检索结果-南通市图书馆

Engineering W/O/W pickering emulsion for the enhanced antigen delivery and immune responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第9期92卷 224-233页

作者： sihua Wu Xiaonan Huang Yin Ma Naoki Asakawa Yufei Xia State Key laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China Key laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Sinovac Biotech ltd. Beijing100085China School of Chemical Engineering Nanjing Tech UniversityNanjing211816China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Tumor immunotherapy,particularly cancer vaccines,holds promise for combating cancer by harnessing tailored immune responses against malignant ***,conventional approaches face challenges in efficiently delivering antigens for optimal immune *** adjuvants,like MF59,enhance cellular uptake but struggle to induce robust CD8^(+)T cell ***,we introduce a novel strategy employing a water-in-oil-in-water(W/O/W)multiple Pickering emulsion(mPE)for antigen *** mPE,utilizing biocompatible,pH-sensitive particles,encapsulates antigens within the inner water phase,ensuring enhanced intracellular processing and dictating the intracellular fate of antigens for improved *** vitro and in vivo studies demonstrated that mPEs induced robust dendritic cells activation and antigen cross-presentation,leading to a significantly enhanced immune ***,calcium phosphate-stabilized mPE(CaP-mPE)illustrated the more robust IFN-γ^(+)T cell *** comparison with traditional surfactant-stabilized multiple emulsions,CaP-mPE significantly inhibit tumor growth and effectively prolong the survival of tumor-bearing *** innovative approach offers a promising avenue for the development of effective cancer vaccines with potent cellular immune responses.

关键词： Cancer vaccine Multiple pickeringemulsion Adjuvant Antigen delivery Anti-tumor response

Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1489-1498页

作者： Jinwang Ye Huali Wan sihua Chen Gong-Ping liu Shenzhen Key laboratory of Marine Biotechnology and Ecology College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong ProvinceChina Department of laboratory Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Co-innovation Center of Neurodegeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older *** features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neurofibrillary tangles,fo rmed by tau protein,in the *** there are amyloid-β-ta rgeting therapies for the treatment of Alzheimer’s disease,these therapies are costly and exhibit potential negative side *** evidence suggests significant involvement of tau protein in Alzheimer’s disease-related *** an important microtubule-associated protein,tau plays an important role in maintaining the stability of neuronal microtubules and promoting axonal *** fact,clinical studies have shown that abnormal phosphorylation of tau protein occurs before accumulation of amyloid-βin the *** therapeutic strategies targeting tau protein have begun to emerge,and are considered possible methods to prevent and treat Alzheimer’s ***,abnormalities in post-translational modifications of the tau protein,including aberrant phosphorylation,ubiquitination,small ubiquitin-like modifier(SUMO)ylation,acetylation,and truncation,contribute to its microtubule dissociation,misfolding,and subcellular *** causes mitochondrial damage,synaptic impairments,gliosis,and neuroinflammation,eventually leading to neurodegeneration and cognitive *** review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer’s disease and discusses tau-targeted treatment of Alzheimer’s disease.

关键词： acetylation Alzheimer’s disease cognitive deficits gliosis mitochondria damage neuroinflammation phosphorylation synaptic impairments tau tau immunotherapy

Analysis of China’s PM_(2.5)and ozone coordinated control strategy based on the observation data from 2015 to 2020

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第4期138卷 385-394页

作者： liuwei Kong Mengdi Song Xin li Ying liu sihua lu limin Zeng Yuanhang Zhang State Key Joint laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

The coordinated control of PM_(2.5)and ozone has become the strategic goal of national air pollution *** the gradual decline in PM_(2.5)concentration and the aggravation of ozone pollution,a better understanding of the coordinated control of PM_(2.5)and ozone is urgently ***,we collected and sorted air pollutant data for 337 cities from 2015 to 2020 to explore the characteristics of PM_(2.5)and ozone pollution based on China’s five major air pollution *** results show that it is necessary to continue to strengthen the emission reduction in PM_(2.5)and ozone precursors,and control NO_(x) and VOCs while promoting a dramatic emission reduction in PM_(2.5).The primary method of curbing ozone pollution is to strengthen the emission control of VOCs,with a long-term strategy of achieving substantial emission reductions in NO_(x),because VOCs and NO_(x) are also precursors to PM_(2.5);hence,their reductions also contribute to the reduction in PM_(2.5).Therefore,the implementation of a multipollutant emission reduction control strategy aimed at the prevention and control of PM_(2.5)and ozone pollution is the only means to realize the coordinated control of PM_(2.5)and ozone.

关键词： PM_(2.5) Ozone Coordinated control Multipollutant reduction

A chorismate mutase from Radopholus similis plays an essential role in pathogenicity

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第3期23卷 923-937页

作者： sihua Yang Junyi li Shuai Yang Shiqiao Tang Huizhong Wang Chunling Xu Hui Xie laboratory of Plant Nematology andResearch Centerof Nematodes of Plant Quarantine Department of Plant Patholo of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China

In the process of infecting plants, plant parasitic nematodes release a series of proteins that play an essential role in the successful infection and pathogenesis of plant cells and tissues through stylets or body walls. In this study,based on transcriptome data, a chorismate mutase gene of Radopholus similis(RsCM) was identified and cloned,which is a single copy gene specifically expressed in the oesophageal gland and highly expressed in juveniles and females. Transient expression of RsCM in tobacco leaves showed that it was localised in the cytoplasm and nucleus of tobacco leaf cells, which inhibited the pattern-triggered immunity(PTI) induced by flg22, including callose deposition and defence gene expression, and cell death induced by immune elicitors BAX, but could not inhibit cell death induced by immune elicitors Gpa2/RBP-1. The RNA interference(RNAi) transgenic tomato of RsCM obviously inhibited the infection, pathogenicity, and reproduction of R. similis. However, the resistance of the overexpression transgenic tomato of RsCM to R. similis infection was significantly reduced, and the expression levels of two salicylic acid(SA) pathway genes(PR1 and PR5) in roots infected by the nematode were significantly down-regulated,which indicated that RsCM might be involved in the inhibition of SA pathway. The results of this study demonstrate that RsCM suppresses the host immune system and might be a new target for the control of R. similis, which also provides new data for the function and mechanism of CM genes of migratory parasitic plant nematodes.

关键词： Radopholus similis chorismate mutase plant defense transgenic tomato

Electronic structure and spin state regulation of vanadium nitride via a sulfur doping strategy toward flexible zinc-air batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 239-249,I0007页

作者： Daijie Deng Honghui Zhang Jianchun Wu Xing Tang Min ling sihua Dong li Xu Henan li Huaming li Institute for Energy Research Institute of Quantum and Sustainable TechnologySchool of Chemistry and Chemical EngineeringSchool of Materials Science and EngineeringJiangsu Province and Education Ministry Co-Sponsored Synergistic Innovation Center of Modern Agricultural EquipmentJiangsu UniversityZhenjiang 212013JiangsuChina Key laboratory of Radio Frequency and Micro-Nano Electronics of Jiangsu Province Nanjing 210023JiangsuChina Zhenjiang Kangyuan Electrical Appliance Co. Ltd.Zhenjiang 212013JiangsuChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina YTO Group Corporation Dongfanghong(Henan)Agricultural Service Technology Co. Ltd.Luoyang 471033HenanChina

Owing to the distinctive structural characteristics,vanadium nitride(VN)is highly regarded as a catalyst for oxygen reduction reaction(ORR)in zinc-air batteries(ZABs).However,VN exhibits limited intrinsic ORR activity due to the weak adsorption ability to O-containing ***,the S-doped VN anchored on N,S-doped multi-dimensional carbon(S-VN/Co/NS-MC)was constructed using the solvothermal and in-situ doping *** sulfur atoms into VN species alters the electron spin state of vanadium in the S-VN/Co/NS-MC for regulating the adsorption energy of vanadium sites to oxygen *** introduced sulfur atoms polarize the V 3d_(z)^(2) electrons,shifting spin-down electrons closer to the Fermi level in the S-VN/Co/***,the introduction of sulfur atoms into VN species enhances the adsorption energy of vanadium sites for oxygen ****OOH dissociation transitions from being unspontaneous on the VN surface to a spontaneous state on the S-doped VN ***,the ORR barrier on the S-VN/Co/NS-MC surface is *** S-VN/Co/NS-MC demonstrates a higher half-wave potential and limiting current density compared to the VN/Co/*** S-VN/Co/NS-MC-based liquid ZABs display a power density of 195.7 m W cm^(-2),a specific capacity of 815.7 m A h g^(-1),and a cycling stability exceeding 250 *** S-VN/Co/NS-MC-based flexible ZABs are successfully employed to charge both a smart watch and a mobile *** approach holds promise for advancing the commercial utilization of VN-based catalysts in ZABs.

关键词： S-doped VN Electronic structures Spin state regulation Oxygen reduction reaction Zinc-air batteries

Classical spin liquid state in a rhombic lattice metal-organic framework

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3407-3412页

作者： sihua Feng Chao Wang Jiyin Zhao Xuguang liu Chaocheng liu Zeming Qi lei Chen Huijuan Wang Minghui Fan Hengli Duan Wensheng Yan National Synchrotron Radiation laboratory University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Discovering more and new geometrically frustrated systems remains an active point of inquiry in fundamental physics for the existence of unusual states of ***,we report spin-liquid-like behavior in a two-dimensional(2D)rhombic lattice Fe-metal-organic framework(Fe-MOF)with frustrated *** Fe-MOF exhibits a high frustration factor f=|θCW|/TN≥315,and its long-range magnetic order is suppressed down to 180 *** theoretical calculations demonstrate strong antiferromagnetic coupling between adjacent Fe3+ions,indicating the potential of a classical spin-liquid-like ***,a T-linear heat capacity parameter,γ,originating from electronic contributions and with magnetic field independence up to 8 T,can be observed in the specific heat capacity measurements at low-temperature,providing further proof for the spin-liquid-like *** work highlights the potential of MOF materials in geometrically frustrated systems,and will promote the research of exotic quantum physics phenomena.

关键词： spin-liquid-like state two-dimensional metal-organic framework(2D MOF) rhombic lattice ultralow temperature(UlT)measurements spin-frustrated

Development of Valence Bands of C_(60)from Submonolayer to Two and Three Dimensionality

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics letters 1993年第2期10卷 119-122页

作者： XUN Kun DENG Junzhuo lIU Fengqin YAO Jun lüsihua WANG Zuquan WU Sicheng Department of Physics Yantai UniversityYantai 264005 laboratory of Synchrotron Radiation Institute of High Energy PhysicsAcademia SinicaBeijing 100039 Department of Physics Peking UniversityBeijing 100871

For submonolayer amounts of C_(60)condensed on Sn substrate,the peaks derived from top two occupied molecular orbitals were broadened by 0.3eV in comparison with solid C_(60).For coverageθlayer,the broadenings are independent of the *** indicates that the delocalizations of electrons in valence bands of C_(60)are weak and the widths do not reflect the true band dispersions.

关键词： monolayer bands occupied

Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

light(Science & Applications) 2024年第5期13卷 894-907页

作者： Fei Yang Zhiyang Wang Wenbin Shi Miao Wang Rui Ma Wuyu Zhang Xipeng li Erqi Wang Wenjie Xie Zhan Zhang Qi Shen Feifan Zhou sihua Yang MOE Key laboratory of laser life Science&Institute of laser life Science South China Normal UniversityGuangzhou 510631China. Guangdong Provincial Key laboratory of laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China. Key laboratory of Biomedical Engineering of Hainan Province School of Biomedical EngineeringHainan UniversityHaikou 570100China. Department of Neurology Sun Yatsen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China. Guangdong Province Key laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510120China. Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter South China Normal UniversityGuangzhou 510006China

Meningeal lymphatic vessels(mlVs)play a pivotal role in regulating metabolic waste from cerebrospinal fluid(CSF).However,the current limitations in field of view and resolution of existing imaging techniques impede understanding the stereoscopic morphology and dynamic behavior of mlVs in ***,we utilized dual-contrast functional photoacoustic microscopy to achieve wide-field intravital imaging of the lymphatic system,including mlVs and glymphatic *** stereoscopic photoacoustic microscopy based on opto-acoustic confocal features has a depth imaging capability of 3.75 mm,facilitating differentiation between mlVs on the meninges and glymphatic pathways within the brain ***,using this imaging technique,we were able to visualize the dynamic drainage of mlVs and identify a peak drainage period occurring around 20–40 min after injection,along with determining the flow direction from CSF to lymph ***,in the Alzheimer’s disease(AD)mouse model,we observed that AD mice exhibit a~70%reduction in drainage volume of mlVs compared to wild-type *** the development of AD,there is be continued decline in mlVs drainage *** finding clearly demonstrates that the AD mouse model has impaired CSF *** study opens up a horizon for understanding the brain’s drainage mechanism and dissecting mlVs-associated neurological disorders.

关键词： lymphatic impaired field

Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan liu Yao Xiao sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all Plume of the hippocampus did not show significant differences during childhood(P>0.05)but was significantly lower than the control group from adolescence to adulthood(both Ply,rTMS was applied to the occipital cortex,which is anatomically connected to the hippocampus,in the MAM models during *** MAM-rTMS group showed a significant increase in hippocampal volume compared to the MAM-sham group(Ple the volume of the striatum remained unchanged(P>0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(Plumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation