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Acceptance on colorectal cancer screening upper age limit in South Korea

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World Journal of Gastroenterology 2020年第27期26卷 3963-3974页

作者： Xuan Quy Luu Kyeongmin Lee Yun Yeong Lee Mina Suh Yeol Kim kui son choi Graduate School of Cancer Science and Policy National Cancer CenterGoyang-si 10408South Korea National Cancer Control Institute National Cancer CenterGoyang-si 10408South Korea

BACKGROUND The Korea National Cancer Screening Program currently provides screening for colorectal cancer(CRC)for adults older than 50 years with no upper age *** general,people are likely to only pay attention to the benefits of cancer screening and to neglect its *** consider the benefits of cancer screening as being far greater than the risks and are unaware that any potential benefits and harms can vary with *** To report acceptance of an upper age limit for CRC screening and factors associated therewith among cancer-free individuals in *** The present study analyzed data from the Korea National Cancer Screening Survey 2017,a nationally representative random sample of 4500 Korean individuals targeted for screening for the five most common types of cancer.A total of 1922 participants were included in the final *** baseline characteristics of the study population are presented as unweighted numbers and weighted *** univariate and multivariate logistic regression models were developed to examine factors related with acceptance of an upper age limit for CRC screening;subgroup analysis was also *** About 80%(1554/1922)of the respondents agreed that CRC screening should not be offered for individuals older than 80 ***,those who had never been screened for CRC had the highest acceptance rate(91%).Overall,screening history for CRC[screened by both fecal occult blood test and colonoscopy,adjusted odds ratio(aOR)=0.33,95%CI:0.22-0.50]and other cancers(aOR=0.55,95%CI:0.34-0.87),as well as a family history of cancer(aOR=0.66,95%CI:0.50-0.87),were negatively associated with acceptance of an upper age limit for CRC *** contrast,metropolitan residents(aOR=1.86,95%CI:1.29-2.68)and people who exercised regularly(aOR=1.42,95%CI:1.07-1.89)were more likely to accept an upper age *** subgrouping,we found gender,marital status,and lifetime smoking history among never-screened individuals and r

关键词： Colorectal cancer Cancer early detection Mass screening Patient participation Elderly Patients dropouts

Assessment of participant satisfaction with upper gastrointestinal endoscopy in South Korea

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World Journal of Gastroenterology 2011年第36期17卷 4124-4129页

作者： Hoo-Yeon Lee Sun Mi Lim Mi Ah Han Jae Kwan Jun kui son choi Myung-Il Hahm Eun-Cheol Park Department of Social Medicine College of MedicineDankook University201Manghyang-roDongnamguCheonan-siChungcheongnam-do 330-714South Korea National Cancer Control Institute National Cancer CenterGyeonggi-do 410-769South Korea Mi Ah HanDepartment of Preventive MedicineCollege of MedicineChosun UniversitySeoseok-dongDong-guGwangju 501-759South Korea Department of Preventive Medicine College of MedicineChosun UniversitySeoseok-dongDong-guGwangju 501-759South Korea National Cancer Control Institute National Cancer CenterGyeonggi-do 410-769South Korea Department of Health Administration and Management College of Medical ScienceSoonchunhyang UniversityShinchang-myunAsan-siChungcheongnam-do 336-745South Korea Department of Preventive Medicine and Institute of Health Services Research College of MedicineYonsei UniversitySeoul 120-752South Korea

AIM:To measure the perceived satisfaction with gastric cancer screening as part of the National Cancer Screening Program (NCSP) in South ***:Data were derived from the participantsin a satisfaction survey of the Quality Evaluation of National Cancer Screening in *** is a populationbased nationwide telephone survey of participants who were screened by the NCSP between May and October *** study included 4412 participants who provided full sets of data and who had upper endoscopies for the purpose of gastric cancer ***:The negative appraisal percentages for each of the seven questions were as follows:explanation in preparation for the upper endoscopy,12.3%;explanation about the process and procedure of the upper endoscopy,13.8%;explanation about any pain or discomfort related to the upper endoscopy,27.5%;level of pain during the procedure,30.3%;physical environment,16.2%;manner of the staff,11.2%,and privacy protection,8.8%.CONCLUSION:The critical issues identified by the Pareto analysis include the adequacy of the explanation about any pain or discomfort associated with the upper endoscopy and the level of pain experienced during the procedure.

关键词： Gastric cancer Cancer screening Upper endoscopy Satisfaction

Unlocking power of neighboring vacancies in boosting hydrogen evolution reactions on two-dimensional NiPS3 monolayer

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eScience 2024年第3期4卷 104-115页

作者： Hyun Gu Han Jae Won choi Minsu son Ki Chul Kim Computational Materials Design Laboratory Department of Chemical EngineeringKonkuk UniversitySeoul 05029The Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul 05029The Republic of Korea

This study investigates the effect of defect engineering on the catalytic activity of a NiPS3 monolayer catalyst for the hydrogen evolution reaction(HER).Three different types of vacancies on the basal plane of the monolayer are explored through a multi-step mechanism involving the dissociative adsorption of a water molecule and subsequent electrochemical adsorption of the dissociated ***-formation of vacancies in both Ni and S sites is found to be the most effective in enhancing the catalytic performance of the monolayer.A key resource for the reaction thermodynamics is the S-substitution-like physisorption of a water molecule on a vacant S site,followed by the dissociative occupation of OH and H into vacant sites of S and Ni elements,boosted by the NiS di-vacancy configuration with low activation energy *** reveals the highest contribution of bonding orbitals to the monolayer-H bond makes it the most desirable defect engineering approach for transition metal phosphorus chalcogenides with high HER ***,this study highlights the significance of controlled defect engineering in augmenting the catalytic performance of NiPS3 monolayer catalysts for HER.

关键词： Hydrogen evolution reaction Defect engineering Transition metal phosphorus trichalcogenide Density functional theory Reaction thermodynamics

Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1903-1918页

作者： Yonghyun choi Wooic son Youngpin Han Jayoung Chae Chul-Su Yang Jonghoon choi School of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Molecular&Life Science Hanyang UniversityAnsan 15588Republic of Korea Center for Bionano Intelligence Education and Research Hanyang UniversityAnsan 15588Republic of Korea

Interaction between tumour cells and macrophages enables cancer cells to evade immune detection and clearance by interfering with macrophage *** anti-phagocytic signals regulated by anti-phagocytic proteins are termed"don't eat me"signals;these signals include sialic acidbinding immunoglobulin-type lectin-10(Siglec-10)and the recently revealed CD24 immune checkpoint(ICP).In this study,we demonstrate that targeting a specific glycan on CD24 exhibits the potential to inhibit *** nigra agglutinin(SNA),a sialic acid-binding lectin,was employed to block CD24 and to enhance phagocytosis in melanoma *** addition,we prepared SNA-conjugated hollow gold-iron oxide nanoparticles for photothermal therapy of *** findings show that the combination treatment of SNA-conjugated photothermal nanoparticles and near-infrared exposure successfully augments tumour cell phagocytosis both in vitro and in vivo models.

关键词： Immunotherapy Macrophages Phagocytosis Lectin Melanoma cancer Photothermal nanoparticles Immune checkpoint Glycan

Exploiting the quantum mechanically derived force field for functional materials simulations

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npj Computational Materials 2021年第1期7卷 1405-1413页

作者： Alexey Odinokov Alexander Yakubovich Won-Joon son Yongsik Jung Hyeonho choi Samsung R&D Institute Russia(SRR) Samsung Electronics12 Dvintsev StreetMoscow 127018Russia Data and Information Technology Center Samsung ElectronicsHwaseong 18448Korea Samsung Advanced Institute of Technology(SAIT) Samsung Electronics130 Samsung-roYeongtong-guSuwon 16678Korea

The computational design of functional materials relies heavily on large-scale atomistic *** simulations are often problematic for conventional classical force fields,which require tedious and time-consuming parameterization of interaction *** problem can be solved using a quantum mechanically derived force field(QMDFF)—a system-specific force field derived directly from the first-principles *** present a computational approach for atomistic simulations of complex molecular systems,which include the treatment of chemical reactions with the empirical valence bond *** accuracy of the QMDFF is verified by comparison with the experimental properties of liquid *** illustrate the capabilities of our methodology to simulate functional materials in several case studies:chemical degradation of material in organic light-emitting diode(OLED),polymer chain packing,material morphology of organometallic *** presented methodology is fast,accurate,and highly automated,which allows its application in diverse areas of materials science.

关键词： functional field quantum

Sulfur-doped hard carbon hybrid anodes with dual lithium-ion/metal storage bifunctionality for high-energy-density lithium-ion batteries

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Carbon Energy 2023年第1期5卷 71-81页

作者： Sungmin Cho Jong Chan Hyun son Ha Yeonhua choi Honggyu Seong Jaewon choi Hyoung-Joon Jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Departmant of Chemistry and Research Institute of Natural Science Gyeongsang National UniversityJinjuSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Division of Energy Engineering Kangwon National UniversityGangwon-doSouth Korea

Bifunctional hybrid anodes(BHAs),which are both a high-performance active host material for lithium-ion storage as well as a guiding agent for homogeneous lithium metal nucleation and growth,exhibit significant potential as anodes for next-generation high-energy-density lithium-ion batteries(LIBs).In this study,sulfur-doped hard carbon nanosphere assemblies(S-HCNAs)were prepared through a hydrothermal treatment of a liquid organic precursor,followed by high-temperature thermal annealing with elemental sulfur for application as BHAs for *** a carbonate-based electrolyte containing fluoroethylene carbonate additive,the S-HCNAs showed high lithium-ion storage capacities in sloping as well as plateau voltage sections,good rate capabilities,and stable *** addition,high average Coulombic efficiencies(CEs)of~96.9%were achieved for dual lithium-ion and lithium metal storage *** the LIB full-cell tests with typical NCM811 cathodes,the S-HCNA-based BHAs containing~400 mA h g^(−1) of excess lithium led to high energy and power densities of~500Wh kg^(−1) and~1695Wkg^(−1),respectively,and a stable cycling performance with~100%CEs was achieved.

关键词： hard carbon hybrid anode lithium-ion batteries lithium metal anode lithium metal batteries sulfur-doped carbon

Depth perception on fundus images using a single-channel stereomicroscopy

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 68-76页

作者： Edalat Radfar Hyunseon Yu Tien son Ho Seung Ho choi Byungjo Jung Department of Biomedical Engineering Yonsei University Wonju-siGangwon-do 26493 Republic of Korea Research Center for Science and Technology in Medicine Tehran University of Medical Sciences Tehran 14185-615Iran Institute of Metabolism and Systems Research University of Birmingham Edgbaston Birmingham B152TTUK

Typical fundus photography produces a two-dimensional *** makes it difficult to observe the microvascular and neural abnormalities,because the depth of the image is *** provide depth appreciation,we develop a single-channel stereoscopic fundus video imaging sys-tem based on a rotating *** respect to the pupil center,the rotating refractor laterally displaces the optical path and the *** allows standard monocular fundus cameras to generate stereo-parallax and image disparity through sequential image *** opti-mize our imaging system,characterize the stereo-base,and image an eyeball model and a rabbit *** virtual realities are considered,our imaging system can be a simple yet efficient technique to provide depth perception in a virtual space that allows users to perceive abnor-malities in the eye fundus.

关键词： Imaging systems ophthalmic optics and devices refraction vision-binocular and stereopsis

Isolation, identification, Pb(Ⅱ) biosorption isotherms and kinetics of a lead adsorbing Penicillium sp. MRF-1 from South Korean mine soil

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Journal of Environmental Sciences 2010年第7期22卷 1049-1056页

作者： Natarajan Velmurugan Grim Hwang Muthuswamy Sathishkumar Tae Kie choi kui-Jae Lee Byung-Taek Oh Yang-Soo Lee Department of Forest Science and Technology Institute of Agriculture and Life SciencesChonbuk National University College of Agriculture and Life Sciences Seoul National University Singapore-Delft Water Alliance National University of Singapore2 Engineering Drive 2 Division of Biotechnology College of Environment and Bioresources SciencesChonbuk National University

A heavy metal contaminated soil sample collected from a mine in Chonnam Province of South Korea was found to be a source of heavy metal adsorbing biosorbents. Chemical analyses showed high contents of lead （Pb） at 357 mg/kg and cyanide （CN） at 14.6 mg/kg in the soil. The experimental results showed that Penicillium sp. MRF-1 was the best lead resistant fungus among the four individual metal tolerant fungal species isolated from the soil. Molecular characterization of Penicillium sp. MRF-1 was determined using ITS regions sequences. Effects of pH, temperature and contact time on adsorption of Pb（Ⅱ） by Penicillium sp. MRF-1 were studied. Favorable conditions for maximum biosportion were found at pH 4 with 3 hr contact time. Biosorption of Pb（Ⅱ） gradually increased with increasing temperature. Efficient performance of the biosorbent was described using Langmuir and Freundlich isotherms. Adsorption kinetics was studied using pseudo first-order and pseudo second-order models. Biosorbent Penicillium sp. MRF-1 showed the maximum desorption in alkali conditions. Consistent adsorption/desorption potential of the biosorbent in repetitive cycles validated the efficacy of it in large scale. SEM studies given notes on surface modification of fungal biomass under metal stress and FT-IR results showed the presence of amino groups in the surface structure of the biosorbent. In conclusion, the new biosorbent Penicillium sp. MRF- 1 may potentially be used as an inexpensive, easily cultivatable material for the removal of lead from aqueous solution.

关键词： heavy metal resistant fungus Penicillium sp. biosorption isotherms kinetics

Changes in the distribution of South Korean forest vegetation simulated using thermal gradient indices

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Science China(Life Sciences) 2010年第7期53卷 784-797页

作者： choi Sungho LEE Woo-Kyun son Yowhan YOO Seongjin LIM Jong-Hwan Department of Environmental Science and Ecological Engineering Korea University Korea Forest Research Institute

To predict changes in South Korean vegetation distribution,the Warmth Index(WI) and the Minimum Temperature of the Coldest Month Index(MTCI) were *** climate data of the past 30 years,from 1971 to 2000,was obtained from the Korea Meteorological *** Fifth-Generation National Center for Atmospheric Research(NCAR) /Penn State Mesoscale Model(MM5) was used as a source for future climatic data under the A1B scenario from the Special Report on Emission Scenario(SRES) of the Intergovernmental Panel on Climate Change(IPCC).To simulate future vegetation distribution due to climate change,the optimal habitat ranges of Korean tree species were delimited by the thermal gradient indices,such as WI and *** categorize the Thermal Analogy Groups(TAGs) for the tree species,the WI and MTCI were orthogonally plotted on a two-dimensional grid *** TAGs were then designated by the analogue composition of tree species belonging to the optimal WI and MTCI *** a result of the clustering process,22 TAGs were generated to explain the forest vegetation distribution in *** primary change in distribution for these TAGs will likely be in the shrinkage of areas for the TAGs related to Pinus densiflora and ***,and in the expansion of the other TAG areas,mainly occupied by evergreen broad-leaved trees,such as Camellia japonica,Cyclobalanopsis glauca,and Schima *** the TAGs to explain the effects of climate change on vegetation distribution on a more regional scale resulted in greater detail than previously used global or continental scale vegetation models.

关键词： climate change forest distribution warmth index minimum temperature thermal analogy group