Effect of verapamil on nitric oxide synthase in a portal veinligated rat model: Role of prostaglandin
Effect of verapamil on nitric oxide synthase in a portal veinligated rat model: Role of prostaglandin作者机构：Division of Hepatology and Gastroenterology Department of Internal MedicineChina Medical University HospitalTaichungChina Division of Gastroenterology Department of Internal MedicineVeterans General HospitalTaipeiNational Yang-Ming University School of MedicineTaipeiChina Institute of Biomedical Sciences Academia SinicaTaiwanChina Department of Medicine Columbia UniversityNew York University Medical CenterNew YorkUSA
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2006年第12卷第15期
页 面：2351-2356页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by the grant from China Medical University Hospital Taichung Taiwan China
主 题：Verapamil Nitric oxide synthase Portal hypertension
摘 要：AIM： To investigate the effects of verapamil on nitric oxide （NO） synthesis in a portal vein-ligated rat model. METHODS： Systemic and splanchnic hemodynamics were measured by radiolabeled microspheres in portal hypertensive rats after acute administration of verapamil （2 mg/kg） on chronic treatment with N^W-nitro-L-arginine （NNA）（80 mg/kg） and/or indomethacin （2 mg/kg） . RESULTS： Verapamil （2 mg/kg） caused a marked fall in both arterial pressure and cardiac output accompanied by an insignificant change in the portal pressure and no change in portal venous inflow. This result suggested that verapamil did not cause a reduction in portal vascular resistance of portal hypertensive rats, which was similar between N^w- nitro-Loarginine-treated and indomethacin-treated groups. CONCLUSION： In portal hypertensive rats pretreated with NNA and/or indomethacin, acute verapamil administration can not reduce the portal pressure, suggesting that NO and prostaglandin play an important role in the pathogenesis of splanchnic arterial vasodilation in portal hypertension.
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