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基于BP人工神经网络的生化处理水水质预测

现代化工 2009年第12期29卷 66-68,70页

作者： ri son-il 侯德刚张振家周伟丽迟莉娜 CHOE Won-il 上海交通大学环境科学与工程学院上海200240 吉林燃料乙醇有限公司吉林吉林132101 咸兴化工大学机械工程系朝鲜咸兴

神经网络具有强大的非线性映射能力和并行处理能力,近年来在水处理领域中被广泛地应用。利用神经网络算法对某污水处理厂的污水处理系统进行了出水水质预测。结果表明,基于BP神经网络的水质预测模型拟合效果较好,模拟出来的化学需氧量(C... 详细信息

神经网络具有强大的非线性映射能力和并行处理能力,近年来在水处理领域中被广泛地应用。利用神经网络算法对某污水处理厂的污水处理系统进行了出水水质预测。结果表明,基于BP神经网络的水质预测模型拟合效果较好,模拟出来的化学需氧量(COD)、pH、固体悬浮物(SS)及生物需氧量(BOD)的数值范围均较接近于实际值,其平均相对标准差分别为6.96%、1.31%、12.09%、15.18%。

关键词：人工神经网络生化处理水质预测

Novel monoclonal antibody against beta 1 integrin enhances cisplatin efficacy in human lung adenocarcinoma cells

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The Journal of Biomedical Research 2016年第3期30卷 217-224页

作者： Min-Young Kim Woon-Dong Cho Kwon Pyo Hong Da Bin Choi Jeong won Hong Soseul Kim Yoo ri Moon Seung-Myoung son Ok-Jun Lee Ho-Chang Lee Hyung Geun song Department of Pathology Chungbuk National University College of MedicineCheongju28644Republic of Korea Research Institute Chungbuk National University College of MedicineCheongju28644Republic of Korea

The use of anti-beta 1 integrin monoclonal antibody in lung cancer treatment has proven beneficial. Here, we developed a novel monoclonal antibody （mAb）, called P5, by immunizing mice with human peripheral blood mononuclear cells （PBMC）. Its anti-tumor effect is now being tested, in a clinical phase Ⅲ trial, in combinato- rial treatments with various chemical drugs. To confirm that P5 indeed binds to beta 1 integrin, cell lysates were immunoprecipitated with commercial anti-beta 1 integrin mAb （TS2/16） and immunoblotted against P5 to reveal a 140 kDa molecular weight band, as expected. Immunoprecipitation with P5 followed by LC/MS protein sequence analysis further verified P5 antigen to be beta 1 integrin. Cisplatin treatment upregulated cell surface expression of beta 1 integrin in A549 cells, while causing inhibition of cell growth. When cells were co-treated with different concentrations of P5 mAb, the cisplatin-mediated inhibitory effect was enhanced in a dose-dependent manner. Our findings show that a combinatorial treatment of P5 mAb and cisplatin in A549 cells resulted in a 30% increase in apoptosis, compared to baseline, and significantly more when compared to either the cisplatin or P5 alone group. The entire peptide sequences in CDR from variable region of Ig heavy and light chain gene for P5 mAb are also disclosed. Together, these results provide evidence of the beneficial effect of P5 mAb in combinatorial treatment of human lung adenocarcinoma.

关键词： CD29 beta 1 integrin lung adenocarcinoma monoclonal antibody cisplatin

印染废水超滤工艺中操作方式对过滤速率的影响

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现代化工 2009年第9期29卷 50-53页

作者： ri son-il 张振家迟莉娜周伟丽 CHOE Won-il 张正林上海交通大学环境科学与工程学院上海200240 咸兴化工大学

对某印染厂废水处理站排水进行了回用处理研究。在恒压条件下,采用聚乙烯(PE)中空纤维膜,进行间歇曝气扫流过滤,分析了不同操作方式对超滤速率变化的影响。结果表明曝气在超滤中能够起到防止污染的作用,解除作用于颗粒上的抽吸力后再采... 详细信息

对某印染厂废水处理站排水进行了回用处理研究。在恒压条件下,采用聚乙烯(PE)中空纤维膜,进行间歇曝气扫流过滤,分析了不同操作方式对超滤速率变化的影响。结果表明曝气在超滤中能够起到防止污染的作用,解除作用于颗粒上的抽吸力后再采用曝气扫流,则能达到更好的扫流效果。周期运行与非周期运行之间的差距较大,按"曝气过滤-暂停-曝气扫流"<"不曝气过滤-暂停-曝气扫流"<"连续曝气扫流"的顺序阻力增大,因此采用周期运行方式在一定程度上可以恢复超滤速率。印染废水过滤中,在抽吸压力小于0.08 MPa的范围内,可以不考虑沉积物的压缩性。

关键词：印染废水超滤曝气周期运行

Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

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Cancer Communications 2023年第4期43卷 455-479页

作者： JungWoo Eun Jung Hwan Yoon Hye ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong Department of Gastroenterology Ajou University School of MedicineSuwonSouth Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedical Sciences AjouUniversity Graduate School of MedicineSuwonSouth Korea Department of Pathology Ajou University School of MedicineSuwonSouth Korea Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea The Moagen IncDaejeonSouth Korea

Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of *** study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to *** then performed in vitro and in vivo experiments to validate selected targets and related *** associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression ***:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI ***1 inhibitors reversed CAF-induced TKI resistance in vitro and in ***-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI ***:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT *** inhibition represents a promising therapeutic strategy against TKI resistance ***,plasma SPP1 level before TKI treatment represents a potential biomar

关键词： drug resistance epithelial-to-mesenchymal transition hepatocellular carcinoma secreted phosphoprotein 1

Comparing upper gastrointestinal X-ray and endoscopy for gastric cancer diagnosis in Korea

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World Journal of Gastroenterology 2010年第2期16卷 245-250页

作者： Hoo-Yeon Lee Eun-Cheol Park Jae Kwan Jun Kui son Choi Myung-Il Hahm National Cancer Control Research Institute National Cancer Center111 Jungbalsan-roIlsandong-guGoyang-si Gyeonggi-do 410-769South Korea Department of U-Healthcare Management College of Medical ScienceSoonChunHyang University646 Eupnae-riShinchang-myeonAsan-siChungnam 336-745 South Korea

AIM:To compare the cost and accuracy of upper gastrointestinal(GI)X-ray and upper endoscopy for diagnosis of gastric cancer using data from the 2002-2004 Korean National Cancer Screening Program(NCSP). METHODS:The study population included 1 503 646 participants in the 2002-2004 stomach cancer screening program who underwent upper GI X-ray or *** accuracy of screening was defined as the probability of detecting gastric *** calculated the probability by merging data from the NCSP and the Korea Central Cancer *** estimated the direct costs of the medical examination and the tests for up- per GI X-ray,upper endoscopy,and biopsy. RESULTS:The probability of detecting gastric cancervia upper endoscopy was 2.9-fold higher than via upper GI *** unit costs of screening using upper GI X-ray and upper endoscopy were$32.67 and$34.89, *** 2008,the estimated cost of identifying one case of gastric cancer was$53094.64 using upper GI X-ray and$16 900.43 using upper *** cost to detect one case of gastric cancer was the same for upper GI X-ray and upper endoscopy at a cost ratio of 1:3.7. CONCLUSION:Upper endoscopy is slightly more costly to perform,but the cost to detect one case of gastric cancer is lower.

关键词： Gastric cancer Mass screening Endoscopy Early diagnosis X-ray diagnosis

TriBOLOGICAL CHARACTEriSTICS ON THE HELICAL GEAR IN COLD FORGING MOLD

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TRIBOLOGICAL CHARACTERISTICS ON THE HELICAL GEAR IN COLD FOR...

第六届材料与热加工物理模拟及数值模拟国际会议

作者： WON SIK CHOI JAE HWAN son INH LEE EUN YOUNG JIN JU ri KWON YOUNG MOON LEE Department of Bio Industrial Mechanical Engineering Pusan National University

The purpose of this study is to find out the tribological characteristics on the various lubricants in helical gear forging mold which is new development part in mobile *** are 7-kinds of lubricant in this study as L1,L2,L3,L4,L5,L6 and *** study has used the pin-on-disk type of friction wear test system and has used the dead weight for the normal load applied to the test specimen,adjustable in the range of 20N,40N,60N,80N and *** was operated at the speed range of 0.06,0.10,0.14,0.18,0.22,0.26,0.30 and 0.34m/*** study could obtain the following conclusions from the result of friction and wear test for 7 types lubricants in forging mold *** friction coefficient in the higher kinematic viscosity oils which were L-1,L-2,L-4 and L-5 tends to increase slowly as the velocity *** the increasing range of the friction coefficient tends to higher in lower driving *** friction coefficient tends to decrease as the velocity increase in low kinematic viscosity oil *** friction coefficients of Bondelube and Bondelite were 3 times of L-1 and L-5 lubricant *** to the Stribeck curve,there were hydrodynamic lubrication in L-1,L-2,L-4 and L-5,L-3 were in boundary lubrication *** worn surface after the wear test could be found a scratch,adhesive wear,adhesion wear,scarping and so on by SEM.

关键词： Tribology Lubrication Bondelube Bondelite Helical gear forging mold.

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微滤膜部分堵塞过滤模型的建立和机理探讨

华东理工大学学报（自然科学版） 2007年第4期33卷 466-469页

作者：李鲜日周颖王学军许振良华东理工大学化学工程研究所上海200237

膜过滤机理是目前膜过滤工艺需要研究解决的关键问题之一。为描述微滤过程的速率变化数学模型,通过假设膜通道均为连通的网络型通道,将Kozeny-Carman方程与Darcy方程联立,建立了微滤膜部分堵塞过滤机理模型,并以孔隙率与水力半径为关键... 详细信息

膜过滤机理是目前膜过滤工艺需要研究解决的关键问题之一。为描述微滤过程的速率变化数学模型,通过假设膜通道均为连通的网络型通道,将Kozeny-Carman方程与Darcy方程联立,建立了微滤膜部分堵塞过滤机理模型,并以孔隙率与水力半径为关键因素,推导了基于Darcy方程的微滤速率变化规律。在恒压条件下,通过醋酸纤维素(CA)平板膜死端过滤实验对上述模型进行了验证,在线测定了微滤速率和滤液量随时间的变化关系。结果表明:实验测得的数据和推导的模型基本吻合;且微滤存在Hermans-Bredee的3种机理(即机理指数n=2,3/2,1)以外的堵塞过滤机理,即n=4/3次方的机理。本文提出的部分堵塞过滤机理,可以与传统精密过滤中的基于Poiseuilles方程的堵塞过滤理论一起,应用于包括微-超滤的精密过滤研究中。

关键词：微滤膜机理模型部分堵塞微分方程 Darcy方程

Toxicological study of the hepatotherapeutic herbal formula,Chunggan extract,in beagle dogs

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World Journal of Gastroenterology 2006年第46期12卷 7497-7502页

作者： Woo-Jin Choi Jang-Woo Shin Jin-Young son Dong-Seok Seo Hark-Soo Park Seung-Hyun Han Ha-lung Sung Jung-Hyo Cho Chong-Kwan Cho Hwa-Seung Yoo Yeon-Weol Lee Chang-Gue son East-West Cancer Center Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University 1136Dunsan-dong Seo-gu Daejeon 302-122 South Korea Safety Assess-ment Center Korea Testing and Research Institute for Chemical Industry 7-6 Gomak-ri Wolgot-myeon Gimpo-si Kyonggi-doKorea Department of Oromaxillofacial Infection & Immunity and Dental Research Institute School of DentistrySeoul National University 28 Yongon-Dong Chongno-Gu Seoul110-749 South Korea

AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis. RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopa- thology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug. CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

关键词： Hepatotherapeutics Herbal remedy Chung-gan extract Safety Toxicological study

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n维空间中质点之间距离分布及其特征

天津师范大学学报（自然科学版） 2007年第3期27卷 44-47页

作者：张春生李光鲜汉光龙南开大学数学科学学院天津300071 金日成综合大学数学力学学院

提出了随机分配的质点之间距离分布的概念,给出了最近距离分布公式,得到了最近距离和k次距离分布的众数,矩及质点空间密度D的充分统计量和极大似然估计.

关键词：质点之间距离距离分布充分统计量极大似然估计