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Blockchain-Based Key Management Scheme Using Rational Secret Sharing

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Computers, Materials & Continua 2024年第4期79卷 307-328页

作者： Xingfan Zhao Changgen Peng Weijie tan kun Niu State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China Guizhou Big Data Academy Guizhou UniversityGuiyang550025China

Traditional blockchain key management schemes store private keys in the same location,which can easily lead to security issues such as a single point of failure.Therefore,decentralized threshold key management schemes have become a research focus for blockchain private key protection.The security of private keys for blockchain user wallet is highly related to user identity authentication and digital asset security.The threshold blockchain private key management schemes based on verifiable secret sharing have made some progress,but these schemes do not consider participants’self-interested behavior,and require trusted nodes to keep private key fragments,resulting in a narrow application scope and low deployment efficiency,which cannot meet the needs of personal wallet private key escrow and recovery in public blockchains.We design a private key management scheme based on rational secret sharing that considers the self-interest of participants in secret sharing protocols,and constrains the behavior of rational participants through reasonable mechanism design,making it more suitable in distributed scenarios such as the public blockchain.The proposed scheme achieves the escrow and recovery of personal wallet private keys without the participation of trusted nodes,and simulate its implementation on smart contracts.Compared to other existing threshold wallet solutions and keymanagement schemes based on password-protected secret sharing(PPSS),the proposed scheme has a wide range of applications,verifiable private key recovery,low communication overhead,higher computational efficiency when users perform one-time multi-key escrow,no need for trusted nodes,and personal rational constraints and anti-collusion attack capabilities.

关键词： Blockchain smart contract rational secret sharing key management

Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： Xiao-xia BAN Hao WAN Xin-xing WAN Ya-ting tan Xi-min HU Hong-xia BAN Xin-yu CHEN kun HUANG Qi ZHANG kun XIONG Department of Human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human body.During normal metabolism,the human body maintains copper homeostasis.Copper deficiency or excess can adversely affect cellular function.Therefore,copper homeostasis is stringently regulated.Recent studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular copper.Cuproptosis induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster proteins.In neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper homeostasis.This review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative diseases.This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

Dynamic mechanical characteristics of deep Jinping marble in complex stress environments

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 630-644页

作者： Chendi Lou Heping Xie Ru Zhang Hai Ren Hao Luo kun Xiao Yuan Peng Qiang tan Li Ren Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610207China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science&Engineering Sichuan UniversityChengdu610065China Yalong River Hydropower Development Company Ltd.Chengdu610051China (Chongqing)International Engineering Technology Company Ltd.Chongqing401121China

To reveal the dynamic mechanical characteristics of deep rocks,a series of impact tests under triaxial static stress states corresponding to depths of 300-2400 m were conducted.The results showed that both the strain rates and the stress environments in depth significantly affect the mechanical characteristics of rocks.The sensitivity of strain rate to the dynamic strength and deformation modulus shows a negative correlation with depth,indicating that producing penetrative cracks in deep environments is more difficult when damage occurs.The dynamic strength shows a tendency to decrease and then increase slightly,but decreases sharply finally.Transmissivity demonstrates a similar trend as that of strength,whereas reflectivity indicates the opposite trend.Furthermore,two critical depths with high dynamically induced hazard possibilities based on the China Jinping Underground Laboratory(CJPL)were proposed for deep engineering.The first critical depth is 600-900 m,beyond which the sensitivity of rock dynamic characteristics to the strain rate and restraint of circumferential stress decrease,causing instability of surrounding rocks under axial stress condition.The second one lies at 1500-1800 m,where the wave impedance and dynamic strength of deep surrounding rocks drop sharply,and the dissipation energy presents a negative value.It suggests that the dynamic instability of deep surrounding rocks can be divided into dynamic load dominant and dynamic load induced types,depending on the second critical depth.

关键词： Rock mechanics Split-Hopkinson pressure bar Coupled static‒dynamic loading Different depths Holmquist-Johnson-Cook(HJC)model

Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

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China Foundry 2024年第1期21卷 82-90页

作者： kun Gao Yan Peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting process.The effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in detail.In each rotation,the casting wheel passes through four different spray zones.The results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,respectively.The temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones

Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo kun-Che Chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness worldwide.There is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after injury.Human stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative diseases.In this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation outcomes.Next,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and clusters.This review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

Limited value of procalcitonin,C-reactive protein,white blood cell,and neutrophil in detecting bacterial coinfection and guiding antibiotic use among children with enterovirus infection

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World Journal of Pediatrics 2022年第3期18卷 230-233页

作者： Rui-Mu Zhang kun tan Shu Fu Ji-Kui Deng Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China

Procalcitonin(PCT),C-reactive protein(CRP),and white blood cell(WBC)have been used as markers of bacterial infection in children for decades.Previous studies have suggested PCT,CRP,WBC,and percentage of neutrophils(%N)may be useful in detecting bacterial infection in children[1-4].However,elevated levels of these biomarkers have also been noted in children with enterovirus infection[5-7].In a study involving 5692 hospitalized children with herpangina or hand,foot,and mouth disease(HFMD)in two periods of years,the medians of CRP were 50.1 and 42.5 mg/L,respectively.

关键词： enterovirus infection elevated

Insight into the Permeability and Microstructure Evolution Mechanism of the Sliding Zone Soil: A Case Study from the Huangtupo Landslide, Three Gorges Reservoir, China

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Journal of Earth Science 2024年第3期35卷 941-954页

作者： Qianyun Wang Huiming tang Pengju An kun Fang Junrong Zhang Minghao Miao Qingwen tan Lei Huang Shengming Hu Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan 430074China Faculty of Engineering China University of GeosciencesWuhan 430074China Institute of Rock Mechanics Ningbo UniversityNingbo 315211China National and Provincial Joint Engineering Laboratory for the Hydraulic Engineering Safety and Efficient Utilization of Water Resources of Poyang Lake Basin Nanchang Institute of TechnologyNanchang 330099China

A large number of laboratory investigations related to the permeability have been conducted on the sliding zones.Yet little attention has been paid to the particular sliding zones of the slideprone Badong Formation.Here,we experimentally investigate the permeability nature and the mechanism of seepage in the viscous sliding zone of the Huangtupo Landslide.Saturated seepage tests have been performed first with consideration of six dry densities and thirteen hydraulic gradients,in conjunction with the mercury intrusion porosimetry test and scanning electron microscopy test for the microstructure analysis after seepage.The results show that seepage in the sliding zone soil does not follow Darcy’s Law,since there is a threshold hydraulic gradient(i0)below which no flow is observed and a critical hydraulic gradient(icr)over which the hydraulic conductivity(K)tends to be stable.The percentage of bound water could be responsible for the occurrence of i0 and icr.Furthermore,pore size distributions(PSD)less than 0.6µm and between 10 and 90µm exhibit positive and negative correlations with the i0,respectively,indicating that the i0 is related to the PSD.The mechanism accounting for this result is that pore water pressure forces fine clay particles into the surrounding large pores and converts arranged particles to discretely distributed ones,thereby weakening the connectivity of pores.The seepages in the sliding zones behave differently from that in the sliding mass and sliding bed in response to the permeability.

关键词： reservoir landslides sliding zone soil permeability microstructure seepage.

Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1193-1194页

作者： kun Wu Shuai Liu Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education) Affiliated Mental Health Center (ECNU) School of Psychology and Cognitive Science East China Normal University Shanghai Changning Mental Health Center NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai

Parkinson’s disease(PD) is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely overlo... 详细信息

关键词： MEMORY

Numerical simulation of fluid flow and free surface fluctuations during wheel and belt casting process

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1117-1126页

作者： kun Gao Yan Peng National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

The unstable fluid flow and severe free surface fluctuations in the wheel and belt caster can affect the quality of the cast bar.The lower level height tends to entrap inclusions in the molten metal.On the other hand,the higher level height makes the production process more dangerous due to the overflow of high temperature fluid from the mold.A computational model of the molten metal pouring process was established.The transient fluid flow and free surface fluctuations behavior were calculated using the three-dimensional large eddy simulation model and the volume of fluid model.The results show that the flow velocity of the main jet gradually decreases under the influence of the low kinetic energy fluid in the mold.There is an obvious oscillation in the tail of the jet,while the flow field is asymmetric in space.The jet is closer to the inside radius side due to the Coanda effect,and there is a recirculation zone on the inside radius and the outside radius respectively,according to the 10 s time-averaged results.Compared with the industrial observation and simulation results,the shape of the free surface is a wave that varies with time.In addition,the free surface height is lowest and the flow velocity is highest in the region near the jet.

关键词： Fluid flow Free surface Wheel and belt caster Large eddy simulation Volume of fluid method