检索结果-南通市图书馆

Submicron size-scale mapping of carbonate effective elastic properties from FIB-SEM images and finite element method

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2017年第3期60卷 557-575页

作者： CHENG HuiHong ZHU BoJing David A YUEN shi YaoLin Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences Beijing 100049China College of Earth Science University of Chinese Academy of SciencesBeijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Rock Mechanics and Carbon Store Lab Department of Earth SciencesDurham UniversityDurhamDH13LEUK Department of Earth Science and Minnesota Supercomputing Institute University of MinnesotaMinneapolis 55455USA

In this paper, an automatic unstructured focused ion beam （FIB） and scanning electron microscopy （SEM） images induced representative volume element （RVE） finite element （FE） method is developed to predict submicron scale carbonate rock effective Young＇s and bulk moduli and Poisson＇s ratio on parallel CPU-GPU platform. Based on high resolution-contrast surface morphology and internal fabric-texture structure images from carbonate rock specimen （covered 0.12-64 μm2 area and 8000 μm3 domain）, the cubic RVE FE models are constructed from different sites through Avizo with user-defined parameters Matlab coding. The effective Young＇s and bulk moduli and Poisson＇s ratio of the different RVEs and porosity and pore size are computed by using periodic boundary condition in the well-known FE software Abaqus. FE mesh sensitivity analysis has been conducted where all moduli converge to a certain constant value at larger FE mesh density. The effect of fabric-texture （pore size, shape, and distribution） on the elastic properties is discussed. The correlations between the computed effective elastic properties and pore size, porosity, RVE size have been established. The simulation results show that the effective Young＇s and bulk moduli and Poisson＇s ratio have strong anisotropic behavior and depend on RVE size, porosity and pore size. The RVE size, porosity and pore size are three independent factors in affecting of the effective elastic moduli, the effect mechanism of porosity and pore size is same while the effect mechanism of RVE size is difference.

关键词： Carbonate effective elastic properties Finite element analysis Focused ion beam Nano-porosity Nano pore size

A transgenic monkey model for the study of human brain evolution

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2019年第3期40卷 236-238页

作者： Lei shi Bing Su State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming Yunnan 650223China

Why humans have large brains with higher cognitive abilities is a question long asked by ***,much remains unknown,especially the underlying genetic *** the use of a transgenic mon key model,we showed that human-specific sequenee changes of a key brain development gene(Primary microcephaly 1,MCPH7)could result in detectable molecularand cognitive changes resembling human neoteny,a no table characteristic developed during human *** study was published in National Science Review(shi et al.,2019).

关键词： human brain evolution key model

Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第3期39卷 459-468页

作者： shi-Zhe Xie Ke Yao Bei Li Cheng Peng Xing-Lou Yang Zheng-Li shi State Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China Hubei Jiangxia Laboratory Wuhan430200China

Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human *** are considered reservoirs of these viruses because related filoviruses have been discovered in ***,due to the requirement for maximum containment laboratories when studying infectious viruses,the characterization of bat filoviruses often relies on pseudoviruses and minigenome *** this study,we used RACE technology to sequence the 30-leader and 50-trailer of Mengla virus(MLAV)and constructed a *** to MARV,the transcription activities of the MLAV minigenome are independent of *** further assessed the effects of polymorphisms at the 50 end on MLAV minigenome activity and identified certain mutations that decrease minigenome reporter efficiency,probably due to alterations in the RNA secondary *** reporter activity upon recombination of the 30-leaders and 50-trailers of MLAV,MARV,and EBOV with those of the homologous or heterologous minigenomes was compared and it was found that the polymerase complex and leader and trailer sequences exhibit intrinsic ***,we investigated whether the polymerase complex proteins from EBOV and MARV support MLAV minigenome RNA synthesis and found that the homologous system is more efficient than the heterologous *** efficiently inhibited MLAV as well as EBOV *** summary,this study provides new information on bat filoviruses and the minigenome will be a useful tool for high-throughput antiviral drug screening.

关键词： Bat filovirus Mengla virus(MLAV) Minigenome Replication Antiviral drug screening

Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province,southwest of China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2009年第1期36卷 51-58页

作者： Yufeng Yao 1, Li shi 1, Lei shi, Keqin Lin, Yufen Tao, Liang Yu, Hao Sun, Xiaoqin Huang, Yanhan Li, Jiayou Chu Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, kunming 650118, China [a]Institute of Medical Biology Chinese Academy of Medical Sciences & Peking Union Medical College Kunming 650118 China

The associations of polymorphic Alu insertions （POALINs） with major histocompatibility complex （MHC） class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations. For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province, we investigated frequencies of five POALINs, their associations with HLA-A and -B, the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region. We found that a strong positive association between AluHG and HLA-A＊02 is in Jinuo, but not in Yunnan Han. These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations.

关键词： MHC I haplotype POALINs

Chemical constituents and biological activities of lycophytes and ferns

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第12期17卷 887-891页

作者： ZHU Qin-Feng ZHAO Qin-shi State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and *** Chinese lycophytes and ferns flora,with approximately 2000 species,contributes a substantial component to the global lycophytes and ferns diversity,with estimates of 12000 *** them,about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural *** paper reviewed the research history and current status of chemical constituents and biological activities of lycophytes and ferns,which had highlighted the research progress of our group.

关键词： Lycophytes Ferns Chemical constituents Biological activities Lycopodium alkaloids

Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2017年第12期15卷 950-954页

作者： LI shi-Fei LI Shun-Lin Institute of Molecular Science Shanxi University State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C(1) and its glucoside, cycloccidentaliside VI(2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC_(50) value of 1.44 μmol·L^(-1) and TI(Therapeutic Index) value of 15.59.

关键词： Cycloartane triterpenoid Cassia occidentalis Cycloccidentalic acid C Cycloccidentaliside Ⅵ

Tree shrew (Tupaia belangeri)as a novel laboratory disease animal model

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2017年第3期38卷 127-137页

作者： Ji Xiao Rong Liu Ce-shi Chen Medical Faculty of kunming University of Science and Technology Kunming Yunnan 650500 China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China

The tree shrew （Tupaia belangeri） is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shrew an ideal subject for the study of human disease. Numerous tree shrew disease models have been generated in biological and medical studies in recent years. Here we summarize current tree shrew disease models, including models of infectious diseases, cancers, depressive disorders, drug addiction, myopia, metabolic diseases, and immune-related diseases. With the success of tree shrew transgenic technology, this species will be increasingly used in biological and medical studies in the future.

关键词： Tree shrew (Tupaia belangeri) Animal model Transgenic Disease

在线全文

学校读者我要写书评

暂无评论

超声内镜引导下胆道引流术研究进展

中华肝胆外科杂志 2020年第4期26卷 315-320页

作者：陶为杰石小举郑昆明赵永捷天津市人民医院普外科 300121 吉林大学白求恩第一医院肝胆胰外一科长春130021

超声内镜引导下胆道引流术(EUS-BD)凭借其手术安全性和有效性正逐步发展并取代经皮肝穿胆管引流术,成为良性及恶性胆道梗阻患者ERCP治疗失败后的有效替代方案。临床操作时,术者可以依据患者自身病情及解剖特点选择合适的手术方法。本文... 详细信息

超声内镜引导下胆道引流术(EUS-BD)凭借其手术安全性和有效性正逐步发展并取代经皮肝穿胆管引流术,成为良性及恶性胆道梗阻患者ERCP治疗失败后的有效替代方案。临床操作时,术者可以依据患者自身病情及解剖特点选择合适的手术方法。本文通过对近年来国内外发表的相关文献资料进行汇总,对EUS-BD技术的临床应用情况及其研究进展作一综述。

关键词：胆道梗阻超声内镜引导下胆道引流术内镜下逆行胰胆管造影术

A Surface-Simplex Swarm Evolution Algorithm

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2017年第1期22卷 38-50页

作者： QUAN Haiyan shi Xinling Faculty of Information Engineering and Automation Kunming University of Science and Technology Information College Yunnan University

In the paper,a particle surface-simplex search（PSSS） is designed based on particle surface-simplex and particle surface-simplex *** PSSS and an evolutionary strategy of multi-states swarm,a surface-simplex swarm evolution（SSSE） algorithm for numerical optimization is *** the experiments,SSSE is applied to solve 17 benchmark problems and compared with the other intelligent optimization *** the application,SSSE is used to analyze the three intrinsic independent components of gravity earth *** results demonstrate that SSSE can accurately find optima or close-to-optimal solutions of the complex functions with *** performance of SSSE is stable and efficient.

关键词： evolutionary computation global optimization par-ticle surface-simplex surface-simplex swarm evolution multi-states swarm gravity earth tide