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Improving anammox activity and reactor start-up speed by using CO_(2)/NahCO_(3) buffer

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Journal of Environmental Sciences 2024年第5期139卷 60-71页

作者： Shaoan Cheng huahua li Xinyuan he hua Chen longxin li State Key laboratory of Clean Energy Utilization College of Energy EngineeringZhejiang UniversityHangzhou 310027China

Anammox bacteria grow slowly and can be affected by large ph *** suitable buffers could make the start-up of anammox reactors easy and *** this study,the effects of three kinds of buffers on the nitrogen removal and growth characteristics of anammox sludge were *** with CO_(2)/NahCO_(3)buffer solution(CCBS)performed the best in nitrogen removal,while 4-(2-hydroxyerhyl)piperazine-1-ethanesulfonic acid(hePES)and phosphate buffer solution(PBS)inhibited the anammox *** with 50 mmol/l CCBS could start up in 20 days,showing the specific anammox activity and anammox activity of 1.01±0.10 gN/(gVSS·day)and 0.83±0.06 kgN/(m^(3)·day),*** Kuenenia was the dominant anammox bacteria,with a relative abundance of 71.8%.Notably,anammox reactors could also start quickly by using 50 mmol/l CCBS under nonstrict anaerobic *** findings are meaningful for the quick start-up of engineered anammox reactors and prompt enrichment of anammox bacteria.

关键词： Anammox bacteria Buffer solution CO_(2)/NahCO_(3) Physiological characteristics Microbial community shift

Construction of algal-bacterial consortia using green microalgae Chlorella vulgaris and As(Ⅲ)-oxidizing bacteria:As tolerance and metabolomic profiling

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Journal of Environmental Sciences 2024年第5期139卷 258-266页

作者： Xiaoman he Guobing lin Jiayuan Zeng Zhaoguang Yang lin Wang College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Key laboratory of hunan Province for Water Environment and Agriculture Product Safety Central South UniversityChangsha 410083China

Bioremediation became a promising technology to resolve arsenic(As)contamination in aquatic *** monoculture such as microalgae or bacteria was sensitive to environmental disturbance and vulnerable to contamination,green microalgae Chlorella vulgaris and arsenite(As(Ⅲ))-oxidizing bacteria Pseudomonas ***11 were co-cultured to construct algal-bacterial consortia in the current *** effects of algae-bacteria(A:B)ratio and exposure As(Ⅲ)concentration on algal growth,As speciation and metabolomic profile were *** growth arrested when treated with 100 mg/l As(Ⅲ)without the co-cultured *** contrast,co-cultured with strain SMS11 significantly enhanced As tolerance in *** especially with A:B ratio of 1:*** the As(Ⅲ)in culture media of the consortia were oxidized into As(Ⅴ)on day *** of As was observed on day *** 1% and 0.5% of total As were converted into dimethylarsinic acid(DMA)after 21days cultivation when the initial concentrations of As(Ⅲ)were 1 and 10 mg/l,*** analysis was further performed to reveal the response of consortia metabolites to external As(Ⅲ).The enriched metabolomic pathways were associated with carbohydrate,amino acid and energy *** acid cycle and glyoxylate and dicarboxylate metabolism were upregulated under As stress due to their biological functions on alleviating oxidative stress and protecting *** carbohydrate and amino acid metabolisms provided precursors and potential substrates for energy production and cell protection under abiotic *** of the pathways relevant to carbohydrate or amino acid metabolism were triggered by energy requirement.

关键词： Microalgae Algal-bacterial consortia As(Ⅲ)-oxidizing bacteria Metabolomics Energy metabolism

hepatocardiorenal syndrome in liver cirrhosis:Recognition of a new entity?

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World Journal of Gastroenterology 2024年第2期30卷 128-136页

作者： henry h l Wu Amina Rakisheva Arvind Ponnusamy Rajkumar Chinnadurai Renal Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Department of Cardiology City Cardiological CenterAlmaty 050000Kazakhstan Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Donal O’Donoghue Renal Research Centre&Department of Renal Medicine Northern Care Alliance National Health Service Foundation TrustSalford M68HDUnited Kingdom

Emerging evidence and perspectives have pointed towards the heart playing an important role in hepatorenal syndrome(hRS),outside of conventional understanding that liver cirrhosis is traditionally considered the sole origin of a cascade of pathophysiological mechanisms directly affecting the kidneys in this *** the absence of established heart disease,cirrhotic cardiomyopathy may occur more frequently in those with liver cirrhosis and kidney *** is a specific form of cardiac dysfunction characterized by blunted contractile responsiveness to stress stimuli and altered diastolic relaxation with electrophysiological *** the clinical description of these potential cardiac-related complications of the liver,the role of the heart has traditionally been an overlooked aspect of circulatory dysfunction in *** from a physiological sense,temporality(prior onset)of cardiorenal interactions in hRS and positive effects stemming from portosystemic shunting demonstrated an important role of the heart in the development and progression of kidney dysfunction in cirrhotic *** this review,we discuss current concepts surrounding how the heart may influence the development and progression of hRS,and the role of systemic inflammation and endothelial dysfunction causing circulatory dysfunction within this *** temporality of heart and kidney dysfunction in hRS will be *** a subgroup of patients who receive portosystemic shunting,the dynamics of cardiorenal interactions following treatment is *** research to determine the unknowns in this topic is anticipated,hopefully to further clarify the intricacies surrounding the liver-heart-kidney connection and improve strategies for management.

关键词： hepatorenal syndrome Cardiorenal syndrome Cirrhosis Cardiac dysfunction Circulatory dysfunction

Bacterial and cancerous cell membrane fused liposome coordinates with PD-l1 inhibitor for cancer immunotherapy

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Nano Research 2024年第9期17卷 8389-8401页

作者： Xianjin luo Chenglong li Zhaofei Guo hairui Wang Penghui he Yuanhao Zhao Yi lin Chunting he Yingying hou Yongshun Zhang Guangsheng Du Key laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Pharmaceutical Biotechnology Department of PharmacyLMU MunichButenandt Strasse 5-13Munich 81377Germany Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Although tumor cell membranes with broad-spectrum antigens have been explored for cancer vaccines for decades,their relatively poor capacity to stimulate immune responses,especially cellular immune responses,has limited their ***,we presented a novel bacterial and cancerous cell membrane fusogenic liposome for co-delivering cell membrane-derived antigens and ***,a programmed death-ligand 1(PD-l1)inhibitor,JQ-1,was incorporated into the formulation to tackle the up-regulated PD-l1 expression of antigen-presenting cells(APCs)upon vaccination,thereby augmenting its anti-tumor *** fusogenic liposomes demonstrated significantly improved cellular uptake by APCs and effectively suppressed PD-l1 expression in bone marrow-derived dendritic cells(BMDCs)in *** subcutaneous vaccination,the nano-vaccines efficiently drained to the tumor-draining lymph nodes(TDlNs),and significantly inhibited PD-l1 expression of both dendritic cells(DCs)and macrophages within the TDlNs and *** a result,the liposomal vaccine induced robust innate and cellular immune responses and inhibited tumor growth in a colorectal carcinoma-burden mouse *** summary,the fabricated cell membrane-based fusogenic liposomes offer a safe,effective,and easily applicable strategy for tumor immunotherapy and hold potential for personalized cancer immunotherapy.

关键词： fusogenic liposome tumor cell membrane adjuvant programmed death-ligand 1(PD-l1)inhibitor tumor draining lymph nodes

harnessing overlapped temperature-salinity gradient in solar-driven interfacial seawater evaporation for efficient steam and electricity generation

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Journal of Energy Chemistry 2024年第8期95卷 694-700,I0015页

作者： Peida li Dongtong he Jingchang Sun Jieshan Qiu Zhiyu Wang State Key lab of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029LiaoningChina College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Solar-driven interfacial water evaporation(SIWE)offers a superb way to leverage concentrated solar heat to minimize energy dissipation during seawater *** also engenders overlapped temperaturesalinity gradient(TSG)between water-air interface and adjacent seawater,affording opportunities of harnessing ***,the efficiency of conventional SIWE technologies is limited by significant challenges,including salt passivation to hinder evaporation and difficulties in exploiting overlapped TSG ***,we report self-sustaining hybrid SIWE for not only sustainable seawater desalination but also efficient electricity generation from *** enables spontaneous circulation of salt flux upon seawater evaporation,inducing a self-cleaning evaporative interface without salt passivation for stable steam ***,this design enables spatial separation and simultaneous utilization of overlapped TSG to enhance electricity *** benefits render a remarkable efficiency of90.8%in solar energy utilization,manifesting in co-generation of solar steam at a fast rate of 2.01 kg m^(-2)-h^(-1)and electricity power of 1.91 W m^(-2)with high *** interfacing the hybrid SIWE with seawater electrolyzer constructs a system for water-electricity-hydrogen co-generation without external electricity *** produces hydrogen at a rapid rate of 1.29 l h^(-1)m^(-2)and freshwater with 22 times lower Na+concentration than the World health Organization(WhO)threshold.

关键词： Solar-driven interfacial water evaporation Steam generation Electricity generation Seawater

Rational design of AgGaS/ZnS/ZnS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： h.X.lu h.liu Z.Z.Fu Y.Y.Chen h.Q.Dai Z.hu W.l.Zhang R.Q.Guo Institute for Electric light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/ZnS/ZnS QDs showed an excellent photoluminescence quantum yield(PlQY)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PlQY reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when ZnCl_(2)was employed,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloyed core/shell interface

Role of phosphorus on the biogeochemical behavior of cadmium in the contaminated soil under leaching and pot experiments

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Journal of Environmental Sciences 2024年第3期137卷 488-499页

作者： hui Jia YifanWu Mengqi Zhang Jinhui Ye Daolin Du he Wang Institute of Environment and Ecology School of Emergency ManagementJiangsu UniversityZhenjiang 212013China School of the Environment and Safety Engineering&Institute of Environment and Ecology Jiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China Xuzhou Medical University Affiliated HospitalXuzhou 221004China

Phosphorus(P)is involved in various biochemical reactions in plant growth,so it is beneficial to plants growing in soils contaminated by metals,including cadmium(Cd).however,few studies have reported on the mechanistic roles of P in mitigating Cd toxicity to ryegrass root,and especially in alleviating the disruption of the mitochondrial function of living *** this study,the physiological and biochemical mechanisms associated with ryegrass growth under various Cd and P treatments were investigated using leaching and pot *** concentration of Cd in soil leachates showed a significantly positive relationship with redox potential(Plationship(Ph leachate ph values and dissolved organic carbon(DOC),indicating that exogenous P addition(as h_(2)PO_(4)*)may decrease Cd leaching from contaminated *** to the control(without P addition),the cumulative Cd content was reduced by 53.3%and 64.5%in the soil leachate with exogenous P application(20 mg/l and 80 mg/l),***,application of P decreased the Cd concentrations in the symplastic fractions and increased the Cd concentrations in the apoplastic fractions in root tips,which may help to alleviate Cd stress to the ***,exogenous P was found to play a positive role in mitochondrial function and Ca^(2+)variation in root cells under Cd stress,which provides novel insights into the mechanisms of exogenous P in alleviating plant Cd injury.

关键词： Phosphorus Cadmium stress Protoplast Biogeochemical behavior Mitochondrial function

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey hong lily Song William Wagstaff Rex C.haydon hue h.luu Sherwin h.ho Jason Strelzow Russell R.Reid Tong-Chuan he lewis l.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and lRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

Small holes,big impact:Stomata in plant–pathogen–climate epic trifecta

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Molecular Plant 2024年第1期17卷 26-49页

作者： Shuguo hou Olivier Rodrigues Zunyong liu libo Shan Ping he Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China School of Municipal&Environmental Engineering Shandong Jianzhu UniversityJinanShandong 250101China Unitéde Recherche Physiologie Pathologie et Génétique VégétalesUniversitéde Toulouse Midi-PyrénéesINP-PURPAN31076 ToulouseFrance Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

The regulation of stomatal aperture opening and closure represents an evolutionary battle between plants and pathogens,characterized by adaptive strategies that influence both plant resistance and pathogen *** ongoing climate change introduces further complexity,affecting pathogen invasion and host *** review delves into recent advances on our understanding of the mechanisms governing immunity-related stomatal movement and patterning with an emphasis on the regulation of stomatal opening and closure dynamics by pathogen patterns and host *** addition,the review explores how climate changes impact plant–pathogen interactions by modulating stomatal *** light of the pressing challenges associated with food security and the unpredictable nature of climate changes,future research in this field,which includes the investigation of spatiotemporal regulation and engineering of stomatal immunity,emerges as a promising avenue for enhancing crop resilience and contributing to climate control strategies.

关键词： stomatal movement stomatal patterning plant resistance pathogen virulence apoplastic immunity and climate change