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A historical re-analysis of the calamitous midget typhoon passing through Hong kong region on 18 September 1906 and its storm surge impact to Hong kong region

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Tropical Cyclone Research and Review 2022年第3期11卷 174-218页

作者： Hing Yim Mok Chi Ming Shun Stephen Davies Wing Hong Lui Dick Shum Lau Kai Chun Cheung kwan yin kong Sai Tick Chan Hong kong Observatory Hong KongChina Hong kong Maritime Museum Hong KongChina US National Oceanic and Atmospheric Administration USA

A typhoon passed through Hong kong region suddenly and unexpectedly on 18 September 1906(the“Typhoon 1906”)and had a disastrous impact on Victoria Harbour and its surroundings in just a couple of *** the year 1906 was the“Bingwu”year in the Chinese calendar,the typhoon is also known historically as the“Bingwu Typhoon”.Tremendous loss of lives and property resulted,and the shipping and fishing communities were *** mysteries arising from this calamitous typhoon have existed to date:1)Why the Hong kong region Observatory was not able to provide any forewarning?2)whether the storm surge reported in some contemporary records is entirely credible?This paper will focus on both of *** this paper,we re-analyse historical weather observations recorded in various historical documents and estimate the possible storm size,intensity and track of Typhoon 1906 using tropical cyclone *** on the re-analyses,the storm surges,storm tides and wave heights in Hong kong region are also estimated using storm surge and wave *** results reveal that Typhoon 1906 was a midget typhoon,with a radius of maximum winds of 11 km or smaller,during its passage through Hong kong *** explains why it was technically impossible for a forewarning to be given at that time when real-time weather observations from ships,meteorological satellites and radars were *** also estimate that the maximum storm surges(storm tides)in Hong kong region were not higher than 0.82 m(2.43 mCD)and 1.98 m(4.15 mCD)in Victoria Harbour and Tolo Harbour *** figures are found to be limited by the intensity and the storm size of the ***,we conclude that the previously documented storm surge figures are not supported by the present study.

关键词： Bingwu typhoon Midget typhoon Storm surge Historical re-analysis Hong kong region

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge yin Tingting Fu Jing Liu Yuji Du Jiahui kong Rongrong Chang Jian Ni Xingbin yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

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Learning of medical pharmacology via innovation:a personal experience at McMaster and in Asia

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Acta Pharmacologica Sinica 2004年第9期25卷 84-92页

作者： Chiu-yin kwan Canada Department of Medicine HSC-4N40 Faculty of Health Sciences Hamilton L8N 3Z5 McMaster University Ontario

Pharmacology in the traditional medical curriculum has been treated as a discrete "preclinical" discipline identifying itself distinctly different from the other preclinical sciences or clinical subjects in knowledge base as well as learning/teaching instructions. It is usually run in series with other pre-clinical courses (eg, anatomy, biochemistry, physiology etc), but in parallel with other paraclinical courses such as pathology, microbiology and community medicine. Clinical pharmacology was only introduced relatively recently designed to overcome the perceived deficiency in "preclinical" pharmacology regarding its therapeutic relevance and application to medicine. In many universities, both preclinical and clinical pharmacology courses co-exist, usually independently offered by two separate, sometimes non-interacting Departments of Pharmacology and Clinical Pharmacology. In this model, pharmacology is generally taught in a teacher-centered, discipline-oriented, and knowledge-based curriculum. Further

关键词： problem-based learning pharmacology medical education self-directed learning small group tutorial

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Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action

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Acta Pharmacologica Sinica 2002年第12期23卷 4-15页

作者： Chiu-yin kwan Canada Department of Medicine Hamilton McMaster University Ontario

Tetrandrine (TET), a bis-benzylisoquinoline alkaloid purified and identified an active ingredient in a Chinese medicinal herb, Radix Stephanae tetrandrae, has been used traditionally for the treatment of congestive circulatory disorder and inflammatory diseases. TET, together with a few of its structural analogues, has long been demon-strated to have antihypertensive action in clinical as well as animal studies. Presumably, the primary anti-hyperten-sive action of TET is due to its vasodilatory properties. TET prevents or inhibits vascular contraction induced by membrane depolarization with KC1 or α-adrenoceptor activation with phenylephrine (PE). TET (30 μmol/L) also inhibits the release of endothelium-derived nitric oxide (NO) as well as NO production by inducible NO synthase. TET apparently inhibits multiple Ca2+ entry pathways as demonstrated in cell types lacking the L-type Ca2+ channels. In cardiac muscle cells, TET inhibits both L- and T-type Ca2+ channels. In addition to its actions on cardiov

关键词： alkaloids tetrandrine calcium channel blockers alpha adrenergic receptors vasodilator agents anti-inflammatory agents antihypertensive agents Chinese traditional medicine isoquinoline

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A ketone-functionalized aromatic saddle as a potential building block for negatively curved carbon nanobelts

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Chinese Chemical Letters 2019年第8期30卷 1506-1508页

作者： kwan yin Cheung Qian Miao Department of Chemistry The Chinese University of Hong Kong

A novel ketone-functionalized aromatic saddle consisting of 72 sp^2 carbon atoms is successfully synthesized and unambiguously identified with X-ray *** can,in principle,be used as a building block for synthesis of ne... 详细信息

关键词： Polycyclic arenes Synthesis Negatively curved carbon allotropes Carbon nanobelts Scholl reaction

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Calcium signaling: the role of inositol phosphates and the mechanisms of Ca~(2+) entry

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中国药理学与毒理学杂志 1991年第4期5卷 246-254页

作者： Haruo TAKEMURA Chiu-yin kwan Oepartment of Pharmacology Sapporo Medical College S. 1 W. 17 Sapporo 060 Japan Smooth Muscle Research Program Department of Biomedical Sciences McMaster University Hamilton Ontario. Canada L8N 3Z5

Activation of surface membrane receptors provokes a variety of cellular responses by initiating a series of specific biochemical reactions which are responsible for the membrane transducing mechanisms and the subsequent Ca2+signaling process. Ca2+ is well known as a second messenger that an early consequence of receptor activation is usually the synthesis

关键词：药理学毒理学杂志

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Empirical Likelihood for Generalized Linear Models with Longitudinal Data

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Journal of Systems Science & Complexity 2023年第5期36卷 2100-2124页

作者： yin Changming AI Mingyao CHEN Xia kong Xiangshun School of Mathematics and Information Science Guangxi UniversityNanning 530004China LMAM School of Mathematical Sciences and Center for Statistical SciencePeking UniversityBeijing 100871China School of Mathematics and Statistics Shaanxi Normal UniversityXi'an 710062China School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China

Generalized linear models are usually adopted to model the discrete or nonnegative *** this paper,empirical likelihood inference for fixed design generalized linear models with longitudinal data is *** some mild conditions,the consistency and asymptotic normality of the maximum empirical likelihood estimator are established,and the asymptotic χ^(2) distribution of the empirical log-likelihood ratio is also *** with the existing results,the new conditions are more weak and easy to *** simulations are presented to illustrate these asymptotic properties.

关键词： Empirical likelihood ratio generalized linear model longitudinal data maximum empirical likelihood estimator

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Changes of Residential Land Density and Spatial Pattern from 1989 to 2004 in Jinan City,China

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Chinese Geographical Science 2011年第5期21卷 619-628页

作者： yin Haiwei kong Fanhua ZHANG Xiang Department of Urban Planning and Design Nanjing University Nanjing 210093 China International Institute for Earth System Science Nanjing University Nanjing 210093 China

Urban sprawl is driven by a myriad of factors, the predominant one of which is the development of residential land. Selecting part of Jinan City for a case study, we use the landscape metric of percent of landscape (PLAND) to capture residential land growth and density changes in 1989, 1996 and 2004 to illuminate the dynamic process of residential land development. The results indicate that the moving window method and the landscape metrics method are efficient ways to describe residential land density. The residential land showed the greatest change among the built-up land with 1995.68 ha from 1989 to 2004, which is mainly transformed from agriculture land and green space. The urban center area of study area is primarily covered with medium density residential land, and surrounded by high density residential land. The development pattern of residential land exhibited both fill-in (new growth occurs through infilling the free spaces within the developed area) and sprawl processes, influenced by a series of factors, such as urban development policy, conservation of springs, recreational and aesthetic amenities. The findings of the study will help to guide urban planning with a focus on the management and protection of the environment and resources.

关键词： residential land density landscape metric urban sprawl moving window Jinan

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Progress in approved drugs from natural product resources

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Chinese Journal of Natural Medicines 2024年第3期22卷 195-211页

作者： LUO Zhongwen yin Fucheng WANG Xiaobing kong Lingyi State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impactson the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs orindirectly through modifications of NPs. This review presents an overview of NP drugs recently approved in China, the United States,and other countries, spanning various disease categories, including cancers, cardiovascular and cerebrovascular diseases, centralnervous system disorders, and infectious diseases. The article provides a succinct introduction to the origin, activity, development process, approval details, and mechanism of action of these NP drugs.

关键词： New drugs Natural products Structural modification

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