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Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

World Journal of Gastroenterology 2012年第38期18卷 5360-5368页

作者： kunihiro hosono Eiji Yamada Hiroki Endo Hirokazu Takahashi Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima Division of Gas-troenterology Yokohama City University School of Medicine Yokohama 2360004 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 1040045 Japan

AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis.

关键词：肿瘤坏死因子受体肠腺人类 caspase-3 血清浓度共聚焦显微镜免疫组化 c-Jun

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Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis

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World Journal of Gastroenterology 2010年第4期16卷 484-489页

作者： Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo kunihiro hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima Gastroenterology Division Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohama 236-0004Japan

AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis.

关键词： Barrett’s epithelium Esophagitis Endoscopy

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characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases

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World Journal of Gastroenterology 2012年第33期18卷 4557-4562页

作者： Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida kunihiro hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima Gastroenterology Division Yokohama City University School of Medicine Yokohama 236-0004 Japan Department of Medical Education Yokohama City University School of Medicine Yokohama 236-0004 Japan Department of Neurology Yokohama City University School of Medicine Yokohama 236-0004 Japan

AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP.

关键词：线粒体疾病肠梗阻患者假性死亡原因 CIP 心肌病生存时间

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Early effects of oral administration of omeprazole and roxatidine on intragastric pH

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO kunihiro hosono Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology Division Yokohama City University School of Medicine Department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词：奥美拉唑胃溃疡 pH值口服早期质子泵抑制剂相关性疾病受体拮抗剂

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IL-6 Plays Crucial Roles in Sporadic Colorectal Cancer through the Cytokine Networks including CXCL7

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Journal of Cancer Therapy 2012年第6期3卷 874-879页

作者： Takashi Uchiyama Hirokazu Takahashi Hiroki Endo Eiji Sakai kunihiro hosono Yoji Nagashima Atsushi Nakajima Department of Molecular Pathology Yokohama City University School of Medicine Yokohama Japan Division of Gastroenterology Yokohama City University School of Medicine Yokohama Japan

IL-6 is a multifunctional cytokine and involved in variety of carcinogenesis. However, the association between IL-6 and sporadic colorectal cancer has not been fully explained. Here, we investigated the role of IL-6 signaling and the cytokine network in sporadic colorectal cancer. We investigated the serum IL-6 levels in patients with sporadic colorectal adenoma, cancer patients, and normal controls. In addition, the expressions of IL-6, gp130, and the IL-6 receptor subunit were investigated in biopsy specimens collected from these subjects. Furthermore, the expressions of CXCL7 and CXCR2, a chemokine and its receptor involved in IL-6 production, were also investigated. We observed an elevated level of serum IL-6 in colorectal cancer patients and an increased expression of IL-6 in colorectal cancer tissues, compared with the levels in a control group and in patients with adenoma. The phosphorylation of gp130 was also increased in the colorectal cancer tissues, compared with that in control and adenoma tissues. The expressions of CXCL7 and CXCR2 in the colorectal cancer tissues were also higher than those in control and adenoma tissues. IL-6 signaling is involved in sporadic colorectal cancer. In addition, the increased expressions of CXCL7 and CXCR2 might, in turn, increase the expression of IL-6 in colorectal cancer. Further studies are required to elucidate the function of the IL-6 signaling and the cytokine network in sporadic colorectal cancer.

关键词： IL-6 Colorectal Cancer gp130 CXCL7

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Relationship of human rectal aberrant crypt foci and formation of colorectal polyp:One-year following up after polypectomy

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World Journal of Gastrointestinal Endoscopy 2012年第12期4卷 561-564页

作者： Hirokazu Takahashi Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Takashi Uchiyama kunihiro hosono Hiroki Endo Atsushi Nakajima Gastroenterology Division Yokohama City University Graduate School of Medicine

AIM:To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal polyp.METHODS:Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital.All patients had baseline adenomas removed at year 0 colonoscopy.Aberrant crypt foci(ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters,often with oval or slit-like lumens and a thicker epithelial lining.RESULTS:A total of 366 ACFs were identified in 89 patients;all had baseline adenomas removed at the first examination(year 0) colonoscopy and returned for the second(year 1).ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers,0-3 or over 3.All participants were examined in the number and maximum size of adenoma.There was no statistical difference in number and maximum size of ACF at year 0,however,maximum size of adenoma was larger in over 3 group than 0-3 group at year 1.CONCLUSION:The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.

关键词： Aberrant crypt foci Colorectal carcinogenesis Visceral fat Adiponectin

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Early life history affects fish size mainly by indirectly regulating the growth during each stage:a case study in a demersal fish

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Marine Life Science & Technology 2023年第1期5卷 75-84页

作者： Rui Wu Qinghuan Zhu Satoshi Katayama Yongjun Tian Jianchao Li kunihiro Fujiwara Yoji Narimatsu Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES)and Key Laboratory of Mariculture Ministry of EducationOcean University of China5 Yushan RoadQingdao266003China Graduate School of Agricultural Science Tohoku University1-1 Tsutsumidori AmamiyamachiAobaSendai981-8555Japan Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and TechnologyQingdao266237China Niigata Field Station Fisheries Resources InstituteJapan Fisheries Research and Education AgencyYokohama220-6115Japan Hachinohe Field Station Fisheries Resources InstituteJapan Fisheries Research and Education AgencyYokohama220-6115Japan

The complex life histories of demersal fishes are artificially separated into multiple stages along with changes in morphology and habitat.It is worth exploring whether the phenotypes expressed earlier and later during the life cycle are related or decoupled.The life stages of first year Pacific cod(Gadus macrocephalus)were tracked over different hatch years and regions to test whether the early life history had a long-lasting effect on subsequent growth.We further explored the contribution of growth in the early and subsequent life history stages to body size at the end of each stage.In addition to the accessory growth centre and the first annual ring,the other two checks on the otolith possibly related to settlement and entering deeper waters were identified in 75 Pacific cod individuals.The direct and indirect relationships among the life history stages was interpreted based on path analysis.The results showed that growth prior to the formation of the accessory growth centre had a significant effect on the absolute growth of the fish before and after settlement and migration to deep water.However,there was no or moderate evidence that early growth affected the body size at each stage,which was mainly regulated by growth during the stage.This study supports the lasting effect of early growth and clarifies that it affects size mainly by indirectly regulating staged growth.Quantifying the phenotype relationships and identifying the internal mechanisms form the basis for assessing population dynamics and understanding the processes behind the changes.

关键词： Early life history Gadus macrocephalus Otolith Path analysis Staged growth Body size

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S-1 induced hepatic steatosis in patients with pancreatic cancer:Retrospective analysis

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World Journal of Gastrointestinal Oncology 2017年第8期9卷 314-318页

作者： kunihiro Tsuji Hisashi Doyama Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 920-8530Japan

AIM To determine whether S-1 induces hepatic steatosis in patients being treated for pancreatic cancer.METHODS This retrospective study evaluated 22 patients who received oral S-1 as a first-line treatment for pancreatic cancer between January 2008 and July 2015 at the Ishikawa Prefectural Central Hospital. Patients underwent abdominal computed tomography(CT) scans before chemotherapy and within 3 mo from the start of treatment. CT numbers of the liver and spleen were measured before and after S-1 administration. Steatosis was diagnosed when the ratio of the CT number of the liver to that of the spleen(liver/spleen ratio) was < 0.9.RESULTS Median patient age was 68 years(range, 48-85 years), and median body mass index was 21 kg/m^2(range, 18-27 kg/m^2). Of the 22 patients, six(27%) regularly consumed alcohol, and five(23%) had liver metastases. The mean ratio of CT number of the liver to the spleen was significantly higher before administration of S-1(1.27 vs 1.09, P = 0.012) compared with after. Of the 22 patients, five(23%) had hepatic steatosis and 17(77%) did not. The pretreatment demographic and clinical characteristics of these two groups showed no significant differences. The relationship between liver/spleen ratio and alanine transaminase activity in these patients. A statistically significant inverse correlation was observed(r =-0.417, P < 0.027).CONCLUSION Of the 22 patients with pancreatic cancer, five(23%) experienced S-1 induced hepatic steatosis. Care should be taken during S-1 treatment of patients with pancreatic cancer.

关键词： S-1 肝的脂肪变性胰腺的癌症药导致了肝炎 5 氟尿嘧啶

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Recent Research and Development of Optical Fiber Monitoring in Communication Systems

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Photonic Sensors 2013年第4期3卷 304-313页

作者： kunihiro TOGE Fumihiko ITO NTT Access Network Service Systems Laboratories NTT Corporation Tsukuba Ibaraki 305-0805 Japan

Recent progress on optical fiber monitoring in the optical communication systems is reviewed along with current optical fiber monitoring and diagnosing problems in deployed access, trunk and submarine communication sy... 详细信息

关键词：光通信系统光纤监测开发光纤监控诊断问题

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Synthesis of a stroboscopic image from a hand-held camera sequence for a sports analysis

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Computational Visual Media 2016年第3期2卷 277-289页

作者： kunihiro Hasegawa Hideo Saito Keio University

This paper presents a method for synthesizing a stroboscopic image of a moving sports player from a hand-held camera sequence. This method has three steps: synthesis of background image,synthesis of stroboscopic image, and removal of player's shadow. In synthesis of background image step, all input frames masked a bounding box of the player are stitched together to generate a background image. The player is extracted by an HOG-based people detector.In synthesis of stroboscopic image step, the background image, the input frame, and a mask of the player synthesize a stroboscopic image. In removal of shadow step, we remove the player's shadow which negatively affects an analysis by using mean-shift. In our previous work, synthesis of background image has been timeconsuming. In this paper, by using the bounding box of the player detected by HOG and by subtracting the images for synthesizing a mask, computational speed and accuracy can be improved. These have contributed greatly to the improvement from the previous method.These are main improvements and novelty points from our previous method. In experiments, we confirmed the effectiveness of the proposed method, measured the player's speed and stride length, and made a footprint image. The image sequence was captured under a simple condition that no other people were in the background and the person controlling the video camera was standing still, such like a motion parallax was not occurred. In addition, we applied the synthesis method to various scenes to confirm its versatility.

关键词： sports vision stroboscopic image stitching mask synthesis

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