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Al.ohol.c Hepatitis:l.st in Transl.tion

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2018年第1期6卷 89-96页

作者： Benjamin l. Wool.right Hartmut Jaeschke Department of Pharmacol.gy Toxicology&TherapeuticsUniversity of Kansas Medical CenterKansas CityKansasUSA

Al.ohol.c hepatitis is the most severe and acute form of al.ohol.c l.ver *** mortal.ty rate associated with al.ohol.c hepatitis is high,l.rgel. due to the l.ck of suitabl. pharmacol.gical.*** there has been substantial.research in the area,generating pharmacol.gical.interventions has been pl.gued by the l.ck of a robust mouse model.both for testing and for understanding the underl.ing pathol.gy.A number of major notabl. advances have been made in this area recentl.,with the goal.of generating a mouse model.of al.ohol.c *** purpose of this articl. is to review recent advances in model.ng al.ohol.c l.ver disease both in vitro and in vivo in the mouse,and pl.ce them in the context of the greater spectrum of al.ohol.c l.ver disease,with a focus on how we can transl.te current advances into a high-fidel.ty model.of al.ohol.c *** addition,we wil. review the basic mechanisms of al.ohol.c hepatitis as it is currentl. understood,focusing on recent advancements in diagnosis,prognosis and current pathophysiol.gy,especial.y as it rel.tes to the profound immune dysfunction present during al.ohol.c hepatitis.

关键词： Al.ohol.c hepatitis Al.ohol l.ver disease Cirrhosis Prognosis Keratin-18

Considerations for pediatric burn sedation and anal.esia

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Burns & Trauma 2017年第4期5卷 218-228页

作者： Al.ce Fagin Tina l. Pal.ieri Arkansas Chil.ren's Hospital 1 Children's Way Little Rock AR 72202 USA Shriners Hospital. for Chil.ren Northern Cal.fornia and University of Cal.fornia Davis 2425 Stockton Blvd Suite 718 Sacramento CA USA

Burn patients experience anxiety and pain in the course of their injury, treatment, and recovery. Hence, treatment of anxiety and pain is paramount after burn injury. Chil.ren, in particul.r, pose chal.enges in anxiety and pain management due to their unique physiol.gic, psychol.gic, and anatomic status. Burn injuries further compl.cate pain management and sedation as such injuries can have effects on medication response and el.mination. Burn injuries further compl.cate pain management and sedation as such injuries can have effects on medication response and el.mination. The purpose of this review is to describe the chal.enges associated with management of anxiety, pain, and sedation in burned chil.ren and to describe the different options for treatment of anxiety and pain in burned chil.ren.

关键词： Pediatric Sedation Burns

Charmed baryon resonances with heavy-quark symmetry

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Chinese Physics C 2009年第12期33卷 1323-1326页

作者： l. Tol.s C. Garcia-Recio V. K. Magas T. Mizutani J. Nieves A. Ramos l. l. Sal.edo Theory Group KVI University of Groningen Zernikelaan 25 9747 AA Groningen The Netherlands Departamento de Física Atómica Molecular y Nuclear Universidad de Granada E-18071 Granada Spain Departament d'Estructura i Constituents de l. Matèria and Institut de Ciències del.Cosmos Universitat de Barcelona E-08028 Barcelona Spain Department of Physics Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA Instituto de Física Corpuscul.r (centro mixto CSIC-UV) Institutos de Investigación de Paterna Aptdo. 22085 E-46071 Valencia Spain

We study charmed baryon resonances that are generated dynamical.y from a coupl.d-channel.unitary approach that impl.ments heavy-quark symmetry. Some states can al.eady be identified with experimental.observations, such as Ac（2595）, Ac（2660）, Ec（2902） or Ac（2941）, whil. others need a compil.tion of more experimental.data as wel. as an extension of the model.to incl.de higher order contributions. We al.o compare our model.to previous SU（4） schemes.

关键词： charmed baryon resonances heavy-quark symmetry SU(8) and SU(4) spin-fl.vor symmetry

Study on the pyroel.ctric properties of Pl./P(VDF-TrFE) nanocomposites

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Chinese Science Bul.etin 1998年第2期43卷 111-114页

作者： Qingqi Zhang H. l. W. Chan Qifa Zhou C. l. Choy Hong Kong Pol.tech Univ Dept Appl Phys Hung Hom Hong Kong Hong Kong Pol.tech Univ Mat Res Ctr Hung Hom Hong Kong

l.ad l.nthanum titanate (Pl.) nanocrystal.ine powder prepared by the sol.gel.process was incorporated into a pol.vinyl.dene fl.oride/trifl.oroethyl.ne (P(VDF_TrEF)) copol.mer matrix to form Pl./P(VDF_TrFE) nanocomposites. The permittivities (ε) of the nanocomposites as a function of vol.me fraction of ceramic  were model.d using the Bruggeman model. The pyroel.ctric coefficients (p) and figure of merit (p/ε) were measured as functions of the pol.ng fiel. E. The nanocomposite has p and p/ε val.es higher than those of the copol.mer, and has good potential.in pyroel.ctric appl.cations.

关键词： nanocomposites pyroel.ctric.

Comments on the rel.ase l.boratory Manual.for the Human Semen of the 5th edition of the WHO Examination and Processing of

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Asian Journal.of Androl.gy 2010年第1期12卷 59-63页

作者： W. C. l. Ford Obstetrics ＆ Gynaecol.gy Unit Clinical Science at South Bristol University of Bristol St Michael＇s Hospital Bristol BS28EG UK

The authors of the Worl. Heal.h Organization Semen Anal.sis Manual.are to be congratul.ted on producing a new edition; it is an essential.tool.to disseminate good practice in androl.gy. However, the tests described have poor prognostic power to predict a man＇s fertil.ty and show l.ttl. about the underl.ing causes of sub-fertil.ty. This commentary urges a revival.of research into the diagnosis of mal. fertil.ty. It suggests that fertil.ty shoul. be regarded as a continuum and that the artificial.binary division between fertil. and infertil. shoul. be abandoned. Model. to predict a sub-fertil. coupl.＇s chance of conception in a year shoul. be devel.ped on the basis of prospective data. These model. woul. al.ow for sophisticated decision making about management. The future l.es in the identification of tests to detect underl.ing pathol.gies open to specific treatment. l.ads such as oxidative stress, defects in the intracel.ul.r regul.tion and the devel.ping fiel. ofproteomics shoul. be expl.red.

关键词： diagnosis mal. infertil.ty oxidative stress predictive val.e of tests sperm count

Advances in l.D BMPs research and practice for urban runoff control.in China

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Frontiers of Environmental.Science & Engineering 2013年第5期7卷 709-720页

作者： Haifeng JIA Hairong YAO Shaw l. YU School.of Environment Tsinghua University Beijing 100084 China Col.ege of Engineering China Agricultural University Beijing 100083 China Department of Civil.& Environmental.Engineering University of Virginia Charlottesville VA22904 USA

China is at present experiencing a very rapid urbanization process, which has brought a number of adverse impacts upon the water environment. In particul.r, urban runoff quantity and qual.ty control.have emerged as one of the key concerns for municipal.official.. One of the strategies being considered is the use of a l.w Impact Devel.pment type of Best Management Practices （l.D BMPs） for urban storm water runoff quantity and qual.ty control. In this paper, the situation surrounding urban runoff control.in China is reviewed first. Then the conventional.strategy and technol.gies for the construction and management of urban drainage systems are discussed, whil. expl.ring their inherent dil.mmas. The l.D BMPs are then introduced to control.urban runoff in the context of urban sustainabl. water systems. After the comprehensive anal.sis of the various l.D BMPs, the advances in l.D BMPs research and practice for urban runoff control.in China are investigated and summarized. At l.st, the difficul.ies of impl.menting l.D BMPs in China are discussed, and a direction for the future is proposed.

关键词： urbanization urban runoff control l.w Impact Devel.pment type of Best Management Practices(l.D BMPs) China

Biol.gical.imaging without autofl.orescence in the second near-infrared region

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Nano Research 2015年第9期8卷 3027-3034页

作者： Shuo Diao Guosong Hong Al.xander l. Antaris Jeffrey l. Bl.ckbum Kai Cheng Zhen Cheng Hongjie Dai Department of Chemistry Stanford University Stanford California 94305 USA Chemical.and Material. Science Center National Renewable Energy Laboratory Colorado 8040 I USA Mol.cul.r Imaging Program at Stanford (MIPS) and Department of Radiol.gy Stanford University California 94305 USA

Fl.orescence imaging is capabl. of acquiring anatomical.and functional.infor- mation with high spatial.and temporal.resol.tion. This imaging technique has been indispensabl. in biol.gical.research and disease detection/diagnosis. Imaging in the visibl. and to a l.sser degree, in the near-infrared （NIR） regions bel.w 900 nm, suffers from autofl.orescence arising from endogenous fl.orescent mol.cul.s in biol.gical.tissues. This autofl.orescence interferes with fl.orescent mol.cul.s of interest, causing a high background and l.w detection sensitivity. Here, we report that fl.orescence imaging in the 1,500-1,700-nm region （termed ＂NIR-IIb＂） under 808-nm excitation resul.s in nearl. zero tissue autofl.orescence, al.owing for background-free imaging of fl.orescent species in otherwise notoriousl. autofl.orescent biol.gical.tissues, incl.ding l.ver. Imaging of the intrinsic fl.orescence of individual.fl.orophores, such as a singl. carbon nanotube, can be readil. achieved with high sensitivity and without autofl.orescence background in mouse l.ver within the 1,500-1,700-nm wavel.ngth region.

关键词： fl.orescence imaging,second near-infrared,nanotechnol.gy autofl.orescence

Modul.ting Wnt signal.ng to improve cel. repl.cement therapy for Parkinson＇s disease

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Journal.of Mol.cul.r Cel. Biol.gy 2014年第1期8卷 54-63页

作者： Cl.re l. Parish l.chl.n H. Thompson Fl.rey Institute of Neuroscience and Mental.Heal.h The University of Melbourne Parkville VIC 3010 Australia

Cl.nical.trial. have demonstrated the capacity for dopamine neurons, transpl.nted ectopicaUy into the striatum, to structural.y inte- grate, restore dopamine transmission, and induce l.ng-term functional.benefits for Parkinson＇s disease （PD） patients. Despite this proof of principl., a number of l.mitations have hindered the devel.pment of cel. repl.cement therapy over the past 20 years, particu- l.rl. tissue avail.bil.ty, graft survival. and adequate reinnervation of the host brain. With a greater understanding of fail.re in prior cl.nical.trial., increased knowl.dge of midbrain dopamine devel.pment （now incl.ding Wnts）, and the devel.pment of pl.ripotent stem cel. technol.gies, we are better equipped than ever to re-address a number of these chal.enges. This review summarizes the trial., tribul.tions, and progress in cel. repl.cement therapy for PD. We discuss the prospects of modul.ting canonical.and non-canon- ical.Wnt signal.ngto improve cel. therapy based upon their rol.s in dopamine neural.devel.pment and the adul. brain. This wil. incl.de the potential.of Wnts to （i） expand fetaUy derived tissue in vitro and foUowing transpl.ntation, （ii） promote the differentiation of pl.ripotent stem cel.s, （iii） increase graft integration and restoration of neural.circuitry, and final.y （iv） enhance graft survival.

关键词： Wnt dopamine Parkinson's disease cel. transpl.ntation neurogenesis axon growth motor function

Transporters Contributing to Iron Trafficking in Pl.nts

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Mol.cul.r Pl.nt 2011年第3期4卷 464-476页

作者： Sarah S. Conte El.beth l. Wal.er University of Massachusetts Amherst Biology Department 611 No. Pleasant St Amherst MA 01002 USA

This review wil. discuss recent progress in understanding the many rol.s of transporters in the whol.-pl.nt physiol.gical.processes that maintain iron （Fe） homeostasis. These processes incl.de uptake from the soil.via roots, control.of transport from roots to above-ground parts of the pl.nt, unl.ading of Fe from the xyl.m in above-ground parts, l.ading of Fe into mitochondria and pl.stids, transport of Fe to reproductive parts of the pl.nt, and Fe mobil.zation during seed germination. In addition, we wil. discuss the mechanisms that pl.nts use to cope with an apparentl. unintended conse- quence of Fe acquisition： the uptake of toxic heavy metal. via Fe transporters. Rapid progress has been made in under- standing the transport processes invol.ed in each of these areas in the l.st 5 years and this review wil. focus on this recent progress. We wil. al.o highl.ght the key questions regarding transport steps that remain to be el.cidated.

关键词： Nutrient and metal.transport transporters gene regul.tion iron nicotianamine phytosiderophores.