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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-chien Chen lin-Ju Chou Shih-Chen Huang Ta-Wei Chu Shang-Sen lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACkGROUND The prevalence of non-alcoholic fatty liver(NAFlD)has increased *** with NAFlD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MlR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-l)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFlD(NAFlD+,NAFlD-)and to rank their *** To uses three different Mach-l methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MlR,three Mach-l methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFlD+group,while other factors were all significantly higher except for smoking ***-l had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFlD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(lDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFlD+group compared to the NAFlD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

Can rifaximin for hepatic encephalopathy be discontinued during broad-spectrum antibiotic treatment?

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World Journal of Hepatology 2024年第2期16卷 115-119页

作者： chien-Hao Huang Piero Amodio Division of Hepatology Department of Gastroenterology and HepatologyChang-Gung Memorial HospitalLinkou Medical CenterTaoyuan 333Taiwan Department of Clinical and Experimental Medicine University of PaduaPadova 35122Italy

Hepatic encephalopathy(HE)is a formidable complication in patients with decompensated cirrhosis,often necessitating the administration of rifaximin(RFX)for effective ***,is a gut-restricted,poorly-absorbable oral rifamycin derived antibiotic that can be used in addition to lactulose for the secondary prophylaxis of *** has shown notable reductions in infection,hospital readmission,duration of hospital stay,and ***,limited data exist about the concurrent use of RFX with broad-spectrum antibiotics,because the patients are typically excluded from studies assessing RFX efficacy in HE.A pharmacist-driven quasi-experimental pilot study was done to address this *** argue against the necessity of RFX in HE during broad-spectrum antibiotic treatment,particularly in critically ill patients in intensive care unit(ICU).The potential for safe RFX discontinuation without adverse effects is clearly illuminated and valuable insight into the optimization of therapeutic strategies is *** findings also indicate that RFX discontinuation during broadspectrum antibiotic therapy was not associated with higher rates of delirium or coma,and this result remained robust after adjustment in multivariate ***,rates of other secondary clinical and safety outcomes,including ICU mortality and 48-hour changes in vasopressor requirements,were ***,since the activity of RFX is mainly confined to the modulation of gut microbiota,its potential utility in patients undergoing extensive systemic antibiotic therapy is debatable,given the overlapping antibiotic ***,this suggests that the action of RFX on HE is class-specific(related to its activity on gut microbiota),rather than drug-specific.A recent double-blind randomized controlled(ARiE)trial provided further evidence-based support for RFX withdrawal in critically ill cirrhotic ICU patients receiving broad-spectrum *** studies prompt further discussion about

关键词： Rifaximin discontinuation Hepatic encephalopathy Broad-spectrum antibiotics Crit-ically ill Medical intensive care unit Pharmacist-driven protocol

Effect of Thermal Refining on Mechanical Properties of Annealed SAE 4130 by Multilayer GTAW

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Journal of Iron and Steel Research International 2012年第7期19卷 71-78页

作者： I k lee C l Chung Y T lee Y T chien Department of Materials Science and Engineering Da-Yeh University

During the first welding process in manufacturing a precise seam container, the steel material must first undergo a full annealing treatment. Multilayer welding operations are conducted and then applied with refining treatment to obtain the goal by hardening. The influence of thermal refining on mechanical properties of annealed SAE 4130 by multilayer GTAW （gas tungsten arc welding） was discussed. The AW （annealing＋welding） and AWST （annealing＋welding＋solution＋tempering） occurred with a minimum hardness value at GGHAZ （grain growth heat affected zone） due to coarse grain growth~ the hardness occurred with sudden drops between the multilayer welding, but was still larger than the minimum value at HAZ （heat affected zone）. The welded joint efficiency of the AWST was 89.9%, with the elongation reduced to 77.2% of AST （annealing＋solution＋tempering）. The cross section of the tensile samples both appeared with a uniform dimple-shaped structure, and however the necking for AST was greater than that for AWST. The impact value for AWST was 166.5% of AST. Moreover, from microstructure observations, it was found that AWST had a greater tendency to ductile failure than AST. These results can be inferred., the process of steady pressure and the initial position of the precision tube breakage HAZ. However, when stress occurs instantly, HAZ can absorb more energy, therefore the initial damage does not occur.

关键词： thermal refining SAE 4130 multilayer welding GTAW

High-pressure Mossbauer Study of Metastable 304 Stainless Steel with bcc Structure

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Chinese Physics letters 1995年第4期12卷 241-244页

作者： lI Fashen SUN Jijun C.l.chien Department of Physics Lanzhou UniversityLanzhou 730000 Department of Physics and Astronomy The Johns Hopkins UniversityBaltimoreMaryland 21218U.S.A.

The ferromagnetic metastable bcc 304 stainless steel film was studied by means of ^(57)Fe high-pressure Mossbauer *** fcc phase was observed under the pressure up to 36 ***,the magnetization direction of the sample was found to reorientate under the high-pressure,and showed the strongest tendency to the out-of-plane under the pressure 8 kbar,then was gradually close to the in-plane with increasing pressure.

关键词： spectroscopy. steel Mossbauer

Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-Hao Huang li-Wen lee Jrhau lung Yu-Che Ou chien-Hui Hung Huei-Chieh Chuang Min-Chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACkGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(le PFS(≥1 year).Simple logistic models revealed that the patients with a completeness of cytoreduction score of 0(CC-0)or length of CRS≤6 h had a favorable PFS[odds ratio(OR)=0.141,P=0.004;and OR=0.361,P=0.027,respectively].In multiple logistic regression,achieving CC-0 was the strongest prognostic factor for a favorable PFS(OR=0.131,P=0.005).A peritoneal cancer index score>12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,PlUSION Achieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

Poling Effects of Dielectric and Optical Properties on Pb(Zn1/3Nb2/3)1-xTixO3 Crystal

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Journal of Rare Earths 2006年第z1期24卷 166-168页

作者： Tu Chi Shun Wang Fu Tang chien R R Hugo Schmidt V Chew l l Graduate Inst.of Applied Science and Engineering Fu Jen University Taipei 242 China Graduate Inst.of Applied Science and Engineering Fu Jen University Taipei 242 China Department of Physics Montana State University Bozeman MT 59717 USA Department of Physics Montana State University Bozeman MT 59717 USA Department of Mechanical Engineering National University of Singapore Singapore

Dipolar relaxation and dielectric/piezoelectric resonance in a (001)-cut Pb(Zn1/3Nb2/3)0.9Ti0.1O3 (PZNT10%) single crystal before and after electric (E)-field poling were presented. Dielectric permittivities were measured as functions of temperature, frequency and poling E-field strength. Frequency-dependent dielectric spectroscopy in the poled sample exhibits multiple piezoelectric resonances between 0.1 and 1 MHz, which can be described by the forced-damped-oscillator model. The resonant spectra show significant changes while phase transitions are taking place. The unpoled crystal shows almost no optical birefringence, indicating that the average structure symmetry is isotropic. Birefringence of the crystal is significantly enhanced by a prior E-field poling.

关键词： Pb(Zn1/3Nb2/3)1-xTixO3 dielectric permittivity phase transitions refractive indices

On Three Differential Equations Associated with Chebyshev Polynomials of Degrees 3,4 and 6

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Acta Mathematica Sinica,English Series 2017年第1期33卷 21-36页

作者： li chien SHEN Department of Mathematics University of Florida Gainesville FL 32611-8105

We shall study the differential equation y^l2=Tn（y）-（1-2μ2）;where μ2 is a constant, Tn（x） are the Chebyshev polynomials with n = 3,4,6. The solutions of the differential equations will be expressed explicitly in terms of the Weierstrass elliptic function which can be used to construct theories of elliptic functions based on 2F1 （1/4, 3/4; 1; z）, 2F1 （l/3, 2/3; 1; z）, 2F1 （1/6, 5/6; 1; z） and provide a unified approach to a set of identities of Rmanujan involving these hypergeometric functions.

关键词： Chebyshev polynomials Eisenstein series Jacobi theta functions Weierstrass ellipticfunction

QUINAPRIlAT INCREASES TOTAl BODY VASCUlAR COMPlIANCE IN RATS WITH MYOCARDIAl INFARCTION

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中华医学杂志(英文版) 1992年第5期105卷 382-389页

作者： Yongwei chien Edward D. Frohlich Allan A. MacPhee Barbara l. Pegram Alton Ochsner Medical Foundation New Orleans LA 70121 USA

To test whether quinaprilat,a new angiotensinconverting enzyme inhibitor,has any venous effect,itsimmediate effects were measured on mean circulatoryfilling pressure(MCFP),intravascular volume and to-tal body vascular(i.e.,venous)compliance in consciousrats with mild congestive heart failure induced bycoronary artery *** was determined by in-flating a right atrial balloon to arrest the circulationinstantly and *** body vascular compli-ance was derived from total circulatory pressure-vol-ume relationships as determined by seriesmeasurements of MCFP with different intravascularvolume *** 8 rats with mean infarct size of26±4%,30-minute infusion of quinaprilat(0.1mg/kg/min)decreased both mean arterial andcentral venous pressures by 8 mmHg and 0.7 mmHg,respectively(Plood volume remained *** control vehicle infusion,quinaprilat increased thetotal body vascular compliance(2.09±0.12 vs 2.69±0.23ml/kg/mmHg;Plated unstressed circulating volume(34.96±1.10 vs 28.53±2.55ml/kg;Plat produces possible venodilationthrough immediately improved total body vascularcompliance thereby reducing cardiac preload in this ratmodel of chronic heart failure.

关键词： CONGESTIVE HEART-FAIlURE CONVERTING ENZYME-INHIBITORS PRESSURE-VOlUME RElATIONSHIP ATRIAl NATRIURETIC PEPTIDE CONSCIOUS RAT NITROGlYCERIN CAPTOPRIl CAPACITY THERAPY MODEl

Effects of acute aerobic exercise on motor response inhibition:An ERP study using the stop-signal task

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Journal of Sport and Health Science 2015年第1期4卷 73-81页

作者： chien-Heng Chu Brandon l.Alderman Gao-Xia Wei Yu-kai Chang Graduate Institute of Athletics and Coaching Science National Taiwan Sport University Department of Exercise Science and Sport Studies Rutgers University key laboratory of Mental Health Institute of PsychologyChinese Academy of Sciences

Purpose： The purpose of this study was to determine the effects of acute exercise on motor response inhibition using both behavioral and electrophysiological approaches. Methods： The P3 and N1 event-related potential （ERP） components were recorded while performing a stop-signal task in 21 college students following a moderately intense acute exercise bout for 30 min and a sedentary control session that involved reading. Results： Acute exercise induced a shorter stop signal response time （SSRT） as compared to control; however, the go response time （Go RT） remained unchanged. In examining the ERP data, acute exercise increased both P3 amplitude and latency but did not affect the N1 component. Conclusion： Acute exercise has a selective and beneficial effect on cognitive function, specifically affecting the motor response inhibition aspect of executive function. Furthermore, acute exercise predominately impacts later stages of information processing during motor response inhibition, which may lead to an increase in attentional resource allocation and confer the ability to successfully withhold a response to achieve motor response inhibition.

关键词： Cognition Executive function Inhibitory control NI P3