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Expanding the Boundaries of the Chemical Space of DNA methyltransferase 1 modulators

1987年

作者：（美）l.m.墨尔尼克等

书名原文:Determination of Gaseous El.m.nts in metals:著者原题:l.m.墨尔尼克:本书共20章,介绍了金属中气体元素测定的基础理论。

关键词：金属材料气体分析

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Computational.m.lecular Bioscience 2024年第1期14卷 1-16页

作者： massyel S. martínez-Cortés Diana l. Prado-Romero José l. medina-Franco DIFACQUIm Research Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltransferase 1 (DNmT1), one of the main epigenetic targets, is involved in the duplication of the DNA methylation pattern during replication, and it is essential for proper mammalian development. Small.m.lecule DNmT1 modulators are attractive for biochemical epigenetic studies and have the potential to become drugs. So far, more than five hundred small.m.lecules have been reported as DNmT1 inhibitors. However, only a l.m.ted number of DNmT1 activators have been disclosed because, at least in part, DNmT1 activators are typically regarded as negative data in virtual screening campaigns or optimization projects. This manuscript aims to report the chemical structures and biological activity of small.m.lecules that increase the enzymatic activity of DNmT1. Results of the biochemical experimental assays are discussed. It was found that small.m.lecule activators have a large variety of chemical scaffolds but share pharmacophore features. Visual analysis of the chemical space and multiverse based on molecular fingertips supported that activators are structurally diverse. This is the first report of eight small.m.lecules that increase the enzymatic activity of DNmT1 by more than 400% in an enzymatic-based assay. The outcome warrants further investigation of the epigenetic activity of the compounds in a counter-screen assay, e.g., cell-based and in vivo context.

关键词： Chemical.m.ltiverse Chemoinformatics Epigenetics Pharmacophore Hypothesis Small.m.lecules

STUDY ON THE FRACTURE PROCESS OF AN AS CAST Zn 27WT% Al AllOY

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Acta metallurgica Sinica(English letters) 1999年第4期12卷 578-580页

作者： Z.m. Ding and l.m. Zhang Departmentof material Science and Engineering, Dalian Railway Institute,Dalian 116028 ,China

Thefracture processof an ascast ZA27 alloy under thetensiletest atthe room temperature wasstudied. Theresultsshow thatthecracksof ZA27 alloy form at(α+ η)eutectic phaseand develop bypropagatingalongthe(α+ η) phaseandcuttingthroughthe dendriteαphaseand εphase. Theinfluenceof every phasein ZA27 on thestrength and ductility was ana lyzed.

关键词： SZA27 alloy tensilefracture fracture process

预处理技术--家庭生物废弃物处理过程中的微塑料制造者

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Engineering 2024年第1期32卷 116-126页

作者： Tian Hu Fan lü Zhan Yang Zhenchao Shi Yicheng Yang Hua Zhang Pinjing He Institute of Waste Treatment and Recl.m.tion Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Jiaxing-Tongji Environmental Research Institute jiaxing 314000China

mechanical pretreatment is an indispensable process in biological treatment plants that remove plastics and other impurities from household biogenic waste(HBW).However,the imperfect separation of plastics in these pretreatment methods has raised concerns that they pose a secondary formation risk for microplastics(mPs).To validate this presumption,herein,quantities and properties of plastic debris and mPs larger than 50 μm were examined in the full chain of three different pretreatment methods in six *** facilities received HBW with or without prior depackaging at the *** key points in the secondary formation of mPs were ***,flux estimates of mPs were released,and an analysis of mPs sources was provided to develop an overview of their fate in HBW *** output can contain a maximum of(1673±279) to(3198±263) mP particles per kilogram of wet weight(particles·kg^(-1)ww) for those undepackaged at source,and secondary mPs formation is primarily attributed to biomass crushers,biohydrolysis reactors,and rough ***,HBW depackaged at the source can greatly reduce mPs by 8%-72%,regardless of pretreatment *** pretreatment,4.6-205.6 million mP particles were present in 100 tonnes of *** are produced at a rate of 741.11-33124.22 billion mP particles annually in anaerobic digester feedstock(ADF).This study demonstrated that HBW pretreatment is a competitive source of mPs and emphasized the importance of impl.m.nting municipal solid waste segregation at the ***,depackaging biogenic waste at the source is recommended to substantially alleviate the negative effect of pretreatment on mPs formation.

关键词： microplastics Plastic debris Household biogenic waste Depackage Pretreatment

Dynamic of woody debris between riparian forest and stream ecosystem:a case study on broad-leaved Korean pine forest in Changbai mountains

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Dynamic of woody debris between riparian forest and stream e...

Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

第三世界生态高峰会

作者： Zhong l.~(1,2) Dai l.m.~1 Zhou l.~(1,2) ~1Institute of Applied Ecology,Chinese Academy of Sciences.China ~2Groduate University of Chinese Academy of Seiences.China

Woody debris,which consists of both standing dead trees and material that has fallen to the ground in riparian forest,is a dynamic resource to stream ***,dynamic of woody debris between forest and water ecosystem in temperate forest is not well understood,which might be influenced by riparian forest heterogeneity and historical contingency,stream transportation,woody debris decomposition and other non-linear *** order to find out the implications of woody debris in stream and riparian forest and its habitat-related ecological functions,the pattern of woody debris,which includes species,biomass and decay classes,needs to be *** to different stream orders and logging practices,we selected eight 100-meter-long segments of streams and sixteen 10m×30m plots(2 for each side of each segment)to investigation in broad-leaved Korean pine forest in Changbai mountains,in Northeast *** stream,all woody debris was measured including species,long,top diameter,base diameter and decay *** riparian forest,all live trees were measured as dbh and all woody debris was measured like those in *** of much different in woody debris decay classes, vol.m. and mass,we found species from riparian and stream ecosystems were *** the decomposition of in-stream woody debris originating from riparian forest is complex and involves many biological and physical processes such as animal activity,temperature. humidity and water erosion,the pattern of woody debris and the decomposition processes are different between two *** to the longevity of in-stream woody debris is longer than in forest land, we could use a non-linear modal to rebuild forest more than 100 years ago in the origin area of broad-leaved Korean pine forest in Changbai *** result of the modal showed that these stream ecosystems had excessive quantity of woody debris in decay class Ⅱ, Ⅲ compared with those in researches in North *** simul

关键词： dynamic of woody debris riparian forest and stream ecosystem Changbai mountains

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben Zhong Tang Jonathan l.Sessler Feihe Huang Stoddart Institute of molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint laboratory of Self-Assembling Functional.m.terials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 mOE Key laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential compl.m.nt to through-bond conjugation(TBC)-based strategies for constructing l.m.nescent ***,the design of efficient l.m.nogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of l.m.nogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of l.m.nogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active l.m.nogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted l.m.nogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission l.m.nescence twisted conformation

Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： muteb H.Alshammari Ahmed Onayzan Alshammari mohamed Tharwat Elabbasy Rafat Zreiq Faris mohammed Albati m.A.El.m.rsy A.A.menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential.m.dical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCl) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEm). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCl NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the pol.m.ric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCl, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCl as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCl, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCl. Regarding biological responses, the cell exposed to 2.5 μg/m l of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCl shows cell viability of 119.31%, while 5 μg/m l hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCl scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

Effectiveness of biofertilizers foliar application on yield and quality traits of flax(linum usitatissimum l.)

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Oil Crop Science 2024年第2期9卷 91-101页

作者： Saied El Sayed A.B.Bakry O.A.Nofal.m.A.Abo Horish Plant Nutrition Department National Research Centre33 El-Behouth St12622DokkiCairoEgypt Field Crops Department National Research Centre33 El-Behouth St12622DokkiCairoEgypt

Flax is considered to be one of the most significant dual-purpose crops for oil and fiber production in Egypt and *** have a substantial impact on various metabolic processes,including increased photo-synthesis,endogenous hormone levels,ion absorption,nucleic acid synthesis,and protein *** factors collectively contribute to the growth and development of ***,this study aims to investigate how three biofertilizers(Algae extract,CmS as a by-product of yeast,and metalosate multi minerals as amino acids)can enhance both the quantity and quality of flax seed yield under sandy soil *** field experiments were conducted at the Experimental Station of National Research Centre in Nubaria District,Behira Governorate,Egypt during two seasons(2021/2022)using a randomized complete block design(RCBD).The results revealed significant differences among all tested biofertilizers in terms of various characteristics studied in *** application of algae extract at a rate of 1.50 ml/l resulted in an increase in seed yield(ton/ha)by 26.69%&19.89%,straw yield(ton/ha)by 8.08%&17.12%,and oil yield(kg/ha)by 47.72%&33.69%compared to the control group during both seasons *** applications of algae extract at a rate of 1.50 ml/l along with CmS at a rate of 5 m l/l and amino acids at a rate of 1.50 ml/l demonstrated significantly higher macronutrient contents(N,P,K),micronutrient contents(Fe,Zn,mn),seed oil content,and protein content in flax seeds during both *** highest values for seed oil content and protein content%were obtained through foliar application of amino acids at a rate of 1.50 ml/*** can be concluded that foliar sprays with these bio-fertilizers effectively improved flax performance by increasing seed straw and oil yields,nutrients oil,protein and fatty acids seeds contents.

关键词： Flax Bio fertilizers Seeds yield Nutrient contents Quality

language development from theory to practice Khara l. Pence, laura m. Justice.

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