatic brain *** the present study,we investigated the temporal expression profile of these inflammatory miRNAs in mitochondria and cytosol fractions at more chronic post-injury times following severe controlled cortical impact injury in *** addition,several inflammatory genes were analyzed in the cytosol *** analysis showed that while elevated levels were observed in cytoplasm,the mitochondria-enriched miRNAs,miR-142-3p and miR-142-5p continued to be significantly reduced in mitochondria from injured hippocampi for at least 3 days and returned to near normal levels at 7 days *** not statistically significant,miR-146a also remained at reduced levels for up to 3 days following controlled cortical impact injury,and recovered by 7 *** contrast,miRNAs that are not enriched in mitochondria,including miR-124a,miR-150,miR-19b,miR-155,and miR-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 *** one exception was that miR-223 levels were reduced in mitochondria at 1 day following *** major alterations were observed in sham operated *** temporal pattern was unique to mitochondria-enriched miRNAs and correlated with injury-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory *** observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory miRNAs and may reflect an intracellular mechanism by which specific miRNAs regulate injury-induced inflammatory *** test this,we utilized a novel peptide-based

关键词： cell permeable peptide-delivery controlled cortical impact inflammatory pathway mitochondria-associated microRNA nanoparticle nuclear factor-kappa B traumatic brain injury

effect of iron ion configurations on Ni^(2+) removal in electrocoagulation

在线全文

学校读者我要写书评

暂无评论

Journal of environmental Sciences 2023年第2期124卷 823-834页

作者： Xiaoliu lü Tao Xu Yihui Zhou Qingjuan Peng Jinhua Ou Bonian Hu Zhihui Xie Xiping lei Gang Yu College of Chemistry and Chemical engineering Hunan UniversityChangsha 410082China Research Institute of New Building Materials Hunan Institute of TechnologyHengyang 421008China Chemical Synthesis and Pollution Control Key laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China Hunan Zihong ecology Technology Co. Ltd.Changsha 410000China

electrocoagulation(eC)has been widely used to treat the heavymetal wastewater in industry.A novel process of sinusoidal alternating current electrocoagulation(SACC)is adopted to remove Ni2+in wastewater in this *** morphology of precipitates and the distribution of the main functional iron configurations were *** timed complex spectroscopy can identify the monomeric iron configurations[Fe(a)],oligomeric iron configurations[Fe(b)]and polymeric iron configurations[Fe(c)].The optimal operating conditions of SACC process were determined through single-factor *** maximum Ni2+removal efficiency[Re(Ni^(2+))]was achieved under the conditions of pH0=7,current density(j)=7 A/m^(2),electrolysis time(t)=25 min,c0(Ni^(2+))=100 mg/*** pH=7,the proportion of Fe(b)and Fe(c)in the system was 50.4 at.% and 23.1 at.%,*** the SACC process,Fe(b)and Fe(c)are themain iron configurations in solution,while Fe(c)are the vastmajority of the iron configurations in the direct current electrocoagulation(DCC)***(Ni2+)is 99.56% for SACC and 98.75% for DCC under the same optimum conditions,*** precipitates produced by SACC have a high proportion of Fe(b)configurations with sphericalα-FeOOH andγ-FeOOH structures which contain abundant hydroxyl ***,it is demonstrated that Fe(b)has better adsorption capacity than Fe(c)through adsorption experiments of methyl orange(MO)***(a)configurations in the homogeneous solution had no effect on the removal of nickel.

关键词： electrocoagulation Nickel wastewater Iron configurations Alternating current Polynuclear iron-hydroxyl complex

Recent trends in liver transplantation for alcoholic liver disease in the United States

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2017年第36期9卷 1315-1321页

作者： Catherine e Kling James D Perkins Robert l Carithers Dennis M Donovan lena Sibulesky Division of Transplant Surgery Department of Surgery University of Washington Division of Gastroenterology and Hepatology Department of Medicine University of Washington Department of Psychiatry and Behavioral Sciences University of Washington

AIM To examine temporal changes in the indications for liver transplantation(lT) and characteristics of patients transplanted for alcoholic liver disease(AlD).MeTHODS We performed a retrospective cohort analysis of trends in the indication for lT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for AlD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with AlD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).ReSUlTS Of 74216 liver transplant recipients, AlD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for AlD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for AlD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and AlD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and *** There has been a dramatic increase in the number of transplants for AlD starting in 2013.

关键词： Alcoholic liver disease liver transplantation Cirrhosis epidemiology Hepatitis C

Sensitivity Study of the RegCM4’s Surface Schemes in the Simulations of West Africa Climate

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Climate Sciences 2022年第1期12卷 86-104页

作者： Adjon Anderson Kouassi Brahima Kone Siélé Silue Alima Dajuma Toure e. N’datchoh Marcellin Adon Arona Diedhiou Véronique Yoboue laboratoire des Sciences et Technologie de l’environnement (lSTe) Université Jean Lorougnon Guédé Daloa C&#244 te d’Ivoire laboratoire des Sciences de la Matière de l’Environnement et de l’Energie Solaire (LASMES) Université Félix Houphou&#235 t-Boigny Abidjan C&#244 te d’Ivoire Université Péléforo Gon Coulibaly Korhogo C&#244 te d’Ivoire Université Grenoble Alpes IRD CNRS Grenoble INP IGE Grenoble France

Two simulations of five years (2003-2007) were conducted with the Regional Climate models RegCM4, one coupled with land surface models BATS and the other with ClM4.5 over West Africa, where simulated air temperature and precipitation were analyzed. The purpose of this study is to assess the performance of RegCM4 coupled with the new ClM4.5 land le="font-family:Verdana;">surface scheme and the standard one named BATS in order to find the best configuration of RegCM4 over West African. This study could improve our understanding of the sensitivity of land surface model in West Africa climate simulation, and provide relevant information to RegCM4 users. The results show fairly realistic restitution of West Africa’s climatology and indicate correlations of 0.60 to 0.82 between the simulated fields (BATS and ClM4.5) for precipitation. The substitution of BATS surface scheme by ClM4.5 in the model configuration, leads mainly to an improvement of precipitation over the Atlantic Ocean, however, the impact is not sufficiently noticeable over the continent. While the ClM4.5 experiment restores the seasonal cycles and spatial distribution, the biases increase for precipitation and temperature. Positive biases already existing with BATS are amplified over some sub-regions. This study concludes that temporal localization (seasonal effect), spatial distribution (grid points) and magnitude of precipitation and temperature (bias) are not simultaneously improved by ClM4.5. The introduction of the new land surface scheme ClM4.5, therefore, leads to a performance of the same order as that of BATS, albeit with a more detailed formulation.

关键词： Regional Climate Model land Surface Scheme West Africa Climate RegCM Precipitation West African Monsoon Simulated Data

立德树人视域下当代民航精神育人价值弘扬路径

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

交通企业管理 2024年第3期39卷 136-138页

作者：张序罗凤娥张成伟卫昌波中国国际航空股份有限公司运行控制中心西南分控中心中国民航飞行学院空中交通管理学院中国民航飞行学院国际合作部

当代民航精神为我国民航事业快速稳定发展提供强大动力,是民航安全的根基和永恒主题,应在行业内充分弘扬和践行。2016年,两架民航客机圆满完成南沙永署礁新建机场试飞工作,期间展现出的当代民航精神是民航行业职业精神的高度凝练,是新... 详细信息

当代民航精神为我国民航事业快速稳定发展提供强大动力,是民航安全的根基和永恒主题,应在行业内充分弘扬和践行。2016年,两架民航客机圆满完成南沙永署礁新建机场试飞工作,期间展现出的当代民航精神是民航行业职业精神的高度凝练,是新形势下社会主义精神文明建设、社会主义核心价值观与民航强国建设实践相结合的成果,是劳模精神、劳动精神、工匠精神在民航各工作岗位的生动体现,是民航员工在民航强国梦建设道路的重要支撑和无穷动力。

关键词：当代民航精神立德树人深厚内涵育人价值弘扬路径

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

家禽业抗生素替代品研究进展

现代畜牧科技 2024年第5期 134-136页

作者：杨胜波莫玉兵潘永徐景峨贵州省平塘县农业农村局养殖业发展中心贵州平塘558300 贵州省平塘县通州镇农业综合服务中心贵州平塘558300 贵州省畜牧兽医研究所贵州贵阳550005

家禽业在过去30年中经历了快速增长,抗生素在生产中长期被作为生长促进剂和治疗剂使用,而耐药菌的出现、药物残留以及消费者对无抗产品需求增加等因素加快寻找能替代抗生素而不造成生产水平和质量降低的替代品。家禽的肠道健康一直是家... 详细信息

家禽业在过去30年中经历了快速增长,抗生素在生产中长期被作为生长促进剂和治疗剂使用,而耐药菌的出现、药物残留以及消费者对无抗产品需求增加等因素加快寻找能替代抗生素而不造成生产水平和质量降低的替代品。家禽的肠道健康一直是家禽生产中的重点研究领域,胃肠道是接触皮肤附近大多数环境病原体的器官。因此,家禽生产的主要目标是保持良好的肠道健康和功能,如果肠道功能和健康受损,营养素的消化和吸收都会受到影响,进而影响禽类整体健康和生产性能,最终影响家禽生产的经济性。目前,家禽业中此类替代品包括有机酸、益生菌、益生元、合生元、维生素、矿物质、中药提取物、抗菌肽、生物素。该文将对已开发或正在探索的抗生素替代品进行论述。

关键词：家禽抗生素中药益生菌

维普期刊数据库博看期刊

Immersion in the Design: Design-for-assembly of Cable Harnesses

在线全文

学校读者我要写书评

暂无评论

厦门大学学报（自然科学版） 2002年第S1期41卷 205-206页

作者： J e l Simmons J M Ritchie P O'B Holt G T Russell Manufacturing Systems Research Group Manufacturing Systems Research Group Image Systems Engineering LaboratoryHeriot-Watt UniversityImage Systems Engineering LaboratoryHeriot-Watt University Edinburgh UKEdinburgh UK

Approaches to efficiency in manufacturing and assem bl y over the past 100 years have concentrated frequently on the twin themes of div iding jobs done by people into defined segments and to automating as many of tho se segments as possible. This approach to manufacturing engineering may be char acterised as one of deconstruction and replacement so far as the role of the hum an being is concerned. More recently design engineering has been approached in a similar light with research into ’intelligent’ methods involving, for example, expert systems or genetic algorithms to handle an increasing proportion of desi gn tasks. expert systems are predicated on the idea that it is possible to capture and systemise significant amounts of professional knowledge: a task that has proved with experience to be much more difficult than when such systems wer e first proposed. Genetic algorithms, notwithstanding considerable research eff ort, have yet to make significant inroads into the practise of design and manufa cture. This paper will draw on new and previous experimental work carried out with supp ort from industry to propose an alternative approach that is enabled by the prod ucts of modern information technology. In this paradigm it is recognised that t he involvement of the human design expert is, for the time being at least, inevi table. Rather than seeking to reduce or even eliminate the " expert" with his or her tacit knowledge, the aim is to provide the expert with interactive to ols including immersive virtual reality so that implicit, human expertise can be applied effectively in the design cycle. The proposed approach is considered in the context of a particularly costly and difficult task, namely the design and planning for manufacture and assembly of c able harnesses for use in electro-mechanical artefacts. The efficient and reli able manufacture of cabling systems for many such products in the aerospace, aut omotive and IT sectors provides diverse challenges to des

关键词： Immersion in the Design

COVID-19 Severity Prediction Using enhanced Whale with Salp Swarm Feature Classification

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第7期72卷 1685-1698页

作者： Nebojsa Budimirovic e.Prabhu Milos Antonijevic Miodrag Zivkovic Nebojsa Bacanin Ivana Strumberger K.Venkatachalam Singidunum University Belgrade11000Serbia Department of electronics and Communication engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamCoimbatore641112India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic

Computerized tomography(CT)scans and X-rays play an important role in the diagnosis of COVID-19 and *** the basis of the image analysis results of chest CT and X-rays,the severity of lung infection is monitored using a *** researchers have done in diagnosis of lung infection in an accurate and efficient takes lot of time and *** overcome these issues,our proposed study implements four cascaded ***,for pre-processing,a mean filter is ***,texture feature extraction uses principal component analysis(PCA).Third,a modified whale optimization algorithm is used(MWOA)for a feature selection *** severity of lung infection is detected on the basis of age ***,image classification is done by using the proposed MWOAwith the salp swarm algorithm(MWOA-SSA).MWOA-SSA has an accuracy of 97%,whereas PCA and MWOA have accuracies of 81%and 86%.The sensitivity rate of the MWOA-SSA algorithm is better that of than PCA(84.4%)and MWOA(95.2%).MWOA-SSA outperforms other algorithms with a specificity of 97.8%.This proposed method improves the effective classification of lung affected images from large datasets.

关键词： PCA WOA CT-image lung infection COVID-19