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Project of a Fast Neutron Target Based on a 10 MeV, 300 kW Proton Accelerator

The Second Asian Particle Accelerator Conference

作者： M.Avilov K.Gubin N.Kot P.logatchev P.Martyshkin S.Morozov S.Shiyankov A.Starostenko V.Plokhoi S.Samarin V.Menshenin Y.Kandiev A.Andrighetto l.Stroe l.tecchio BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly BINP Russia VNIITFRussiaLNL-INFNItaly

＜正＞ A number of materials is considered in terms of possibility of high intense neutron target fabrication on the basis of proton *** calculations of neutron yield are presentedfor thick targets made of high temperature carbon-and boron-containing materials as well *** and results of thermo-mechanical test are presented when materials areirradiated by intense electron beam with the energy up to 5 MeV,that simulated the thermal

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Project of a Fast Neutron Target Based on a 10 MeV, 300 kW P...

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

The Second Asian Particle Accelerator Conference

作者： M.Avilov K.Gubin N.Kot P.logatchev P.Martyshkin S.Morozov S.Shiyankov A.Starostenko A.Andrighetto Y.W.Bao l.tecchio Ya.Kandiev V.Plokhoi S.Samarin BINP Russia BINP Russia BINP Russia BINP Russia BINP Russia BINP Russia BINP Russia BINP Russia lNl-INFN Italy lNl-INFN Italy lNl-INFN Italy VNIITF Russia VNIITF Russia VNIITF Russia

＜正＞ The project of high intense source of fast neutrons is *** source is based on thetarget irradiated by the proton beam with energy 10 MeV and mean power up to 300 *** of fabrication of such a target are *** hot ...

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Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina tecchio Marco Antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(lDNs) normal-density neutrophils(NDNs)

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients

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Neural Regeneration Research 2019年第7期14卷 1237-1246页

作者： Filippo Zappasodi Franca tecchio laura Marzetti Vittorio Pizzella Vincenzo Di lazzaro Giovanni Assenza Department of Neuroscience Imaging and Clinical Sciences and Institute for Advanced Biomedical Imaging"G.D'Annunzio" University laboratory of Electrophysiology for Translational NeuroScience(lET’S) ISTC-CNRand Fondazione Policlinico Gemelli IRCCS Unit of Neurology NeurophysiologyNeurobiologyDepartment of MedicineUniversità Campus Bio-Medico di Roma

The identification of individual factors modulating clinical recovery after a stroke is fundamental to personalize the therapeutic intervention to enhance the final clinical *** this framework,electrophysiological factors are promising since are more directly related to neuroplasticity,which supports recovery in stroke patients,than neurovascular *** this retrospective observational study,we investigated brain neuronal activity assessed via spectral features and Higuchi's fractal dimension(HFD) of electroencephalographic signals in acute phase(2–10 days from symptom onset,T0) and sub-acute phase(2.5 months,T1) in 24 patients affected by unilateral middle cerebral artery *** assessment of the clinical deficits was performed using the National Institutes of Health Stroke Scale(NIHSS),together with the effective recovery calculated as the ratio between difference of NIHSS at T0 and T1 over the NIHSS value at *** observed that delta and alpha band electroencephalographic signal power changed between the two phases in both the hemispheres ipsilateral(IlH) and contralateral(CHl) to the ***,at T0,bilateral higher delta band power correlated with worse clinical conditions(Spearman's rs = 0.460,P = 0.027 for IlH and rs = 0.508,P = 0.013 for ClH),whereas at T1 this occurred only for delta power in IlH(rs = 0.411,P = 0.046) and not for ***-hemispheric difference(IlH ***) of alpha power in patients was lower at T0 than at T1(P = 0.020).HFD at T0 was lower than at T1(P = 0.005),and at both phases,IlH HFD was lower than ClH HFD(P = 0.020).These data suggest that inter-hemispheric low band asymmetry and fractal dimension changes from the acute to the sub-acute phase are sensitive to neuroplasticity processes which subtend clinical *** study protocol was approved by the Bioethical Committee of Ospedale San Giovanni Calibita Fatebenefretelli(No.40/2011) on July 14,2011.

关键词： mono-hemispheric stroke delta band fractal dimension inter-hemispheric asymmetries EEG plasticity

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Sustainability Perspectives When Crop Use Is Implemented in Different Sectors:A life Cycle Assessment Approach

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 334-336页

作者： DE BENEDETTI Bruno tecchio Paolo ROllINO Sara FOSCHIA Marina PIGNATEllI Sonia Politecnico di Torino Corso Duca degli Abruzzi24-10129 TorinoItaly

The present study aims to provide a preliminary overview of the sustainability concept when biomasses conceived for food goals become the raw materials upon which different sectors,such as plastic or energy industry,can develop innovative strategies,according to a so called "greener" *** the results hereafter presented,the definition of sustainability perspectives,according to the use of a life cycle assessment(lCA) approach,will be described for maize use as raw material in different *** current biopolymer industry and conventional biofuel technologies,the so called first-generation biofuels,are the more and more in competition with the food *** presented environmental evaluation,in terms of air emissions,energy and water consumption,is useful in order to understand the sustainability of a bio-sourced product,in comparison with the equivalent item produced by fossil fuels.

关键词： biomass maize biopolymer life cycle assessment bio-sourced materials sustainability

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array