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Effects of chronic and subtoxic chlorobenzenes on adrenocor.icotrophic hormone release

Journal of Environmental Sciences 2015年第8期27卷 165-170页

作者： Zsolt molnár regina Pálf?ldi Anna lászló marianna radács Krisztián Sepp Péter Hausinger lászló Tiszlavicz Zsuzsanna Valkusz márta Gálfi institute of Applied Science Department of Environmental Biology and Education Gyula Juhász Faculty of Education University of Szeged Department of Pulmonology Faculty of Medicine University of Szeged Department of medical Physics and informatics Faculty of Medicine University of Szeged Endocrine Unit of First Department of internal medicine Faculty of Medicine University of Szeged invasive Car.iology Department Second Department of Internal Medicine and Cardiology Faculty of Medicine University of Szeged Department of Pathology Faculty of Medicine University of Szeged

many environmental chemicals and pesticides have been found to alter neuroendocrine communication in exposed biological objects. The environmental loads have primary and secondary effects that can alter the homeostatic regulation potential. Since it is difficult to avoid human exposition, a potentially important area of research to develop in vivo and in vitro experimental models. in this context, the primary aim of this study was to demonstrate the effects of chlorobenzenes on adrenocor.icotrophic hormone（ACTH） release. in our experimental study, male Wistar rats were exposed to 0.1, 1.0 and 10 μg/b.w.（body weight） kg of 1,2,4-trichlorobenzene and hexachlorobenzene（Cl B） mix via gastric tube for 30, 60 or 90 days. At the endpoints of the experiment blood samples were taken and animals were decapitated. Primary,monolayer adenohypophysis cell cultures were prepared by enzymatic and mechanical digestion. The ACTH hormone content in serum and supernatant media was measured by immuno-chemiluminescence assay. The mg2＋-dependent ATPase activity was deter.ined by modified method of mar.in and Dotty. Significant differences were detected in the hormone release between the control and treated groups. The hormone release was enhanced characteristically in exposed groups depending upon the dose and duration of exposure. The mg2＋-ATPase activity enhanced after chronic and subtoxic Cl B exposition. light microscopy revealed that the adenohypophysis seemed to be more abundant. results indicate that Wistar rats exposed to subtoxic Cl B have direct and indirect effects on hypothalamus–hypophysis–adrenal axis.

关键词： Chlorobenzenes Subtoxic Adrenocor.icotrophic hormone release mg2+ -dependent ATPase

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On the neutrality of two symmetric TSP solvers toward instance specification

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Science China(information Sciences) 2019年第11期62卷 198-200页

作者： Gloria Cerasela Cri?AN lászló Barna iANTOViCS lászló KOVáCS Faculty of Sciences Vasile Alecsandri University Faculty of Sciences and letters University of MedicinePharmacy Sciences and Technology Faculty of mechanical Engineering and informatics University of Miskolc

Dear editor,Currently, many computationally difficult problems can be solved using very efficient *** of these state-of-the-art methods have online implementations. The research question addressed her.in is how sensit... 详细信息

关键词： On the neutrality of two symmetric TSP solvers toward instance specification

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Polysorb^r(an absorbable lactomer) staples, a safe closure technique for distal pancreatic resection

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World Journal of Gastroenterology 2014年第45期20卷 17185-17189页

作者： Gyula Farkas lászló leindler János márton Gyorgy lázár Gyula Farkas Department of Surgery Faculty of medicine Univer.ity of Szeged H-6701 SzegedHungary

Aim:To investigate twenty-year experience evaluated the use of the Polysorbr(an absorbable lactomer)staples for distal pancreatic ***:The data on 150 patients[92 men,58women,mean age 52(24-72)years]who underwent distal pancreatectomy(DP)in the last 20 years were collected prospectively from an electronic *** diagnosis was confirmed by endoscopic retrograde cholangiopancreatography,sonography,computed tomography and/or magnetic resonance *** indications for DP were focal pancreatic necrosis,spontaneous pancreatic fistulas,abscesses,pseudocysts,segmental chronic obstructive pancreatitis in the tail,traumatic disruption,and benign(cystadenomas,insulinomas,or glucagonomas)or malignant *** distal resections were performed without splenectomy in 29 of the 150 patients(19%).in the event of splenectomy,the splenic artery and vein were individually ligated,the TA-55 Auto Suture stapler,loaded with Premium Polysorbr 55 staples(5.5mm),was placed across the gland,and the trigger was pulled,the action of which produced two staggered absorbable suture *** gland distal to the stapler wasthen amputated with a scalpel on the TA-55 stapler and the two rows of staples were left in the proximal pancreatic *** the distal resection,a dr.inage tube was inserted into the pancreatic ***:The average duration of the operation was150 min(range:90-210 min)and no transfusion was indicated during the *** DP in one patient a type B fistula was diagnosed,which was treated successfully by conservative treatment comprising of 12-d octreotide medication(3×0.1 mg/d)and jejunal *** incidence of postoperative pancreatic fistula was therefore0.6%.Another 2 patients suffered postoperative pancreatitis,which was also conservatively *** were performed in 2 patients on the first or second postoperative day,necessitated by bleeding from the retroperitoneal *** mor.idity was 3.3%(5 patients),but no mortality

关键词： Distal pancreatic resection Polysorbr sta-ples Closure technique long-term experience Pancre-atic fistula

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multi-layer 3D chirality:its enantioselective synthesis and aggregation-induced emission

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National Science review 2021年第1期8卷 7-9页

作者： Junliang Zhang lászló Kür.i Department of Chemistry Fudan University Department of Chemistry Rice University

Chirality has been extensively studied in inter.isciplinary fields for almost two centuries since its ubiquity was discovered by louis Pasteur.in 1848, when he successfully separated a pair of enantiomers. indeed, chirality is present at all levels in nature—in the form of subatomic par.icles, macromolecules such as proteins and DNA, microscopic living organisms such as helical bacteria and even in the form of macroscopic objects such as sea shells and spiral galaxies.

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recent Advances in Catalytic Carbonylation reactions in Alternative reaction media

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Chinese Journal of Chemistry 2024年第4期42卷 406-429页

作者： Csaba Árvai lászló T.mika Department of Chemical and Environmental Process Engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or roelen reaction)and the reppe-reaction,the transition metal-catalyzed carbonylation reactions,providing versatile,facile,and even atom-economic methods for the selective incorporation of C=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we over.iew the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVl),2-methyltetrahydrofuran(2-meTHF),ionic liquids(ils),deep eutectic solvents(DES),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environmentally benign nature of carbonylation protocols.

关键词： Carbonylation Catalysis Solvents Green chemistry Carbon monoxide Transition metals Homogeneous catalysis Palladium

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Differences in migration phenology of warblers at two stopover sites in eastern russia suggest a longitudinal migration pattern

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Avian research 2023年第1期14卷 7-12页

作者： lászlóBozó Yury Anisimov Wieland Heim Eötvös loránd Univer.ity Department of Systematic Zoology and Ecology1117BudapestPáazmány Péter sétány1/CHungary Baikalsky State Nature Biosphere reserve TankhoyRussia Turku Univer.ity Department of BiologyFI-20014TurkuFinland münster Univer.ity Institute of Landscape EcologyMünsterGermany

long-distance migratory birds often face major geographical bar.iers on their *** some species are able to cross them,others use longer routes to avoid such *** is known about the strategies of Siberian landbird migrants,which either cross or circumvent the deserts and mountain ranges of Central Asia en route to their non-breeding sites in Southeast *** we compare data on migration phenology and morphology from two bird ringing stations in eastern russia,situated at similar latitudes but with a longitudinal difference of 1500 km,to hypothesise migration *** found significant differences in timing between the two sites(birds migrated significantly ear.ier.in spring and significantly later.in autumn in the east),suggesting longitudinal migration as a result of migration ***,morphological differences show a less clear *** argue that most Siberian landbirds might opt for a detour through the russian Far East instead of a direct route in order to avoid unfavourable stop-over habitat in Central ***,tracking studies will be necessary to prove this.

关键词： East Asian flyway Bar.ier Detour migration Passerine Phylloscopus

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Utilization of α-olefins obtained by pyrolysis of waste high density polyethylene to synthesize α-olefin-succinic-anhydride based cold flow improvers

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燃料化学学报 2009年第3期37卷 302-310页

作者： Norbert miSKOlCZi richard SAGi lászló BArTHA lívia FOrCEK Univer.ity of Pannonia Chemical Engineering and Process Engineering Institute Department of Hydrocarbon and Coal Processing Egyetem street 10 Veszprém H-8200 HUNGARY

浪费聚合物热分解获得的石蜡富人烃部分的利用的一条新线路被调查。-olefin-succinic-anhydride 基于中介倒点镇静剂添加剂因为柴油被综合，在哪个反应需要的石蜡被废物的热分解获得高密度的聚乙烯(HDPE ) 。石蜡的部分被塑料废物的de... 详细信息

浪费聚合物热分解获得的石蜡富人烃部分的利用的一条新线路被调查。-olefin-succinic-anhydride 基于中介倒点镇静剂添加剂因为柴油被综合，在哪个反应需要的石蜡被废物的热分解获得高密度的聚乙烯(HDPE ) 。石蜡的部分被塑料废物的de聚合在 500 滓鲥?在一个试管反应堆生产???????????????????????禧?????迋????骤??????吗鲥??????禧哉????嫪????滓?????篤?廯??????可??????????????裍??妢???????臙???????蚨?蚨？？

关键词：添加剂石油炼制成份燃料化学高温分解

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neur.immunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diver.ity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with var.ing myelination ***,modern molecular.investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Diagnostic role of secretin-enhanced mrCP in patients with unsuccessful ErCP

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World Journal of Gastroenterology 2004年第20期10卷 3034-3038页

作者： lászló Czakó Tamás Takács Zita morvay lászló Csernay János lonovics First Department of medicine University of SzegedSzegedHungary international medical Center SzegedHungary

Aim:To evaluate the value of mr cholangiopancreatography (mrCP)in patients in whom endoscopic retrograde cholangiopancreatography(ErCP)was unsuccessfully performed by experts in a ter.iary center. mETHODS:From January 2000 to June 2003,22 patients fulfilled the inclusion *** indications for ErCP were obstructive jaundice(n=9),abnormal liver enzymes(n=8), suspected chronic pancreatitis(n=2),recurrent acute pancreatitis(n=2),or suspected pancreatic cancer(n=1). The reasons for the ErCP failure were the postsur.ical anatomy(n=7),duodenal stenosis(n=3),duodenal diver.iculum(n=2),and technical failure(n=10).mrCP images were evaluated before and 5 and 10 r.in after.i.v. administration of 0.5 iU/kg secretin. rESUlTS:The mrCP images were diagnosed in all 21 *** patients gave normal mr findings and required no further *** revealed abnormalities(primary sclerosing cholangitis,chronic pancreatitis,cholangitis,cholecystolithiasis or common bile duct dilation)in 20 patients,who were followed up *** patients subsequently underwent laparotomy(hepaticojejunostomy in consequence of common bile duct stenosis caused by unresectable pancreatic cancer;hepaticotomy+Kehr dr.inage because of insufficient biliary-enteric anastomosis;choledochoj- ejunostomy,gastrojejunostomy and cysto-Wirsungo gastrostomy because of chronic pancreatitis,or choledochojejunostomy because of common bile duct stenosis caused by chronic pancreatitis).Three patients par.icipated in therapeutic percutaneous transhepatic *** indications were choledocholithiasis with choledochojejunostomy,insufficient biliary-enteric anastomosis,or cholangiocar.inoma. CONClUSiON:mrCP can assist the diagnosis and management of patients in whom ErCP is not possible.

关键词： Adult Aged Aged, 80 and over Biliary Tract Diseases Cholangiography Cholangiopancreatography, Endoscopic retrograde Diagnosis, Differential Female Humans Jaundice, Obstructive magnetic resonance imaging male middle Aged Pancreatitis Prospective Studies research Support, Non-U.S. Gov't Secretin Sensitivity and Specificity

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Complement-dependent neur.inflammation in spinal cord injury:from pathology to therapeutic implications

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Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neur.inflammation,a similar role for complement in spinal neur.inflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neur.inflammation neuroplasticity regeneration spinal cord injury targeted therapy

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