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Open Journal of Nursing 2020年第11期10卷 1038-1047页

作者： Natsuko Kojima kyoko Asazawa Division of Nursing Faculty of Nursing Tokyo Healthcare University Tokyo Japan

Background: The aim of this study was to investigate Japanese students and employed adults’ characteristic features, and sexual situation, and to find the correlated factors of lesbian, gay, bisexual, transgender (LGBT) recognition in order to obtain suggestions for improved relationships with sexual minorities in a diversifying society. Methods: This quantitative cross-sectional descriptive correlational study occurred during 2018 to 2019 when 2210 questionnaires were distributed to a purposive sample of eligible participants. A total of 1534 completed questionnaires (69.4%) were returned, of which 1439 (65.1%) were suitable for analyses. The survey included respondents’ 1) characteristics, 2) sexual situation, and 3) LGBT recognition scale. Data were analyzed with descriptive statistics, factor analysis, reliability analysis, and structural equation modeling. SPSS ver. 26.0 (SPSS, Chicago, IL, USA) was used for data analysis at a 5% significance level. Results: The LGBT recognition score was significantly affected by suffering from gender identity (standardized partial regression coefficient: β = 0.17, p −0.19, p Conclusions: Suffering from gender identity, learning about LGBT experience, experience of disclosure from LGBT person, sexual problem with intimate relationship, and diversity penetration had a positive effect, whereas age had negative effects on the LGBT recognition score.

关键词： Sexual and Gender Minorities Cross-Sectional Studies Covariance Structure Analysis

Large edge magnetism in oxidized few-layer black phosphorus nanomeshes

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Nano Research 2017年第2期10卷 718-728页

作者： Yudai Nakanishi Ayumi Ishi Chika Ohata David Soriano Ryo Iwaki kyoko Nomura~ Miki Hasegawa Taketomo Nakamura Shingo Katsumoto Stephan Roche Junji Haruyama Faculty of Science and Engineering Aoyama Gakuin University 5- I0-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Chemistry and Biological Science Aoyama Gakuin University 5-10-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Institucio Catalana de Recercai Estudis Avancats (ICREA) 08010 Barcelona Spain Institute for solid state physics The University of Tokyo 5- I-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan

The formation and control of a room-temperature magnetic order in two- dimensional （2D） materials is a challenging quest for the advent of innovative magnetic- and spintronic-based technologies. To date, edge magnetism in 2D materials has been experimentally observed in hydrogen （H）-terminated graphene nanoribbons （GNRs） and graphene nanomeshes （GNMs）, but the measured magnetization remains far too small to allow envisioning practical applications. Herein, we report experimental evidences of large room-temperature edge ferromagnetism （FM） obtained from oxygen （O）-terminated zigzag pore edges of few-layer black phosphorus （P） nanomeshes （BPNMs）. The magnetization values per unit area are -100 times larger than those reported for H-terminated GNMs, while the magnetism is absent for H-terminated BPNMs. The magnetization measurements and the first-principles simulations suggest that the origin of such a magnetic order could stem from ferromagnetic spin coupling between edge P with O atoms, resulting in a strong spin localization at the edge valence band, and from uniform oxidation of full pore edges over a large area and interlayer spin interaction. Our findings pave the way for realizing high-efficiency 2D flexible magnetic and spintronic devices without the use of rare magnetic elements.

关键词： black phosphorus nanomesh edge magnetism spintronics zigzag edge oxygen termination rare-metal free

Predictors of Mothers’ Early Postpartum Fatigue: A Cross-Sectional Study

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Open Journal of Nursing 2020年第9期10卷 890-902页

作者： Natsuko Kojima kyoko Asazawa Division of Nursing Faculty of Nursing Tokyo Healthcare University Tokyo Japan

Background: Most postpartum mothers experience fatigue. However, it was unclear which day after birth during hospitalization mothers are the most fatigued, and if the mothers’ background is a factor. The aim of this study was to investigate hospitalized mothers’ characteristic features, fatigue, and relaxation, and then to find the correlated factors of fatigue in order to obtain suggestions for mothers’ early postpartum care. Methods: This quantitative cross-sectional descriptive correlational study occurred during May to December 2016. A purposive sample of early postpartum hospitalized mothers at a postpartum unit in a Tokyo hospital completed an anonymous self-filled questionnaire survey. The survey included respondents’ characteristics, fatigue scale, and relaxation scale. Data were analyzed with descriptive statistics, independent t-test, one-way analysis of variance, multiple regression analyses, and structural equation modeling. Results: Returned questionnaires were 251 (83.4%). Fatigue was significantly higher for mothers with longer postpartum days compared to shorter postpartum days (F = 5.7, p β = −0.30, p β = 0.26, p β = 0.14, p Conclusions: No relaxation, longer postpartum days, and previous disease were associated with Fatigue for early postpartum mothers. These results suggest that focusing on previous disease, length of postpartum days, and mother’s relaxation is needed to provide full support to early postpartum mothers.

关键词： Postpartum Mothers Fatigue Relaxation

Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai Minako Ito kyoko Komai Mana Iizuka-Koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura Department of Microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report

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World Journal of Gastroenterology 2008年第35期14卷 5474-5477页

作者： Atsushi Takahashi Yukiko Kanno Yuta Takahashi Natsumi Sakamoto kyoko Monoe Hironobu Saito Kazumichi Abe Junko Yokokawa Atsushi Irisawa Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of MedicineFukushimaJapan

A 43-year-old woman with multiple sclerosis （MS） was treated with pulsed methylprednisolone and interferon 13 at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis （AIH）. She was successfully treated with corticosteroids. As ataxia developed after i year, she was treated with pulsed methylprednisolone for 3 days, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.

关键词： Multiple sclerosis Autoimmune hepatitis Pulsed methylprednisolone

Pharmacy residency system in Gunma University Hospital

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 215-216页

作者： Asami Matsushita Daisuke Nagano Mikako Shimone kyoko Obayashi Takuya Araki Koujirou Yamamoto Department of Pharmacy Gunma University Hospital3-39-15 Showa-machiMaebashi 371-8511Japan Department of Clinical Pharmacology Gunma University Graduate School of Medicine3-39-22 Showa-machiMaebashi 371-8511Japan

Recently,undergraduate and postgraduate pharmaceutical education systems have been changing greatly in *** 2006,undergraduate pharmacist program was changed from 4 years course to 6 years course to train higher-quality pharmacists who can deal with the changes in the progression of medical technology and meet social demands for medication safety[1].As a postgraduate training system,pharmacy residency system was started in several hospital in 2002,and around 35 hospitals have pharmacy residency system at 2015[2].

关键词： Pharmacy residency system Postgraduate pharmaceutical program Teaching program Japanese pharmacy

Supplementing Conventional Treatment with Pycnogenol(R) May Improve Hepatitis C Virus-Associated Type 2 Diabetes:A Mini Review

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 228-233页

作者： Sayeh Ezzikouri Fatima Zahra Jadid Salsabil Hamdi Lahcen Wakrim kyoko Tsukiyama-Kohara Soumaya Benjelloun Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc Casablanca Morocco Virology Unit Immunovirology Laboratory Institut Pasteur du Maroc Casablanca Morocco Laboratory of Animal Hygiene Joint Faculty of Veterinary MedicineKagoshima University Kagoshima Japan Transboundary Animal Diseases Centre Joint Faculty of Veterinary MedicineKagoshima University Kagoshima Japan

Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) present a significant health burden,with increasing complications and mortality rates ***(R) (PYC),a natural product,possesses antidiabetic and antiviral properties that may improve HCV-associated *** this review,we present previously published data on the effectiveness of PYC against HCV replication and *** believe that supplementing conventional treatment with PYC may improve the current HCV therapy,attenuate HCV-associated T2DM,and reduce the risk of complications such as cirrhosis or hepatocellular carcinoma and cardiovascular disease.

关键词： T2DM Hepatitis C Pycnogenol(R) Complementary medicine

A plant sesquiterpene lactone and its derivative reduce cutaneous side effect of vemurafenib,a BRAF inhibitor drug to treat late stage melanoma

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中国药理学与毒理学杂志 2015年第S1期29卷 90-91页

作者： Meng-ting CHANG Jia-hua FENG kyoko NAKAGAWA-GOTO Kuo-Hsiung LEE Lie-Fen SHYUR Agricultural Biotechnology Research Center Academia Sinica Chinese Taipei 115 Institute of Plant Biology College of Life Science National Taiwan University Chinese Taipei 106 College of Medical Pharmaceutical and Health Sciences Kanazawa University Kakuma-machi Kanazawa 920-1192 Japan Natural Products Research Laboratories Eshelamn School of Phamacy University of North Carclina Chape Hill North Carolina 27599 USA

OBJECTIVE To investigate the pharmacological effect of a plant sesquiterpene lactone(designated D)and its semi-organically synthesized novel derivative(designated S)and the role of lipid mediators,viz.,oxylipins in attenuating vemurafenib-induced cutaneous side *** A DMBA/TPAinduced skin carcinogenesis mouse model mimicking cutaneous side effect caused by vemurafenib was established to evaluate the efficacy of compound D and S in reversal of vemurafenib side *** oxylipin metabolomics platform using UPLC-TQD mass spectrometry coupled with partial least squares-discriminant analysis(PLS-DA)analysis,cell-based assays,and immunochemistry analysis were performed to elucidate the mechanism insights of DET and S compounds and the role of specific oxylipins in skin cancer *** Vemurafenib treatment expedited the skin papillomas formation in DMBA-TPA treated mouse from week 6 to week *** D and S compounds could suppress the vemurafenib side effect and also decrease total papillomas numbers(55% to 72%)and average sizes(66% to 89%).Oxylipins metabolome analysis shows that specific arachidonic acid metabolites may play a role in vemurafenib-induced squamous cell carcinoma or keratoacanthomas formation in mouse skin that can be deregulated by D or S compound ***,S compound can inhibit vemurafenib-induced paradoxical activation of MAP kinases in mouse skin or in NRAS mutant melanoma *** Our results indicate that plant sesquiterpene lactone D and its novel analog can reduce cutaneous side effect of vemurafenib through novel modes of action by inhibiting paradoxical activation of MAP kinases and de-regulating pro-inflammation mediators COX-2 and specific ecosanoid-type of *** study may suggest a novel adjuvant therapy approach in treatment of BRAFV600 Emutant melanoma.

关键词： vemurafenib sesquiterpene lactone two-stage carcin

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Open Journal of Nursing 2017年第3期7卷 449-462页

作者： Miho Satoh Ikue Watanabe kyoko Asakura Tokyo Healthcare University Tokyo Japan Tohoku Fukushi University Sendai Japan Graduate School of Medicine Tohoku University Sendai Japan

We identified the factors related to affective occupational commitment among nurses in Japan by conducting a cross-sectional survey in 12 hospitals in the Tohoku and Kanto districts of Japan in 2013. Of the 4046 nurses in these hospitals, 1330 completed the self-report questionnaire (valid response rate: 32.9%). High job satisfaction, high professional autonomy, having a scholarship loan, and being married were strongly related to affective occupational commitment. Conversely, having a high effort-reward imbalance and fewer overtime work hours indicated a low level of such commitment. The findings suggest that professional autonomy and job satisfaction are key factors for developing affective occupational commitment. Programs that promote professional autonomy and make people feel more appreciated for their work should be created to improve such commitment, and it would be important to provide adequate organizational resources to increase job satisfaction and reduce effort-reward imbalance. The fact that longer working hours are related to affective occupational commitment suggests that excessive emotional commitment to one’s occupation can lead to overtime work. Therefore, nurse managers should consider the staff’s working situations more thoroughly.

关键词： Affective Occupational Commitment Psychosocial Work Environment Nurses Japan