检索结果-南通市图书馆

Characterization of chromatin accessibility in psoriasis

第一届建立和谐人机环境联合学术会议（HHME2.05）

作者： SHU Wan-Neng 1+, zheng Shi-Jue 2. chen Guang-Dong3.(The {2. of computer science of Hua {3. Normal University , Wuhan , 43.079,China) 2.The {2. of computer science of Hua {3. Normal University , Wuhan , 43.079,China ) 3.The {2. of computer science of Hua {3. Normal University , Wuhan , 43.079,China )

The in-depth study and development of the project of realcourse in university, urges the server to meet the users’ need for a mass of synchronization requests, causing the appearance of more and more

关键词： VOD cluster server load balancing Genetic Algorithm

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第3期16卷 483-495页

作者： zheng Zhang lu liu Yanyun Shen Ziyuan Meng Min chen {2. lu Xuejun Zhang department of Dermatology Huashan HospitalFudan University.Shanghai 200040China department of Dermatology No.1 Hospital and Key Laboratory of DermatologyMinistry of EducationAnhui Medical UniversityHefei 230032China department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215123China

The pathological hallmarks of psoriasis involve alterations in T cell genes associated with transcriptional levels,which are determined by chromatin ***,to what extent these alterations in T cell transcriptional levels recapitulate the epigenetic features of psoriasis remains ***,we systematically profiled chromatin accessibility on Th1,Th2.Th1-17,Th17,and Treg cells and found that chromatin remodeling contributes significantly to the pathogenesis of the *** chromatin remodeling tendency of different subtypes of Th cells were relatively ***,we profiled chromatin accessibility and transcriptional dynamics on memory Th/Treg *** the memory Th cells,803.increased and 545 decreased chromatin-accessible regions were *** the memory Treg cells,713.increased and 12.6 decreased chromatin-accessible regions were identified.A total of 54 and 53.genes were differentially expressed in the peaks associated with the memory Th and Treg ***1,SPI1,ATF3.NFKB1,RUNX,ETV4,ERG,FlI1,and ETC1 were identified as regulators in the development of *** transcriptional regulatory network showed that NFKB1 and RElA were highly connected and central to the ***1 regulated the genes of CCl3.CXCl2.and *** results provided candidate transcription factors and a foundational framework of the regulomes of the disease.

关键词： psoriasis ATAC-seq epigenetics transcription factor

Rare earth elements and yttrium in ferromanganese deposits from the South China Sea:distribution,composition and resource considerations

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2018年第7期37卷 41-54页

作者： zhong Yi chen zhong GONZAlEZ Francisco Javier {3. Xufeng lI Gang lUO Yun MO Aibin XU Antao WANG Shuhong Key laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China department of Marine Science and engineering Southern University of Science and Technology of ChinaShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Geological Survey of Spain(IGME) Madrid 28003Spain

Ferromanganese nodules and crusts contain relatively high concentration of rare earth elements（REE） and yttrium（REY）,with a growing interest in exploitation as an alternative to land-based REY *** the basis of comprehensive geochemical approach,the abundance and distribution of REY in the ferromanganese nodules from the South China Sea are *** results indicate that the REY contents in ferromanganese deposits show a clear geographic *** REY contents range from 69.1×10^-6 to 2.919.4×10^-6,with an average value of 1 459.5×10^-***,the enrichment rate of Ce content is high,accounting for almost 60% of the total *** REE enrichment is controlled mainly by the sorption of ferromanganese oxides and clay minerals in the nodules and ***,the total REY are higher in ferromanganese deposits of hydrogenous origin than of diagenetic ***,light REE（lREE） and heavy REE（HREE） oxides of the ferromanganese deposits in the study area can be classified into four grades： non-enriched type,weakly enriched type,enriched type,and extremely enriched *** to the classification criteria of rare earth resources,the Xisha and zhongsha platform-central deep basin areas show a great potential for these rare earth metals.

关键词： ferromanganese deposits rare earth elements and yttrium abundance characteristics controlling factors potential source South China Sea

Shed a New light on Spinal Cord Injury-induced Permanent Paralysis with the Brain-spine Interface

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第12期39卷 1898-1900页

作者： Shuang Zou Yang zheng Xuhong Jiang Yu-long lan zhong {2. Cenglin Xu Xinhua Hospital of zhejiang Province The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang ProvinceSchool of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China department of Neurology Zhejiang Provincial Hospital of Chinese MedicineThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China department of Neurosurgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

How to deal with severe spinal cord injuries(SCI)?This question remains an everlasting challenge for *** innovative therapies such as neuromodulation,which targets the surviving tissue,have shown the potential to restore cognitive functions in patients with severe SCI after rehabilitation[1,2..These therapies might enable SCI patients to sustain active movements during rehabilitation training to enhance the reorganization of the neuronal pathways,however,the complete recovery of body movement functions was still not reached with these therapies.A characteristic feature of SCI is the impairment of neural information communication between the neurons in the spinal cord and the brain,which are responsible for regulating body ***-computer interfaces(BCIs)have been successfully applied in dealing with movement dysfunction by establishing a direct connection between brain cortical activity and electrical muscle stimulation,thereby restoring limb function in cases of paralysis[2..

关键词： injuries stimulation thereby

ANAlYSIS OF A CRACK IN A FUNCTIONAllY GRADED STRIP WITH A POWER FORM SHEAR MODUlUS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2009年第5期22卷 465-473页

作者： Jinju Ma zheng zhong Chuanzeng Zhang School of Aerospace engineering and Applied Mechanics Tongji University Shanghai 200092 China department of civil {2. University of Siegen D-57068 Siegen Germany

The plane strain problem of a crack in a functionally graded strip with a power form shear modulus is studied. The governing equation in terms of Airy＇s stress function is solved exactly by means of Fourier transform. The mixed boundary problem is then reduced to a system of singular integral equations and is solved numerically to obtain the stress intensity factor at crack-tip. The maximum circumferential stress criterion and the strain energy density criterion are both employed to predict the direction of crack initiation. Numerical examples are given to show the influence of the material gradation models and the crack sizes on the mode-I and mode-II stress intensity factors. The dependence of the critical kink-angle on the crack size is examined and it is found that the crack kink-angle decreases with the increase of the normalized crack length, indicating that a longer crack tends to follow the original crack-line while it is much easier for a shorter crack to deviate from the original crack-line.

关键词： functionally graded material crack stress intensity factors fracture criterion

A semi-analytical method for the analysis of pile-supported embankments

在线全文

学校读者我要写书评

暂无评论

Journal of zhejiang University-Science A(Applied Physics & engineering) 2012年第11期13卷 888-894页

作者： Wan-huan ZHOU Ren-peng chen lin-shuang ZHAO zheng-{2. XU Yun-min chen department of civil and Environmental {2. University of Macao Macao China MOE Key laboratory of Soft Soils and Geoenvironmental engineering Department of Civil Engineering Zhejiang University Hangzhou 310058 China

In this paper,a semi-analytical method for the analysis of pile-supported embankments is *** mathematic model describes the cooperative behavior of pile,pile cap,foundation soil,and embankment *** on Terzaghi's 1D consolidation theory of saturated soil,the consolidation of foundation soil is *** embankments with two different types of piles:floating piles and end-bearing piles are investigated and *** results of axial force and skin friction distributions along the pile and the settlements of pile-supported embankments are *** is found that it takes a longer time for soil consolidation in the embankment with floating piles,compared with the case using end-bearing *** differential settlement between the pile and surrounding soil at the pile top is larger for the embankment with end-bearing piles,compared with the case of floating piles.

关键词： Pile-supported embankment Soil arching load transfer Equal settlement plane Soft soils

在线全文

学校读者我要写书评

暂无评论

童年创伤问卷简版在大学生中的纵向等值性

中国临床心理学杂志 2024年第2期32卷 299-303页

作者：熊港琴苗正淼蔡晓晴刘苏瑶陈奇虹程明钟明天华南师范大学心理学院心理应用研究中心广州510631 华南师范大学脑认知与教育科学教育部重点实验室广州510631 中南大学湘雅二医院医学心理中心长沙410011 湖南省脑科医院临床心理科长沙410007

目的:检验童年创伤问卷简版(Childhood Trauma Questionnaire-Short Form, CTQ-SF)在中国大学生群体中的纵向测量等值性。方法:583.大学生间隔1个月两次完成CTQ-SF、流调中心用抑郁量表(CES-D)和焦虑自评量表(SAS)。结果:(1)CTQ-SF的... 详细信息

目的:检验童年创伤问卷简版(Childhood Trauma Questionnaire-Short Form, CTQ-SF)在中国大学生群体中的纵向测量等值性。方法:583.大学生间隔1个月两次完成CTQ-SF、流调中心用抑郁量表(CES-D)和焦虑自评量表(SAS)。结果:(1)CTQ-SF的五因子模型在前测(T1)、后测(T2.两个样本数据中均拟合良好,且两个时间点上的形态等值、弱等值、强等值、严格等值模型以及潜均值等值模型均成立。(2.CTQ-SF前后测的Cronbach’s α分别为0.83.0.88,McDonald’s omega分别为0.88和0.91,前后测的组内相关系数为0.62.(3.配对样本t检验结果显示T1、T2.CTQ-SF得分差异不显著(P>0.05),且T1、T2.CTQ-SF得分均与同时间点的CES-D、SAS得分呈显著正相关(r=0.3.5~0.73., P<0.01)。结论:CTQ-SF五因子结构在中国大学生样本中具有良好的纵向测量等值性,支持CTQSF可用于评估成年个体的童年创伤经历。

关键词：童年创伤问卷测量等值性纵向

维普期刊数据库博看期刊

miR-3.a/SIRT1在重症监护病房获得性衰弱中的作用及其机制

在线全文

学校读者我要写书评

暂无评论

解放军医学杂志 2024年第7期49卷 796-803页

作者：林正霄徐朝霞陈娟胡健祝国芸朱忠立冯健李福祥西南交通大学医学院四川成都611756 西部战区总医院重症医学科四川成都610083 西部战区总医院急诊医学科四川成都610083

目的探讨miR-3.a/SIRT1在重症监护病房获得性衰弱(ICU-AW)中的作用及其机制。方法(1)诱导C2.12.鼠骨骼肌细胞分化成肌管,并分为ICU-AW模型组[ICU-AW组,用脂多糖(lPS)干预12.h]与正常对照组(等量无菌水干预12.h)。采用Western blotting... 详细信息

目的探讨miR-3.a/SIRT1在重症监护病房获得性衰弱(ICU-AW)中的作用及其机制。方法(1)诱导C2.12.鼠骨骼肌细胞分化成肌管,并分为ICU-AW模型组[ICU-AW组,用脂多糖(lPS)干预12.h]与正常对照组(等量无菌水干预12.h)。采用Western blotting检测两组肌肉环指蛋白1(MuRF-1)、萎缩相关基因1(Atrogin-1)蛋白、沉默调节蛋白1(SIRT1)表达水平,RT-qPCR检测两组微小核糖核酸-3.a(miR-3.a)及MuRF-1、Atrogin-1、SIRT1 mRNA的表达水平,并在光镜下观察两组小鼠C2.12.骼肌细胞生长及分化情况。(2.将ICU-AW细胞分为对照组(siRNA的转染剂干预)、Scra siRNA组(转染剂和非特异性siRNA干预)、miR-3.a siRNA组(miR-3.a siRNA转染剂和特异性siRNA干预)、Vehicle组(SIRT1激动剂的溶剂二甲基亚砜干预)及SRT172.组(SIRT1激动剂SRT172.干预)。采用Western blotting检测各组SIRT1、Atrogin-1、MuRF-1蛋白表达水平,RT-qPCR检测各组miR-3.a及MuRF-1、Atrogin-1、SIRT1 mRNA表达水平。(3.将ICU-AW细胞分为对照组(miR-3.a siRNA的转染剂干预)、miR-3.a siRNA组(转染剂和特异性siRNA干预)、miR-3.a siRNA+Vehicle组(转染剂、特异性siRNA和二甲基亚砜干预)及miR-3.a siRNA+EX-52.组(转染剂、特异性siRNA和SIRT1抑制剂EX-52.干预),采用Western blotting检测并比较各组Atrogin-1、MuRF-1蛋白表达水平,RT-qPCR检测并比较各组Atrogin-1、MuRF-1 mRNA表达水平。结果光镜下可见第4天C2.12.鼠骨骼肌细胞肌管分化形成,与正常对照组比较,ICU-AW组肌管明显萎缩。RT-qPCR及Western blotting检测结果显示,与正常对照组比较,ICU-AW组Atrogin-1、MuRF-1 mRNA及蛋白相对表达水平明显升高(P3.a相对表达水平明显升高(P3.a siRNA组的miR-3.a及Atrogin-1、MuRF-1 mRNA和蛋白相对表达水平明显降低(Ple组比较,SRT172.组SIRT1 mRNA和蛋白相对表达水平明显升高(P3.a siRNA组比较,Scra siRNA组miR-3.a及Atrogin-1、MuRF-1 mRNA和蛋白相对表达水平明显升高(Plotting检测结果显示,与miR-3.a siRNA+Vehicle组比较,miR-3.a siRNA+EX-52.组Atrogin-1、MuRF-1 mRNA及蛋白表达水平明显升高(P3.a过度激活,通过抑制SIRT1的表达导致骨骼肌萎缩,可能在ICU-AW发病过程中起重要作用。

关键词：重症监护病房获得性衰弱骨骼肌萎缩 miR-3.a 沉默调节蛋白1 萎缩相关基因1 肌肉环指蛋白1

HYPERBRANCHED CONJUGATIVE MACROMOlECUlES CONSTRUCTED FROM TRIPlE-BOND BUIlDING BlOCKS

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2005年第6期23卷 567-591页

作者： Matthias HaeuBler Hong-chen Dong Jacky Wing Yip lam Rong-hua zheng An-jun Qin Ben-{2. Tang department of Chemistry The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China department of Polymer Science and engineering Zhejiang University Hangzhou 310027 China

Polycyclotrimerization and polycoupling of acetylenic monomers respectively furnish hyperbranched polyarylenes and polyynes with high molecular weights （up to 1 × 10^6） in high yields （up to 99.9%）. The polymers possess low intrinsic viscosities and high thermal stabilities, losing little of their weights when heated to 〉 400℃. Upon pyrolysis at 〉 800℃, the polymers graphitize with high char yields （up to 86%）. Hyperbranched polyarylenes efficiently emit deep-blue to blue-green lights with fluorescence quantum yields up to 98% and strongly attenuate intense laser pulses with optical power-limiting performances superior to that of C60, a well-known optical limiter. Poly（alkenephenylenes）, poly（aroylarylenes） and polyynes are readily cross-linkable by UV irradiation, serving as excellent photoresist materials for the generation of patterns with nanometer resolution. Thin films of hyperbranched polyynes exhibit very high refractive indexes （n up to 1.86）. The internal and terminal acetylene moieties of the polyynes readily form complexes with cobalt carbonyls, which can be transformed into soft ferromagnetic ceramics with high magnetic susceptibilities （Ms up to ca. 118 emu/g） and near-zero magnetic losses.

关键词： Hyperbranched polymers Alkyne polycyclotrimerization Alkyne polycoupling Polyarylenes Polyynes Optical materials Photoresists Soft ferromagnetic ceramics