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Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica l.acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research New Zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Origin and diversification of maize: Two teosintes but different contributions

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Molecular Plant 2024年第2期17卷 233-235页

作者： Jonathan acosta-Bayona Gloria leon-Martinez Jean-Philippe Vielle-Calzada Grupo de Desarrollo Reproductivo y Apomixis UGA Laboratorio Nacional de Genomica para la BiodiversidadCinvestav IrapuatoIrapuato Gto CP36825Mexico

The unique topographic,climatic,and latitudinal heterogeneity of Mesoamerica is crucial to understanding the evolutionary emergence of one of the richest cultural and biological regions in the planet and its impact on food *** divided between two regions of large biodiversity-lowland tropical or coastal zones and temperate or subtropical highlands sculpted by parallel sierras and their central plateau-the Mexican territory harbors more than 2000 endemic monocotyledonous species,including several hundred grasses(Poaceae),particularly those belonging to the genus Zea,composed of maize(Zea mays ***)and its wild relatives,collectively referred as teosintes.

关键词： collective planet harbor

Review of the Cretaceous avian diversity of Antarctica:a changing scenario for the evolution of early Neornithine birds

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Advances in Polar Science 2024年第1期35卷 1-13页

作者： Carolina acosta HOSPITAlECHE Facundo IRAZOQUI Paula BONA Ariana PAUlINA-CARABAJAl División Paleontología de Vertebrados Museo de La PlataFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataPaseo del Bosque s/nLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina División Paleontología Vertebrados Museo de La Plata-Anexo ⅡFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataCalles 122 y 60La Plata B1900FWAArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional del ComahueSan Carlos de Bariloche R8400GAMArgentina

The worldwide record of Cretaceous Neornithes and Neornithine-like birds is both controversial and poorly ***,in recent years,the Antarctic continent has yielded a substantial number of Maastrichtian avian specimens,contributing significantly to our understanding of the early evolution of this ***,the keen interest and collaborative efforts of various paleornithologists have resulted in a wealth of knowledge,which we have thoroughly reviewed,updated,and discussed in the context of recent discoveries.

关键词： Maastrichtian Antarctic Peninsula Vega Island Seymour(Marambio)Island Neornithes birds

The Ilux^(®) compared to the mechanical meibomian gland expression for the treatment of moderate and severe meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1042-1048页

作者： María Ximena Núñez Andrea acosta-Ortega Guillermo Raul Vera-Duarte Catalina Gómez-Duarte Unit of Cornea Cataract and Refractive SurgeryVision Sana Research GroupClínica de Oftalmología de CaliFaculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Department of Ophthalmology Faculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Department of Ophthalmology Hospital de ClínicasNational University of AsunciónAsunción 111421Paraguay

AIM:To compare the safety and effectiveness of eyelid treatment with the Ilux®-MGD Treatment System in one session versus five sessions of mechanical meibomian gland expression(MMGE)in patients with moderate to severe meibomian gland dysfunction(MGD).METHODS:A prospective,randomized,open-label,and controlled clinical trial that compared one session of the Ilux®MGD Treatment System versus five sessions of MMGE in both eyes of 130 patients aged≥18y with Ocular Surface Disease Index(OSDI)scores≥13,total meibomian gland scores(MGS)oflower eyelid of each eye,and non-invasive tear break-up time(NI-TBUT)lux®or ***:The mean age was 58±*** total MGS scores in both treatment groups were *** follow-up,there were significant differences in total MGS and per sector with Plysis was performed using generalized estimating equations corresponding to the generalized linear model for repeated means to determine the treatment relationship with total MGS,NIBUT,and *** was a significant difference between Ilux®and MMGE(Pllow-up from the first to the twelfth month in MGS,NI-BUT,and OSDI *** adverse events were ***:Ilux®treatment compared to MMGE significantly improves symptoms and signs in patients with moderate to severe MGD for one year without adverse events.

关键词： meibomian gland dysfunction Ilux® ocular surface dry eye

Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa Merchan-Ramirez Guillermo Sanchez-Delgado lucas Jurado-Fasoli Francisco M acosta Manuel Munoz-Torres Jose M.llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(iMUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of Medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear Medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the Mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

Fungi Associated with Sand and Plants from Marine Coastlines: Potential Relevance for Human Health

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Advances in Microbiology 2024年第6期14卷 303-316页

作者： Marina Carrasco-acosta Pilar Garcia-Jimenez Department of Biology Universidad de Las Palmas de Gran Canaria Campus de Tafira Las Palmas Spain

The fungal community associated with beach sand and plants located along marine coasts are an under-studied area of research despite its potential relevance to human health. In this study, we isolated and identified the cultivable mycobiota associated with sand and plants collected along the coast of Gran Canaria (Spain) using culture-dependent and -independent methods. Clinically relevant species belonging to Cryptococcus spp. and related genera such as Naganishia and Papilotrema were isolated and identified from shoreline plants. Moreover, Candida tropicalis was isolated from beach sand, and Aspergillus fumigatus and Aspergillus terreus strains were associated with both types of samples (i.e., plants and beach sand). We conclude that beach sand and shoreline plants are potential reservoirs of fungi of high clinical interest. We recommend including beach sand and plants from the environment when assessing the quality of marine coastal systems. Our results open a framework for studying the natural marine environment and its role in the epidemiology of infectious diseases in order to more accurately manage public health.

关键词： Sand Beach Shoreline Plants Reservoir of Pathogenic Fungi Cryptococcus spp. Aspergillus spp.

Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots

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Molecular Plant 2024年第8期17卷 1307-1327页

作者： Yaming liu Dario Esposto lisa K.Mahdi Andrea Porzel Pauline Stark Hidayat Hussain Anja Scherr-Henning Simon Isfort Ulschan.Bathe Ivan F.acosta Alga Zuccaro Gerd U.Balcke Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryHalleGermany Institute for Plant Sciences Cluster of Excellence on Plant Sciences(CEPLAS)Cologne BiocenterUniversity of CologneCologneGermany Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalleGermany Max Planck Institute for Plant Breeding Research CologneGermany Horticultural Sciences University of FloridaGainesvilleFLUSA.

Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense *** include the induction of a cocktail of defense metabolites that typically restrict pathogen ***,we investigate the interaction between barley roots and the fungal pathogens Bipolaris sorokiniana(Bs)and Fusarium graminearum(Fg)at the metabolite *** identify hordedanes,a previously undescribed set of labdane-related diterpenoids with antimicrobial properties,as critical players in these *** of barley roots by Bs and Fg elicits hordedane synthesis from a 60o-kb gene *** reconstruction of the biosynthesis pathway in yeast and Nicotiana benthamiana produced several hordedanes,including one of the most functionally decorated products 19-β-hydroxy-hordetrienoic acid(19-OH-HTA).Barley mutants in the diterpene synthase genes of this cluster are unable to produce hordedanes but,unexpectedly,show reduced Bs *** contrast,colonization by Fusarium graminearum,another fungal pathogen of barley and wheat,is 4-fold higher in the mutants completely lacking ***,19-OH-HTA enhances both germination and growth of Bs,whereas it inhibits other pathogenic fungi,including *** of microscopy and transcriptomics data suggest that hordedanes delay the necrotrophic phase of *** together,these results show that adapted pathogens such as Bs can subvert plant metabolic defenses to facilitate root colonization.

关键词： barley Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum

Revisit to Two-Proton Radioactivity of 19Mg and Observation of Two-Proton Decay of 30Ar

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原子核物理评论 2016年第2期33卷 197-202页

作者：徐晓栋 I.Mukha l.acosta E.Casarejos A.A.Ciemny W.Dominik J.Duénas-Díaz V.Dunin J.M.Espino A.Estradé F.Farinon H.Geissel A.Fomichev T.A.Golubkova A.Gorshkov l.V.Grigorenko Z.Janas G.Kamiński O.Kiselev R.Knbel S.Krupko M.Kuich Yu.A.litvinov G.Marquinez-Dur'an I.Martel C.Mazzocchi C.Nociforo A.K.Ord'uz M.Pfützner S.Pietri M.Pomorski A.Prochazka S.Rymzhanova A.M.S'anchez-Benítez C.Scheidenberger P.Sharov H.Simon B.Sitar R.Slepnev M.Stanoiu P.Strmen I.Szarka M.Takechi Y.K.Tanaka H.Weick M.Winkler J.S.Winfield Ⅱ.Physikalisches Institut Justus-Liebig-Universitt Gie?en GSI Helmholtzzentrum für Schwerionenforschung Gmb H School of Physics and Nuclear Energy Engineering Beihang University National Research Centre "Kurchatov Institute" INFN Laboratori Nazionali del Sud Instituto de Física Universidad Nacional Autónoma de México University of Vigo Faculty of Physics University of Warsaw Department of Applied Physics University of Huelva Veksler and Baldin laboratory of High Energy Physics Department of Atomic Molecular and Nuclear PhysicsUniversity of Seville University of Edinburgh Flerov laboratory of Nuclear Reactions Advanced Educational and Scientific Center Moscow State University FSBI "SSC RF ITEP"of NRC "Kurchatov Institute" National Research Nuclear University "MEPh I" Institute of Nuclear Physics PAN Faculty of Physics Warsaw University of Technology Faculty of Mathematics and Physics Comenius University IFIN-HH University of Tokyo

An experiment aimed to investigate the two-proton(2p) decay of the previously unknown nucleus ^(30)Ar was performed at GSI. By tracking the decay products in-flight with silicon micro-strip detectors, the 2p decays of ^(30)Ar were observed for the first time. For the calibration purpose, 2p decays of ^(19)Mg were also remeasured by tracking the coincident ^(17)Ne+p+p trajectories. By comparing the measured angular p-17 Ne correlations with those obtained from the corresponding Monte Carlo simulations,the simultaneous 2p decay of ^(19)Mg ground state and the sequential 2p emission of several known excited states of ^(19)Mg were confirmed. One new excited state in ^(19)Mg and two new excited states in ^(18)Na were observed.

关键词： proton drip line decay by proton emission nuclear energy level

On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

On calculating glacial isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： l.M.Cathles Cornell University IthacaNY 14853USA

Modeling the earth's fluid and elastic response to the melting of the glaciers of the last ice age is the most direct way to infer the earth's radial viscosity ***,we compare two methods for calculating the viscoelastic response to surface *** one,the elastic equation of motion is converted to a viscoelastic equation using the Correspondence *** the other,elastic deformation is added to the viscous flow as isostatic adjustment *** two modeling methods predict adjustment histories that are different enough to potentially impact the interpretation of the observed glacial isostatic adjustment(GIA).The differences arise from buoyancy and whether fluid displacements are subjected to hydrostatic *** methods agree if they use the same equations and boundary *** origin of the differences is determined by varying the boundary conditions and pre-stress application.

关键词： Glacial isostatic adjustment Viscoelastic normal modes Hydrostatic pre-stress Elastic buoyancy Correspondence principle