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Molecular Plant 2017年第2期10卷 345-348页

作者： Bu, Shuo-lei liu, Chao liu, Ning Zhao, Ji-long Ai, lian-Feng Chi, Hao li, kathy l. chien, Chih-Wei Burlingame, Alma l. Zhang, Sheng-Wei Wang, Zhi-Yong Hebei Normal Univ Hebei Collaborat Innovat Ctr Cell Signaling Hebei Key Lab Mol & Cellular Biol Coll Life Sci Shijiazhuang 050024 Hebei Peoples R China Carnegie Inst Sci Dept Plant Biol 290 Panama St Stanford CA 94305 USA Chinese Acad Sci Key Lab Intelligent Informat Proc Inst Comp Technol Beijing 100190 Peoples R China Univ Calif San Francisco Dept Pharmaceut Chem San Francisco CA 94158 USA

Dear Editor ABA induces the phosphorylation of three basic helix-loop-helix （bHlH） transcription factors, called AkSs （ABA-responsive ki- nase substrates; AkS1, AkS2, and AkS3）. The unphosphorylated AkSs facilitate stomatal opening through promoting the tran- scription of genes encoding inwardly rectifying k＋ channels （Takahashi et al., 2013）. AkS1 and AkS3 are also regulators of flowering （Ito et al., 2012）. However, the kinases and phosphatases that directly control the phosphorylation status of AkSs in vivo have not been fully characterized. Here,

关键词： Spectrometry Phosphatase Arabidopsis

Nanoscale plasma-activated aerosol generation for in situ surface pathogen disinfection

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Microsystems & Nanoengineering 2022年第2期8卷 161-173页

作者： Nicholas S.l.Chew kiing S.Wong Wei S.Chang chien W.Ooi leslie Y.Yeo Ming k.Tan Mechanical Engineering Discipline School of EngineeringMonash University MalaysiaBandar SunwaySelangorMalaysia Chemical Engineering Discipline School of EngineeringMonash University MalaysiaBandar SunwaySelangorMalaysia Micro/Nanophysics Research laboratory RMIT UniversityMelbourneVICAustralia

Plasma treatment constitutes an efficient method for chemical-free disinfection.A spray-based system for dispensing plasma-activated aerosols onto surfaces would facilitate disinfection of complex and/or hidden surfaces inaccessible to direct line-of-sight(for example,UV)*** complexity and size of current plasma generators(for example,plasma jet and cometary plasma systems)-which prohibit portable operation,together with the short plasma lifetimes,necessitate a miniaturized in situ technique in which a source can be simultaneously activated and administered on-demand onto ***,we demonstrate this possibility by combining two nanoscale technologies for plasma and aerosol generation into an integrated device that is sufficiently small and *** is generated on a carpet of zinc oxide nanorods comprising a nanoneedle ensemble,which when raised to a high electric potential,constitutes a massive point charge array with near-singular electric fields to effect atmospheric *** plasma is then used to activate water transported through an underlying capillary wick,that is subsequently aerosolized under MHz-order surface acoustic *** show that the system,besides being amenable to miniaturization and hence integration into a chipscale device,leads to a considerable improvement in plasma-activation over its macroscale cometary discharge predecessor,with up to 20%and 127%higher hydrogen peroxide and nitrite ion concentrations that are respectively generated in the plasma-activated ***,in turn,leads to a 67%reduction in the disinfection time to achieve 95%bacterial load reduction,therefore demonstrating the potential of the technology as an efficient portable platform for on-demand field-use surface disinfection.

关键词： surface portable aerosol

Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

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Regenerative Biomaterials 2022年第1期9卷 424-433页

作者： chien-liang Ho lynn l.H.Huang Shyh-Jou Shieh Institute of Clinical Medicine College of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Division of Plastic and Reconstructive Surgery Department of SurgeryNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Research Center of Excellence in Regenerative Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina Department of Biotechnology and Bioindustry Sciences College of Bioscience and BiotechnologyNational Cheng Kung University1 University RoadTainan 70101Taiwan International Center for Wound Repair and Regeneration National Cheng Kung University1 University RoadTainan 70101TaiwanChina School of Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina

Autologous chondrocytes(C cells)are effective sources of cell therapy for engineering cartilage tissue to repair chondral defects,such as degenerative *** expansion of cells with C cell characteristics has become a major challenge due to inadequate donor sites and poor proliferation of mature C *** perichondrial progenitor cells(P cells)from the cambium layer of the perichondrium possessed significantly higher mesenchymal stem cell markers than C *** the transwell co-culture system,P cells increased the passaging capacity of C cells from P6 to P9,and the cell number increased 128 *** system increased the percentage of Alcian blue-positive C cells from 40%in P6 to 62%in P9,contributing about 198 times more Alcian blue-positive C cells than the control group.C cells co-cultured with P cells also exhibited higher proliferation than C cells cultured with P cellconditioned *** results were obtained in nude mice that were subcutaneously implanted with C cells,P cells or a mixture of the two cell types,in which the presence of both cells enhanced neocartilage formation in ***,P cells enhanced the proliferation of C cells in a dose–dependent manner and prolonged the longevity of mature C cells for clinical applications.

关键词： chondrocytes cell proliferation perichondrial progenitor cells paracrine effect neocartilage formation

MRI Investigation of New Approach to Improve the Recovery of Myocardial Ischemia Reperfusion Injury by Treatment with Intralipid^®

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World Journal of Cardiovascular Diseases 2016年第10期6卷 352-371页

作者： Yijen l. Wu li liu Fang-Cheng Yeh Bedda l. Rosario chien Ho Rangos Research Center Animal Imaging Core Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center Pittsburgh PA USA Department of Developmental Biology School of Medicine University of Pittsburgh Pittsburgh PA USA Department of Biological Sciences Carnegie Mellon University Pittsburgh PA USA Department of Neurological Surgery University of Pittsburgh Pittsburgh PA USA Department of Epidemiology University of Pittsburgh Pittsburgh PA USA

Background: Despite advances in revascularization and thrombolytic therapy, the outcome of patients after acute myocardial infarction (MI) could be complicated by ischemia reperfusion injury (IRI) and subsequent ventricular remodeling. Inflammation plays a central role in IRI. Intralipid® has been shown to reduce infarct size after IRI, but its effects on myocardial inflammation have not been addressed. The goal of this study is to investigate the effects of Intralipid® on in-situ myocardial inflammation and to better characterize its cardio-protective effects. Methods and Results: Cellular MRI was used to evaluate myocardial inflammation of iron-oxide-labeled macrophage infiltration. Cardiac MRI was used to evaluate global and regional ventricular wall motion, as well as myocardial perfusion and infarction in a rat model. Our results show that the Intralipid® treatment following IRI can preserve global and regional ventricular wall motion, and reduce the infarct size. The In-tralipid®-treated rats exhibit reduced myocardial macrophage infiltration, indicating reduced in-situ myocardial inflammation. Conclusions: Our results indicate that the Intralipid® treatment can protect the heart against IRI and can specifically reduce in-situ myocardial inflammation. Additional study is needed to assess if treatment using Intralipid® after lAD occlusion could improve the recovery of patients suffering from a heart attack and also reduce future development of heart failure.

关键词： Ischemic Reperfusion Injury Infarction Intralipid® Magnetic Resonance Imaging Macrophage/Monocyte

Prevotella oris-caused meningitis and spinal canal infection:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3830-3836页

作者： Wei-Wei Zhang Chao Ai chien-Tai Mao Dong-kang liu Yi Guo Department of Clinical Pharmacy Beijing Tsinghua Changgung HospitalSchool of MedicineTsinghua UniversityBeijing 102218China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of MedicineTsinghua UniversityBeijing 102218China

BACkGROUND Prevotella oris-induced meningitis and Prevotella oris-induced meningitis concomitant with spinal canal infection are extremely *** the best of our knowledge,only 1 case of Prevotella oris-induced central system infection has been *** is the second report on meningitis combined with spinal canal infection due to Prevotella *** SUMMARY We report a case of a 9-year-old boy suffering from meningitis and spinal canal *** patient presented to the neurosurgery department with lumbosacral pain for 1 mo and headache and vomiting for 1 *** had been treated with cephalosporin and nonsteroidal anti-inflammatory drugs for fever,otalgia and pharyngalgia in a local hospital 2 mo prior to this *** hospitalization,magnetic resonance imaging suggested meningitis and l3-S1 lumbosacral dural sac *** cerebrospinal fluid and blood cultures were negative,but the cerebrospinal fluid specimen indicated the presence of Prevotella oris by metagenomic next-generation *** cases of Prevotella oris infection were retrieved from PubMed to characterize the clinicopathological features and identify the prognostic factors and related antimicrobial treatment of infection due to Prevotella *** This report shed light on the characteristics of Prevotella oris infection and highlighted the role of metagenomic next-generation sequencing in pathogen detection.

关键词： Prevotella oris Meningitis Spinal canal infection Metagenomic next-generation sequencing Central nervous system infection Case report

Effect of verapamil on nitric oxide synthase in a portal veinligated rat model: Role of prostaglandin

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World Journal of Gastroenterology 2006年第15期12卷 2351-2356页

作者： Chii-Shyan lay CMY May Fa-Yauh lee Yang-Te Tsai Shou-Dong lee Shu chien Shiomoh Sinchon Division of Hepatology and Gastroenterology Department of Internal Medicine China Medical University HospitalTaichungChina Division of Gastroenterology Department of Internal Medicine Veterans General HospitalTaipeiNational Yang-Ming University School of MedicineTaipeiChina Institute of Biomedical Sciences Academia Sinica TaiwanChina Department of Medicine Columbia University New York University Medical CenterNew YorkUSA

AIM： To investigate the effects of verapamil on nitric oxide （NO） synthesis in a portal vein-ligated rat model. METHODS： Systemic and splanchnic hemodynamics were measured by radiolabeled microspheres in portal hypertensive rats after acute administration of verapamil （2 mg/kg） on chronic treatment with N^W-nitro-l-arginine （NNA）（80 mg/kg） and/or indomethacin （2 mg/kg） . RESUlTS： Verapamil （2 mg/kg） caused a marked fall in both arterial pressure and cardiac output accompanied by an insignificant change in the portal pressure and no change in portal venous inflow. This result suggested that verapamil did not cause a reduction in portal vascular resistance of portal hypertensive rats, which was similar between N^w- nitro-loarginine-treated and indomethacin-treated groups. CONClUSION： In portal hypertensive rats pretreated with NNA and/or indomethacin, acute verapamil administration can not reduce the portal pressure, suggesting that NO and prostaglandin play an important role in the pathogenesis of splanchnic arterial vasodilation in portal hypertension.

关键词： Verapamil Nitric oxide synthase Portal hypertension

GIS-based Evaluation on the Fault Motion-Induced Coseismic landslides

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Journal of Mountain Science 2012年第5期9卷 601-612页

作者： Ming-Wey HUANG chien-Yuan CHEN Tzu-Hsiu WU Chi-ling CHANG Sheu-Yien lIU Ching-Yun kAO Taiwan Science & Technology Center for Disaster Reduction Sindian City Taipei County 231 Chinese Taipei Taiwan Chiayi University Department of Civil & Water Resources Engineering Chiayi City 60004 Chinese Taipei Chia Nan University of Pharmacy and Science Institute of Industrial Safety & Disaster Prevention Tainan City 71710 Chinese Taipei

Earthquake-induced potential landslides are commonly estimated using landslide susceptibility maps. Nevertheless, the fault location is not identified and the ground motion caused by it is unavailable in the map. Thus, potential coseismic landslides for a specific fault motion-induced earthquake could not be predicted using the map. It is meaningful to incorporate the fault location and ground motion characteristics into the landslide predication model. A new method for a specific fault motion-induced coseismic landslide prediction model using GIS （Geographic Information System） is proposed herein. location of mountain ridges, slope gradients over 45~, PVGA （Peak Vertical Ground Accelerations） exceeded o.15 g, and PHGA （Peak Horizontal Ground Accelerations） exceeded o.25 g of slope units were representing locations that initiated landslides during the 1999 Chi-Chi earthquake in Taiwan. These coseismic landslide characteristics were used to identify areas where landslides occurred during Meishan fault motion-induced strong ground motions in Chiayi County in Taiwan. The strong ground motion （over 8 Gal in the database, 1 Gal = 0.0l m/s2, and 1 g = 981 GaD characteristics were evaluated by the fault length, site distance to the fault, and topography, and their attenuation relations are presented in GIS. The results of the analysis show that coseismic landslide areas could be identified promptly using GIS. The earthquake intensity and focus depthhave visible effects on ground motion. The shallower the focus depth, the larger the magnitude increase of the landslides. The GIS-based landslide predication method is valuable combining the geomorphic characteristics and ground motion attenuation relationships for a potential region landslide hazard assessment and in disaster mitigation planning.

关键词： Coseismic landslide GIS Chi-Chiearthquake

Protein kinase C-δ and -β coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes

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Journal of Molecular Cell Biology 2014年第6期8卷 458-472页

作者： Shu-Yi Wei Ting-Er lin Wei-li Wang Pei-ling lee Min-chien Tsai Jeng-Jiann Chiu Institute of Cellular and System Medicine 'National' Health Research Institutes Miaoli 350 Department of Physiology and Biophysics 'National' Defense Medical Center Taipei 114 Institute of Biomedical Engineering 'National' Tsing Hua University Hsinchu 300 Institute of Biomedical Engineering 'National' Cheng Kung University Tainan 701

T-tym phocyte migration under flow is critical for immune responses, but the mechanisms by which flow modulates the migratory beha- viors of T-lymphocytes remain unclear. Human peripheral blood T-lymphocytes （PBTls）, when stimulated with phorbol 12-myristate 13-acetate （PMA）, stretched their ceU bodies dramatically and moved alongthe flow direction. In contrast, stromal ceil-derived factor- lα-stimulated PBTI.s deformed and migrated in a random manner. Here we elucidated the molecular mechanisms underlying flow- induced directionality and deformation of PMA-stimulated PBTls. PMA primed PBTls for polarization under flow, with protein kinase C （PkC）-δ enriched in the leading edge, PkC-β1 in the microtubuie organizing center, and PkC-1311 in the uropod and peripheral region. PkC-δ regulated cell protrusions in the leading edge through Tiaml/Racl/calmoduUn, whereas PkC-β regulated RhoA/Rho- associated kinase activity and microtubule stability to modulate uropod contractility and detachment. Our findings indicate that PkC-δ and -β coordinate in the cell leading edge and uropod, respectively, to modu｜ate the directionality and deformability of migratory T-lymphocytes under flow.

关键词： deformability directionality migration PkCs T-lymphocyte

Preliminary nitrite, nitrate and colour analysis of Malaysian edible bird’s nest

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Information Processing in Agriculture 2015年第1期2卷 1-5页

作者： Meei chien Quek Nyuk ling Chin Yus Aniza Yusof Sheau Wei Tan Chung lim law Department of Process and Food Engineering Faculty of EngineeringUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia laboratory of Vaccines and Immunotherapeutics Institute of BioscienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Chemical Engineering Faculty of EngineeringUniversity of NottinghamMalaysia CampusJalan Broga43500 SemenyihSelangorMalaysia

The high nitrite content in edible bird’s nests is a major concern to the local swiftlet *** lowers the price of the edible bird’s nests and it brings severe health hazards to consumers and *** research investigated the nitrite and nitrate contents of eight types of local edible bird’s nests by using ion chromatography system and evaluating its colour using the CIE system in l^*a^*b^**** nitrite content obtained ranged from 5.7 lg/g for the house nests to 843.8 lg/g for the cave *** nitrate content for the house and cave nests was 98.2 lg/g and 36,999.4 lg/g,*** cave nests with darker and redder colour had higher nitrite and nitrate contents than the brighter and more yellow house *** likely suggests that the nitrite and nitrate contents have correlations with edible bird’s nests *** studies suggested that the nitrite content had high correlations with colour parameters,l^*a^*b^*of edible bird’s nests at significant level of Ple bird’s nests’colour may be a useful indicator for measuring nitrite and nitrate contaminations.

关键词： Nitrite Nitrate Colour Ion chromatography Edible bird’s nest

Origin of Colossal Magnetoresistance in Nd1-xCaxMnO3

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电子显微学报 1997年第4期 69-70页

作者： k.liu\ X.W.Wu\ k.H.Ahn\ C.l.chien (Dept. of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218) John Q.Xiao (Dept. of Physics and Astronomy, University of Delaware, Newark, DE 19716)

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关键词： Nd Ca Origin Colossal Magnetoresistance x)CaxMnO3