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Electrochemically metal-doped reduced graphene oxide films:Properties and applications

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Journal of Materials Science & Technology 2020年第5期40卷 72-80页

作者： Myung-Sic.chae Tae Ho Lee kyung Rock Son Tae Hoon Park Kyo Seon Hwang Tae Geun Kim School of Electrical Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Department of clinical Pharmacology and Therapeutics College of MedicineKyung Hee UniversitySeoul 02447South Korea

The fine control of doping levels in graphene materials such as reduced graphene oxide(RGO)is important to properly manipulate their ambipolar transport characteristics for various device ***,conventional doping methods involve complex chemical reactions,large-scale doping processes,and poor ***,a simple and controllable electrochemical doping treatment(EDT),performed via the conductive channels created at the RGO surface by the application of an electric field,is introduced to tailor the electrical properties of RGO films.X-ray photoelectron spectroscopy and Raman spectroscopy measurements are performed to detect the presence of Ni atoms in RGO films after the EDT(EDT-RGO).Then,EDT-RGO field-effect transistors(FETs)are fabricated with different doping areas(0 to 100%fractional area)on the RGO active channel to investigate the effect and selective-area doping capability of the *** to p-type doping compensation by the intercalated Ni atoms,the electron mobility of the EDT-RGO FET decreases from 1.40 to 0.12 cm2 V-1s-1 compared with that of the undoped RGO-FET,leading to the conversion from ambipolar to unipolar p-type transfer characteristics.

关键词： Reduced graphene oxide Electrochemical doping treatment Electrical breakdown process Field-effect transistor

Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East china Sea and Yellow Sea

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Acta Oceanologica Sinica 2015年第12期34卷 19-28页

作者： JUN Ki cheon JEONG Weon Mu cHOI Jin Yong PARK Kwang Soon JUNG kyung Tae KIM Mee kyung chae Jang Won QIAO Fangli coastal Disaster Research center Korea Institute of Ocean Science and Technology coastal & Environmental Engineering Division Korea Institute of Ocean Science and Technology Marine Radionuclide Research center Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

Record-breaking high waves occurred during the passage of the typhoon Bolaven（1215）（TYB） in the East china Sea（EcS） and Yellow Sea（YS） although its intensity did not reach the level of a super *** and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and *** order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical *** winds were generated using the Tc96 typhoon wind model with the best track data calibrated with the *** then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave *** fields were simulated using WAM4.5 with adjustment of c_d for gust of winds and bottom friction for the study *** the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than *** is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon *** the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction.

关键词： extreme waves typhoon measurements numerical simulation East china Sea

Improvement of machining quality of copper-plated roll mold by controlling temperature variation

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Transactions of Nonferrous Metals Society of china 2011年第A01期21卷 37-41页

作者： Tae-Jin JE Eun-chae JEON Sang-cheon PARK Doo-Sun cHOI kyung-Hyun WHANG Myung-chang KANG Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Daejeon 305-343 Korea National core Research center for Hybrid Materials Solution Pusan National University

Micro prism film used in LcD industry can be manufactured by roll to roll method with copper-plated roll mold. As copper-plated roll mold is getting larger, pitch error is getting severer. The pitch error drops the quality of micro prism film. The main cause of the pitch error was investigated during machining large roll mold whose machined length was 1 200 mm. The temperature of machining system was elevated during machining roll mold, and this elevation induced thermal expansion of the system. The temperature variation around the roll mold also made thermal expansion of the roll mold. The amount of thermal expansion had strong relationship to the amount of pitch error. Therefore, the roll mold was machined after warming-up of machining system and precise temperature controller around copper-plated roll mold was installed, which minimized the temperature variation. Finally, precise micro prism patterns without pitch error were machined on the large roll mold.

关键词： copper-plated roll mold machining prism pattern temperature variation

Effects of Bacillus subtilis cSL2 on the composition and functional diversity of the faecal microbiota of broiler chickens challenged with Salmonella Gallinarum

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Journal of Animal Science and Biotechnology 2017年第2期8卷 450-458页

作者： Ju Kyoung Oh Edward Alain B.Pajarillo Jong Pyo chae In Ho Kim Dong Soo Yang Dae-kyung Kang Department of Animal Resources Science Dankook University119 Dandae-roCheonan 31116Republic of Korea Abson Biochem Inc10-1 Yangjimaeul-gilSangrok-guAnsan 15524Republic of Korea

Background： The chicken gastrointestinal tract contains a diverse microbiota whose composition and structure play important roles in gut functionality. In this study, microbial shifts resulting from feed supplementation with Bacillus subtilis cSL2 were evaluated in broilers challenged and unchallenged with Salmonella Gallinarum. To analyse bacterial community composition and functionality, 454 GS-FLX pyrosequencing of 16 S r RNA gene amplicons was ***： The Quantitative Insights into Microbial Ecology（QIIME） pipeline was used to analyse changes in the faecal microbiota over a 24-h period. A total of 718,204 sequences from broiler chickens were recorded and analysed. At the phylum level, Firmicutes, Bacteroidetes, and Proteobacteria were the predominant bacterial taxa. In Salmonellainfected chickens（Sc）, Bacteroidetes were more highly abundant compared to control（Nc） and Bacillus-treated（BT）chickens. At the genus level, in the Nc and BT groups, Lactobacil us was present at high abundance, and the abundance of Turicibacter, unclassified Enterobacteriaceae, and Bacteroides increased in Sc broilers. Furthermore, taxon-independent analysis showed that the Sc and BT groups were compositional y distinct at the end of the 24-h period. Further analysis of functional properties showed that B. subtilis cSL2 administration increased gut-associated energy supply mechanisms（i.e. carbohydrate transport and metabolism） to maintain a stable microbiota and protect gut ***： This study demonstrated that S. Gallinarum infection and B. subtilis cSL2 supplementation in the diet of broiler chickens influenced the diversity, composition, and functional diversity of the faecal microbiota. Moreover, the findings offer significant insights to understand potential mechanisms of Salmonel a infection and the mode of action of probiotics in broiler chickens.

关键词： Bacillus subtilis Broiler chicken Microbiome Salmonel a Gallinarum 16S rRNA gene

Electric resistivity of partially ionized plasma in the lower solar atmosphere

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Research in Astronomy and Astrophysics 2021年第9期21卷 193-201页

作者： Jongchul chae Yuri ELitvinenko Astronomy Program Department of Physics and AstronomySeoul National UniversitySeoul 08826Korea Department of Mathematics University of WaikatoP.B.3105Hamilton 3240New Zealand

The lower solar atmosphere is a gravitationally stratified layer of partially ionized *** calculate the electric resistivity in the solar photosphere and chromosphere,which is the key parameter that controls the rate of magnetic reconnection in a Sweet-Parker current *** calculation takes into account the collisions between ions and hydrogen atoms as well as the electron-ion collisions and the electron-hydrogen atom *** find that under the typical conditions of the quiet Sun,electric resistivity is determined mostly by the electron-hydrogen atom collisions in the photosphere,and mostly by the ion-hydrogen collisions,*** diffusion,in the *** magnetic reconnection events with strong magnetic fields,the ambipolar diffusion,however,may be insignificant because the heating by the reconnection itself may lead to the full ionization of hydrogen *** conclude that ambipolar diffusion may be the most important source of electric resistivity responsible for the magnetic flux cancelation and energy release in chromospheric current sheets that can keep a significant fraction of neutral hydrogen atoms.

关键词： plasmas atomic processes magnetohydrodynamics(MHD) Sun:atmosphere Sun:chromosphere

corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat

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World Journal of Gastroenterology 2017年第21期23卷 3825-3831页

作者： kyung-Jo Kim Ki Bae Kim Soon Man Yoon Joung-Ho Han Hee Bok chae Seon Mee Park Sei Jin Youn Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine Chungbuk National University College of Medicine

AIM To measure exogenous corticotropin-releasing factor(cRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on cRF-induced motility. METHODS The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous cRF was administered in a stepwise manner and the concentration of cRF yielding maximal colonic motility was selected. After recording basal colonic motility, hexamethonium, phentolamine, propranolol, atropine and tetrodotoxin were infused into the isolated colon. Initially, only the test drug was infused; then, cRF was added. The motility index was expressed as percentage change over basal level. RESULTS Administration of 1.4, 14.4, 144 and 288 pmol/L cRF progressively increased colonic motility in the proximal and distal colon. Infusion of atropine or tetrodotoxin reduced cRF-induced motility of both the proximal and distal colon, whereas hexamethonium, phentolamine and propranolol had no *** cRF-induced colonic motility appears to be mediated by local cholinergic signaling via muscarinic receptors. Muscarinic receptors are potential targets for counteracting cRF-induced colonic hypermotility.

关键词： Gastrointestinal motility Rats Stress colon corticotropin-releasing factor

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与Ⅱ型猪圆环病毒相关的综合征和疾病

国外畜牧学（猪与禽） 2005年第6期25卷 42-48页

作者： c.chae 李春华魏晓锋韩国首尔国立大学兽医学院和农业生物技术学院兽医病理系

Ⅱ型猪圆环病毒(PcV-2)对猪的感染可导致临床表现不同的多种综合征和疾病,如仔猪断奶后多系统消耗性综合征(PMWS)、猪皮炎和肾病综合征(PDNS)、繁殖障碍、猪呼吸道疾病复合症(PRDc)、肉芽肿性肠炎、坏死性淋巴结炎,还可能渗出性表皮炎... 详细信息

Ⅱ型猪圆环病毒(PcV-2)对猪的感染可导致临床表现不同的多种综合征和疾病,如仔猪断奶后多系统消耗性综合征(PMWS)、猪皮炎和肾病综合征(PDNS)、繁殖障碍、猪呼吸道疾病复合症(PRDc)、肉芽肿性肠炎、坏死性淋巴结炎,还可能渗出性表皮炎相关。仔猪的先天性震颤是否与PcV-2相关仍存在争议。除了PMWS之外,PcV-2在猪病中的涉及程度目前知之甚少。本综述着重介绍除PMWS以外的与PcV-2相关的综合征和疾病。

关键词：断奶后多系统消耗性综合征猪呼吸道疾病复合症 Ⅱ型猪圆环病毒 PcV-2 PMWS 肾病综合征先天性震颤临床表现繁殖障碍肉芽肿

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-kyung So Hyebeen Kim Jinwoo Lee chang-Lim You chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single cell Network Research center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Je-chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung chae,kyung-mi PARK,Geun-youn LEE,Gi-seup JEONG,Hyung-rae PARK,Hyung-min KIM,Soo-wan chae,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of cardiovascular Research School of Medicine chonbuk National University Jeonju chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan chonbuk 570-749 South Korea Department of Pharmacology college of Oriental Medicine kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of cardiovascular Research School of Medicine chonbuk National University Jeonju chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-chun-Jun (JcJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, Ac-DEVD-AMc (caspase-3), Ac-VEID-AMc (caspase-8) or Ac-LEHD-AFc (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JcJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JcJ. cells treated with 10 g/L JcJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells