检索结果-南通市图书馆

Chinese Chemical Letters 2017年第5期28卷 1114-1118页

作者： Jong-Woon Jung Kongara Damodar jin-kyung Kim Jong-Gab Jun Department of Chemistry and Institute of Applied Chemistry Hallym University Department of Biomedical Science College of Natural ScienceCatholic University of Daegu

A modular and efficient synthesis of the biologically significant C-methylisoflavones isosideroxylin（1）,6,8-dimethylgenistein（2） and their analogues（3-8） is established for the first *** synthesis is realized in 7-8 steps in overall yields of 16%-24%from commercially inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction,Friedel-Crafts acylation,Gammill＇s protocol and Suzuki coupling as the pivotal ***,these compounds evaluated for their inhibitory potency on the production of nitric oxide（NO） in lipopolysaccharide（LPS）-activated RAW-264.7 cells as an indicator of anti-inflammatory *** results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC_（50） values are found in the range of 10.17-33.88 μmol/*** note,compounds 3 followed by 1,7 and 8 show comparable inhibitory activity with positive control（N-monomethyl-L-arginine,L-NMMA）.

关键词： Isosideroxylin 6 8-Dimethylgenistein Vilsmeier-Haack reaction Suzuki coupling Nitric oxide(NO) Anti-inflammatory

Acoustic radiation force impulse elastography for hepatocellular carcinoma-associated radiofrequency ablation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第14期17卷 1874-1878页

作者： Hee-jin Kwon Myong-jin Kang jin-Han Cho Jong-Young Oh kyung-jin Nam Sang-Yeong Han Sung Wook Lee Department of Radiology Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea Department of Internal Medicine Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea

AIM:To evaluate the potential usefulness of acoustic radiation force impulse (ARFI) images for evaluation of hepatocellular carcinomas (HCC)-associated radiofrequency ablation. METHODS:From January 2010 to June 2010,a total of 38 patients with HCC including recurred HCCs after RFA underwent ARFI elastography. The brightness of tumor was checked and the shear wave velocity was measure-d for the-quantification of stiffne-ss. According to theb-rightne-ss,the-tumors we-re-classifie-d as b-righte-r,samecolor and darker compared with adjacent parenchyma. Using the same methods,8 patients with recurred HCCs after RFA state were evaluated about the brightness compared with adjacent RFA ablation area. RESULTS:In the 38 patients with HCCs,20 (52.6%)were brighter than surrounding cirrhotic parenchyma. Another 13 (34.2%) were darker. The others (5 cases,13.2%) were seen as the same color as the adjacent liver parenchyma. Post-RFA lesions were darker than previous tumor and surrounding parenchyma in all 38 cases. However,recurred HCCs were brighter than the treated site in all 8 cases. CONCLUSION:Using ARFI technique is helpful for differential diagnosis in order to detect recurred HCCs more easily in patients with confusing status.

关键词： Hepatocellular carcinoma Elastography Radiofrequency ablation

Negative impact of sedation on esophagogastric junction evaluation during esophagogastroduodenoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第18期20卷 5527-5532页

作者： Eun Soo Kim Ho Young Lee Yoo jin Lee Bo Ram Min Jae Hyuk Choi kyung Sik Park Kwang Bum Cho Byoung Kuk Jang Woo jin chung Jae Seok Hwang Division of Gastroenterology and Hepatology Department of Internal MedicineKeimyung University School of MedicineDaegu 700-712South Korea

AIM: To compare the esophagogastric junction (EGJ) areas observed in sedated and non-sedated patients during esophagogastroduodenoscopy (EGD).

关键词： Esophagogastric junction Endoscopy Esophagus Propofol Midazolam

Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1698-1710页

作者： Young-jin Choi Meiqi Fan Nishala Erandi Wedamulla Yujiao Tang Eun-kyung Kim Department of Food Science and Nutrition Dong-A UniversityBusan 49315Republic of Korea Center for Silver-targeted Biomaterials Brain Busan 21 Plus programDong-A UniversityBusan 49315Republic of Korea Department of Health Sciences the Graduate School of Dong-A UniversityBusan 49315Republic of Korea Division of Food Bioscience College of Biomedical and Health SciencesKonkuk UniversityChungju 27478Republic of Korea Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla 90000Sri Lanka School of Bio-Science and Food Engineering Changchun University of Science and TechnologyChangchun 130600China Nutritional Education Major Graduate School of EducationDong-A UniversityBusan 49315Republic of Korea Nutrinomics Lab.Co. Ltd.Busan 49315Republic of Korea

We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and *** was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were *** effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP *** IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also *** metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent *** also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 *** BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing ***,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

关键词： Isoquercetin Benign prostatic hyperplasia Androgen receptor signaling PI3K/Akt/mtor pathway

An update on the regulatory mechanisms of NLRP3 inflammasome activation

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第5期18卷 1141-1160页

作者： Seungwha Paik jin kyung Kim Prashanta Silwal Chihiro Sasakawa Eun-Kyeong Jo Department of Microbiology Chungnam National University School of MedicineDaejeonKorea Infection Control Convergence Research Center Chungnam National University School of MedicineDaejeonKorea

The NOD-,LRR-,and pyrin domain-containing protein 3(NLRP3)inflammasome is a multiprotein complex involved in the release of mature interleukin-1βand triggering of pyroptosis,which is of paramount importance in a variety of physiological and pathological *** the past decade,considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing(Signal 1)and assembly(Signal 2)involved in NLRP3 inflammasome ***,a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational *** this review,we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions,posttranslational modifications,and spatiotemporal regulation of the NLRP3 inflammasome *** also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly.A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

关键词： NLRP3 inflammasome inflammation mechanism interaction

Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第2期10卷 223-226页

作者： Sang Kil Lee Yong Chan Lee Jae Bock chung Chae Yoon Chon Young Myoung Moon jin kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Department of Internal Medicine NHIC Ilsan HospitalIlsanSouth Korea Department of Radiation Oncology Yonsei University College of MedicineSeoulSouth Korea Department of Pathology Yonsei University College of MedicineSeoulSouth Korea

AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed. RESULTS:Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (Hpylori) regimen *** duration to reach complete remission was 12 months (85 percentile,2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases. CONCLUSION:Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloriinfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication.

关键词： Adult Aged Endoscopy, Digestive System Follow-Up Studies Gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Lymphoma, Mucosa-Associated Lymphoid Tissue Middle Aged Pyloric Antrum Remission Induction Retrospective Studies Stomach Ulcer

Effects of oxygen concentration and flow rate on cognitive ability and physiological responses in the elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第3期8卷 264-269页

作者： Hyun-Jun Kim Hyun-kyung Park Dae-Woon Lim Mi-Hyun Choi Hyun-Joo Kim In-Hwa Lee Hyung-Sik Kim jin-Seung Choi Gye-Rae Tack Soon-Cheol chung Department of Obstetrics & Gynecology Konkuk University Department of Laboratory Medicine Seoul Clinical Laboratories Department of Information & Communication Engineering Dongguk University Department of Biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University

The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.

关键词： neural regeneration clinical practice highly concentrated oxygen cognitive task 1-back task cognitive ability blood oxygen saturation heart rate physiological responses elderly grant-supported paper neuroregeneration

Empirical Analysis of Agricultural Cultural Resources Value Evaluation under DEA Model

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第11期65卷 1411-1424页

作者： Wei Liang Yang Ni Tingyi Li Xuejiao Lin Soo-jin chung Division of Business Administration Wonkwang UniversityIksan-si54538Korea Shandong Agriculture and Engineering University Jinan250100China Weinan Normal University Weinan714099China

Agricultural culture is a productive activity about education and *** aims at high efficiency and high quality,uses technology as its means,and takes nature as its *** cultural resources are the product of the rapid development of modern *** promotes the development of the national economy and profoundly affects people's production and *** model,also known as data envelope analysis method,is an algorithm that uses multiple data decision units for input and output training to obtain the final *** article explains the concept and basic characteristics of agricultural *** questionnaire surveys and expert interviews,we collected development data,screened human,material,and financial data,and calculated information on economic and social *** this basis,this paper establishes the evaluation index of agricultural culture based on DEA ***,through empirical analysis from a specific perspective,it can be concluded that increasing human,material and financial input can achieve economic and social *** speaking,cultural investment can promote the development of the *** research results of this paper laid a theoretical foundation for the development of agricultural culture,and put forward a development model focusing on technology development,improving investment efficiency,and investing in material resources.

关键词： Agricultural culture DEA model empirical analysis development model

Comparison Study and Forensic Analysis between Experiment and Coupled Dynamics Simulation for Submerged Floating Tunnel Segment with Free Ends under Wave Excitations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第10期137卷 155-174页

作者： Woo Chul chung chungkuk jin Moo Hyun Kim Ju-young Hwang Division of Mechanical Engineering Korea Maritime&Ocean UniversityBusanSouth Korea Department of Ocean Engineering and Marine Sciences Florida Institute of TechnologyMelbourneFLUSA Department of Ocean Engineering Texas A&M UniversityCollege StationTXUSA Department of Civil Engineering Dong-Eui UniversityBusanSouth Korea

This paper presents dynamic-behavior comparisons and related forensic analyses of a submerged floating tunnel(SFT)between numerical simulation and physical experiment under regular and irregular *** experiments are conducted in the 3Dwave tank with 1:33.3 scale,and the corresponding coupled time-domain simulation tool is devised for *** entire SFT systemconsists of a long concrete tunnel and 12 tubular aluminummooring *** numerical simulation models,the Cummins equation with 3D potential theory including second-order wave-body interaction effects and the much simpler Morison-equation-based formula with the lumped-massbased line model,are designed and *** analyses for mooring-line adjustments in the simulation are carried out in view of the best representation of the physical *** that,the measured pre-tension distribution and systemstiffness of twelvemooring lines arewell reproduced in the ***,the dynamic responses and mooring tensions of the SFT are compared under regular and irregular *** measured and simulated results coincide reasonably well for both regular-and irregular-wave conditions.

关键词： Submerged floating tunnel comparative study forensic analysis mooring-line modeling dynamic response mooring tension

Actinomycosis of the appendix mimicking appendiceal tumor:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第3期16卷 395-397页

作者： Sang-Yun Lee Hee-jin Kwon jin-Han Cho Jong-Young Oh kyung-jin Nam jin-Hwa Lee Seong-Kuk Yoon Myong-jin Kang jin-Sook Jeong Department of Radiology Dong-A University Hospital Department of Pathology Dong-A University Hospital

Actinomycosis is an uncommon chronic infectious disease. Common sites of involvement include the cervicofacial, thoracic and abdominopelvic regions. In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site. In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis. We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration. Here, we report the computed tomography and ultrasound findings.

关键词： Actinomyces Actinomycosis Appendiceal neoplasms Appendicitis