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Associations between IL-1RN variable number of tandem repeat, IL-1β (-511) and IL-1β (+3954) gene polymorphisms and urolithiasis in Uighur children of China

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Asian Journal of Urology 2022年第1期9卷 51-56页

作者： Jiefeng Xiao Shukai Zheng Zhaolong Qiu kusheng wu Department of Preventive Medicine Shantou University Medical CollegeShantouGuangdongChina

Objective:Interleukin-1(IL-1)is a pro-inflammatory cytokine which may be related to *** polymorphisms of the interleukin-1beta(IL-1β)have been proposed as markers for urolithiasis in some *** to the high incidence of urolithiasis in Uighur children(Xinjiang,China)and existence of ethnic difference,our aim is to explore the potential of IL-1 gene polymorphisms and urolithiasis among these ***:Genomic DNA extracted from peripheral blood of 115 patients and 98 controls were used for genotype polymorphisms ***-1 receptor antagonist(IL-1RN)gene variable number of tandem repeat(VNTR)gene polymorphisms were analyzed by PCR ***-based restriction analysis was done for the IL-1β(-511)and IL-1β(+3954)gene polymorphisms by endonucleases Ava I and Taq I,*** genotype distribution,allele frequencies,carriage rate,and haplotype frequencies were statistically ***:No significant differences were observed in genotypic frequencies between pediatric urolithiasis patients and control group for IL-1RN gene(χ^(2)=1.906,p=0.605),IL-1β(-511)gene(χ^(2)=0.105,p=0.949),or IL-1β(+3954)gene(χ^(2)=3.635,p=0.169).There were yet no significant differences of the allele frequencies of IL-1RN VNTR gene(p=0.779),IL-1β(-511)gene(p=0.941),and IL-1β(+3954)gene(p=0.418)in the case and control groups,as well as the carriage rate and haplotype of them(all p>0.05).Conclusions:The associations between IL-1RN VNTR,IL-1β(-511)and IL-1β(+3954)genes polymorphisms and urolithiasis were not significant in Uighur *** results need to be confirmed in studies with larger population sample size,as well as in other ethnic groups.

关键词： Urolithiasis Single nucleotide polymorphisms IL-1RN variable number of tandem repeat gene IL-1β(-511)gene IL-1β(+3954)gene Uighur children

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Internet科技信息资源的查找与利用

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情报探索 1999年第2期 34-35页

作者：吴库生汕头大学医学院图书馆汕头515031

介绍了Internet的发展状况,从网上获取本学科信息资源的途径和查询技巧,以及网上虚拟图书馆和在线服务的相关知识。

关键词： Internet 信息检索虚拟图书馆科技信息资源在线服务查询途径

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下世纪医药信息服务业的发展战略

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医学信息学杂志 1998年第1期25卷 1-3页

作者：吴库生汕头大学医学院图书馆 515031

我国的医药信息事业经过近一二十年的发展,已为医学科研和教学、加速社会主义经济建设作出了卓越贡献,特别是在改革开放年代,适应形势需要,加强市场经营观念,实行结构调整和人才分流,大力加强基础设施建设和信息服务,收到了显著效果。... 详细信息

我国的医药信息事业经过近一二十年的发展,已为医学科研和教学、加速社会主义经济建设作出了卓越贡献,特别是在改革开放年代,适应形势需要,加强市场经营观念,实行结构调整和人才分流,大力加强基础设施建设和信息服务,收到了显著效果。随着信息工作的不断深入和革新,医药信息学理论也取得了可喜的进展。现在正处于世纪之交。

关键词：医药信息服务业医药信息学发展战略下世纪信息产品信息产业社会主义经济建设市场经营观念世纪之交医药信息系

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乳腺癌术后患者心理弹性及其影响因素分析

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中国医药科学 2017年第20期7卷 24-29页

作者：陈玮吴库生惠州卫生职业技术学院护理系广东惠州516025 汕头大学医学院公共卫生与预防医学教研室广东汕头515041

目的对乳腺癌术后患者的心理弹性进行现状调查,并对其相关影响因素进行分析;为增强乳腺癌术后患者心理弹性、提高乳腺癌术后患者生活质量提供科学依据。方法采用横断面调查方法对惠州市某三甲医院肿瘤门诊的220例乳腺癌术后患者,应用一... 详细信息

目的对乳腺癌术后患者的心理弹性进行现状调查,并对其相关影响因素进行分析;为增强乳腺癌术后患者心理弹性、提高乳腺癌术后患者生活质量提供科学依据。方法采用横断面调查方法对惠州市某三甲医院肿瘤门诊的220例乳腺癌术后患者,应用一般情况调查表、心理弹性量表、一般自我效能感量表、家庭坚韧力量表、社会支持评定量表进行现状调查,分析影响乳腺癌术后患者心理弹性的相关因素。乳腺癌术后患者的心理弹性与自我效能感、家庭弹性力量、社会支持量采用Pearson相关分析,以心理弹性为因变量,单因素分析有统计学意义的变量纳入方程进行多元回归分析。结果乳腺癌术后患者心理弹性较差,其心理弹性与自我效能感(r=0.191,P<0.01)、家庭弹性(r=0.478,P<0.01)、社会支持(r=0.718,P<0.01)呈正相关,多元线性回归分析显示肿瘤分期、辅助治疗疗程、术后参与锻炼强度、家庭坚韧力承担、控制两个维度、社会支持主观支持维度,6个因子进入回归方程,可解释乳腺癌术后患者心理弹性的60.1%。结论可通过对肿瘤分期等6个因素的干预增强乳腺癌术后患者心理弹性。

关键词：乳腺癌心理弹性影响因素多元回归分析

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细胞色素P450 2E1基因多态性与食管癌易感性关系的Meta分析

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肿瘤基础与临床 2006年第1期19卷 13-16页

作者：吴库生李克汕头大学医学院预防医学教研室广东汕头515041

目的探讨细胞色素P450 2E1（CYP2E1）基因多态性与食管癌易感性的关系。方法检索CBMdisc、CMCC、CNKI、Medline、Pubmed等数据库，并收集未公开发表的文章及硕、博士学位论文，获得有关CYP2E1基因多态性与食管癌易感性的关系的文献进行M... 详细信息

目的探讨细胞色素P450 2E1（CYP2E1）基因多态性与食管癌易感性的关系。方法检索CBMdisc、CMCC、CNKI、Medline、Pubmed等数据库，并收集未公开发表的文章及硕、博士学位论文，获得有关CYP2E1基因多态性与食管癌易感性的关系的文献进行Meta分析，以病例组及对照组CYP2E1基因型分布的比值比（OR值）为效应指标，确定纳入标准，对文献进行筛选，异质性检验，然后应用Meta分析软件RevMan4．2．2对各研究原始数据进行统计处理，计算合并OR值及95％可信区间。结果按照纳入标准，最终进入系统评价的文献共有11篇病例对照研究，其中食管癌患者1094例，对照1329例，Meta分析结果合并OR=2．61，95％可信区间为1．68—4．05，说明CYP2E1基因型频率分布与食管癌的关联有统计学意义。结论对目前相关研究结果的Meta分析显示，CYP2E1基因多态性与食管癌易感性之间存在相关，即携带Rsa Ⅰ／PstⅠ识别的野生型CYP2E1基因纯合子的个体发生食管癌的危险性较高。

关键词：食管癌细胞色素P450 2E1 基因多态 Meta分析

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Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

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Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao Xuyang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower expected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the expected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery

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New findings on the influence of El Nino events on tropical cyclone formation

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Science China Earth Sciences 2024年第3期67卷 892-893页

作者： Liguang wu Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China

Tropical cyclones typically form over warm tropical and subtropical ocean surfaces, as their formation and intensification rely primarily on the energy provided by the ocean. Pioneering research by Gray (1968) revealed that the formation of tropical cyclones requires the sea surface temperature (SST) to be no less than 26.5℃. Consequently, SST is commonly recognized as a crucial parameter among the environmental factors influencing tropical cyclone formation(Gray, 1979;Emanuel and Nolan, 2004).

关键词： tropical cyclone ocean

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Two-dimensional semiconductor heterostructures for photocatalytic CO_(2)conversion

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Science China Chemistry 2024年第8期67卷 2434-2447页

作者： Yang wu Mingyu wu Yongfu Sun Yi Xie Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China

The CO_(2)reduction into carbon-contained fuel via solar energy offers the powerful tools to realize the zero-emission carbon *** to the intriguing features of the two-dimensional(2D)heterostructures,it is susceptible to modulate the electronic structure as well as the surface geometry for optimizing the photocatalytic CO_(2)*** this perspective,we surveyed the fundamental insights of 2D semiconductor heterostructures,involving the fabrication strategies and classification of the 2D semiconductor ***,we have detailly discussed the overview of 2D semiconductor heterostructure for optimizing CO_(2)photocatalytic influenced factors,including the solar energy utilization,photogenerated carriers separation,and redox reaction ***,we showed the significant advantages of 2D heterostructures in elevating CO_(2)photoreduction performance,focusing on activity,selectivity and *** analyzing the limitations and developments,we ended by putting forward insights into the further researches about the CO_(2)photocatalysts and reactor design,even industrial applications.

关键词： two-dimensional semiconductor heterostructures photocatalysis CO_(2)conversion

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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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