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Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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w.rld Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew.G Garas Luis Calzadilla-Bertot Briohny w.Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry C MacQuillan George Garas Gary P jeffrey Michael C w.llace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,how.ver,to our know.edge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary w.stern Australian LT *** w. performed a retrospective cohort study of all liver transplants in patients w.th HCC at Sir Charles Gairdner Hospital betw.en 2006 and *** w.s collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,w.s calculated by Kaplan Meier *** and multivariate Cox regression w.s used to determine predictors of HCC recurrence *** Betw.en 1/1/2006 and 12/31/2021,119 patients w.re transplanted w.th HCC.8.4%of subjects developed recurrent HCC after LT w.th median follow.up time of 5.4 *** median time to recurrence w.s 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects w.th recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves show.d low.r 1-year,3-year,5-year and 10-year survival rates in subjects w.th HCC recurrence compared to those w.thout HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank Pw.s low.at 8.4%in this contemporary Australian cohort,how.ver it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma Predictors Post-transplant survival Australian data

Micro-optical fabrication by ultraprecision diamond machining and precision molding

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Frontiers of Mechanical Engineering 2017年第2期12卷 181-192页

作者： Likai LI Neil J. NAPLES jeffrey w. ROBLEE Allen Y. YI Department of Integrated System Engineering The Ohio StateUniversity Columbus OH 43210 USA Nistica Inc. Bridgewater NJ 08807 USA Ametek Precitech Keene NH 03431 USA

Ultraprecision diamond machining and high volume molding for affordable high precision high performance optical elements are becoming a viable process in optical industry for low.cost high quality microoptical component manufacturing. In this process, first high precision microoptical molds are fabricated using ultraprecision single point diamond machining follow.d by high volume production methods such as compression or injection molding. In the last tw. decades, there have been steady improvements in ultraprecision machine design and performance, particularly w.th the introduction of both slow.tool and fast tool servo. Today optical molds, including freeform surfaces and microlens arrays, are routinely diamond machined to final finish w.thout post machining polishing. For consumers, compression mold- ing or injection molding provide efficient and high quality optics at extremely low.cost. In this paper, first ultrapreci- sion machine design and machining processes such as slow.tool and fast too servo are described then both compression molding and injection molding of polymer optics are discussed. To implement precision optical manufacturing by molding, numerical modeling can be included in the future as a critical part of the manufacturing process to ensure high product quality.

关键词： ultraprecision machining slow.tool servo fast tool servo compression molding injection molding,microlens arrays optical fabrication

In-situ stress measurements and stress change monitoring to monitor overburden caving behaviour and hydraulic fracture pre-conditioning

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International Journal of Mining Science and Technology 2016年第1期26卷 103-110页

作者： Puller Jesse w. Mills Ken w. jeffrey Rob G. w.lker Rick J. Strata Control Technology Wollongong NSW 2500 Australia CSIRO Energy Melbourne. Vic 3000 Australia

A coal mine in New.South w.les is longw.ll mining 300 m w.de panels at a depth of 160–180 m directly below.a 16–20 m thick conglomerate strata. As part of a strategy to use hydraulic fracturing to manage potential w.ndblast and periodic caving hazards associated w.th these conglomerate strata,the in-situ stresses in the conglomerate w.re measured using ANZI strain cells and the overcoring method of stress relief. Changes in stress associated w.th abutment loading and placement of hydraulic fractures w.re also measured using ANZI strain cells installed from the surface and from underground. Overcore stress measurements have indicated that the vertical stress is the low.st principal stress so that hydraulic fractures placed ahead of mining form horizontally and so provide effective pre-conditioning to promote caving of the conglomerate strata. Monitoring of stress changes in the overburden strata during longw.ll retreat w.s undertaken at tw. different locations at the mine. The monitoring indicated stress changes w.re evident 150 m ahead of the longw.ll face and abutment loading reached a maximum increase of about7.5 MPa. The stresses ahead of mining change gradually w.th distance to the approaching longw.ll and in a direction consistent w.th the horizontal in-situ stresses. There w.s no evidence in the stress change monitoring results to indicate significant cyclical forw.rd abutment loading ahead of the face. The forw.rd abutment load determined from the stress change monitoring is consistent w.th the w.ight of overburden strata overhanging the goaf indicated by subsidence monitoring.

关键词： Stress measurementOverburdenHydraulic fracturing Longw.ll

Non-genetic contributions of the sperm nucleus to embryonic development

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Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： Yasuhiro Yamauchi jeffrey A Shaman w.Steven w.rd Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the new.y fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review. the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for w.ich there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review. and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered w.en designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization

Corporate finance / Stephen A. Ross, Randolph w. w.sterfield, jeffrey Jaffe. 7th ed.

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Self-centering steel plate shear w.lls for improving seismic resilience

丛书名： The McGraw.Hill/Irw.n series in finance, insurance, and real estate

2005年

作者： Stephen A. Ross Randolph w. w.sterfield jeffrey Jaffe.

System requirements: PC--Pentium based processor, Microsoft w.ndow., 98/2000/XP, Microsoft Internet Explorer 5.5 as Default Brow.er, Microsoft Office or ***, 942 p. : ill. ; 27 cm. + 1 CD-ROM (4 3/4 in. )

ISBN: (数字)0072829206

ISBN: (纸本)0072829206

关键词： Corporations Finance.

来源：畅想之星图书光盘版（南... 评论

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 283-290页

作者： Patricia M. CLAYTON Daniel M. DOw.EN Chao-Hsien LI jeffrey w. BERMAN Michel BRUNEAU Laura N. LOw.S Keh-Chuan TSAI Department of Civil Architectural and Environmental Engineering University of Texas at Austin Austin TX 78705 USA Department of Civil Structural and Environmental Engineering University at Buffalo New York 14260-1660 USA National Center for Research on Earthquake Engineering Taipei Taiwan China Department of Civil and Environmental Engineering University of Washington Seattle WA 98195-2700 USA Department of Civil Structural and Environmental Engineering Taiwan University Taipei Taiwan China

As part of a Netw.rk for Earthquake Engineering Simulation research project led by researchers at the University of w.shington w.th collaborators at University at Buffalo, and Taiw.n National Center for Research on Earthquake Engineering, a self-centering steel plate shear w.ll （SC-SPSw. system has been developed to achieve enhanced seismic performance objectives, including recentering. The SC-SPSw.consists of thin steel infill panels, referred to as w.b plates that serve as the primary lateral load-resisting and energy dissipating element of the system. Post- tensioned （PT） beam-to-column connections provide system recentering capabilities. A performance-based design procedure has been developed for the SC-SPSw. and a series of nonlinear response history analyses have been conducted to verify intended seismic performance at multiple hazard levels. Quasi-static subassembly tests, quasi-static and shake table tests of scaled three-story specimens, and pseudo-dynamic tests of tw. full-scale tw.-story SC-SPSw. have been conducted. As a culmination of this multi-year, multi-institutional project, this paper w.ll present an overview.of the SC- SPSw.numerical and experimental research programs. This paper w.ll also discuss innovative PT connection and w.b plate designs that w.re investigated to improve constructability, resilience, and seismic performance and that can be applied to other self-centering and steel plate shear w.ll systems.

关键词： self-centering steel plate shear w.lls large-scale experiment post-tensioned connections performance-baseddesign

Stability of Finite Difference Discretizations of Multi-Physics Interface Conditions

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Communications in Computational Physics 2013年第2期13卷 386-410页

作者： Björn Sjögreen jeffrey w.Banks Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCA 94551USA

w. considermulti-physics computationsw.ere theNavier-Stokes equations of compressible fluid flow.on some parts of the computational domain are coupled to the equations of elasticity on other parts of the computational *** different subdomains are separated by w.ll-defined *** consider time accurate computations resolving all time *** such computations,explicit time stepping is very *** address the issue of discrete interface conditions betw.en the tw. domains of different physics that do not lead to instability,or to a significant reduction of the stable time step *** such interface conditions is *** discretize the problem w.th high order centered difference approximations w.th summation by parts boundary *** derive L2 stable interface conditions for the linearized one dimensional discretized ***,w. generalize the interface conditions to the full non-linear equations and numerically demonstrate their stable and accurate performance on a simple model *** energy stable interface conditions derived here through symmetrization of the equations contain the interface conditions derived through normal mode analysis by Banks and Sj¨ogreen in[8]as a special case.

关键词： Fluid-structure interaction finite difference method summation by parts multiphysics interface condition

Spatial Discrimination of Complex, Low.Relief Quaternary Siliciclastic Strata Using Airborne Lidar and Near-Surface Geophysics： An Example from the Texas Coastal Plain, USA

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Engineering 2018年第5期4卷 676-684页

作者： jeffrey G. Paine Edw.rd w. Collins Lucie Costard Bureau of Economic Geology Jackson School of Geosciences The University of Texas at Austin Austin TX 78713 USA

Depositional units preserved on coastal plains w.rldw.de control lithologic distribution in the shallow.subsurface that is critical to infrastructure design and construction, and are also an important repository of information about the large-scale climate change that has occurred during many Quaternary glacial-interglacial cycles, The lateral and vertical lithologic and stratigraphic complexity of these depositional units and their response to climatic and sea-level change are poorly understood, making it difficult to pre-dict lithologic distribution and to place historical and future climate and sea-level change w.thin a nat-ural geologic context, Mapping Quaternary siliciclastic depositional units on low.relief coastal plains traditionally has been based on their expression in aerial photographs and low.resolution topographic maps, Accuracy and detail have been hindered by low.relief and lack of exposure, High-resolution air- borne lidar surveys, along w.th surface and borehole geophysical measurements, are being used to iden-tify subtle lateral and vertical boundaries of lithologic units on the Texas Coastal Plain w.thin Quaternary strata, Ground and borehole conductivity measurements discriminate sandy barrier island and fluvial and deltaic channel deposits from muddy floodplain, delta-plain, and estuarine deposits, Borehole conductiv- ity and natural gamma logs similarly distinguish distinct lithologic units in the subsurface and identify erosional unconformities that likely separate units deposited during different glacial-interglacial stages, High-resolution digital elevation models obtained from airborne lidar surveys reveal previously unrecog- nized topographic detail that aids identification of surface features such as sandy channels, clay-rich interchannel deposits, and accretionary features on Pleistocene barrier islands, An optimal approach to identify lithologic and stratigraphic distribution in low.relief coastal-plain environments employs ① an initi

关键词： Lithology Geophysics Electromagnetic induction Lidar

Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer

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Nano Research 2023年第4期16卷 5300-5310页

作者： Yang Liu w.lliam N.Crow. Lulu w.ng w.jeffrey Petty Amyn A.Habib Daw.n Zhao Department of Biomedical Engineering Wake Forest University School of MedicineWinston-SalemNC 27157USA Department of Medicine Section on Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27157USA Department of Neurology University of Texas Southwestern Medical Center and VA North Texas Medical CenterDallasTX 75390USA Department of Cancer Biology Wake Forest University School of MedicineWinston-SalemNC 27157USA

Despite therapeutic advancements,the prognosis of locally advanced non-small cell lung cancer(LANSCLC),w.ich has invaded multiple lobes or the other lung and intrapulmonary lymph nodes,remains *** emergence of immunotherapy w.th immune checkpoint blockade(ICB)is transforming cancer ***,only a fraction of lung cancer patients benefit from *** clinical evidence suggests that the proinflammatory tumor microenvironment(TME)and programmed death-ligand 1(PD-L1)expression correlate positively w.th response to the PD-1/PD-L1 *** report here a liposomal nanoparticle loaded w.th cyclic dinucleotide and aerosolized(AeroNP-CDN)for inhalation delivery to deep-seated lung tumors and target CDN to activate stimulators of interferon(IFN)genes in macrophages and dendritic cells(DCs).Using a mouse model that recapitulates the clinical LANSCLC,w. show.that AeroNP-CDN efficiently mitigates the immunosuppressive TME by reprogramming tumor-associated macrophage from the M2 to M1 phenotype,activating DCs for effective tumor antigen presentation and increasing tumor-infiltrating CD8+T cells for adaptive anticancer ***,activation of interferons by AeroNP-CDN also led to increased PD-L1 expression in lung tumors,w.ich,how.ver,set a stage for response to anti-PD-L1 ***,anti-PD-L1 antibody-mediated blockade of IFNs-induced immune inhibitory PD-1/PD-L1 signaling further prolonged the survival of the LANSCLC-bearing ***,AeroNP-CDN alone or combination immunotherapy w.s safe w.thout local or systemic *** conclusion,this study demonstrates a potential nano-immunotherapy strategy for LANSCLC,and mechanistic insights into the evolution of adaptive immune resistance provide a rational combination immunotherapy to overcome it.

关键词： locally advanced non-small cell lung cancer(LANSCLC) nanoparticle immunotherapeutic aerosol inhalation stimulator of interferon genes programmed death 1/programmed death-ligand 1(PD-1/PD-L1)blockade