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In situ observation of atomic movement in a ferroelectric film under an external electric field and stress

Nano Research 2018年第7期11卷 3824-3832页

作者： Hyeon Jun lee Er-Jia Guo Taewon Min seung Hyun Hwang Su Yong lee Kathrin Dorr Jaekwang lee Ji Young Jo School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea Quantum Condensed Matter Division Oak Ridge National Laboratory Oak Ridge TN 37830 USA Institute for Physics Martin-Luther-University Halle-Wittenberg Halle 06099 Germany Department of Physics Pusan National University Busan 46241 Republic of Korea Pohang AccelerotorLaboratory Pohang 37673 Republic of Korea

Atomic movement under application of external stimuli （i.e., electric field or mechanical stress） in oxide materials has not been observed due to a lack of experimental methods but has been well known to determine the electric polarization. Here, we investigated atomic movement arising from the ferroelectric response of BiFeO3 thin films under the effect of an electric field and stress in real time using a combination of switching spectroscop）6 time-resolved X-ray microdiffraction, and in situ stress engineering. Under an electric field applied to a BiFeO3 film, the hysteresis loop of the reflected X-ray intensity was found to result from the opposing directions of displaced atoms between the up and down polarization states. An additional shift of atoms arising from the linearly increased dielectric component of the polarization in BiFeO3 was confirmed through gradual reduction of the diffracted X-ray intensity. The electric-field- induced displacement of oxygen atoms was found to be larger than that of Fe atom for both ferroelectric switching and increase of the polarization. The effect of external stress on the BiFeO3 thin film, which was controlled by applying an electric field to the highly piezoelectric substrate, showed smaller atomic shifts than for the case of applying an electric field to the film, despite the similar tetragonality.

关键词： in situ measurement atomic displacementunder electric field time-resolved X-ray microdiffraction ferroelectrics in situ strain engineering

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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

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Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu lee Bong-Ki Hong Saseong lee Naeun lee seung-Whan Kim Donghyun Kim Wan-Uk Kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

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Long-term performance of fiber-grid-reinforced asphalt overlay pavements: A case study of Korean national highways

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 366-382页

作者： Jong-Hoon lee seung-Beom Baek Kang-Hoon lee Jo-Soon Kim Jin-Hoon Jeong Department of Civil Engineering Inha UniversityIncheon 22212South Korea Civil&Environmental BG Doosan Engineering&ConstructionSeoul 06057South Korea Department of Infrastructure Safety Research Korea Institute of Civil Engineering and Building TechnologyGoyang-si 10223South Korea SN Construction Co. LtdDaejeon 34573South Korea

The objective of this study was to verify the effect of fiber grid reinforcement on the longterm performance of asphalt overlay pavements by performing field investigation, laboratory test, and finite element analysis. Crack, rutting, roughness, and other miscellaneous distresses of fiber-grid-reinforced overlay sections and ordinary overlay sections were compared. Pavement conditions of fiber grid overlay sections before and after the overlay were also compared. Cores were obtained from the fiber-grid-reinforced and ordinary sections to measure bonding shear strength between the intermediate and overlay *** energy, displacement after yield, and shear stiffness of the cores were also obtained by analyzing the test results. Finite element analysis was performed by using the test results to validate the effect of the fiber grid reinforcement on the long-term performance of asphalt overlay pavements. Rutting and fatigue cracking were predicted for three cases: 1) fiber grid was not used;2) glass fiber grid was used;and 3) carbon fiber grid was used. The cracking ratio of fiber-grid-reinforced sections was much smaller than that of ordinary sections. The results of field investigation, laboratory test, and finite element analysis showed that the fiber grid reinforcement improved the long-term performance of asphalt overlay pavements.

关键词： Asphalt pavement Fiber grid reinforcement Overlay pavement Finite element analysis Bonding shear strength

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Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： seung Soo Yoo Shin Yup lee Sun Ha Choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** SUMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report

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Immunostimulating activities and anti-cancer efficacy of rhamnogalacturonan-I rich polysaccharide purified from Panax ginseng leaf

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Food Bioscience 2023年第3期53卷 1218-1227页

作者： seung-U Son Hee Won lee Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

This study aimed to evaluate the anti-cancer effects as well as stimulation of various immune related factors such as complementary system,macrophages,and NK cells of polysaccharides isolated from Panax ginseng(***)*** polysaccharide fractions(PGEP,PGEP-I,-II,and-III)isolated from *** were contained rhamnose(Rha),arabinose(Ara),galactose(Gal),galacturonic acid(GalA),and glucuronic acid(GlcA),all of which are typical sugar components of rhamnogalacturonan(RG)-*** PGEP-I reacted with theβ-glucosyl Yariv reagent(37.29%),indicating the presence of type-II ***,methylation analysis indicated the PGEP-I mainly comprised 19 different sugar linkages including 4-linked GalpA,2,4-linked Rhap,3,6-linked Galp,5-linked Araf,terminal GlcpA,and terminal Arap which are characteristics of ***,PGEP-I enhanced the production of cytokines such as interleukin(IL)-6,IL-12,and tumor necrosis factor-αand augmented the complement *** intravenous administration of PGEP-I activated the natural killer(NK)cells in a dose-dependent manner against *** intravenous administration of PGEP-I significantly suppressed Colon26-M3.1 carcinoma inoculation-induced lung cancer(48.7%).Moreover,the anti-cancer effects of PGEP-I were significant even though NK cell functions were blocked by anti-asialo *** findings suggest that PGEP-I,an RG-I polysaccharide,not only activates the complement system,macrophages and NK cells,but also has strong anticancer effects that inhibit lung cancer.

关键词： Immune system Panax ginseng Rhamnogalacturonan-I

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Semantics-oriented approach for information interoperability and governance:towards user-centric enterprise architecture management

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第4期11卷 227-240页

作者： Imran GHANI Choon Yeul lee Sung Hyun JUHN seung Ryul JEONG School of Business IT Kookmin University

Enterprise architecture (EA) efforts focus on business, technology, data, and application architecture, and their integration. However, less attention has been given to one of the most critical EA elements, i.e., users (EA audiences). As a result, existing EA management systems (EAMS) have become old, large, content-centric document-repositories that are unable to provide meaningful information of use to the enterprise users and aligned with their needs and functional scope. We argue that a semantic technology based mechanism focusing on enterprise information and user-centricity has the potential to solve this problem. In this context, we present a novel ontology-based strategy named the user-centric semantics-oriented EA (U-SEA) model. Based on this model, we have developed a user-centric semantics-oriented enterprise architecture management (U-SEAM) system. Our approach is generic enough to be used in a wide variety of user-centric EAM applications. The results obtained show computational feasibility to integrate and govern enterprise information and to reduce complexity with respect to interoperability between enterprise information and users.

关键词： Enterprise architecture management system (EAMS) Ontology Recommender system User-centric Semantic Web Framework

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CrysXPP:An explainable property predictor for crystalline materials

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npj Computational Materials 2022年第1期8卷 424-434页

作者： Kishalay Das Bidisha Samanta Pawan Goyal seung-Cheol lee Satadeep Bhattacharjee Niloy Ganguly Indian Institute of Technology Kharagpur KharagpurIndia Indo Korea Science and Technology Center BangaloreIndia Leibniz University of Hannover HannoverGermany

We present a deep-learning framework,CrysXPP,to allow rapid and accurate prediction of electronic,magnetic,and elastic properties of a wide range of *** lowers the need for large property tagged datasets by intelligently designing an autoencoder,*** important structural and chemical properties captured by CrysAE from a large amount of available crystal graphs data helped in achieving low prediction ***,we design a feature selector that helps to interpret the model’s *** notably,when given a small amount of experimental data,CrysXPP is consistently able to outperform conventional DFT.A detailed ablation study establishes the importance of different design *** release the large pre-trained model *** believe by fine-tuning the model with a small amount of property-tagged data,researchers can achieve superior performance on various applications with a restricted data source.

关键词： materials. property crystalline

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Journal of Central South University 2014年第9期21卷 3534-3540页

作者： lee Sang-hyuk YAN Sun JEONG Yoon-su SHIN seung-soo Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University International Business School Suzhou Xi'an Jiaotong-Liverpool University Department of Information Communication Engineering Mokwon University Department of Information Security Tongmyong University

Information analysis of high dimensional data was carried out through similarity measure application. High dimensional data were considered as the a typical structure. Additionally, overlapped and non-overlapped data were introduced, and similarity measure analysis was also illustrated and compared with conventional similarity measure. As a result, overlapped data comparison was possible to present similarity with conventional similarity measure. Non-overlapped data similarity analysis provided the clue to solve the similarity of high dimensional data. Considering high dimensional data analysis was designed with consideration of neighborhoods information. Conservative and strict solutions were proposed. Proposed similarity measure was applied to express financial fraud among multi dimensional datasets. In illustrative example, financial fraud similarity with respect to age, gender, qualification and job was presented. And with the proposed similarity measure, high dimensional personal data were calculated to evaluate how similar to the financial fraud. Calculation results show that the actual fraud has rather high similarity measure compared to the average, from minimal 0.0609 to maximal 0.1667.

关键词： high dimensional data similarity measure difference neighborhood information financial fraud

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Anticipating the lifespan: Predicting the durability of an anode-supported solid oxide fuel cell short stack over 50,000 h

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Progress in Natural Science:Materials International 2024年第3期34卷 606-613页

作者： Muhammad Zubair Khan Amjad Hussain seung-Bok lee Tak-Hyoung Lim Rak-Hyun Song Department of Materials Science & Engineering Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology Hydrogen Energy Research Division Korea Institute of Energy Research Department of Advanced Energy and System Engineering Korea University of Science and Technology (UST)

In the present study, the operational lifetime of a solid oxide fuel(SOFC) short stack is predicted by investigating the performance degradation of both the short stack and its cells throughout 1000 h at 800°C. The short stack and integral cell voltages are continuously measured during the long-term test, with electrochemical impedance spectroscopy(EIS) conducted every 200 h. The short stack voltage decreased rapidly for the initial 200–300 h and afterwards, it decreased at a slow rate due to the increase in the Ohmic and polarization resistances in the same manner. Scanning electron microscopy results show that there is no delamination or cracking among constituent layers of the short-stack cells. The single degradation effects of the Ni coarsening in the anode, cation migration and surface segregation in cathode and oxide scale growth in metallic interconnect mesh are successfully integrated into a comprehensive lifetime prediction model. The experimentally measured voltage degradation data of the short stack fits well with the developed mathematical model and allows the successful prediction of the lifetime up to 50,000 h.

关键词： Degradation Impedance Lifetime SOFC Stack

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Serrated flow accompanied with dynamic type transition of the Portevin-Le Chatelier effect in austenitic stainless steel

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Journal of Materials Science & Technology 2023年第2期133卷 154-164页

作者： seung-Yong lee Sita Chettri Ritupan Sarmah Chikako Takushima Jun-ichi Hamada Nobuo Nakada Department of Materials Science and Engineering Tokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohama-shiKanagawa-ken 226-8503Japan Department of Physics Tezpur UniversityNappamTezpur 784028India Research and Development Center Nippon Steel Stainless Steel CorporationHikari 743-8550Japan

In order to further understand high-temperature deformation behavior and its-related mechanical prop-erties,the Portevin-Le Chatelier(PLC)effect in an Fe-19Cr-13Ni-0.2C austenitic stainless steel was in-vestigated using high-temperature digital image correlation(DIC)*** the tensile testing at temperatures from 473 to 623 K,different types of serrated flow appeared even at a constant applied strain rate,and the type transition took place dynamically in a certain order with deformation *** analysis revealed that the dynamic type transition of the serrated flow obeys the PLC band propagation behavior,and that the transition of the PLC band propagation behavior could be attributed to the PLC band nucleation *** modeling also proved that the nucleation manner of PLC band nu-cleation is determined by the spatial-temporal coupling effect.

关键词： Dynamic strain aging(DSA) Austenitic stainless steel(γ-STS) Portevin-Le Chatelier(PLC)effect Digital image correlation(DIC) Local strain distribution

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