Sir,We have reported two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed abundant glycogen in their liver parenchyma but a marked reduction of glycogen content in HCC.[1]It was...
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Sir,We have reported two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed abundant glycogen in their liver parenchyma but a marked reduction of glycogen content in HCC.[1]It was suggested that the latter was associated with appearance of a Warburg type glycolysis[1]and discussed in some detail.[2]
This article reports two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed marked changes in hepatocellular glycogen *** acid-Schiff(PAS)-positive and diastase-PAS-negative(glyco...
详细信息
This article reports two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed marked changes in hepatocellular glycogen *** acid-Schiff(PAS)-positive and diastase-PAS-negative(glycogen-storing)hepatocytes were detected in both background liver parenchyma and in HCC *** HCC tissues,the number of glycogen-storing cells resembling hepatocytes was considerably reduced and unevenly distributed as compared with hepatocytes in background *** be known,changes in hepatocellular glycogen content in T2DM patients have not been previously *** is hypothesized that the reduction in glycogen content in both patients was likely associated with the emergence of Warburg type of glycolysis.
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