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Study of Differential Serum Metabolites in Patients with Adenomatous Polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry

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Chinese Journal of Integrative Medicine 2022年第5期28卷 403-409页

作者： DU Wen-zhang ZHANG Ai-hua REN Jun-ling lyu kun TUO Lu-yao XU Wei Department of Integrated Traditional Chinese and Western Medicine First Affiliated Hospital of Harbin Medical UniversityHarbin(150001)China Metabolomics Laboratory Heilongjiang University of Chinese MedicineHarbin(150001)China

Objective:To study the differences between the serum metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those without colon polyps and with balanced constitution,and look for biomarkers that can be used to distinguish between the two ***:General patient information was gathered,and Chinese medicine constitutions were collected in 940 patients who underwent electronic colonoscopy.A total of 119 patients with adenomatous polyps of the colon and yang-deficiency constitution were included in the experimental group,and 150 patients without colon polyps and with balanced constitution were included in the control *** analysis was performed on the fasting venous blood obtained from each patient in both *** component analysis and orthogonal partial least squares discriminant analysis were performed on the detection results,potential biomarkers were screened,metabolic pathway changes were determined,and the metabolic processes involved were ***:A total of 59 differential biomarkers between the experimental group and the control group were *** differential metabolites were found mainly in the glycerophospholipid metabolism pathway,and the bile acid 3-oxo-4,6-choladienoic acid was the biomarker that distinguished the experimental group from the control ***:With the help of metabolomics analysis,the differential metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those in patients without colon polyps and with balanced constitution could be *** biomarker 3-oxo-4,6-choladienoic acid may have potential diagnostic value in patients with adenomatous polyp of the colon and yang-deficiency constitution.(Trial Registration ***02986308)

关键词： ultra-performance liquid chromatography-mass spectrometry adenomatous polyps yang-deficiency constitution Chinese medicine metabolomics biomarkers

Multi-alleles predict primary non-response to infliximab therapy in Crohn’s disease

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Gastroenterology Report 2021年第5期9卷 427-434,I0002页

作者： Cai-Bin Zhang Jian Tang Xue-Ding Wang kun-Sheng lyu Min Huang Xiang Gao Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Southern China Center for Statistical Science School of Mathematics Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Infliximab(IFX)is the first-line treatment for patients with Crohn’s disease(CD)and is noted for its relatively high *** therapeutic efficacy of IFX has noticeable individual *** single-gene polymorphisms(SNPs)are inadequate for predicting non-response to *** this study,we aimed to identify new genetic factors associated with IFX-therapy failure and to predict non-response to IFX by developing a multivariate predictive ***:In this retrospective study,we collected and analysed the data of Chinese patients with CD who received IFX therapy at one hospital between June 2013 and June *** non-response(PNR)and non-durable response(NDR)were evaluated using a simple endoscopic score for CD(SES-CD).A total of 125 SNPs within 44 genes were genotyped.A multivariate logistic-regression model was established to predict non-response to *** area-under-the-receiver-operatingcharacteristics curve(AUROC)was applied to evaluate the predictive model ***:Forty-two of 206(20.4%)patients experienced PNR and 15 of 159(9.4%)patients experienced *** SNPs were associated with PNR(P<0.05).A PNR predictive model was established,incorporating 2-week high-sensitivity C-reactive protein(hs-CRP),rs61886887,rs61740234,rs357291,rs2269330,and rs111504845,and the AUROC on training and testing data sets were 0.818(P<0.001)and 0.888(P<0.001),*** week 14,hs-CRP levels≥2.25 mg/L were significantly associated with NDR(AUROC=0.815,P<0.001).PNR-associated SNPs were not mutually associated with NDR,suggesting distinct mechanisms between PNR and ***:Genetic polymorphisms are significantly associated with response to IFX among Chinese CD patients.

关键词： infliximab Crohn’s disease single nucleotide polymorphism therapeutic response

Association of polymorphisms in C1orf106,IL1RN,and IL10 with post-induction infliximab trough level in Crohn’s disease patients

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Gastroenterology Report 2020年第5期8卷 367-373,I0002页

作者： Jian Tang Cai-Bin Zhang kun-Sheng lyu Zhong-Ming Jin Shao-Xing Guan Na You Min Huang Xue-Ding Wang Xiang Gao Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouGuangdongP.R.China Southern China Center for Statistical Science School of Mathematics Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Trough levels of the post-induction serum infliximab(IFX)are associated with short-term and long-term responses of Crohn’s disease patients to IFX,but the inter-individual differences are *** aimed to elucidate whether single gene polymorphisms(SNPs)within FCGR3A,ATG16L1,C1orf106,OSM,OSMR,NF-jB1,IL1RN,and IL10 partially account for these differences and employed a multivariate regression model to predict patients’post-induction IFX ***:The retrospective study included 189 Crohn’s disease patients undergoing IFX ***-induction IFX levels were measured and 41 tag SNPs within eight genes were *** between SNPs and IFX levels were ***,a multivariate logistic-regression model was developed to predict whether the patients’IFX levels achieved the threshold of therapy(3 lg/mL).Results:Six SNPs(rs7587051,rs143063741,rs442905,rs59457695,rs3213448,and rs3021094)were significantly associated with the post-induction IFX trough level(P=0.015,P<0.001,P=0.046,P=0.022,P=0.011,P=0.013,respectively).A multivariate prediction model of the IFX level was established by baseline albumin(P=0.002),rs442905(P=0.025),rs59457695(P=0.049),rs3213448(P=0.056),and rs3021094(P=0.047).The area under the receiver operating characteristic curve(AUROC)of this prediction model in a representative training dataset was *** result was verified in a representative testing dataset,with an AUROC of ***:Polymorphisms in C1orf106,IL1RN,and IL10 play an important role in the variability of IFX post-induction levels,as indicated in this multivariate prediction model of IFX levels with fair performance.

关键词： infliximab inflammatory bowel disease single nucleotide polymorphism trough level multivariate prediction model

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血管生成与髁突生长发育的关系及其临床价值

中华口腔医学杂志 2016年第12期51卷 774-777页

作者：董婷吕坤武汉大学口腔医学院口腔颌面创伤与整形美容外科 430079

血管生成是髁突软骨内骨化过程至关重要的步骤,受一系列内源性生长因子和调节因子调控.本文综述下颌骨髁突的生长发育与血管生成的关系,以及血管生成在调控髁突生长中的作用,并分析临床价值,以期为探讨髁突生长调控提供参考.

关键词：新生血管化,生理性下颌骨髁状突生长

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采动影响下特厚煤层巷道围岩支护技术

煤矿安全 2021年第2期52卷 105-112页

作者：吕坤煤炭科学技术研究院有限公司安全分院北京100013 煤炭资源高效开采与洁净利用国家重点实验室(煤炭科学研究总院) 北京100013 辽宁工程技术大学安全科学与工程学院辽宁阜新123000

针对酸刺沟煤矿特厚煤层巷道受2次采动影响后围岩支护困难的问题,采用理论分析、数值模拟与工程实践相结合的方法,分析了采动影响下特厚煤层巷道围岩破坏规律,提出了采动影响下特厚煤层巷道围岩分次支护技术,并进行了工程实践。结果表明... 详细信息

针对酸刺沟煤矿特厚煤层巷道受2次采动影响后围岩支护困难的问题,采用理论分析、数值模拟与工程实践相结合的方法,分析了采动影响下特厚煤层巷道围岩破坏规律,提出了采动影响下特厚煤层巷道围岩分次支护技术,并进行了工程实践。结果表明:一次采动影响下,巷道围岩塑性区呈“增大-平稳”趋势,主要表现为滞后影响,工作面后方300 m外,塑性区保持不变,二次采动影响下,巷道围岩塑性区呈“减小-平稳”趋势,工作面30 m范围内影响较大,随后逐渐趋于稳定,试验巷道围岩能够保持稳定。

关键词：特厚煤层采动影响塑性区破坏机理巷道支护

A novel experience of deferential vessel-sparing microsurgical vasoepididymostomy

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Asian Journal of Andrology 2018年第6期20卷 576-580页

作者： kun-Long lyu ]in-Tao Zhuang Philip S Li Yong Gao Liang Zhao Ya-Dong Zhang Ming-Kuan Zhou jing-Wei Yu Xin Feng Xiang-Zhou Sun Chun-Hua Deng Xiang-An Tu Department of Urology and Andrology The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000 China Department of Urology and Andrology The First Affiliated Hospital of Zhengzheu University Zhengzhou 450000 China Center for Male Reproductive Medicine and Microsurgery Department of Urology Weill Cornell Medicine of Cornell University New York NY 10065 USA Center for Reproductive Medicine Guangdong Provincial Key Laboratory of Reproductive Medicine The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000 China

Microsurgical longitudinal intussusception vasoepididymostomy （LIVE） has been widely used to treat epididymal obstructive azoospermia since 2004. Although the deferential vasculature plays an important role in supplying blood to the testis and epididymis, little attention has been paid to the potential benefits of sparing the deferential vessels during the anastomosis in LIVE. This study aimed to evaluate the efficacy and safety of deferential vessel-sparing LIVE in humans. From December 2013 to December 2015, 69 azoospermic men with epididymal obstruction due to a genital infection, trauma, or idiopathic factors underwent deferential vessel-sparing LIVE in the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. The outcomes of these patients were analyzed retrospectively. The mean age was 31.1 years for men and 28.3 years for their partners. Fifty-nine （85.5%, 59/69） men were followed up after surgery for approximately 16 months. Patency was noted and confirmed by semen analysis （〉10 000 sperm/ml） in 83.1% （49159） of men. The natural pregnancy rate was 40.7% （24/59） by the end of the study, with 87.5% （21124） of these natural pregnancies achieved within 12 months after surgery. No severe adverse events or complications were observed. In this study, we present a novel technique for sparing the deferential vessels during LIVE. The preliminary outcomes show this technique to be safe with favorable patency and pregnancy rates.

关键词： azoospermia infertility microsurgery vasoepididymostomy

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基于涡旋电磁波体制的三维SAR成像方法

雷达学报（中英文） 2021年第5期10卷 691-698页

作者：吕坤马晖刘宏伟西安电子科技大学雷达信号处理国家重点实验室西安710071

涡旋电磁波得名于其传播时围绕行进轴的旋转现象,该电磁属性被称为轨道角动量。基于其在方位角上的目标分辨能力,该文将涡旋电磁波引入传统的合成孔径成像中,提出了一种新的三维成像方案。在结合轨道角动量模态域之后,将合成孔径雷达二... 详细信息

涡旋电磁波得名于其传播时围绕行进轴的旋转现象,该电磁属性被称为轨道角动量。基于其在方位角上的目标分辨能力,该文将涡旋电磁波引入传统的合成孔径成像中,提出了一种新的三维成像方案。在结合轨道角动量模态域之后,将合成孔径雷达二维回波扩展到三维。首先,基于波形分集理论,获取同时多模态回波数据,并利用傅里叶变换(FT)变换到方位角维,形成距离-合成孔径方位-方位角三维数据。然后,基于Radon-FT,提出了一种联合二维方位压缩算法来生成三维目标成像。仿真结果验证了系统和算法的性能,证明了涡旋电磁三维合成孔径成像雷达系统的优越性。

关键词：涡旋电磁雷达轨道角动量合成孔径雷达拉东变换联合二维方位压缩

Experimental Simulation and Verification of Position Servo Control of Mechanical Rodless Cylinder

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Mechanical Engineering Science 2020年第2期2卷 25-34,I0005页

作者： Yeming ZHANG Kaimin LI Hongwei YUE Shuangyang HE Dongyuan LI kun lyu Feng WEI School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuoChina

In order to improve the position control accuracy of rodless cylinder,the valve control cylinder system based on pneumatic proportional servo is studied *** to the working principle of the mechanical rodless cylinder control system,under the condition of uniform speed,the driving voltage of the proportional valve is changed to measure multiple sets of friction force and corresponding velocity *** the physical structure of each component in pneumatic system,established the mathematical model of pneumatic system,and introduced MATLAB system identification toolbox to identify the parameters of the transfer *** the experiment verifies its correctness.

关键词： mechanical rodless cylinder friction characteristics mathematical model parameter identification

基于灰色GM(2,1)模型的工作面瓦斯涌出量预测

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煤炭技术 2014年第8期33卷 30-32页

作者：吕坤坤吕品张文庆安徽理工大学安徽淮南232001

利用灰色GM(2,1)模型理论建立了数学模型,对国投新集刘庄煤矿171302工作面进行了瓦斯涌出量预测。结果表明预测值与实际值之间的最大相对误差为8%,最小相对误差为0.09%,平均相对误差为4.64%,精度较高,可以应用于煤矿安全生产管理,减少... 详细信息

利用灰色GM(2,1)模型理论建立了数学模型,对国投新集刘庄煤矿171302工作面进行了瓦斯涌出量预测。结果表明预测值与实际值之间的最大相对误差为8%,最小相对误差为0.09%,平均相对误差为4.64%,精度较高,可以应用于煤矿安全生产管理,减少煤矿瓦斯事故的发生。

关键词： GM(2,1)模型瓦斯涌出量灰色理论