Relationship of human rectal aberrant crypt foci and formation of colorectal polyp:One-year following up after polypectomy

作     者：Hirokazu Takahashi Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Takashi Uchiyama Kunihiro Hosono Hiroki Endo Atsushi Nakajima 

作者机构：Gastroenterology DivisionYokohama City University Graduate School of Medicine 

出 版 物：《World Journal of Gastrointestinal Endoscopy》 (世界胃肠内镜杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第12期

页      面：561-564页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grant-in-Aid for Research on the Third Term Comprehensive Control Research for Cancer from the Ministry of Health,Labour and Welfare,Japan to Nakajima A a grant from the National Institute of Biomedical Innovation (NBIO) to Nakajima A a grant from the Ministry of Education,Culture,Sports,Science and Technology,Japan (KIBAN-B) to Nakajima A and (KIBAN-C) to Takahashi H 

主　　题：Aberrant crypt foci Colorectal carcinogenesis Visceral fat Adiponectin 

摘      要：AIM:To clarify the relationship of human rectal aberrant crypt foci and formation of colorectal ***:Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University *** patients had baseline adenomas removed at year 0 *** crypt foci(ACF) were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters,often with oval or slit-like lumens and a thicker epithelial ***:A total of 366 ACFs were identified in 89 patients;all had baseline adenomas removed at the first examination(year 0) colonoscopy and returned for the second(year 1).ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers,0-3 or over *** participants were examined in the number and maximum size of *** was no statistical difference in number and maximum size of ACF at year 0,however,maximum size of adenoma was larger in over 3 group than 0-3 group at year ***:The number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.