检索结果-南通市图书馆

非线性系统的观测反馈线性化及其在活性污水处理过程中的应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

武汉工业大学学报 1989年第2期11卷 185-196页

作者：黄曙磬程代展 won-kyoo lee 武汉工业大学自动化系中科院系统科学研究所 Ohio State University

本文首先证明了一类非线性系统完全线性化的充分和必要条件,并且提出一种用于线性化系统的闭环观测器的设计方法,然后将上述结果具体地运用在活性污水处理过程的研究。计算机模拟结果表明:具有闭环观测器的完全线性化方法是行之有效的。

关键词：非线性系统线性化污水处理

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Decomposing class responsibilities using distance-based method similarity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2016年第4期10卷 612-630页

作者： Junha lee Dae-kyoo KIM Suntae KIM Sooyong PARK Department of Electronic and Computer Engineering Oakland University Rochester M148309 USA Department of Computer Science and Engineering Oakland University Rochester M148309 USA Department of Software Engineering Chonbuk National University Chonju 561-756 South Korea Department of Computer Science and Engineering Sogang University Seoul 121-741 South Korea

Cohesion is a design quality that has a great im- pact on the posterior development and maintenance. As software evolves, the cohesion of the system becomes weaker due to the changes introduced during evolution. Over evolution, a single responsibility class may be unintentionally assigned other responsibilities, which makes the class less cohesive and more complex and consequently increases the complexity of the entire system. There has been much work on decomposing class responsibilities based on internal class relationships such as method-attribute referencing and internal method calls. However, object-oriented systems involve significant external class relationships carrying important behavioral semantics, which should be taken into account in identifying class responsibilities. In this paper, we present a novel approach for identifying and decomposing classes responsibilities based on method similarity using both internal and external class relationships. We extend the existing work for measuring similarity of internal class relationships and present a distance-based method for measuring external class relationships. We evaluate the approach using three open source applications -- JMeter, JHotDraw, and ArgoUML. The evaluation shows that the presented approach improves precision over the existing work. We validate the results using independent samples T-test and ANOVA applied to a set of hypotheses. The validation confirms that the results are statistically significant.

关键词： class decomposition cohesion external rela-tionships identifying responsibility method similarity

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Single-cell and spatial omics:exploring hypothalamic heterogeneity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

SUBic:A Scalable Unsupervised Framework for Discovering High Quality Biclusters

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2013年第4期28卷 636-646页

作者： Jooil lee Yanhua Jin won Suk lee Department of Computer Science Yonsei University

A biclustering algorithm extends conventional clustering techniques to extract all of the meaningful subgroups of genes and conditions in the expression matrix of a microarray dataset. However, such algorithms are very sensitive to input parameters and show poor scalability. This paper proposes a scalable unsupervised biclustering framework, SUBic, to find high quality constant-row biclusters in an expression matrix effectively. A one-dimensional clustering algorithm is proposed to partition the attributes, that is, columns of an expression matrix into disjoint groups based on the similarity of expression values. These groups form a set of short transactions and are used to discover a set of frequent itemsets each of which corresponds to a bicluster. However, a bicluster may include any attribute whose expression value is not similar enough to others, so a bicluster refinement is used to enhance the quality of a bicluster by removing those attributes based on its distribution of expression values. The performance of the proposed method is comparatively analyzed through a series of experiments on synthetic and real datasets.

关键词： biclustering clustering expression matrix frequent itemset sub-matrix

Two macrophages, osteoclasts and microglia: from development to pleiotropy

在线全文

学校读者我要写书评

暂无评论

Bone Research 2021年第2期9卷 143-152页

作者： Ji-won lee In-Hee lee Tadahiro Iimura Sek won Kong Department of Nephrology Transplant Research ProgramBoston Children’s HospitalBostonMA 02115USA Department of Pharmacology Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Computational Health Informatics Program Boston Children’s HospitalBostonMA 02115USA Department of Pediatrics Harvard Medical SchoolBostonMA 02115USA

Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments,activated by various inflammatory signals and modulated by genetic and environmental *** and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and Alzheimer’s disease(AD),*** is more frequently observed in individuals with AD compared to the prevalence in general *** of AD is often delayed until underlying pathophysiological changes progress and cause irreversible damages in structure and function of *** such earlier diagnosis and intervention of individuals at higher risk would be indispensable to modify clinical *** is the phenomenon that a genetic variant affects multiple traits and the genetic correlation between two traits could suggest a shared molecular *** this review,we discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain,respectively,is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD.

关键词： diagnosis osteoporosis osteoclast

Catalysts for electrochemical ammonia oxidation:Trend,challenge,and promise

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2022年第12期65卷 3334-3352页

作者： Sol A lee Mi Gyoung lee Ho won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Electrical and Computer Engineering University of TorontoToronto M5S 3G4OntarioCanada Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea

Developing sustainable and clean energy technology is critial to address the current energy and environmental *** an energy carrier,hydrogen has been getting attention due to its abundance,high energy density,and zero carbon *** to the difficulty of hydrogen storage and transport,the electro-oxidation of ammonia shows great potential for renewable energy since it satisfies both energy supply and environmental protection as a carbon-free fuel with high hydrogen ***,ammonia electro-oxidation is a sluggish reaction and shows low *** the complicated mechanism and intermediates is conducive to developing efficient electrocatalysts with high catalytic activity and *** review begins with the ammonia oxidation technologies and their *** two typical mechanisms for ammonia electro-oxidation,Oswin-Salomon mechanism and Gerischer-Mauerer mechanism,are discussed,and attention to the poisoning species is ***,the electrocatalysts for ammonia reaction are classified into Pt-based catalysts and non-noble metal-based catalysts,and their performances are reviewed with various *** on the progress on the electrochemical ammonia oxidation catalysts,the challenges and future insight on ammonia oxidation reaction are discussed and proposed.

关键词： NH3 oxidation reaction electrocatalysts green hydrogen