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A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

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Microsystems & Nanoengineering 2019年第1期5卷 356-366页

作者： Jungpyo Lee kyungmin ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun Il-Joo Cho Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Convergence Research Center for Diagnosis Treatmentand Care System of DementiaKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Glia-Neuron Interaction Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and TechnologyUSTYuseong-guDaejeon 34113Republic of Korea

Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain *** there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound *** addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still *** determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular ***,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial *** piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural *** designed the ultrasound transducer as an array structure to enable localized modulation in the target *** addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain *** this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied *** also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer.

关键词： neural stimulation system

Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： Jinsol Kim Juho Jeong Seung Hwan ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzyme Antibody Health care

Programmable directional color dynamics using plasmonics

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Microsystems & Nanoengineering 2024年第1期10卷 325-334页

作者： Gyurin Kim Doeun Kim Soeun ko Jang-Hwan Han Juhwan Kim Joo Hwan ko Young Min Song Hyeon-Ho Jeong School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Semiconductor Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Artificial Intelligence(AI)Graduate School Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

Adaptive multicolor filters have emerged as key components for ensuring color accuracy and resolution in outdoor visual ***,the current state of this technology is still in its infancy and largely reliant on liquid crystal devices that require high voltage and bulky structural ***,we present a multicolor nanofilter consisting of multilayered‘active’plasmonic nanocomposites,wherein metallic nanoparticles are embedded within a conductive polymer *** nanocomposites are fabricated with a total thickness below 100 nm using a‘lithography-free’method at the wafer level,and they inherently exhibit three prominent optical modes,accompanying scattering phenomena that produce distinct dichroic reflection and transmission ***,a pivotal achievement is that all these colors are electrically manipulated with an applied external voltage of less than 1 V with 3.5 s of switching speed,encompassing the entire visible ***,this electrically programmable multicolor function enables the effective and dynamic modulation of the color temperature of white light across the warm-to-cool spectrum(3250 K-6250 K).This transformative capability is exceptionally valuable for enhancing the performance of outdoor optical devices that are independent of factors such as the sun’s elevation and prevailing weather conditions.

关键词： directional prevailing exceptional

Advances in wearable and implantable bioelectronics for precision medicine

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Bio-Design and Manufacturing 2024年第4期7卷 383-387页

作者： Kaichen Xu Seung Hwan ko Jun Chen State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoul 08826Republic of Korea Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1599USA

The continuous pursuit for a better quality of life promotes continuous advancements in intelligent *** wearable and implantable bioelectronics have emerged as an innovative complement to rigid material-based electronic devices[1-3].Due to their distinct advantages in terms of ductile,ultrathin,and biocompatible features,these elastic and soft bioelectronic devices can be seamlessly mounted onto various real or artificial tissues and organs.

关键词： wear mounted pursuit

Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.H.Sy Ho ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide Perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： Pui Kei ko Jonathan E.HALPERT Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(PLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(EL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LEDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

Comparison of commercial silicon-based anode materials for the design of a high-energy lithium-ion battery

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Nano Research 2024年第6期17卷 5270-5277页

作者： Minhong Choi Eunhan Lee Jaekyung Sung Namhyung Kim Minseong ko Division of Convergence Materials Engineering Pukyong National UniversityBusan 48547Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Department of Materials System Engineering Pukyong National UniversityBusan 48547Republic of Korea

Silicon(Si)is considered a potential alternative anode for next-generation Li-ion batteries owing to its high theoretical capacity and ***,the commercial use of Si anodes is hindered by their large volume expansion(~300%).Numerous efforts have been made to address this *** these efforts,Si-graphite co-utilization has attracted attention as a reasonable alternative for high-energy anodes.A comparative study of representative commercial Si-based materials,such as Si nanoparticles,Si suboxides,and Si−Graphite composites(SiGC),was conducted to characterize their overall performance in high-energy lithium-ion battery(LIB)design by incorporating conventional ***-Si was found to exhibit poor electrochemical performance,with severe volume expansion during *** suboxide provided excellent cycling stability in a full-cell evaluation with stable volume variation after 50 cycles,but had a large irreversible capacity and remarkable volume expansion during the first *** displayed a good initial Coulombic efficiency and the lowest volume change in the first cycle owing to the uniformly distributed nano-Si layer on graphite;however,its long-term cycling stability was relatively *** complement each disadvantage of Si suboxide and SiGC,a new combination of these Si-based anodes was suggested and a reasonable improvement in overall battery performance was successfully achieved.

关键词： silicon-based anode high-energy comparison lithium ion battery blended electrode

Tuning the reactivity of TiO_(2)layer with uniform distribution of Sub-5 nm Fe_(2)O_(3)particles via in situ voltage-assisted oxidation for robust catalytic reduction

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Nano Materials Science 2024年第2期6卷 223-234页

作者： Nisa Nashrah Abdelkarim Chaouiki Wail Al Zoubi Young Gun ko Integrated Materials Chemistry Laboratory School of Materials Science and EngineeringYeungnam UniversityGyeongsan38541Republic of Korea

The trade-off between efficiency and stability has limited the application of TiO_(2)as a catalyst due to its poor surface ***,we present a modification of a TiO_(2)layer with highly stable Sub-5 nm Fe_(2)O_(3)nanoparticles(NP)by modulating its structure-surface reactivity relationship to attain efficiency-stability balance via a voltage-assisted oxidation *** situ simultaneous oxidation of the Ti substrate and Fe precursor using high-energy plasma driven by high voltage resulted in uniform distribution of Fe_(2)O_(3)NP embedded within porous TiO_(2)*** surface characterizations with density functional theory demonstrated an improved electronic transition in TiO_(2)due to the presence of surface defects from reactive oxygen species and possible charge transfer from Ti to Fe;it also unexpectedly increased the active site in the TiO_(2)layer due to uncoordinated electrons in Sub-5 nm Fe_(2)O_(3)NP/TiO_(2)catalyst,thereby enhancing the adsorption of chemical functional groups on the *** unique embedded structure exhibited remarkable improvement in reducing 4-nitrophenol to 4-aminophenol,achieving approximately 99%efficiency in 20 min without stability decay after 20 consecutive cycles,outperforming previously reported TiO_(2)-based *** finding proposes a modified-electrochemical strategy enabling facile construction of TiO_(2)with nanoscale oxides extandable to other metal oxide systems.

关键词： Titanium dioxide Oxide nanoparticle Electrochemical oxidation Surface reactivity Efficiency Stability

Remarkable N_(2)-selectivity enhancement of NH_(3)-SCR over HPMo modified MnCo-BTC@SiO_(2) catalyst

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Journal of Environmental Sciences 2024年第4期138卷 482-495页

作者： Songjin ko Xiaolong Tang Fengyu Gao Honghong Yi Hengheng Liu Ning Luo Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Department of Chemistry Pyongyang University of ArchitecturePyongyangDPR of Korea

In this work,the phosphomolybdate(HPMo)modification strategy was applied to improve the N_(2) selectivity of Mn Co-BTC@SiO_(2)catalyst for the selective catalytic reduction of NO_(x),and further,the mechanism of HPMo modification on enhanced catalytic performance was *** Mn Co-BTC@SiO_(2-x) catalysts with different HPMo concentrations,Mn CoBTC@SiO_(2)-0.75 catalyst exhibited not only the highest NH_(3)-SCR performance(95% at 200-300℃)but also the best N_(2)selectivity(exceed 80% at 100-300℃)due to the appropriate redox capacity,greater surface acidity.X-ray photoelectron spectrometer(XPS)and temperature programmed reduction of H_(2)(H_(2)-TPR)results showed that the modification with HPMo reduced the oxidation-reduction performance of the catalyst due to electron transfer from Mo^(5+)to Mn^(4+)/Mn^(3+)and prevent the excessive oxidation of ammonia adsorption ***_(3)temperature-programmed desorption of(NH_(3)-TPD)results showed that the modification with HPMo could significantly improve the surface acidity and NH_(3)adsorption,which enhance the catalytic activity and N_(2)***-situ diffused reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS)revealed that modification with HPMo increased significantly the amount of adsorbed NH_(3)species on the Bronsted acid site and C_(B)/C_(L),it suppressed the production of N_(2)O by inhibiting the production of NH species,the deep dehydrogenation of ammonia adsorption *** study provided a simple design strategy for the catalyst to improve the low-temperature catalytic performance and N_(2)selectivity.

关键词： Metal organic framework(MOF) MnCo-BTC@SiO_(2) NH_(3)-SCR HPMo N_(2)selectivity