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A green light-enhanced cytosolic protein delivery platform based on BODIPY-protein interactions

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Nano Research 2023年第1期16卷 1042-1051页

作者： Yang Zhou Yifan Gao Li Pang Weirong Kang kwan man Weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research Centre The University of Hong KongHong KongChina Department of Surgery School of Clinical MedicineHKU-SZH&LKS Faculty of MedicineThe University of Hong KongHong KongChina

Development of cytosolic protein delivery platforms brings new possibilities for various incurable *** based on polymer/protein self-assembly have shown their potential in protein ***,versatile photocontrolled platforms based on self-assembly for protein delivery are seldom ***,we report a boron-dipyrromethene(BODIPY)-modified polyamidoamine(PAMAM)with excellent photo-controllability and efficiency for the cytosolic delivery of various *** serum stability was achieved by coating hyaluronic acid and human serum albumin on the surface of BODIPY-modified PAMAM/protein *** nanoparticles under green light irradiation allowed efficient intracellular delivery of multiple cargo proteins with different charges and molecular weights and promoted endosome *** study provides valuable guidance for the development of BODIPY derivative-based protein delivery systems and advances the research in intracellular protein delivery.

关键词： photoresponsive nanoparticles intracellular delivery protein delivery polyamidoamine(PAMAM) boron-dipyrromethene(BODIPY)

Highly transparent and super-wettable nanocoatings hybridized with isocyanate-silane modified surfactant for multifunctional applications

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Nano Materials Science 2022年第2期4卷 151-168页

作者： man kwan Law Ying Zhao Weibin Zhang Rui Wang Mingcheng Shi Yunxiao Zhang Shusheng Chen Jinglei Yang Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayHong Kong SARChina

Highly transparent and super-wettable nanocoatings for multifunctional applications with outstanding physical properties are in high ***,such nanocoatings resistant to water invasion and Ultraviolet(UV)weathering remain a significant *** this work,physically durable coatings based on inorganic nanoparticles(NPs)and an organic segment(isocyanate-silane modified surfactant)have been synthesized via a sol-gel *** is noteworthy the isocyanate-silane with-NH-C=O-functional group creates a strong bonding between the highly hydrophilic surfactant and the inorganic *** in-house synthesized organic segment can render the coating long-lasting wetting properties and resist to be washed away by water,while the inorganic NPs can form sturdy covalent bonds with the nano-scale hierarchical structure on the glazing substrate to improve the *** nanocoating demonstrates high transparency with superwetting property(water contact angle,WCA=4.4±0.3°),effective de-frosting *** invasion or UV accelerated weathering tests do not significantly affect the self-cleaning performance of *** properties,including coating adhesion,hardness,Young's modulus,and abrasion resistance are systematically ***,this clear coating shows prominent infrared shielding property attributed to Antimony-doped tin oxide(Sb-doped SnO_(2))*** developed nanocoating process is easy to scale up for larger areas that require multipurpose self-cleaning functions.

关键词： Nanocoating Sol-gel approach Multifunctionality High transparency Superwetting Durability

Feng Xiaocai, Zhengshang Zhongguo： Yu Qiaqing yu ta de shidai （Political Merchants in China： Yu Qiaqing and His Times）

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Frontiers of History in China 2015年第4期10卷 695-696页

作者： kwan man Bun University of Cincinnati

Embroiled in a bidding war in 1927 against powerful revenue farmers for the exclusive right to supply salt to the International Concession in Shanghai, Fan Xudong formed a partnership with Yu Qiaqing （1867-1945）, the city＇s ＂most influential person.＂（Wang Zhifei letter to Fan Xudong, 1927, rescripts from the papers of Jiuda Salt Refinery held at the College of Economics, Nankai University, Tianjin.） Feng Xiaocai, by building on his extensive work on Jiangsu and Zhejiang merchants, has chronicled the life and times of Yu （Feng, Zaishang yanshang, Shanghai： Shanghai Shehui kexue chubanshe, 2004）. Now, thanks to this book, we know much more about Yu.

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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo kwan man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

Monday blues of deceased-donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第1期10卷 26-29页

作者： See Ching Chan Wing Chiu Dai Chung Mau Lo Banny Lam Yuen man kwan Wai Yi Ho Sheung Tat Fan Department of Surgery Queen Mary HospitalThe University of Hong Kong

BACKGROUND:There is a constant and global shortage of deceased-donor organs for *** to identify areas for securing potential deceased-donor organs may improve the supply and hence benefit more patients in need of transplantation. METHODS:We looked into the disparity of the number of deceased-donor liver transplantation(DDLT)performed at our hospital on different days of the weeks from January 2000 to the end of December 2009(237 DDLTs).The number of DDLT performed on each day was compared with the other days of the week. RESULTS:It was apparent that there were fewer DDLTs on Mondays,as shown by the numbers of DDLT performed on different days of the week in an ascending order:Monday 18(7.6%),Sunday 30(12.7%),Thursday 34(14.3%),Friday 36(15.2%),Wednesday 38(16.0%),Tuesday 40(16.9%), and Saturday 41(17.3%).The difference reached statistical significance when Monday was compared with Tuesday (P=0.019),Wednesday(P=0.010),Friday(P=0.021),and Saturday(P=0.007).It was twice as unlikely a DDLT would be performed on Monday as compared with other *** a trend did not change even with an increase in the number of deceased-donor liver grafts in the last *** consent to donation was obtained from the donor family the day before DDLT,fewer consents were thus obtained on ***:These findings suggested that deceased-donor organ donation activities were less active on Sundays and could be *** further raises the concern of possible wastage of potential cases of organ donation.

关键词： deceased-donor liver transplantation graft shortage organ donation

3D/4D printed versatile ﬁbre-based wearables for embroidery, AIE-chemosensing, and unidirectional draining

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Aggregate 2024年第3期5卷 374-383页

作者： Pengchao Liu Chengshengze Chu Wenqi Qiu Lizi Cheng Jialun Gu Zhengyi Mao Zheng Zhao Xinyuan He Guo Liu Chen Peng kwan man Ben Zhong Tang Jian Lu Department of Mechanical Engineering City University of Hong KongKowloonHong KongChina CityU-Shenzhen Futian Research Institute ShenzhenChina Department of Plastic and Aesthetic Center The First Afﬁliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Department of Surgery School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhenChina Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Radiology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdongChina Laboratory of Nanomaterials and Nanomechanics City University of Hong KongHong KongChina

Fibre-based wearables for embroidery,chemosensing,and bioﬂuid’s unidirectional draining with goodﬂexibility,tunability,and designability drive technological ***,synthetic polymerﬁbres are non-degradable,threatening the environment and human ***,we have developed versatile microﬁbre-based wearables by combining many advantages in one platform of biodegradable polylactic acid(PLA)and melt electrowriting *** potential applications of PLA wearables are achieved byﬂexibly designing their printingﬁles,components and ***-dimensional printingﬁles are generated from two-dimensional images to fabricate‘embroidery-like’***/aggregation-induced emissionﬂuorogens(AIE)chemosensors exhibit colorimetric andﬂuorescent colour changes upon exposure to amine *** PLA-cotton textiles with a hydropho-bic/hydrophilic structure could facilitate unidirectional draining of sweats which is favourable for the management of temperature and humidity on the surface of *** proposed platform can not only broaden the design possibilities in 3D/4D printing but also offer wide potential applications for functional wearables.

关键词： 3D/4D printing aggregation-induced emission chemosensing ﬁbre-based wearable polylactic acid unidirectional draining

宗教在公共领域的角色——哈贝马斯的后世俗反思

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安徽大学学报（哲学社会科学版） 2011年第3期35卷 22-28页

作者：关启文香港浸会大学宗教与哲学系

宗教在公共领域的角色是一个争议性课题,不少自由主义者认为信仰是私人的事情,所以宗教不应在公共领域中担任重要角色。早期的哈贝马斯也有类此看法,然而近年他对宗教持较同情和肯定的态度,甚或对"世俗主义社会"的自足性提出深刻的反思... 详细信息

宗教在公共领域的角色是一个争议性课题,不少自由主义者认为信仰是私人的事情,所以宗教不应在公共领域中担任重要角色。早期的哈贝马斯也有类此看法,然而近年他对宗教持较同情和肯定的态度,甚或对"世俗主义社会"的自足性提出深刻的反思。在哈贝马斯与拉辛格主教(教宗本笃十六世)的对话里,哈贝马斯提出"后世俗社会"的新概念,批判僵化的和排斥宗教的世俗主义。一方面,哈贝马斯仍然坚持他的后形而上学和沟通伦理的观点,相信世俗自由社会可在宗教或形而上世界观之外找到基础。另一方面,他看到世俗理性的限制,并肯定整体而言宗教对维系健全的民主是有良性作用的。他甚至认为哲学必须愿意从神学身上学习。他相信在后世俗社会里,宗教会持续存在,而我们也要对宗教的真理存开放性。在现代社会中,哈贝马斯关于后世俗社会的构想,应有助于激烈争辩的多方能更和平、更理性地沟通。

关键词：哈贝马斯宗教公共领域后世俗社会自由社会

组织科学中的可重复性检验与理论发展: 以批判实在论为视角

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实证社会科学 2018年第1期 47-80页

作者： Eric W.K.Tsang Kai man kwan 谢恩[译] 不详西安交通大学管理学院

在此文中我们从批判实在视角评估了可重复性检验在理论发展中所扮演的角色。我们首先概述了批判实在论,而后将之运用于回应可重复性检验并不适用于社会科学的观点。之后我们将可重复性分为6类和2个维度。最后,我们详尽论证了可重复性检... 详细信息

在此文中我们从批判实在视角评估了可重复性检验在理论发展中所扮演的角色。我们首先概述了批判实在论,而后将之运用于回应可重复性检验并不适用于社会科学的观点。之后我们将可重复性分为6类和2个维度。最后,我们详尽论证了可重复性检验在社会科学研究中的重要性,并提出了一个可与组织科学其他分散模式整合的知识积累多焦点模式。

关键词：批判实在论可重复性知识积累社会科学研究模式整合扮演的角色视角重要性

组织科学中的可重复性检验与理论发展:以批判实在论为视角

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组织科学中的可重复性检验与理论发展:以批判实在论为视角