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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang qiuxia Peng Wen Qin Xuebing yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Rapid detection and risk assessment of soil contamination at lead smelting site based on machine learning

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 3054-3068页

作者： Sheng-guo XUE Jing-pei FENG Wen-shun KE Mu LI kun-yan qiu Chu-xuan LI Chuan WU Lin GUO School of Metallurgy and Environment Central South UniversityChangsha 410083China Henan Key Laboratory of Monitoring and Remediation in Heavy Metal Polluted Soil Jiyuan 454650China Henan Academy of Geology Zhengzhou 450000China

A general prediction model for seven heavy metals was established using the heavy metal contents of 207soil samples measured by a portable X-ray fluorescence spectrometer(XRF)and six environmental factors as model correction *** eXtreme Gradient Boosting(XGBoost)model was used to fit the relationship between the content of heavy metals and environment characteristics to evaluate the soil ecological risk of the smelting *** results demonstrated that the generalized prediction model developed for Pb,Cd,and As was highly accurate with fitted coefficients(R^(2))values of 0.911,0.950,and 0.835,*** presented the highest ecological risk,and there existed high potential ecological risk at some positions with different depths due to high mobility of ***,the application of machine learning significantly increased the accuracy of pXRF measurements,and identified key environmental *** adapted potential ecological risk assessment emphasized the need to focus on Pb,Cd,and As in future site remediation efforts.

关键词： smelting site potentially toxic elements X-ray fluorescence potential ecological risk machine learning

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Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li Qing Zhao Dong-Ao Mao kun Zhou Bao-Kuan Chen yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan yang Xinxin yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

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基于随机模拟的冶炼场地重金属污染及生态风险评价

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Transactions of Nonferrous Metals Society of China 2023年第10期33卷 3222-3234页

作者：罗兴华曾嘉庆吴川邱坤艳李超然可文舜薛生国中南大学冶金与环境学院长沙410083 河南大学纳米杂化材料应用技术国家地方联合工程研究中心开封475004

选择某铅冶炼场地,采用地统计学和铅同位素示踪法分析重金属空间分布格局和污染来源,并基于不确定性理论的风险模型,系统评估场地重金属生态风险。结果表明,土壤铅、锌、砷、镉、铬和汞污染严重,空间异质性强。采用MixSIAR模型解构3个... 详细信息

选择某铅冶炼场地,采用地统计学和铅同位素示踪法分析重金属空间分布格局和污染来源,并基于不确定性理论的风险模型,系统评估场地重金属生态风险。结果表明,土壤铅、锌、砷、镉、铬和汞污染严重,空间异质性强。采用MixSIAR模型解构3个潜在源的铅同位素贡献密度分布,土壤重金属主要来自冶炼活动(49.9%),燃煤(16.4%)和土壤母质(33.7%)。基于随机模拟的潜在生态风险指数(RI)表明,场地重金属处于中等生态风险;其中冶炼活动对RI累积贡献最大;镉、砷、铅和汞对RI的方差贡献最大,对场地的污染起主导作用。因此,应该优先关注场地土壤镉、砷、铅和汞污染的防控及潜在冶炼源的处置。

关键词：冶炼场地重金属铅同位素随机模拟生态风险

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凸轮高速磨削廓形误差模糊自适应PID迭代学习控制

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组合机床与自动化加工技术 2016年第9期 106-109,115页

作者：陈砚坤韩秋实彭宝营夏怀健北京信息科技大学机电工程学院北京100192

为提高凸轮轮廓加工精度,减少廓形误差,引入了模糊自适应PID迭代学习控制方法。基于X-C轴联动误差模型,通过分别对X、C轴进行模糊自适应PID迭代学习控制减少单轴的跟踪误差,从而减少凸轮廓形误差。基于MATLAB建立X、C轴模糊自适应PID迭... 详细信息

为提高凸轮轮廓加工精度,减少廓形误差,引入了模糊自适应PID迭代学习控制方法。基于X-C轴联动误差模型,通过分别对X、C轴进行模糊自适应PID迭代学习控制减少单轴的跟踪误差,从而减少凸轮廓形误差。基于MATLAB建立X、C轴模糊自适应PID迭代学习控制仿真模型并在不同磨削速度下进行仿真实验。结果表明:与常规控制方法相比,模糊自适应PID迭代学习控制能够在一定程度上提高凸轮的加工精度,并有效较小廓形误差。

关键词：凸轮廓形误差自适应迭代学习控制

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A 3-D Supramolecular Network with 1-D Cation Metal-organic Coordination Polymers,and Diverse Motifs from Hydrogen-bonded[M(H2O)4]-Carboxylates

A 3-D Supramolecular Network with 1-D Cation Metal-organic C...

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重庆市化学化工学会2009学术年会

作者： kun-Lin Huang~(a,*),yan-qiu Zuo~a,Jie Sun~b,Xin Chen~a,Hong-Ju Miao~a,Xi Liu~a and Hong Xu~a aCollege of Chemistry,Chongqing Normal University Chongqing 400047 bInstitute of Chemical Materials,China Academ y of Engineering Physics Mianyang 621900

The self-assembly of metal-organic supramolecular network from transition metal ions and organic moieties is in rapid progress because of their interesting molecular structures as well as their potential applications(such as catalysis, molecular recognition and their optical property) in the area of functional materials.M(HO) hydrated ion is an interesting subject for the investigation of the coordination behavior of metal ions and mixed ligands in water solution, and the construction of metal-organic hybrid materials in crystal engineering4].Although ditopic symmetry 1,

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美丽园区建设的路径研究

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生态经济 2025年第1期41卷 44-51页

作者：陈吕军严坤田金平清华大学环境学院北京100084 清华大学生态文明研究中心北京100084 清华大学碳中和研究院北京100084

建设美丽中国是全面建设社会主义现代化国家、实现中华民族永续发展的重要举措。中国工业园区历经四十多年发展历程,已经成为建设实体经济、引领区域发展的先行者,目前已聚集全国80%的工业企业,推动工业园区建设成为人与自然和谐共生的... 详细信息

建设美丽中国是全面建设社会主义现代化国家、实现中华民族永续发展的重要举措。中国工业园区历经四十多年发展历程,已经成为建设实体经济、引领区域发展的先行者,目前已聚集全国80%的工业企业,推动工业园区建设成为人与自然和谐共生的美丽园区,对我国生态文明建设意义重大。论文回顾了中国工业园区的发展历程,面向新发展阶段存在的新挑战和新机遇,提出了工业园区在新时代需承担的高质量发展使命任务。在此基础上,本文针对园区社会、经济、自然三个子系统,从六个方面解析并详细阐述了中国工业园区打造美丽园区、支撑美丽中国建设的关键内涵。进一步地,根据国家对美丽中国建设提出的目标和计划,结合我国生态工业园区发展过程中形成的实践经验,从八个维度提出工业园区推进美丽中国建设的关键行动,支撑工业园区生态文明建设和美丽中国行动。

关键词：美丽中国工业园区美丽园区绿色发展生态文明

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几种杂交鲟水库网箱养殖对比试验

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水产学杂志 2009年第3期22卷 47-50页

作者：孙剑刘传忠王坤朱艳秋泗水县虹鳟鱼良种场山东泗水273206

选择两杂交(史氏鲟♀×西伯利亚鲟♂)、小杂交(小体鲟♀×史氏鲟♂)、三杂交(史氏鲟♀×国外杂交鲟♂)、俄罗斯杂交(史氏鲟♀×俄罗斯鲟♂)、反杂交(西伯利亚鲟♀×史氏鲟♂)、大杂交(西伯利亚鲟♀×达氏鳇♂)进行了网箱养殖对比试验,... 详细信息

选择两杂交(史氏鲟♀×西伯利亚鲟♂)、小杂交(小体鲟♀×史氏鲟♂)、三杂交(史氏鲟♀×国外杂交鲟♂)、俄罗斯杂交(史氏鲟♀×俄罗斯鲟♂)、反杂交(西伯利亚鲟♀×史氏鲟♂)、大杂交(西伯利亚鲟♀×达氏鳇♂)进行了网箱养殖对比试验,选择两种国产鲟鱼饲料进行了试验对比,根据试验数据,计算成活率、饵料系数、公斤鱼的饲料成本、饲料经济效率、饲料蛋白质效率、群体相对增重率和群体重量生长率等相关经济技术指标,结果表明:两杂交、大杂交、反杂交、小杂交均体现出了较好的养殖效果,而三杂交、俄罗斯杂交则存在一定的问题。饲料对比结果A料的饲料蛋白质效率、群体相对增重率和群体重量生长率优于B料,但饲料经济效率不如B料。

关键词：网箱杂交鲟对比

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Performance analysis of a hybrid OCDMA/WDM system

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Frontiers of Optoelectronics 2009年第1期2卷 15-20页

作者： Hui yan kun qiu Yun LING Key Lab of Broadband Optical Fiber Communication and Communication Networks Technology University of Electronic Science and Technology of China

The performance of the hybrid optical codedivision multiple-access(OCDMA) and wavelength division multiplexing(WDM) network is analyzed. End-toend bit error rate(BER) of the network adopting error correction coding is calculated, and the expressions which show spectral efficiency performance, including the effects of polarization mode dispersion(PMD), are derived. The result demonstrates that PMD can decrease spectral efficiency dramatically. Analysis of the blocking performance with and without orthogonal optical codes(OOCs)and wavelength conversion shows that OOC and wavelength can improve the performance of the network. Since the wavelength conversion is much more costly than OOC conversion, a scheme for spare placement wavelength conversion is introduced to balance the cost and performance.

关键词： 52\98\fd\c3\hcm0000078371.html

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