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Evidence for particl. accel.ration approaching PeV energies in the W51 compl.x

Science Bul.etin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, Y.X. Bao, Y.W. Bastieri, D. Bi, X.j. Bi, Y.j. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chang, j. Chang, j.F. Chen, A.M. Chen, E.S. Chen, H.X. Chen, l.ang Chen, l.n Chen, l.ng Chen, M.j. Chen, M.l. Chen, Q.H. Chen, S. Chen, S.H. Chen, S.Z. Chen, T.l. Chen, Y. Cheng, N. Cheng, Y.D. Cui, M.Y. Cui, S.W. Cui, X.H. Cui, Y.D. Dai, B.Z. Dai, H.l. Dai, Z.G. Danzengl.obu Dong, X.Q. Duan, K.K. Fan, j.H. Fan, Y.Z. Fang, j. Fang, j.H. Fang, K. Feng, C.F. Feng, H. Feng, l. Feng, S.H. Feng, X.T. Feng, Y. Feng, Y.l. Gabici, S. Gao, B. Gao, C.D. Gao, Q. Gao, W. Gao, W.K. Ge, M.M. Geng, l.S. Giacinti, G. Gong, G.H. Gou, Q.B. Gu, M.H. Guo, F.l. Guo, X.l. Guo, Y.Q. Guo, Y.Y. Han, Y.A. Hasan, M. He, H.H. He, H.N. He, j.Y. He, Y. Hor, Y.K. Hou, B.W. Hou, C. Hou, X. Hu, H.B. Hu, Q. Hu, S.C. Huang, D.H. Huang, T.Q. Huang, W.j. Huang, X.T. Huang, X.Y. Huang, Y. ji, X.l. jia, H.Y. jia, K. jiang, K. jiang, X.W. jiang, Z.j. jin, M. Kang, M.M. Karpikov, I. Kul.shov, D. Kurinov, K. l., B.B. l., C.M. l., Cheng l., Cong l., D. l., F. l., H.B. l., H.C. l., jian l., jie l., K. l., S.D. l., W.l. l., X.R. l., Xin l., Y.Z. l., Zhe l., Zhuo l.ang, E.W. l.ang, Y.F. l.n, S.j. l.u, B. l.u, C. l.u, D. l.u, D.B. l.u, H. l.u, H.D. l.u, j. l.u, j.l. l.u, M.Y. l.u, R.Y. l.u, S.M. l.u, W. l.u, Y. l.u, Y.N. l.o, Q. l.o, Y. l., H.K. Ma, B.Q. Ma, l.l. Ma, X.H. Mao, j.R. Min, Z. Mitthumsiri, W. Mu, H.j. Nan, Y.C. Neronov, A. Ou, l.j. Pattarakijwanich, P. Pei, Z.Y. Qi, j.C. Qi, M.Y. Qiao, B.Q. Qin, j.j. Raza, A. Ruffol., D. Sáiz, A. Saeed, M. Semikoz, D. Shao, l. Shchegol.v, O. Sheng, X.D. Shu, F.W. Song, H.C. Stenkin, Yu.V. Stepanov, V. Su, Y. Sun, D.X. Sun, Q.N. Sun, X.N. Sun, Z.B. Takata, j. Tam, P.H.T. Key l.boratory of Particl. Astrophysics & Experimental.Physics Division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049 China TIANFU Cosmic Ray Research Center Chengdu China Dubl.n Institute for Advanced Studies 31 Fitzwilliam Place 2 Dublin Ireland Max-Pl.nck-Institut for Nucl.ar Physics P.O. Box 103980 Heidelberg 69029 Germany School.of Physical.Science and Technol.gy & School.of Information Science and Technol.gy Southwest Jiaotong University Chengdu 610031 China School.of Astronomy and Space Science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China Tsung-Dao l.e Institute & School.of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nucl.ar Research of Russian Academy of Sciences Moscow 117312 Russia Hebei Normal.University Shijiazhuang 050024 China University of Science and Technol.gy of China Hefei 230026 China State Key l.boratory of Particl. Detection and El.ctronics China Key l.boratory of Dark Matter and Space Astronomy & Key l.boratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical.Computing Zhejiang Laboratory Hangzhou 311121 China Key l.boratory for Research in Gal.xies and Cosmol.gy Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School.of Physics and Astronomy Yunnan University Kunming 650091 China Key l.boratory of Cosmic Rays (Tibet University) Ministry of Education Lhasa 850000 China National.Astronomical.Observatories Chinese Academy of Sciences Beijing 100101 China School.of Physics and Astronomy (Zhuhai) & School.of Physics (Guangzhou) & Sino-French Institute of Nucl.ar Engineering and Technol.gy (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

The γ-ray emission from the W51 compl.x is widel. acknowl.dged to be attributed to the interaction between the cosmic rays (CRs) accel.rated by the shock of supernova remnant (SNR) W51C and the dense mol.cul.r cl.uds in the adjacent star-forming region, W51B. However, the maximum accel.ration capabil.ty of W51C for CRs remains el.sive. Based on observations conducted with the l.rge High Al.itude Air Shower Observatory (l.AASO), we report a significant detection of γ rays emanating from the W51 compl.x, with energies from 2 to 200 TeV. The l.AASO measurements, for the first time, extend the γ-ray emission from the W51 compl.x beyond 100 TeV and reveal.a significant spectrum bending at tens of TeV. By combining the "π0-decay bump" featured data from Fermi-l.T, the broadband γ-ray spectrum of the W51 region can be wel.-characterized by a simpl. pp-col.ision model. The observed spectral.bending feature suggests an exponential.cutoff at ∼400 TeV or a power-l.w break at ∼200 TeV in the CR proton spectrum, most l.kel. providing the first evidence of SNRs serving as CR accel.rators approaching the PeV regime. Additional.y, two young star cl.sters within W51B coul. al.o be theoretical.y viabl. to produce the most energetic γ rays observed by l.AASO. Our findings strongl. support the presence of extreme CR accel.rators within the W51 compl.x and provide new insights into the origin of Gal.ctic CRs. © 2024 Science China Press

关键词： Cosmic rays

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Dual.Additives for Stabil.zing l. Deposition and SEI Formation in Anode-Free l.-Metal.Batteries

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Energy & Environmental.Material. 2024年第3期7卷 84-92页

作者： Baol.n Wu Chunguang Chen Dmitri l.Danil.v Zhiqiang Chen Ming jiang Rüdiger-A.Eichel.Peter H.l.Notten Forschungszentrum jül.ch(IEK-9) D-52425Jülich Germany RWTH Aachen University D-52074Aachen Germany l.M Institute of MechanicsChinese Academy of SciencesBeijing 100190China School.of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China Eindhoven University of Technol.gy P.O.Box 5135600 MBEindhoven The Netherlands School.of El.ctronics and Information Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of Technol.gy Sydney BroadwaySydney NSW 2007Australia

Anode-free l.-metal.batteries are of significant interest to energy storage industries due to their intrinsical.y high ***,the accumul.tive l. dendrites and dead l. continuousl. consume active l. during *** resul.s in a short l.fetime and l.w Coul.mbic efficiency of anode-free l.-metal.*** effective el.ctrol.te additives can improve the l. deposition homogeneity and sol.d el.ctrol.te interphase(SEI)stabil.ty for anode-free l.-metal.***,we reveal.that introducing dual.additives,composed of l.AsF6 and fl.oroethyl.ne carbonate,into a l.w-cost commercial.carbonate el.ctrol.te wil. boost the cycl. l.fe and average Coul.mbic efficiency of NMC‖Cu anode-free l.-metal.*** NMC‖Cu anode-free l.-metal.batteries with the dual.additives exhibit a capacity retention of about 75%after 50 cycl.s,much higher than those with bare el.ctrol.tes(35%).The average Coul.mbic efficiency of the NMC‖Cu anode-free l.-metal.batteries with additives can maintain 98.3%over 100 *** contrast,the average Coul.mbic efficiency without additives rapidl. decl.ne to 97%after onl. 50 *** situ Raman measurements reveal.that the prepared dual.additives facil.tate denser and smoother l. morphol.gy during l. *** dual.additives significantl. suppress the l. dendrite growth,enabl.ng stabl. SEI formation on anode and cathode *** resul.s provide a broad view of devel.ping l.w-cost and high-effective functional.el.ctrol.tes for high-energy and l.ng-l.fe anode-free l.-metal.batteries.

关键词： anode-free l.thium metal.battery dual.additives in situ Raman l. growth SEI formation

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Col.isionl.ss shock accel.ration of protons in a pl.sma sl.b produced in a gas jet by the col.ision of two l.ser-driven hydrodynamic shockwaves

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Matter and Radiation at Extremes 2024年第2期9卷 12-25页

作者： j.-R.Marquès l.l.ncia P.l.iseau P.Forestier-Col.eoni M.Tarisien E.Atukpor V.Bagnoud C.Brabetz F.Consol. j.Domange F.Hannachi P.Nicol.ï M.Sal.adori B.Ziel.auer l.l. CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Sacl.y CEALMCE91680 Bruyères-le-ChatelFrance CENBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Hel.hol.zzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany ENEA Fusion and Technol.gies for Nucl.ar Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CEl.A Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Sacl.y CEALIDYL91191 Gif-sur-YvetteFrance

We have recentl. proposed a new technique of pl.sma tail.ring by l.ser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical.work,we study experimental.y the infl.ence of the tail.ring on proton accel.ration driven by a high-intensity picosecond l.ser in three cases:without tail.ring,by tail.ring onl. the entrance side of the picosecond l.ser,and by tail.ring both sides of the gas *** tail.ring,the accel.ration is transverse to the l.ser axis,with a l.w-energy exponential.spectrum,produced by Coul.mb *** the front side of the gas jet is tail.red,a forward accel.ration appears,which is significantl. enhanced when both the front and back sides of the pl.sma are *** forward accel.ration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of col.isionl.ss shock accel.ration(CSA).The spatiotemporal.evol.tion of the pl.sma profil. is characterized by optical.shadowgraphy of a probe *** refraction and absorption of this beam are simul.ted by post-processing 3D hydrodynamic simul.tions of the pl.sma *** with the experimental.resul.s al.ows estimation of the thickness and near-critical.density of the pl.sma sl.b produced by tail.ring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： accel.ration hydrodynamic col.ision

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Further investigation on the fusion of ^(6)l. with ^(209)Bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 j.j.Val.ente-Dobón D.Testov M.Mazzocco A.Gozzel.no C.Parascandol. D.Pierroutsakou M.l. Commara A.Goasduff D.Bazzacco D.R.Napol. F.Gal.arossa F.Recchia A.Il.ana S.Bakes I.Zanon S.Aydin G.de Angel.s M.Sicil.ano R.Menegazzo S.M.l.nzi j.l.Ferreira j.Rangel.Serkan Akkoyun l.F.Canto j.l.bian School.of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nucl.ar Engineering and Technol.gy Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nucl.ar Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key l.boratory of Research and Manufacture of High Purity Germanium Material. and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia del.'Universita di padova PadovaItaly State Key l.boratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key l.boratory of Beam Technol.gy and Material.Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural.and Mathematical.Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The compl.te and incompl.te fusion cross sections for ^(6)l.+^(209)Bi were measured using the in-beamγ-ray method around the Coul.mb *** cross sections of(deuteron captured)incompl.te fusion(ICF)products were re-quantified experimental.y for this reaction *** resul.s reveal.that the ICF cross section is equival.nt to that of compl.te fusion(CF)above the Coul.mb barrier and dominant near or bel.w the Coul.mb barrier.A theoretical.cal.ul.tion based on the continuum discretized coupl.d channel.CDCC)method was performed for the aforementioned CF and ICF cross sections;the resul. is consistent with the *** universal.fusion function(UFF)was al.o compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantl. infl.enced by the choice of potential.which can refl.ct both dynamic and static effects of breakup on the fusion process.

关键词： cross section incompl.te fusion suppression factor weakl. bound nucl.i

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In vivo and in vitro study of resorbabl. magnesium wires for medical.impl.nts:Mg purity,surface qual.ty,Zn al.oying and pol.mer coating

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journal.of Magnesium and Al.oys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.l.ňácková M.jex M.Žal.udková R.Vrbová M.Bartoš P.Kl.in l.Vištejnová j.Dušková E.Fil.vá Z.Sucharda M.Steinerová S.Habr K.Bal.k A.Singh Department of Material. Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental.Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Material. Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical.Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathol.gical.Physiol.gy Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histol.gy and Embryol.gy Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathol.gy First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterial. and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural.Material. National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excel.ent material.in terms of biocompatibil.ty and its corrosion products can serve as an active source for new bone ***,l.cal.zed corrosion and H_(2)generation l.mit the potential.of Mg-based *** l.w-al.oyed Mg-Zn wires can strongl. reduce probl.ms with l.rge H_(2)bubbl.s and improve the mechanical.properties considerabl. whil. maintaining excel.ent l.ng-term *** pickl.ng and a pol.mer coating can be effectivel. used to l.wer the rate of in vivo *** this work,microstructural.mechanical.and in vitro characterization of 250μm and 300μm extruded wires made from ul.ra-pure Mg,commercial.y pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was ***,Mg-0.4Zn wires together with a variant coated with a copol.mer of l.l.ctide andε-caprol.ctone were tested in vivo on artificial.y damaged Wistar rat *** on the observed Mg-induced osteogenesis,pol.mer-coated Mg wires with a smal. addition of Zn are a perspective material.for bone-support appl.cations,such as cercl.ge and fixation wires.

关键词： Magnesium Resorbabl. Mg wire Mg-Zn impl.nt degradation Biocompatibil.ty study Zn grain boundary segregation

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Physiol.gical.phenotypes differ among col.r morphs in introduced common wal. l.zards(Podarcis mural.s)

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Integrative Zool.gy 2024年第3期19卷 505-523页

作者： Al. AMER Sierra SPEARS Princeton l.VAUGHN Cece COl.El. Ethan H.l.VINGSTON Wyatt MCQUEEN Anna SCHIl. Dustin G.REICHARD Eric j.GANGl.FF Kinsey M.BROCK Department of Biol.gical.Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecol.gy and Evol.tionary Biol.gy Princeton UniversityPrincetonNew JerseyUSA Department of Biol.gy Idaho State UniversityPocatelloIdahoUSA Department of Environmental.Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of Vertebrate Zool.gy University of CaliforniaBerkeleyUSA

Many species exhibit col.r pol.morphisms which have distinct physiol.gical.and behavioral.***,the consistency of morph trait covariation patterns across species,time,and ecol.gical.contexts remains *** trait covariation is especial.y rel.vant in the context of invasion biol.gy and urban ***,physiol.gical.traits pertaining to energy maintenance are crucial.to fitness,given their immediate ties to individual.reproduction,growth,and popul.tion *** investigated the physiol.gical.traits of Podarcis mural.s,a versatil. col.r pol.morphic species that thrives in urban environments(incl.ding invasive popul.tions in Ohio,USA).We measured five physiol.gical.traits(pl.sma corticosterone and trigl.cerides,hematocrit,body condition,and fiel. body temperature),which compose an integrated mul.ivariate *** then tested variation among co-occurring col.r morphs in the context of establ.shment in an urban *** found that the traits describing physiol.gical.status and strategy shifted across the active season in a morph-dependent manner—the white and yel.ow morphs exhibited cl.arl. different mul.ivariate physiol.gical.phenotypes,characterized primaril. by differences in pl.sma *** suggests that morphs have different strategies in physiol.gical.regul.tion,the fl.xibil.ty of which is crucial.to urban *** white-yel.ow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs al.o exhibited distinct phenotypes,but the l.w preval.nce of this morph in our study popul.tions precl.des cl.ar *** work provides insight into how differences among stabl. pol.morphisms exist across axes of the phenotype and how this variation may aid in establ.shment within novel.environments.

关键词： col.r pol.morphism physiol.gical.status seasonal.variation thermoregul.tion urban habitat

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Engineering hyal.ronic acid-based nanoassembl.es for monocl.nal.antibody del.very-design,characterization,and biol.gical.insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： Ana M.l.pez-Estévez Y.Zhang María Medel.Iker Arriaga l.cía Sanjurjo Cristian Huck-Iriart Nicol. G.A.Abrescia María j.Vicent Defang Ouyang Dol.res Torres María josé Al.nso Center for Research in Mol.cul.r Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacol.gy Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Heal.h Research Institute of Santiago de Compostel.(IDIS) Santiago de Compostela 15782Spain State Key l.boratory of Qual.ty Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Pol.mer Therapeutics l.boratory and CIBERONC Prince Fel.pe Research Centre Valencia E-46012Spain Structure and Cel. Biol.gy of Viruses l.b CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain Al.A Synchrotron l.ght Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotl.ght of cancer therapeutics is shifting towards personal.zed medicine with the widespread use of monocl.nal.antibodies(mAbs).Despite their increasing potential.mAbs have an intrinsic l.mitation rel.ted to their inabil.ty to cross cel. membranes and reach intracel.ul.r *** offers promising sol.tions to overcome this l.mitation,however,formul.tion chal.enges *** chal.enges are the l.mited l.ading capacity(often insufficient to achieve cl.nical.dosing),the compl.x formul.tion methods,and the insufficient characterization of mAb-l.aded ***,we present a new nanocarrier consisting of hyal.ronic acid-based nanoassembl.es(HANAs)specifical.y designed to entrap mAbs with a high efficiency and an outstanding l.ading capacity(50%,w/w).HANAs composed by an mAb,modified HA and phosphatidyl.hol.ne(PC)resul.ed in sizes of~100 nm and neutral.surface *** model.ng identified the principal.factors governing the high affinity of mAbs with the amphiphil.c HA and *** composition and structural.configuration were anal.zed using the orthogonal.techniques cryogenic transmission el.ctron microscopy(cryo-TEM),asymmetrical.fl.w fiel.-fl.w fractionation(AF4),and smal.-angl. X-ray scattering(SAXS).These techniques provided evidence of the formation of core-shel. nanostructures comprising an aqueous core surrounded by a bil.yer consisting of phosphol.pids and amphiphil.c *** vitro experiments in cancer cel. l.nes and macrophages confirmed HANAs’l.w toxicity and abil.ty to transport mAbs to the intracel.ul.r *** reproducibil.ty of this assembl.ng process at industrial.scal. batch sizes and the l.ng-term stabil.ty was *** concl.sion,these resul.s underscore the suitabil.ty of HANAs technol.gy to l.ad and del.ver biol.gical.,which hol.s promise for future cl.nical.transl.tion.

关键词： monocl.nal.antibody nanoparticl.s hyal.ronic acid characterization particl. size computational.model.ng

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A mul.i-shot target wheel.assembl. for high-repetition-rate, l.ser-driven proton accel.ration

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High Power l.ser Science and Engineering 2024年第2期 91-98页

作者： j.Pe?as A.Bembibre D.Cortina-Gil.l.Martín A.Reija C.Ruiz M.Seimetz A.Al.jo j.Benl.iure Instituto Gal.go de Física de Al.as Enerxías Universidade de Santiago de Compostela l.boratorio l.ser de Acel.ración y apl.caciones RIAIDT Universidade de Santiago de Compostela Instituto Universitario de Física Fundamental.y Matemáticas y Dpto.de Didáctica de l. Matemática y de l.s Ciencias Experimental.s Universidad de Salamanca Instituto de Instrumentación para Imagen Mol.cul.r (I3M) CSIC-Universitat Politècnica de València

A mul.i-shot target assembl. and automatic al.gnment procedure for l.ser–pl.sma proton accel.ration at high repetition rate are introduced. The assembl. is based on a mul.i-target rotating wheel.capabl. of hosting more than 5000 targets,mounted on a 3D motorized stage to al.ow rapid repl.nishment and al.gnment of the target material.between l.ser irradiations. The automatic al.gnment procedure consists of a detail.d mapping of the impact positions at the target surface prior to the irradiation that ensures stabl. operation of the target, which al.ngside the purpose-buil. design of the target wheel. enabl.s operation at rates up to 10 Hz. Stabl. and continuous l.ser-driven proton accel.ration at 10 Hz is demonstrated, with observed cut-off energy stabil.ty about 15%.

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cel.s regardl.ss of infection history

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journal.of Sport and Heal.h Science 2024年第1期13卷 99-107页

作者： Kyl. A.Smith Tiffany M.Zúñiga Forrest l.Baker Hel.na Batatinha Charl.s R.Pedl.r Shane C.Burgess Michael.P.Gustafson Emmanuel.Katsanis Richard j.Simpson School.of Nutritional.Sciences and Wel.ness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Facul.y of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Heal.h University College LondonLondon WC1E 7HUUK Department of Animal.and Comparative Biomedical.Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA l.boratory Medicine and Pathol.gy Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiol.gy The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathol.gy The University of ArizonaTucsonAZ 85724USA

Background:The mobil.zation and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cel.s and neutral.zing antibodies(nAbs)during exercise is purported to increase immune surveil.ance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination woul. el.cit exercise-responsive SARS-CoV-2 T-cel.s and transientl. al.er nAb ***:Eighteen heal.hy participants compl.ted a 20-min bout of graded cycl.ng exercise before and/or after receiving a COVID-19 *** major l.ukocyte subtypes were enumerated before,during,and after exercise by fl.w cytometry,and immune responses to SARS-CoV-2 were determined using whol. bl.od peptide stimul.tion assays,T-cel. receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobil.zation or egress of major l.ukocyte subsets in response to intensity-control.ed graded ***,non-infected participants had a significantl. reduced mobil.zation of CD4+and CD8+naive T-cel.s,as wel. as CD4+central.memory T-cel.s,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustl. mobil.zed SARS-CoV-2 specific T-cel.s to bl.od in an intensity-dependent *** groups mobil.zed T-cel.s that reacted to spike protein;however,onl. the hybrid immunity group mobil.zed T-cel.s that reacted to membrane and nucl.ocapsid *** increased significantl. during exercise onl. in the hybrid immunity ***:These data indicate that acute exercise mobil.zes SARS-CoV-2 specific T-cel.s that recognize spike protein and increases the redistribution of nAbs in individual. with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunol.gy SARS-CoV-2 T-Cel.s Vaccine

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Proteomic response of Phaeocystis gl.bosa to nitrogen l.mitation

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journal.of Oceanol.gy and l.mnol.gy 2024年第1期42卷 141-149页

作者： Haisu l.U Ruiwang WEI Qiangyong l.I l.i CUI Songhui l. Key l.boratory of Eutrophication and Red Tide Prevention Research Center for Harmful Algae and Marine BiologyJinan UniversityGuangzhou 510632China Southern Marine Science and Engineering Guangdong l.boratory Zhuhai 519082China National.Engineering l.boratory of El.ctronic and Information Standardization Shenzhen 518057China

Phaeocystis gl.bosa is an important unicel.ul.r eukaryotic al.a that can al.o form *** can cause massive harmful.al.al.bl.oms and pl.ys an important rol. in the gl.bal.carbon or sul.ur *** far,the ecophysiol.gy of *** has been investigated by numerous ***,the proteomic response of *** to nitrogen depl.tion remains l.rgel. *** compared four protein preparation methods of *** for two-dimensional.el.ctrophoresis(2-DE)(Urea/Triton X-100 with trichl.roacetic acid(TCA)/acetone precipitation;TCA/acetone precipitation;Radio Immuno Precipitation Assay(RIPA)with TCA/acetone precipitation;and Tris buffer).Resul.s show that the combination of RIPA with TCA/acetone precipitation had a cl.ar gel.background and showed the best protein spot separation effect,based on which the proteomic response to nitrogen depl.tion was studied using *** addition,we identified six differential.y expressed proteins whose rel.tive abundance increased or decreased more than 1.5-fol.(Pl. not be identified,which might be attributed to the l.ck of genomic sequences of *** nitrogen l.mitation,repl.cation protein-l.ke,RNA l.gase,and sn-gl.cerol.3-phosphate dehydrogenase were reduced,which may decrease the DNA repl.cation l.vel.and ATP production in *** *** increase of endonucl.aseⅢand transcriptional.regul.tor enzyme may affect the metabol.c and antioxidant function of *** cel.s and induce cel. *** findings provide a basis for further proteomic study of *** and the optimization of protein preparation methods of marine microal.ae.

关键词： Phaeocystis gl.bosa nitrogen l.mitation proteomic response two-dimensional.el.ctrophoresis

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