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Barrett’s esophagus:Review of natural history and comparative efficacy of endoscopic and surgical therapies

World Journal of Gastrointestinal Oncology 2022年第3期14卷 568-586页

作者： Kevin kyung ho choi Santosh Sanagapalli AW Morrow Gastroenterology Liver Centre Royal Prince Alfred HospitalSydney 2050NSWAustralia Department of Gastroenterology St Vincent’s HospitalDarlinghurst 2010NSWAustralia

Barrett's esophagus(BE)is the precursor to esophageal adenocarcinoma(EAC).Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately,invasive *** EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival *** guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier,and potentially curative *** last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy(EET)for management of dysplastic and early neoplastic BE,and there have been substantial changes to international consensus guidelines for management of early BE based on evolving *** review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage,and the effectiveness of interventions in attenuating the risk posed by its natural *** findings were as ***-dysplastic Barrett’s is associated with extremely low risk of progression,and interventions cannot be *** annual risk of cancer progression in low grade dysplasia is between 1%-3%;EET can be offered though evidence for its benefit remains confined to highly select ***-grade dysplasia progresses to cancer in 5%-10%per year;EET is similarly effective to and less morbid than surgery and should be routinely performed for this *** of nodal metastases in intramucosal cancer is 2%-4%,which is comparable to operative mortality rate,so EET is usually *** cancer is associated with nodal metastases in 14%-41%hence surgery remains standard of care,except for select situations.

关键词： Barrett’s esophagus Endoscopic eradication therapy Dysplasia Adenocarcinoma Natural history Radiofrequency ablation

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The study of stabilizing low-viscous W/O emulsion using Cell-trap technology

The study of stabilizing low-viscous W/O emulsion using Cell...

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第九届中国化妆品学术研讨会

作者： kyung Nam Kim Ha Jin Jung kyung ho choi Min kyung Shim Yeong Jin choi Hak-Hee Kang Cosmetics & Personal Care Research Institute Amore-Pacific Corporation R&D Center

The purpose of this study is to stabilize the low-viscous W/O emulsion. In previous studies, it is known that the stability of low-viscous emulsion can be enhanced by the contents of emulsifiers and dispersants. We developed a new method of stabilizing low-viscous W/O emulsion by impregnating the low-viscous W/O emulsion into polyurethane foam. Since this method impregnates emulsion contents into the sponge in a uniform manner with good stability, we named it the ‘cell-trap technology’. The stability of emulsion was influenced by the pore size, type, elasticity, thickness of the sponge, as well as the amount of emulsifiers and dispersants. Based on the result, the optimized formulation was established. We applied the technology to a new product called ‘the liquid sun pact’. The long lasting effect of this new product was also researched in various aspects. The long-lasting property was influenced by the type, amount of polymer, and also the type of powder used in the formulation. We developed a sweat-proof complex which is a combination of three kinds of polymers with an excellent long-lasting property. The in-vivo and in-vitro efficacy was also investigated. In result, even in extreme dry and hot sauna condition, we could obtain an excellent make-up lasting effect. This study is expected to contribute to the enhancement of both emulsion stability and long-lasting effect of W/O make-up cosmetics.

关键词： W/O emulsion Make-up Cell-trap technology Sweat-proof

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Color development of BB cream for Chinese women

Color development of BB cream for Chinese women

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第九届中国化妆品学术研讨会

作者： Hye Jeon Cho Jeong Cheol Ha kyung Nam Kim kyung ho choi Yeong Jin choi Chu Li Ling Wang hong Xia Amorepacific corporation R&D Center

It is required to understand the skin color in developing makeup cosmetics. In this study, we aimed to develop the customized BB cream color for Chinese women by understanding their skin color and color preference. It is known that Chinese women have light yellow color, and yellowness and darkening induced by age are evident for the Chinese women. Based on previous studies, we developed two colors and evaluated color preference. The result was that Chinese women preferred pinkish color to yellowish color. We applied this result to BB cream and proposed Chinese customized color. This study demonstrates that the sensuous and rational approach for satisfying color needs and expectations is beneficial in developing makeup cosmetics.

关键词： BB Cream makeup color Chinese women Skin color

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Comparison of Adsorption Isotherms of Methylxanthines on C_(18) Column

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Chemical Research in Chinese Universities 2010年第5期26卷 729-734页

作者： BI Wen-tao choi Dae Ki ROW kyung ho Department of Chemical Engineering Inha University lncheon 402-751 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

A comparison of the adsorption isotherms of caffeine, theophylline and theobromine and the competitive adsorption of the three compounds on a C18 column were investigated. The experimental parameters of the equilibrium isotherms were estimated by linear and nonlinear regression analyses. The linear equation as a function of the adsorption concentration of the single compound in its solution and the competitive adsorption of a single compound in a mixed solution were then determined. The adsorption equilibrium data were then correlated to the linear, Langmuir, Freundlich, Langmuir-Freundlich and stoichiometric displacement theory for adsorption（SDT-A） isotherm models. The mixed compounds of the three compounds were competitively adsorbed on the C18 particles. The expression of stoichiometric displacement theory for adsorption was found to be more suitable for adsorption of methylxanthines on a C18 column.

关键词： Adsorption isotherm Methylxanthine High-performance liquid chromatography

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Effect of Ionic Liquid on Retention of Solutes on C_(18) Column Based on Linear Solvation Energy Relationships

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Chemical Research in Chinese Universities 2009年第3期25卷 306-311页

作者： ROW kyung ho Center for Advanced Bio Technology Department of Chemical Engineering Inha University

Several chromatography systems with ionic liquids and a mixture of water with the modifier as mobile phase were characterized via the linear solvation energy relationships（LSER） model. The effects of the ionic liquids and modifier（methanol） concentrations on the retention of 10 solutes（caffeine, pyridine, aniline, phenol, methylparaben, acetopenone, m-cresol, p-cresol, o-cresol, and benzene） were discussed. The LSER model demonstrated high potential to predict retention factors with high squared correlation coefficients（r^2〉 0.97）. A comparison of predictable and experimental retention factors revealed that LSER can adequately reproduce the experimental retention factors of the solutes under different investigated experimental conditions. This model is a helpful tool to evaluate the retention characteristics of ionic liquid systems and to understand the interactions of solutes and ionic liquids.

关键词： Ionic liquid Linear solvation energy relationships Retention Modifier

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Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells

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The Journal of Biomedical Research 2017年第4期31卷 358-369页

作者： Ji-Youn Kim ho-Gyu choi Hae-Miru Lee Geum-A Lee kyung-A Hwang kyung-Chul choi Laboratory of Biochemistry and Immunology Veterinary Medical Center and College of Veterinary Medicine ChungbukNational University Cheongju Chungbuk 28644 Republic of Korea

Bisphenol-A（BPA） has been considered as an endocrine disrupting chemical（EDC） because it can exert estrogenic *** bisphenol-S（BPS） and bisphenol-F（BPF） that are BPA analogs and substitutes,their risk to estrogendependent cancer has been reported rarely compared with the numerous cases of *** this study,we examined whether BPA,BPS,and BPF can lead to the proliferation,migration,and epithelial mesenchymal transition（EMT） of MCF-7 clonal variant（MCF-7 CV） breast cancer cells expressing estrogen receptors（ERs）.In a cell viability assay,BPA,BPS,and BPF significantly increased proliferation of MCF-7 CV cells compared to control（DMSO） as did17β-estradiol（E2）.In Western blotting assay,BPA,BPS,and BPF enhanced the protein expression of cell cycle progression genes such as cyclin D1 and *** addition,MCF-7 CV cells lost cell to cell contacts and acquired fibroblast-like morphology by the treatment of BPA,BPS,or BPF for 24 *** cell migration assay,BPA,BPS,and BPF accelerated the migration capability of MCF-7 CV cells as did *** relation with the EMT process,BPA,BPS,and BPF increased the protein expression of N-cadherin,while they decreased the protein expression of *** BPA,BPS,and BPF were co-treated with ICI 182,780,an ER antagonist,proliferation effects were reversed,the expression of cyclin D1 and cyclin E1 was downregulated,and the altered cell migration and expression of N-cadherin and E-cadherin by BPA,BPS,and BPF were restored to the control ***,these results imply that BPS and BPF also have the risk of breast cancer progression as much as BPA in the induction of proliferation and migration of MCF-7 CV cells by regulating the protein expression of cell cycle-related genes and EMT markers via the ER-dependent pathway.

关键词： human breast cancer cells endocrine disrupting chemicals bisphenol-A bisphenol-S bisphenol-F epithelial-mesenchymal transition migration

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Adsorption Isotherms of Quercetin and Catechin Compounds on Quercetin-MIP

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Chemical Research in Chinese Universities 2007年第4期23卷 412-416页

作者： ROW kyung ho Center for Advanced Bioseparation Technology and Department of Chemical Engineering Inha University253 Yonghyun-DongNam-KuIncheon 402-751Korea

A molecular imprinted polymer（MIP） was prepared with quereetin as the template and methaerylie acid（MAA） as the functional monomer. Aeetonitrile and methanol were used as the porogen with ethylene glycol dimethaerylate （EGDMA） as the erosslinker and 2,2＇-azobis （ isobutyronitrile ）（ AIBN ） as the initiator. The experimental parameters of the equilibrium isotherms were estimated via linear and nonlinear regression analyses. The linear equadon as the functions of the adsorption concentration of the single compound in its solution and the competitive adsorption of the single compound in its mixed compounds solution was then expressed, and the adsorption equilibrium data were correlated to Langmuir and Freundlich isotherm models. The mixture compounds show competitive adsorption on the specific binding sites of quereetin-MIP. Furthermore, the competitive Langmnir isotherms were applied to the mixture compounds. The adsorption concentrations of quercetin, （＋）eatechin（＋C）, and （-）epieateehin（EC） on the quercetin molecular imprinted polymer were compared. The quercetin-imprinted polymer shows extraordinarily higher adsorption ability for quercetin than for the two eateehin compounds that were also assessed.

关键词： Adsorption isotherm Molecular imprinted polymer Quercetin (+) Catechin (-) Epicatechin

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Evaluation of Retention Factors for Nine Solutes with Ionic Liquid Additives via Linear Solvation Energy Relationships

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Chemical Research in Chinese Universities 2010年第4期26卷 532-536页

作者： ROW kyung-ho Department of Chemical Engineering Inha University

A linear solvation energy relationships（LSERs） model was used to examine the fundamental chemical interactions governing the retention of 9 organic compounds on a C18 column by means of reversed-phase high performance liquid cbromatography（RP-HPLC）. Three ionic liquids, 1-hexyl-3-methylimidazolium tetrafluoroborate （[Hmin][BF4]）, 1-butyl-3-methylimidazolium tetrafluoroborate（[Bmin][BF4]） and 1-octyl-3-methylimidazolium tetrafluoroborate（[OMIm][BF4]） as additives, were added to a methanol-water mobile phase. The effects of these three ionic liquids additives on the retention of nine organic compounds were investigated, and a comparison between the predicted and experimental retention factors was made via the LSERs model, which indicated that the LSERs model could be used to reproduce the experimental retention factors of the solutes under different mobile phase conditions. It is also a useful tool for modeling the interactions of the solutes between the stationary and mobile phases and evaluating the retention characteristics of HPLC.

关键词： Retention factor Ionic liquid Additive Mobile phase Model

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Immunosuppressant treatment for IgG4-related sclerosing cholangitis: A case report

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World Journal of Clinical Cases 2021年第1期9卷 267-273页

作者： Jong-Sun Kim Won ho choi kyung-Ann Lee Hyun-Sook Kim Department of Internal Medicine Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a multi-system fibroinflammatory disorder that can involve any organ,including the salivary glands,pancreas,and biliary *** of immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)is similar to that for IgG4-RD,but progression is irreversible in some *** present a case of IgG4-SC in which an immuno-suppressant induced marked clinical and radiologic *** SUMMARY A 63-year-old male presented with a prominent itching sensation and wholebody *** showed obstructive-pattern jaundice,an elevated IgG4 level,and infiltration of a large number of IgG4-positive cells in the ampulla of *** imaging findings of intrahepatic duct(IHD)and common bile duct dilation,an elevated serum IgG4 level,and characteristic histological findings led to diagnosis of IgG4-SC that compatible with the 2019 ACR/EULAR classification *** planned to treat the patient with high-dose glucocorticoid(GC),followed by cyclophosphamide pulse *** treatment with high-dose GC and an immunosuppressant,imaging studies showed that IHD dilatation had completely *** Prompt diagnosis and appropriate treatment of IgG4-SC are *** there is a risk of relapse of IgG4-SC,the GC dose should be gradually reduced,and a maintenance immunosuppressant should be given.

关键词： Immunoglobulin G4-related disease Immunoglobulin G4-related sclerosing cholangitis Glucocorticoid Immunosuppressant Case report ACR/EULAR classification criteria

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