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Current status and highlights of the ElI-NP research program

Matter and Radiation at Extremes 2020年第2期5卷 2-25页

作者： K.A.Tanaka K.M.Spohr D.l.Balabanski S.Balascuta l.Capponi M.O.Cernaianu M.Cuciuc A.Cucoanes I.Dancus A.Dhal B.Diaconescu D.Doria P.Ghenuche D.G.Ghita S.Kisyov V.Nastasa J.F.Ong F.Rotaru D.Sangwan P.-A.Soderstrom D.Stutman G.Suliman O.Tesileanu l.tudor N.Tsoneva C.A.Ur D.Ursescu N.V.Zamfir Extreme light Infrastructure(ElI-NP)and Horia Hulubei National Institute for R&Din Physics and Nuclear Engineering(IFIN-HH) Str.Reactorului No.30077125 Bucharest–M˘agureleRomania Johns Hopkins University 3400 N.Charles StreetBaltimoreMaryland 21218USA

The emergence of a new era reaching beyond current state-of-the-art ultrashort and ultraintense laser technology has been enabled by the approval of around V 850 million worth of structural funds in 2011–2012 by the European Commission for the installation of Extreme light Infrastructure(ElI).The ElI project consists of three pillars being built in the Czech Republic,Hungary,and *** challenging proposal is based on recent technical progress allowing ultraintense laser fields in which intensities will soon be reaching as high as I0∼1023Wcm−*** tremendous technological advance has been brought about by the invention of chirped pulse amplification by Mourou and *** is hosting the ElI for Nuclear Physics(ElI-NP)pillar in M˘agurele near *** new facility,currently under construction,is intended to serve the broad national,European,and international scientific *** mission covers scientific research at the frontier of knowledge involving two *** first is laser-driven experiments related to NP,strong-field quantum electrodynamics,and associated vacuum *** second research domain is based on the establishment of a Compton-backscattering-based,high-brilliance,and intenseγbeam with Eγ≲19.5 MeV,which represents a merger between laser and accelerator *** system will allow the investigation of the nuclear structure of selected isotopes and nuclear reactions of relevance,for example,to astrophysics with hitherto unprecedented resolution and *** addition to fundamental themes,a large number of applications with significant societal impact will be *** implementation of the project started in January 2013 and is spearheaded by the ElI-NP/Horia Hulubei National Institute for Physics and Nuclear Engineering(IFIN-HH).Experiments will begin in early 2020.

关键词： intense frontier approval

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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FRACTIONAl 2D-STOCHASTIC CURRENTS

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Acta Mathematica Scientia 2013年第6期33卷 1507-1521页

作者： Ciprian A.tudor Maria tudor laboratoire Paul Painlev Universit de Lille 1 F-59655 Villeneuve d’AscqFrance Department of Mathematics Academy of Economical StudiesBucharestRomania

Using multiple stochastic integrals and the stochastic calculus for the frac-tional Brownian sheet, we define and we analyze the 2D-fractional stochastic currents.

关键词： currents multiple stochastic integrals fractional Brownian sheet two-parameter processes Hurst parameter

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Testosterone,cardiomyopathies,and heart failure:a narrative review

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Asian Journal of Andrology 2021年第4期23卷 348-356页

作者： Rodica Diaconu Ionuţ Donoiu Oana Mirea tudor Adrian Bălşeanu Department of Cardiology University of Medicine and PharmacyCraiova 200349Romania Department of Physiology University of Medicine and PharmacyCraiova 200349Romania

Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.

关键词： androgens cardiomyocytes heart disease myocardial prognosis

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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Generalized Rectangular Convexity

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Acta Mathematica Sinica,English Series 2023年第9期39卷 1795-1804页

作者： li Ping Yuan tudor Zamfirescu School of Mathematical Sciences Hebei Normal UniversityShijiazhuang050024P.R.China Hebei International Joint Research Center for Mathematics and Interdisciplinary Science Shijiazhuang050024P.R.China Hebei Key laboratory of Computational Mathematics and Applications Shijiazhuang050024P.R.China Fachbereich Mathematik TU Dortmund44221DortmundGermany Institute of Mathematics“Simion Stoilow” Romanian AcademyBucharestRomania

In this paper we investigate the tr-convexity and the rectangular biconvexity in Euclidean spaces.

关键词： tr-convex thin rectangular convexity rectangular biconvexity

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Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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