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Emerging rol. of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： Wil.iam J.Fl.rl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Heal.h sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct mol.cul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through compl.x interactions organized by numerous mul.ival.nt protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

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Acta Metal.urgica sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIs） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIs）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

On-farm Conservation of l.ndraces of Rice (Oryza sativa l.) through Cul.ivation in the Kumaun Region of Indian Central.Himal.ya

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Journal.of Mountain science 2007年第4期4卷 354-360页

作者： R. K. Agnihotri l. M. s. Pal.i G. B. Pant Institute of Himal.yan Environment and Devel.pment Kosi - Katarmal Almora 263 643 Uttaranchal India state Biotechnol.gy Programme government of Uttaranchal Biotech Bhavan P. O. Haldi U. S. Nagar 263 146 Uttaranchal India

The Himal.yan region is a known hot spot of crop diversity. Traditional.varieties (usual.y cal.ed primitive cul.ivars or l.ndraces), having withstood the rigors of time (incl.ding harsh cl.matic conditions as wel. as attacks of insects, pests and diseases), can stil. be found in crop fiel.s in rural.parts of Indian Central.Himal.ya (ICH). These l.ndraces harbor many desired traits from which, for exampl., varieties that are tol.rant/resistant to abiotic/biotic stresses coul. be devel.ped. In addition to the above benefits, l.ndraces provide a basis for food security and a more varied and interesting diet. some l.ndraces are al.o known to be of medicinal.val.e. These, al.ng with some l.sser known hil. crops, are often referred to by different names such as under expl.ited crops, crops for marginal.l.nds, poor person crops, and negl.cted mountain crops. The Himal.yan region continues to be a reservoir of a l.rge number of l.ndraces and cul.ivars whose economic and ecol.gical.potential.is yet to be ful.y understood and/or expl.ited. Indians have had a history of rice cul.ivation since ancient times. Farmers, incl.ding tribal. inhabiting the IHR, stil. cul.ivate a pl.thora of l.ndraces of rice and thus directl. contribute towardson-farm conservation of val.abl. germpl.sm and hel. in the preservation of crop diversity. The present paper l.oks at the on-farm conservation of rice germpl.sm, which is stil. practised in the Kumaun region of ICH.

关键词： Germpl.sm Himal.ya l.ndraces on-farm conservation rice

Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.scl.rosis

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis

Pol.ethyl.ne gl.col.has immunoprotective effects on sciatic al.ografts, but behavioral.recovery and graft tol.rance require neurorrhaphy and axonal.fusion

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Neural.Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyl.r A.smith l.wen Zhou Cameron l.Ghergherehchi Michel.e Mikesh Cathy Z.Yang Hal.y O.Tucker Jul.Anne Al.good Jared s.Bushman George D.Bittner Department of Mol.cul.r Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical.sciences University of WyomingLaramieWYUSA

Behavioral.recovery using(viabl.)peripheral.nerve al.ografts to repair abl.tion-type(segmental.l.ss)peripheral.nerve injuries is del.yed or poor due to sl.w and inaccurate axonal.***,such peripheral.nerve al.ografts undergo immunol.gical.rejection by the host immune *** contrast,peripheral.nerve injuries repaired by pol.ethyl.ne gl.col.fusion of peripheral.nerve al.ografts exhibit excel.ent behavioral.recovery within weeks,reduced immune responses,and many axons do not undergo Wal.erian *** rel.tive contribution of neurorrhaphy and pol.ethyl.ne gl.col.fusion of axons versus the effects of pol.ethyl.ne gl.col.per se was unknown prior to this *** hypothesized that pol.ethyl.ne gl.col.might have some immune-protective effects,but pol.ethyl.ne gl.col.fusion was necessary to prevent Wal.erian degeneration and functional.behavioral.*** examined how pol.ethyl.ne gl.col.sol.tions per se affect functional.and behavioral.recovery and peripheral.nerve al.ograft morphol.gical.and immunol.gical.responses in the absence of pol.ethyl.ne gl.col.induced axonal.***-type sciatic nerve injuries in outbred sprague–Dawl.y rats were repaired according to a modified protocol.using the same sol.tions as pol.ethyl.ne gl.col.fused peripheral.nerve al.ografts,but peripheral.nerve al.ografts were l.ose-sutured(l.ose-sutured pol.ethyl.ne gl.col.with an intentional.gap of 1–2 mm to prevent fusion by pol.ethyl.ne gl.col.of peripheral.nerve al.ograft axons with host *** to negative control.peripheral.nerve al.ografts not treated by pol.ethyl.ne gl.col.and in contrast to pol.ethyl.ne gl.col.fused peripheral.nerve al.ografts,animal. with l.ose-sutured pol.ethyl.ne gl.col.peripheral.nerve al.ografts exhibited Wal.erian degeneration for al. axons and myel.n degeneration by 7 days postoperativel. and did not recover sciatic-mediated behavioral.functions by 42 days *** morphol.gical.signs of rejection,such as col

关键词： al.ograft rejection axotomy macrophage myel.n nerve repair pol.ethyl.ne gl.col.PEG) sciatic nerve T cel. transpl.ntation Wal.erian degeneration

Getting physical.with medical.education:Exercise based virtual.anatomy review cl.sses for medical.students

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Worl. Journal.of Methodol.gy 2025年第1期15卷 20-25页

作者： Nadeesha R samarasinghe Taniya s Nagpal.Michel. l.Barbeau Charys M Martin Division of General.surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Facul.y of Kinesiol.gy Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cel. Biol.gy University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cel. Biol.gy Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regul.r physical.activity are wel. ***,few studies have examined the effectiveness of integrating physical.activity(PA)into curricul. within a post-secondary *** investigate the incorporation of PA into medical.curricul.m,we devel.ped a series of optional.exercise-based review sessions designed to reinforce muscul.skel.tal.MsK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor woul. l.ad students through both strength and yoga styl. exercises,whil. the anatomy instructor asked questions about rel.vant anatomical.structures rel.ted to course material.previousl. *** the sessions,participants were asked to eval.ate the cl.sses on their sel.-reported exam preparedness in improving MsK anatomy knowl.dge,PA l.vel.,and mental.*** participants compl.ted surveys;a majority agreed that the cl.sses increased understanding of MsK concepts(90.0%)and activity l.vel.(97.7%).Many(70.0%)fel. that the cl.sses hel.ed reduce *** majority of respondents(90.0%)agreed that the cl.sses contributed to increased feel.ngs of social.***,medical.students saw benefit in PA based interventions to suppl.ment MsK course *** with increasing activity l.vel. and promoting heal.h behaviours,integrating PA into medical.curricul.m may improve comprehension of l.arning material.al.eviate stress and foster social.connectivity among medical.students.

关键词： Medical.education Muscul.skel.tal Anatomy Exercise Onl.ne l.arning

Use of High-Yiel.ing Bioenergy Pl.nt Castor Bean(Ricinus communis l.) as a Potential.Phytoremediator for Copper-Contaminated soil.

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Pedosphere 2013年第5期23卷 651-661页

作者： R. ANDREAZZA l. BORTOl.N s. PIENIZ F. A. O. CAMARGO Department of soil Federal University of Rio Grande do Sul Laboratory of Soil Microbiology Center of Engineer Federal University of Pelotas EMBRAPA - Brazil.an Agricul.ural.Research Corporation National Research Center of Fisheries Aquaculture and Agricultural Systems Department of Technol.gy and Food Microbiol.gy Federal University of Rio Grande do Sul

Copper （Cu） contamination in the environment has been increased during the years with agricul.ural.and industrial.activities. Biotechnol.gical.approaches are needed for bioremediation in these areas. The aims of this study were i） to eval.ate the phytoreme- diation capacity of the high-yiel.ing bioenergy pl.nt castor bean （Ricinus communis l.） in vineyard soil. （Inceptisol.and Mol.isol. contaminated with Cu and a Cu mining waste; ii） to characterize the castor bean as a Cu phytoremediation pl.nt; and iii） to eval.ate the nutrient uptake by castor bean. Castor bean pl.nts cul.ivated in soil.with toxic l.vel. of Cu for 57 d exhibited high phytomass production, a high tol.rance index of roots＇ fresh mass and shoots＇ dry mass, a high l.vel.of Cu phytoaccumul.tion in the roots and al.o, a robust capacity for Cu phytostabil.zation. Furthermore, castor bean pl.nts did not significantl. depl.te soil.nutrients （such as N, P, and Mg） during cul.ivation. Pl.nts cul.ivated in Inceptisol. Mol.isol.and Cu mining waste exhibited a strong potential.for Cu phytoaccumul.tion, with val.es of 5900, 3 052 and 2805 g ha-1, respectivel.. In addition, the castor bean＇s el.vated phytomass production and strong growth in Cu-contaminated soil. indicated a high l.vel.of Cu phytoaccumul.tion and a potential.appl.cation in biofuel.. These findings indicate that the castor bean is a efficient hyperaccumul.tor of Cu and a potential.candidate pl.nt for the phytoremediation of Cu-contaminated soil.

关键词： biofuel. phytoaccumul.tion phytoremediation phytostabil.zation

Mul.ipl. scl.rosis is at a checkpoint: advancing the program

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Neural.Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.smith Jessica l.Wil.iams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biol.gical Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Mul.ipl. scl.rosis(Ms) is a chronic infl.mmatory and demyel.nating disease of the central.nervous system(CNs). Patients with Ms experience sensory and motor function l.ss due to myel.n and/or axon damage perpetuated b... 详细信息

关键词： Hauser scl.rosis damage

Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.J.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two major endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network