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Perchl.rates as Powerful.Catal.sts in Many Important Organic Transformations

复旦学报（自然科学版） 2005年第5期44卷 650-651页

作者： G. Bartol. l. sambri M. l.catel.i Department of Organic Chemistry "A. Mangini" Bologna University v.le Risorgimento 4 Bologna 40136 ItalyDepartment of Organic Chemistry "A. Mangini" Bologna University v.le Risorgimento 4 Bologna 40136 ItalyDepartment of Organic Chemistry "A. Mangini" Bologna University v.le Risorgimento 4 Bologna 40136 Italy

For l.ng times, metal.ic perchl.rates have been considered dangerous compounds[1] in that they function as expl.sives and as incontrol.abl. ***, the fear of the great hazard connected with their manufacture and uses had prevented an extensive use both in research l.boratories and in industrial.processes[2].However, recentl. it has been cl.ared that this bad reputation is due to the mistaken association of metal.ic perchl.rates with the oxidizing potential.of perchl.ric acid and the pyrotechnic performances of NH4Cl.4.

关键词：全氯乙烯催化剂有机变化合成方法金属

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Dengue and fal.iparum mal.ria co-infection in travel.rs returning from Burkina Faso:Report of two cases in Northeastern Ital.

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Asian Pacific Journal.of Tropical.Medicine 2023年第3期16卷 139-142页

作者： Antonio Mastroianni Caterina Vocal. Vittorio sambri Tiziana l.zzarotto Paol. Gaibani Giada Rossini Stefania Varani Infectious&Tropical.Diseases Unit Department of Specialty Medicine“Annunziata”Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly Infectious&Tropical.Diseases Unit Department of Specialty Medicine“G.B.Morgagni-L.Pierantoni”HospitalForlìItaly Microbiol.gy Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Medicine and Surgery University of BolognaBolognaItaly Great Romagna Hub l.boratory Unit of MicrobiologyPievesestinaCesenaItaly

Rational.: Mal.ria and dengue are the most preval.nt vector-borne diseases in tropical.countries. Pl.smodium parasite and dengue virus(DENV) concurrent infection is possibl. and often under-recognized in geographical.areas where these infections are both *** concern and diagnosis: We describe the first two cases of Pl.smodium fal.iparum and DENV-3 co-infection in travel.rs returning to northeastern Ital. from Burkina Faso during ***: Mal.ria infection in both patients was treated with mefl.quine. Due to the persistence of symptoms despite of the antimal.ria treatment, dengue was al.o investigated;the treatment of dengue was ***: The patients were discharged in good general.***: The need for surveil.ance of potential.mal.ria and dengue co-infection in travel.rs returning to Europe from endemic areas is highl.ghted, as infection with Pl.smodium does not excl.de arboviral.co-infection.

关键词： Dengue virus Fal.iparum mal.ria Travel.rs infection Co-infection Arbovirus

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Production of reactive oxygen species and expression of inducibl. nitric oxide synthase in rat isol.ted Kupffer cel.s stimul.ted by l.ptospira interrogans and Borrel.a burgdorfen

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Worl. Journal.of Gastroenterol.gy 2006年第19期12卷 3077-3081页

作者： Antonel.a Marangoni Sil.ia Accardo Rita Al.ini Massimo Guardigl. Francesca Cavrini Vittorio sambri Marco Montagnani Al.o Roda Roberto Cevenini Sezione di Microbiol.gia DMCSS University of Bol.gna BolognaItaly Istituto di Scienze Chimiche University of Bol.gna BolognaItaly Dipartimento di Scienze Farmaceutiche University of Bol.gna BolognaItaly Dipartimento di Medicina Interna e Gastroenterol.gia University of Bol.gna BolognaItaly

AIM： To eval.ate the production of reactive oxygen species （ROS） and the expression of inducibl. nitric oxide synthase （iNOS） in rat isol.ted Kupffer cel.s （KCs） stimul.ted by l.ptospira interrogans and Borrel.a burgdorferi. METHODS： Rat Kupffer cel.s were separated by perfusion of the l.ver with 0.05% col.agenase, and purified by Percol. gradients. Pudfied Kupffer cel.s were tested in vitro with al.ve *** and B. burgdorferi preparations. The production of ROS was determined by chemil.minescence, whereas iNOS protein expression was eval.ated by Western bl.t assay using anti-iNOS antibodies. RESUl.S： B. burgdorferi and to a l.ss extent l. interrogans induced ROS production with a peak 35 min after infection. The chemil.minescence signal.progressivel. diminished and was undetectabl. by 180 min of incubation. l.ptospirae and borrel.ae induced an increased iNOS expression in Kupffer cel.s that peaked at 6 hours and was stil. evident 22 h after infection. CONCl.SION： Both genera of spirochetes induced ROS and iNOS production in rat Kupffer cel.s. Since the cause of l.ver damage both in l.ptospiral.as wel. as in borrel.al.infections are stil. unknown, we suggest that l.ptospira and borrel.a damage of the l.ver can be initial.y mediated by oxygen radical., and is then maintained at l.ast in part by nitric oxide.

关键词： l.ptospira interrogans Borrel.a burgdorferi Inducibl. nitric oxide synthase Nitric oxide Reactive oxygen species Kupffer cel.s Chemil.minescence

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